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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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TZID:Europe/Prague
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DTSTART:20260329T010000
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DTSTART:20261025T010000
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DTSTART;TZID=Europe/Prague:20260114T150000
DTEND;TZID=Europe/Prague:20260114T160000
DTSTAMP:20260420T173135
CREATED:20260105T115716Z
LAST-MODIFIED:20260105T121039Z
UID:2471-1768402800-1768406400@www.biomed.cas.cz
SUMMARY:Seminář Viktor Bugajev
DESCRIPTION:“Multiple Layers of Control in Early Sphingolipid Biosynthesis” \nSphingolipids are fundamental components of cellular membranes and key mediators of intracellular signaling. Their de novo synthesis is initiated in the endoplasmic reticulum (ER) and is tightly regulated at the level of the serine palmitoyltransferase (SPT) complex. ORMDL proteins are established canonical negative regulators of SPT activity\, thereby maintaining sphingolipid homeostasis. In this seminar\, we demonstrate that ceramides act as major regulators of ORMDL expression levels and identify a previously unrecognized ORMDL interactor that establishes a novel relationship between ORMDL expression and sphingolipid abundance\, reminiscent of dysregulated sphingolipid metabolism observed in pathological conditions. These findings uncover an additional layer of control over the sphingolipid pathway and highlight unexpected flexibility in ORMDL-dependent regulation of de novo sphingolipid biosynthesis.
URL:https://www.biomed.cas.cz/event/seminar-viktor-bugajev/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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