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DTSTART:20250330T010000
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DTSTART;TZID=Europe/Prague:20250623T150000
DTEND;TZID=Europe/Prague:20250623T160000
DTSTAMP:20260420T085624
CREATED:20250319T134811Z
LAST-MODIFIED:20250319T135059Z
UID:2334-1750690800-1750694400@www.biomed.cas.cz
SUMMARY:Prof. Bradley Launikonis\, The University of Queensland\, Brisbane\, Australia
DESCRIPTION:Lecture „The role of ryanodine receptors in muscle function“ \nRyanodine receptors (RyR) are the Ca2+ release channel of skeletal muscle\, which are responsible for rapidly releasing a large amount of Ca2+ upon electrical stimulation to evoke contraction. In the resting muscle\, RyR leak Ca2+ and require the expenditure of energy to maintain steady state Ca2+ content of the intracellular Ca2+ store. It is this function that regulates multiple processes in the muscle\, including the regulation of Ca2+ permeability of the plasma membrane and distribution of Ca2+ across the intracellular compartments\, non-shivering thermogenesis and adaptation to changes in muscle activity. In this talk I will describe how RyR basal function controls the movements of Ca2+ between cellular compartments following changes in the RyR due to mutations\, intense exercise and changes in activity. To do this I will present novel techniques for measuring Ca2+ movements and heat generation within the fibre that we have used in conjunction with muscle from transgenic mice and fibres isolated from biopsies of human muscle.
URL:https://www.biomed.cas.cz/event/lecture-the-role-of-ryanodine-receptors-in-muscle-function/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250623T150000
DTEND;TZID=Europe/Prague:20250623T160000
DTSTAMP:20260420T085624
CREATED:20250423T073953Z
LAST-MODIFIED:20250423T073953Z
UID:2366-1750690800-1750694400@www.biomed.cas.cz
SUMMARY:Lecture „The role of ryanodine receptors in muscle function“
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/lecture-the-role-of-ryanodine-receptors-in-muscle-function-2/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
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