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DTSTART:20250330T010000
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DTSTART;TZID=Europe/Prague:20251001T150000
DTEND;TZID=Europe/Prague:20251001T160000
DTSTAMP:20260421T214403
CREATED:20250922T140000Z
LAST-MODIFIED:20250922T140000Z
UID:2408-1759330800-1759334400@www.biomed.cas.cz
SUMMARY:Seminář Vadym Sulimenko
DESCRIPTION:“Regulation of microtubule organization in glioblastoma cells by GIT2 phosphorylation” \nGlioblastoma\, the most aggressive common type of brain cancer in humans\, carries a very poor prognosis for patient survival. Microtubules are critical for cell division and mesenchymal migration\, processes that strongly influence tumor viability and invasiveness. While the reorganization of highly dynamic microtubules is central to these events\, the mechanisms by which microtubules contribute to glioblastoma cell motility remain poorly understood. We previously demonstrated that ARF GTPase-activating proteins (GITs) associate with γ-tubulin ring complex (γTuRC) proteins. Here\, we show that GIT2 localizes to centrosomes\, regulates microtubule organization and cell motility. Our findings indicate that the ArfGAP domain of GIT2 and protein kinase C (PKC) are essential for controlling microtubule nucleation. Furthermore\, we demonstrate that glioblastoma cells can be effectively treated with newly developed functionalized upconverting nanoparticles (UCNPs)\, which represent a promising new approach for photodynamic therapy of glioblastoma.
URL:https://www.biomed.cas.cz/event/seminar-vadym-sulimenko/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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