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DTSTART:20260329T010000
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DTSTART;TZID=Europe/Prague:20260218T150000
DTEND;TZID=Europe/Prague:20260218T160000
DTSTAMP:20260418T040535
CREATED:20260209T151442Z
LAST-MODIFIED:20260209T151442Z
UID:2484-1771426800-1771430400@www.biomed.cas.cz
SUMMARY:Seminář Pranav Gulati
DESCRIPTION:“Initiating Mechanisms of Autoinflammatory Osteomyelitis: dysregulated neutrophil recruitment and tyrosine kinase signaling” \nAutoinflammatory diseases result from inappropriate activation of the innate immune system in the absence of infection. Loss of PSTPIP2\, a membrane adaptor protein\, leads to the development of one such disease Chronic Multifocal Osteomyelitis (CMO)\, an autoinflammatory disease in mice which serves as a model for Chronic Recurrent Multifocal Osteomyelitis (CRMO) in humans. Neutrophils are essential for murine CMO initiation and contribute to tissue damage\, but the early events that trigger their pathogenic activity remain poorly defined. Our work shows that early alterations in neutrophil signaling and migration precede both classical inflammatory cytokine responses and the appearance of overt disease symptoms. Pharmacological inhibition of some of these early pathways reduces disease severity and neutrophil activation. Together\, these findings identify the initiating mechanisms of sterile bone inflammation in the mouse model of autoinflammatory osteomyelitis and provide potential targets for therapeutic intervention.
URL:https://www.biomed.cas.cz/event/seminar-pranav-gulati/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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