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X-ORIGINAL-URL:https://www.biomed.cas.cz
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TZID:Europe/Prague
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DTSTART:20230326T010000
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DTSTART:20231029T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231102T140000
DTEND;TZID=Europe/Prague:20231102T144500
DTSTAMP:20260418T205601
CREATED:20231027T103432Z
LAST-MODIFIED:20231027T103844Z
UID:681-1698933600-1698936300@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 11/2023
DESCRIPTION:Single-cell gene expression analysis of developing craniofacial region\nLecturer: Erika Hudáčová\, M.Sc. / Department of Developmental Biology \nThe seminar will take place on 2. 11. 2023 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nAnnotation: In vertebrates\, the skull is composed of various skeletal elements originating from cranial neural crest cells (CNCCs). CNCCs are responsible for the formation of the cranium vault\, frontonasal prominence\, upper and lower jaw\, hyoid bone\, external ear and middle ear. The morphogenesis of the craniofacial region encompasses a number of processes\, from epithelial-mesenchymal induction and mesenchymal condensation to endochondral or intramembranous ossification. However\, the molecular and genetic pathways regulating cranial cartilage shaping and growth during embryogenesis are poorly understood. \nIn our research\, we present Wnt1-Cre2\, Meis2 conditional knock-out (cKO) mice with several craniofacial bone abnormalities resembling severe human pathologies due to improper molecular mechanisms guiding mesenchymal condensation. Using single-cell RNA sequencing\, we further focus on describing the Meis2-dependent gene regulatory network involved in mesenchymal condensation. Comparison of wild-type and Meis2 cKO embryonic stages E12.5 and E13.5 reveals multiple mesenchymal cell types responsible for craniofacial formation. We have identified markers for cell type specification and positional cues in developing craniofacial regions. Furthermore\, differences identified in specific cell types governing mesenchymal condensation and endochondral ossification correlate with the phenotype present in Meis2 cKO mice. Our transcriptomics data in Meis2 cKO show elevated expression of the genes involved in ossification\, cell-cell adhesion and cell-extracellular matrix contact. Altogether\, the identification of hitherto unknown factors controlling the growth and shape of cranial bones may potentially contribute to the mitigation or prevention of human craniofacial abnormalities. \nWe look forward to your participation. \n  \n 
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-11-2023/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231106T150000
DTEND;TZID=Europe/Prague:20231106T160000
DTSTAMP:20260418T205601
CREATED:20231030T111804Z
LAST-MODIFIED:20231030T111804Z
UID:694-1699282800-1699286400@www.biomed.cas.cz
SUMMARY:Lecture "Clocks in our body – how do they synchronize to shape our physiology?"
DESCRIPTION:Prof. PharmDr. Alena Sumová\, DSc.\, Laboratory of Biological Rhythms\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture-clocks-in-our-body-how-do-they-synchronize-to-shape-our-physiology/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231108T150000
DTEND;TZID=Europe/Prague:20231108T160000
DTSTAMP:20260418T205601
CREATED:20231107T075625Z
LAST-MODIFIED:20231107T075625Z
UID:706-1699455600-1699459200@www.biomed.cas.cz
SUMMARY:Seminář – Assoc. Prof. Pavel Plevka
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/seminar-assoc-prof-pavel-plevka/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20231109
DTEND;VALUE=DATE:20231110
DTSTAMP:20260418T205601
CREATED:20231004T074439Z
LAST-MODIFIED:20231004T074439Z
UID:670-1699488000-1699574399@www.biomed.cas.cz
SUMMARY:Den otevřených dveří - FGÚ
DESCRIPTION:Začátek v 9\,00 hod a ve 13\,00 hod.
