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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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BEGIN:VTIMEZONE
TZID:Europe/Prague
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TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
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TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20241027T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240304T150000
DTEND;TZID=Europe/Prague:20240304T160000
DTSTAMP:20260418T081359
CREATED:20240115T114730Z
LAST-MODIFIED:20240115T114730Z
UID:762-1709564400-1709568000@www.biomed.cas.cz
SUMMARY:Lecture "AMPA glutamate receptor signaling – auxiliary subunits and beyond"
DESCRIPTION:Dr. Ingo Greger\, Neurobiology Division MRC Laboratory of Molecular Biology\, Cambridge\, UK
URL:https://www.biomed.cas.cz/event/lecture-ampa-glutamate-receptor-signaling-auxiliary-subunits-and-beyond/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240306T150000
DTEND;TZID=Europe/Prague:20240306T160000
DTSTAMP:20260418T081359
CREATED:20240228T082050Z
LAST-MODIFIED:20240228T082050Z
UID:800-1709737200-1709740800@www.biomed.cas.cz
SUMMARY:Seminář Simona Mikula Mršťáková\, M.Sc.
DESCRIPTION:“Role of pax6 genes in the eye during embryonal development of medaka” \nPax6 is remarkably conserved across a wide range of species\, from flies to humans\, signifying its fundamental role in the regulatory network governing eye formation. In this presentation\, we will delve into the functions of three pax6 genes – Pax6.1\, Pax6.2\, and Pax6.3 – and their specific contributions to eye development during the embryonic stages of the Japanese medaka fish (Oryzias latipes). We will explore how these genes orchestrate the complex process of eye formation\, underscoring their importance in developmental biology and evolutionary studies.
URL:https://www.biomed.cas.cz/event/seminar-simona-mikula-mrstakova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240307T140000
DTEND;TZID=Europe/Prague:20240307T150000
DTSTAMP:20260418T081359
CREATED:20240122T091559Z
LAST-MODIFIED:20240207T112651Z
UID:773-1709820000-1709823600@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 03/2024
DESCRIPTION:Subpopulations of NG2 glia in the adult mouse brain after focal cerebral ischemia.\nLecturer: Mgr. Tomáš Knotek / Department of Cellular Neurophysiology \nAnnotation: Glia expressing NG2 antigen are known predominantly as precursors of oligodendrocytes. However\, their differentiation potential in tissue affected by ischemic injury has not yet been fully explored. To further our understanding of these cells\, we employed single-cell RNA sequencing\, immunohistochemical staining\, RT-qPCR\, and patch-clamp technique on NG2-expressing cells in healthy tissue and in tissue affected by focal cerebral ischemia (FCI). Single-cell RNA sequencing data revealed that NG2 glia form distinct subpopulations\, some of which can be ascribed to the proliferation of NG2 glia and their progression in the oligodendrocyte lineage. However\, we also observed previously described astrocyte-like NG2 glia that appeared both in healthy and ischemic tissue. Interestingly\, this subpopulation also shared properties with neural progenitor cells. Expression of genes linked to neurogenesis was confirmed by immunohistochemical staining and changed at different time points after FCI. Of note\, 28 days after the stroke\, we observed NG2-expressing cells positive for NeuN. Together\, these results provide new insight into the plasticity of NG2 glia following ischemic injury. \nThe seminar will take place on 7. 3. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-03-2024/
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240313T150000
DTEND;TZID=Europe/Prague:20240313T160000
DTSTAMP:20260418T081359
CREATED:20240306T080743Z
LAST-MODIFIED:20240306T080743Z
UID:803-1710342000-1710345600@www.biomed.cas.cz
SUMMARY:Seminář Imtissal Krayem\, Ph.D.
DESCRIPTION:“Transmembrane adaptor protein OPAL1 regulates leukocyte hematopoiesis and thymus development” \nExpression of transmembrane adaptor protein Outcome predictor of acute leukemia 1 (OPAL1)\, has been linked to the ETV6-RUNX1 translocation and favorable prognosis in childhood leukemia. Our research also suggests that it has an important role in leukocyte development. We show that in mice with germline deletion of OPAL1\, hematopoiesis is dysregulated early on\, affecting mainly hematopoietic stem cells and early progenitors. Dysregulations in this compartment also contribute to more efficient engraftment of OPAL1-deficient cells following hematopoietic stem and progenitor cell transplantations. In addition\, the thymi of OPAL1-deficient mice are enlarged\, housing increased numbers of thymocytes across all subsets. This phenomenon may be attributed to the elevated generation of MPP4/LMPP progenitors in the bone marrow\, which subsequently give rise to thymus-seeding progenitors. In summary\, WBP1L emerges as a key player in leukocyte homeostasis\, maintaining leukocyte numbers during steady-state conditions and after bone marrow transplantation.
