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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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TZID:Europe/Prague
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TZOFFSETFROM:+0100
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TZNAME:CEST
DTSTART:20230326T010000
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TZOFFSETFROM:+0200
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DTSTART:20231029T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231206T150000
DTEND;TZID=Europe/Prague:20231206T160000
DTSTAMP:20260417T222838
CREATED:20231204T124305Z
LAST-MODIFIED:20231204T124400Z
UID:729-1701874800-1701878400@www.biomed.cas.cz
SUMMARY:Seminář - Mgr. Luděk Štěpánek\, Ph.D.
DESCRIPTION:„Studying the eukaryotic cilium by a single organelle approach“ \nCilia are present on the surface of many eukaryotic cells and have critical motility\, sensory\, and signalling functions. Yet\, many fundamental aspects of their biology are poorly understood. Taking advantage of the fact\, that the cilia are experimentally well accessible\, I have been developing approaches for imaging and manipulation of individual cilia. These include correlative light and electron microscopy\, blocking transport within the cilia by physical and chemical means\, as well as in vitro reconstitution approaches. In this talk\, I will discuss the development of such methods and present the advancements in our understanding of processes responsible for building and maintenance of the cilia these approaches have enabled.
URL:https://www.biomed.cas.cz/event/seminar-mgr-ludek-stepanek-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231207T140000
DTEND;TZID=Europe/Prague:20231207T150000
DTSTAMP:20260417T222838
CREATED:20231115T140644Z
LAST-MODIFIED:20231205T085824Z
UID:720-1701957600-1701961200@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 12/2023
DESCRIPTION:Sensorineural hearing loss in mice lacking GABAB receptor-associated KCTD12 protein\nLecturer: Mgr. Adolf Melichar / Department of Auditory Neuroscience \nAnnotation: KCTD12 protein is the auxiliary subunit of the G-protein coupled receptor for γ-aminobutyric acid (GABA-B). KCTD12 constitutively binds to the intracellular portion of GABA-B receptor and significantly modulates its structural and functional properties. KCTD12/GABA-B complexes are characterized by high expression levels in the mammalian peripheral and central auditory system\, suggesting their important role in auditory function. In this presentation\, we summarize our results showing that deletion of the KCTD12 gene in mice leads to hearing loss and behavioral manifestations of hyperacusis and tinnitus. \nThe seminar will take place on 7. 12. 2023 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-12-2023/
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231213T150000
DTEND;TZID=Europe/Prague:20231213T160000
DTSTAMP:20260417T222838
CREATED:20231204T124646Z
LAST-MODIFIED:20231204T152228Z
UID:732-1702479600-1702483200@www.biomed.cas.cz
SUMMARY:Seminář - Valeria Buccheri\, M.Sc.
DESCRIPTION:“Canonical RNAi in vivo in mice” \nCanonical RNAi\, i.e. long dsRNA-induced mRNA degradation\, is essentially not operating in vivo in mammalian somatic cells. Low efficiency of dsRNA conversion into small interfering RNA by Dicer was identified as key limiting factor for canonical RNAi in mammals. We have genetically engineered mice to express a more active Dicer variant and investigated how this impacts mouse development and RNAi activity in vivo.
URL:https://www.biomed.cas.cz/event/seminar-valeria-buccheri-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231220T150000
DTEND;TZID=Europe/Prague:20231220T160000
DTSTAMP:20260417T222838
CREATED:20231211T123835Z
LAST-MODIFIED:20231213T135507Z
UID:744-1703084400-1703088000@www.biomed.cas.cz
SUMMARY:Seminář - Miles Joseph Raishbrook\, M.Sc.
DESCRIPTION:„The impact of FAM84B in retinal homeostasis“ \nFam84b is an incompletely characterised protein. Its aberrant expression has been associated with various human cancers\, with a possible reported role in endosomal trafficking. We genetically ablated Fam84b expression in mice\, and extensively characterised the subsequent age-related\, degenerative phenotype in the retinas of knockout animals. The aim of the project is to explain how the lack of Fam84b unsettles retinal homeostasis and induces the presented phenotype.
URL:https://www.biomed.cas.cz/event/seminar-miles-joseph-raishbrook/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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