URL:https://www.biomed.cas.cz/event/den-otevrenych-dveri-fgu/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20231110
DTEND;VALUE=DATE:20231111
DTSTAMP:20260418T205601
CREATED:20231027T104223Z
LAST-MODIFIED:20231027T104417Z
UID:683-1699574400-1699660799@www.biomed.cas.cz
SUMMARY:IEM CAS Open House Day / Week of the Czech Academy of Sciences Festival
DESCRIPTION:Week of the Czech Academy of Sciences is a science festival that follows the previous Week of Science and Technology of the CAS. The festival offers scientific lectures\, exhibitions\, events at institutes\, documentary films\, workshops and many other activities across the Czech Republic and all scientific disciplines. As part of the festival\, the IEM CAS traditionally organises an Open House Day\, which includes individual and group excursions around the research departments\, as well as a cycle of lectures which presents the latest discoveries and achievements of the IEM CAS to the public. The morning programme is focused primarily on high school students. \nRegistration
URL:https://www.biomed.cas.cz/event/open-house-day-of-the-iem-cas-week-of-the-czech-academy-of-sciences-festival/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231113T150000
DTEND;TZID=Europe/Prague:20231113T160000
DTSTAMP:20260418T205601
CREATED:20231030T111844Z
LAST-MODIFIED:20231030T111844Z
UID:697-1699887600-1699891200@www.biomed.cas.cz
SUMMARY:Lecture "Gliflozins in the treatment of non-diabetic cardiovascular diseases"
DESCRIPTION:RNDr. Ivana Vaněčková\, DSc.\, Laboratory of Experimental Hypertension\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture-gliflozins-in-the-treatment-of-non-diabetic-cardiovascular-diseases/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231114T090000
DTEND;TZID=Europe/Prague:20231114T150000
DTSTAMP:20260418T205601
CREATED:20231107T075453Z
LAST-MODIFIED:20231107T075453Z
UID:704-1699952400-1699974000@www.biomed.cas.cz
SUMMARY:Den otevřených dveří ÚMG / IMG Open House Day
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/den-otevrenych-dveri-umg-img-open-house-day/
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231115T150000
DTEND;TZID=Europe/Prague:20231115T160000
DTSTAMP:20260418T205601
CREATED:20231107T122449Z
LAST-MODIFIED:20231108T090525Z
UID:711-1700060400-1700064000@www.biomed.cas.cz
SUMMARY:Seminář - Prof. Jiří Forejt\, M.D.\, Ph.D.\, DSc.
DESCRIPTION:“Genetic architecture of Prdm9-driven reproductive isolation between mouse subspecies” \nHybrid incompatibility\, the inviability or infertility of species hybrids\, has played a central role in speciation research since Darwin’s Origin of Species. However\, the search for genes controlling hybrid sterility\, mainly using Drosophila species hybrids\, has been largely unsuccessful\, revealing a polygenic control with complex epistatic interactions. Fifty years ago\, we identified the first hybrid sterility locus\, Hst1\, in the house mouse genome\, and 14 years ago\, we positionally cloned Prdm9 as the gene responsible for Hst1-controlled hybrid sterility. \nIn this talk\, I will summarize our current understanding of the molecular genetic mechanisms that control this unique model of mammalian hybrid sterility.