URL:https://www.biomed.cas.cz/event/seminar-imtissal-krayem-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240320T150000
DTEND;TZID=Europe/Prague:20240320T160000
DTSTAMP:20260418T081359
CREATED:20240306T080948Z
LAST-MODIFIED:20240306T080948Z
UID:805-1710946800-1710950400@www.biomed.cas.cz
SUMMARY:Seminář  Zuzana Outlá\, M.Sc.
DESCRIPTION:„Targeting plectin-mediated cytoskeletal crosstalk in hepatocellular carcinoma“ \nAnotace: The study’s findings indicate that the elevation of plectin in tumor hepatocytes is associated with the progression of hepatocellular carcinoma (HCC). This progression can be inhibited through genetic or pharmacological targeting of plectin. The oncogenic and invasive potentials of HCC cells are attenuated through plectin ablation\, suggesting that plectin contributes to HCC’s metastatic capacity. These results identify plectin as a potential therapeutic target in HCC.
URL:https://www.biomed.cas.cz/event/seminar-zuzana-outla-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240325T150000
DTEND;TZID=Europe/Prague:20240325T160000
DTSTAMP:20260418T081359
CREATED:20240320T085512Z
LAST-MODIFIED:20240320T085512Z
UID:823-1711378800-1711382400@www.biomed.cas.cz
SUMMARY:Lecture "Hemodynamic mechanisms initiating salt-sensitive hypertension: Prevention options"
DESCRIPTION:Ing. Michal Pravenec\, DrSc.\, Laboratory of Genetics of Model Diseases\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture-hemodynamic-mechanisms-initiating-salt-sensitive-hypertension-prevention-options/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240326T130000
DTEND;TZID=Europe/Prague:20240326T140000
DTSTAMP:20260418T081359
CREATED:20240409T093101Z
LAST-MODIFIED:20240409T121238Z
UID:873-1711458000-1711461600@www.biomed.cas.cz
SUMMARY:IEM CAS μLectures Seminar Series: Cameras and Detectors
DESCRIPTION:μLectures is a new monthly seminar series designed to enhance researchers’ understanding of microscopy’s fundamental workings and principles. Each session\, lasting 30 minutes\, will focus on a specific concept or topic within microscopy. The practical information presented aims to deepen researchers’ comprehension of their microscopy experiments\, giving them a better overview of the options available and enabling them to improve their experimental design and more effectively identify and resolve potential issues. \nAnnotation\nThe second session will focus on cameras and detectors. We will talk about the difference between cameras and detectors\, and what parameters are important for which kind of experiments.\n \nThe seminar will take place on 26. 3. 2024 from 1 p.m. in the Turquoise Auditorium of the IEM CAS. It will also be possible to join online using this link (open in a new window). \nRegistration\nRegistration is not required\, but we will be happy if you let us know (in person or at iva.svecova@iem.cas.cz) and if we have an idea of how many people are planning to come. \nLecturer\nŠtěpán Kortus\, PhD.
URL:https://www.biomed.cas.cz/event/%ce%bclectures-cameras-and-detectors/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240327T150000
DTEND;TZID=Europe/Prague:20240327T160000
DTSTAMP:20260418T081359
CREATED:20240318T080719Z
LAST-MODIFIED:20240318T080719Z
UID:807-1711551600-1711555200@www.biomed.cas.cz
SUMMARY:Seminář Veronika Zimolová\, M.Sc.
DESCRIPTION:“Janus Kinase 2 (JAK2) mutations: implications for blood diseases” \nThe project aims to elucidate the impact of the germline Jak2 R1063H variant on myeloproliferative disorders and its potential implication in myeloid malignancy predisposition. Utilizing a mouse model harboring the Jak2 R1063H mutation\, we observed higher mortality rate\, elevated D-dimer levels indicative of thrombotic events\, and increased platelets counts. Furthermore\, metabolic profiling revealed alterations in platelet bioenergetics and gene expression patterns associated with fatty acid metabolism. Additionally\, we showed aberrations in hematopoietic stem cell functionality\, manifesting as a skewed myeloid progenitor cell expansion and bone marrow remodeling. These findings collectively suggest that Jak2 R1063H variant represents risk factor in the pathogenesis of myeloid cell transformation.
URL:https://www.biomed.cas.cz/event/seminar-veronika-zimolova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
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