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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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TZID:Europe/Prague
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DTSTART:20260329T010000
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DTSTART:20261025T010000
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DTSTART;TZID=Europe/Prague:20260128T150000
DTEND;TZID=Europe/Prague:20260128T160000
DTSTAMP:20260418T072756
CREATED:20260112T073717Z
LAST-MODIFIED:20260112T073717Z
UID:2474-1769612400-1769616000@www.biomed.cas.cz
SUMMARY:Seminář Lorena Arranz
DESCRIPTION:“Therapeutic targeting of stem cells and their niches in myeloid malignancies” \nOur research group “Stem Cells\, Ageing and Cancer” aims at providing insights into mechanisms of hematopoietic stem cell malignant transformation\, including interactions of this cell with its surrounding microenvironment\, and a focus on inflammation\, signaling oncometabolites and various cellular components of the stem cell niche. Our goal is the identification of novel therapeutic targets of potential clinical interest for myeloid malignancies. \nWe will give an overview of our research and present unpublished observations accepted in principle in Nature Communications\, where we have uncovered an important role for the metabolite succinate and its membrane receptor Succinate receptor (Sucnr1) in the regulation of hematopoiesis in health and malignancy. Our work suggests that Sucnr1 signaling restricts hematopoiesis at least partially via the hematopoietic stem and progenitor cell compartment and control of S100a9. The dysregulation of Sucnr1 emerges as contributor to malignancy\, accounting for SUCNR1 expression as a predictor of prognosis in acute myeloid leukemia (AML) patients and opening new potential therapeutic avenues for these patients.
URL:https://www.biomed.cas.cz/event/seminar-lorena-arranz/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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