URL:https://www.biomed.cas.cz/event/seminar-prof-jiri-forejt-m-d-ph-d-dsc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231120T143000
DTEND;TZID=Europe/Prague:20231120T160000
DTSTAMP:20260418T205601
CREATED:20231115T140331Z
LAST-MODIFIED:20231115T140803Z
UID:718-1700490600-1700496000@www.biomed.cas.cz
SUMMARY:IEM CAS Distinguished Guest Seminar Series - Prof. Jens Pahnke
DESCRIPTION:ABC transporter blood-brain barrier function in neurodegenerative and neuroinflammatory diseases – from basic research to treatment\nLecturer: Prof. Jens Pahnke\, M.D.\, Ph.D.\, E.F.N./ University of Oslo\, Faculty of Medicine / Oslo University Hospital\, Department of Pathology\, Norway \nThe seminar will take place on 20. 11. 2023 from 2:30 p.m. in the Turquoise Auditorium of the IEM CAS. \nAnnotation: \nThe current understanding of neurodegenerative diseases focusses on the deposition of toxic peptide species as larger aggregates in the brain of effected individuals. However\, patients with sporadic neurodegenerative diseases do not overexpress these peptides. Moreover\, they are hampered in removing the physiologically produced peptides\, e.g. Aβ and α-synuclein. The blood-brain barrier plays a prominent role in the active and effective removal of metabolites and in the efflux of toxic peptides from the brain into the blood stream. \nHere\, ABC transporters were discovered by us and others to have a fundamental role in the homeostasis of the brain’s environment. In 2011\, we described a new ABC transporter (ABCC1) that increases Aβ in the brain of knock-out animals by 12-14fold. Since then\, we could show that the activation of ABC transporters can be used as a diagnostic tool and a new treatment option in elderly with Alzheimer’s disease and other neurodegenerative diseases\, such as Huntington’s disease. \n1 Pahnke\, J. et al. Free Neuropathol 2\, 33\, (2021)\n2 Pahnke\, J. et al. Neurobiol Dis 72 Pt A\, 54-60\, (2014)\n3 Pahnke\, J. et al. Curr Alzheimer Res 5\, 396-405\, (2008) \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-distinguished-guest-seminar-series-prof-jens-pahnke/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231120T150000
DTEND;TZID=Europe/Prague:20231120T160000
DTSTAMP:20260418T205601
CREATED:20231030T111926Z
LAST-MODIFIED:20231030T111926Z
UID:700-1700492400-1700496000@www.biomed.cas.cz
SUMMARY:Lecture
DESCRIPTION:Laboratory of Developmental Epileptology\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231122T150000
DTEND;TZID=Europe/Prague:20231122T160000
DTSTAMP:20260418T205601
CREATED:20231115T123407Z
LAST-MODIFIED:20231115T134822Z
UID:714-1700665200-1700668800@www.biomed.cas.cz
SUMMARY:Seminář - RNDr. Ondřej Mihola\, Ph.D.
DESCRIPTION:“A chance for fertility despite bad DNA breaks (AKA The effect of crossing-over rate on fertility)” \nProgrammed meiotic DNA breaks are essential for mammalian fertility but dangerous for genome integrity. DNA-binding H3-lysine-trimethyltransferase PRDM9 determines the positions of the meiotic DNA breaks\, which can be repaired as crossovers or noncrossovers. The crossover/noncrossover decision is regulated by many factors that include RING-domain E3 ligase RNF212. The dosage of the Rnf212 gene in mouse affects the crossover rate per meiotic cell and variants in the human RNF212 gene are associated with crossover rates. Deficiency for RNF212 leads to complete arrest of meiosis at the metaphase stage. The deficiency for human and rodent PRDM9 causes partial to complete pachytene arrest\, depending on unknown genetic factors. We will present results demonstrating that the dosage of Rnf212 (and thus crossover rate) affects meiotic progression and germ cell counts of semisterile Prdm9-deficient mice. Our findings offer an insight into the mechanisms and treatment possibilities of some cases of infertility. \n 
URL:https://www.biomed.cas.cz/event/seminar-ondrej-mihola-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20231123
DTEND;VALUE=DATE:20231125
DTSTAMP:20260418T205601
CREATED:20231027T104549Z
LAST-MODIFIED:20231115T140958Z
UID:687-1700697600-1700870399@www.biomed.cas.cz
SUMMARY:IEM CAS Mini-Symposium BIOCEV Regeneration III.
