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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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TZID:Europe/Prague
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DTSTART:20250330T010000
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DTSTART:20251026T010000
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DTSTART;TZID=Europe/Prague:20251126T150000
DTEND;TZID=Europe/Prague:20251126T160000
DTSTAMP:20260420T060521
CREATED:20251118T072631Z
LAST-MODIFIED:20251118T072631Z
UID:2461-1764169200-1764172800@www.biomed.cas.cz
SUMMARY:Seminář Tomas Paulenda
DESCRIPTION:“The immunoregulatory properties of the metabolite itaconate” \nIn this talk I will present my latest findings of the function of immunoregulatory metabolite itaconate. Itaconate accumulates in innate immune cells upon Toll-like receptor stimulation. In response to macrophage activation by lipopolysaccharide\, itaconate inhibits inflammasome activation and boosts type I interferon signalling; however\, the molecular mechanism of this immunoregulation remained unclear. Here\, we show that the enhancement of type I interferon secretion by itaconate depends on the inhibition of peroxiredoxin 5 and on mitochondrial reactive oxygen species. We find that itaconate non-covalently inhibits peroxiredoxin 5\, leading to the modulation of mitochondrial peroxide in activating macrophages. Through genetic manipulation\, we confirm that peroxiredoxin 5 modulates  type I interferon secretion in macrophages. The non-electrophilic itaconate mimetic 2-methylsuccinate inhibits peroxiredoxin 5 and phenocopies immunoregulatory action of itaconate on type I interferon and inflammasome activation\, providing further support for a non-covalent inhibition of peroxiredoxin 5 by itaconate. Our work shows Peroxiredoxin 5 as a novel Type I interferon regulator with big potential to future research of redox regulation of immune responses.
URL:https://www.biomed.cas.cz/event/seminar-tomas-paulenda/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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