DESCRIPTION:Dear Colleagues\, \nWe are pleased to announce the annual Mini-Symposium BIOCEV Regeneration III\, which will be held on 23-24th November 2023 in BIOCEV\, Vestec. \nOur symposium aims to exchange knowledge in regenerative medicine\, tissue engineering\, 3D in vitro modelling\, organoid research\, new tools and technologies in cell culture\, and many more. \nAlong with several lectures given by well-known experts in the fields\, this year\, we encourage early career researchers to contribute to our symposium and share research achievements\, exchange opinions\, or find new contacts and cooperations. To achieve the best welcoming atmosphere during the event\, our organising team comprises PhD students of Charles University working in the Institute of Experimental Medicine of the CAS\, v. v. i. and the Institute of Physiology of the CAS\, v. v. i. \nIn a student-to-student format\, we would like to invite our colleagues (PhD students\, early post-doctoral scientists) to submit the abstracts and share their research via an oral presentation or a poster combined with a short pitch talk. Additionally\, the active participants will benefit from a specially organised Student Workshop on the 24th of November\, where our colleagues from research organisations and companies will share their knowledge in 3D culture\, tissue engineering tools and methods\, advise on the commercialisation of the research or the translation of the results into clinical applications. The Symposium will be held in English. \nThe main topics of the mini-symposium: \n\nTissue engineering\nRegenerative medicine\nIn vitro models\n3D cultures\nOrganoids\nNew tools and technologies in regenerative medicine and tissue engineering\n\nRegistration for the event is free of charge. To register as a delegate as well as an active participant with the abstract submission\, please fill out the registration form here: \n\nRegistration and abstract submission: https://forms.gle/YhLqptsLwnzYuTTj8 (open in a new window)\nThe abstract submission deadline is 24.10. 2023.\nThe registration deadline is 10.11.2023\n\nWe are looking forward to seeing you in November! \nSincerely\, Organising team \n\n\n\n\n\n\n\n\n\n\n\n\nLecturers and Committee Members\n\nPre-confirmed invited lecturers\n\nNatalia Rozwadowska\, PhD (The Institute of Human Genetics of the PAS\, Poznan\, Poland)\nDasa Bohaciaková\, PhD (Masaryk University\, Brno\, Czech Republic)\nOleg Lunov\, PhD (Institute of Physics of the CAS\, Prague\, Czech Republic)\nTomasz Kolanowski\, PhD (The Institute of Human Genetics of the PAS\, Poznan\, Poland)\nLukas Valihrach\, PhD (Institute of Biotechnology of the CAS\, BIOCEV\, Vestec\, Czech Republic)\n\nOrganising committee\n\nJarmila Havelkova\, MSc (Institute of Physiology of the CAS\, v. v. i. & Institute of Experimental Medicine of the CAS\, v. v. i.\, BIOCEV\, Charles University)\nKristyna Sintakova\, MSc (Institute of Experimental Medicine of the CAS\, v. v. i.\, BIOCEV\, Charles University)\nEliska Vavrinova\, MSc (Institute of Experimental Medicine of the CAS\, v. v. i.\, BIOCEV\, Charles University)\n\nScientific committee\n\nAssoc. Prof. Lucie Bacakova\, MD\, PhD (Institute of Physiology of the CAS\, v. v. i.)\nAssoc. Prof. Pavla Jendelova\, PhD (Institute of Experimental Medicine of the CAS\, v. v. i.)\nYuriy Petrenko\, PhD (Institute of Experimental Medicine of the CAS\, v. v. i. & Institute of Physiology of the CAS\, v. v. i.\, BIOCEV)\nOlena Rohulska\, PhD (Institute of Experimental Medicine of the CAS\, v. v. i. & Institute of Physiology of the CAS\, v. v. i.\, BIOCEV)\nNataliya Romanyuk\, PhD (Institute of Experimental Medicine of the CAS\, v. v. i.)\n\n\n\n\n\n\n\n\n\n\n\nOur sponsors\n\n\n\n\n\nEast Port Life Science \nElmarco \nSchoeller Instruments \nSVEN Biolabs \nTATAA Biocenter 
URL:https://www.biomed.cas.cz/event/mini-symposium-biocev-regeneration-iii/
END:VEVENT
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