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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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TZID:Europe/Prague
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DTSTART:20240331T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240403T150000
DTEND;TZID=Europe/Prague:20240403T160000
DTSTAMP:20260731T155736
CREATED:20240320T082234Z
LAST-MODIFIED:20240320T082234Z
UID:816-1712156400-1712160000@www.biomed.cas.cz
SUMMARY:Seminář Jose Ordovas-Montanes\, M.Sc.\, Ph.D.
DESCRIPTION:“Single-cell to tissue-scale memory of infection and inflammation” \nThe role of epithelial and stromal cells in driving inflammation\, together with immune cells\, is being increasingly appreciated. However\, we currently lack tissue-scale frameworks to define and test how inflammation collectively impacts epithelial\, stromal\, and immune cells. This poses a fundamental challenge for understanding the cellular mechanisms that drive or sustain health and disease within\, and across\, barriers such as the skin\, airway\, and intestine. Our lab is addressing this challenge by quantifying and controlling how inflammation changes the ecology of barrier tissues. Our central hypothesis is that inflammation is distributed and stored in multiple cell types\, with the capacity to form tissue-level collective cellular networks. Starting from our human single-cell RNA-sequencing data collected from infectious and inflammatory diseases\, we are developing quantitative approaches to define how static cellular ecosystems are arranged in barrier tissues. These studies are informing time-series modeling of murine inflammatory models focused on Type 1\, 2 and 17 inflammation to understand how the same pressure applied to epithelial\, stromal\, and immune cell subsets shifts functional states and interactions in distinct barrier tissues. We anticipate to identify the gradual inflammatory transitions which maintain essential tissue functionality and critical “tipping points” in tissue state that compromise barrier functions.
URL:https://www.biomed.cas.cz/event/seminar-jose-ordovas-montanes-m-sc-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240404T140000
DTEND;TZID=Europe/Prague:20240404T143000
DTSTAMP:20260731T155736
CREATED:20240207T113012Z
LAST-MODIFIED:20240402T080600Z
UID:784-1712239200-1712241000@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 04/2024
DESCRIPTION:Maternal diet quality and health status of newborns\nLecturer: Mgr. Jitka Pavlíková\, Ph.D. / Department of Toxicology a Molecular Epidemiology \nAnnotation: Persistent organic pollutants are compounds of mostly anthropogenic origin that persist in the environment for a long time\, become part of food chains\, and some of them accumulate in living organisms. These substances are being monitored for their adverse effects on organisms\, and the use of some of them has already been banned or at least significantly restricted. In our study\, we analyzed possible associations between the health status of newborns (birth weight\, oxidative damage levels) and maternal diet. We obtained information about diet quantity and quality from the maternal diet records and determined the concentrations of 67 different persistent organic pollutants in the collected samples. \nThe seminar will take place on 4. 4. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-04-2024/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240408T150000
DTEND;TZID=Europe/Prague:20240408T160000
DTSTAMP:20260731T155736
CREATED:20240320T085651Z
LAST-MODIFIED:20240320T085651Z
UID:825-1712588400-1712592000@www.biomed.cas.cz
SUMMARY:Lecture "Cancer metabolism"
DESCRIPTION:RNDr. Katarína Smolková\, Ph.D.\, Laboratory of Mitochondrial Physiology\, IPHYS \n 
URL:https://www.biomed.cas.cz/event/lecture-cancer-metabolism/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240410T150000
DTEND;TZID=Europe/Prague:20240410T160000
DTSTAMP:20260731T155736
CREATED:20240320T082325Z
LAST-MODIFIED:20240320T082325Z
UID:818-1712761200-1712764800@www.biomed.cas.cz
SUMMARY:Seminář Takashi Akera\, Ph.D.
DESCRIPTION:“The impact of genetic cheating on mammalian reproduction and speciation” \n Selfish DNA violate Mendel’s Law of Segregation by biased segregation to the egg cell. This genetic cheating\, meiotic drive\, is a widespread phenomenon across eukaryotes with associated fitness costs such as fertility issues. I will discuss our recent work on the cell biological mechanism of meiotic drive and how it can impact mammalian reproduction and speciation.
URL:https://www.biomed.cas.cz/event/seminar-takashi-akera-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240415T150000
DTEND;TZID=Europe/Prague:20240415T160000
DTSTAMP:20260731T155736
CREATED:20240320T085807Z
LAST-MODIFIED:20240320T085807Z
UID:827-1713193200-1713196800@www.biomed.cas.cz
SUMMARY:Lecture "How Foxk1 and Foxk2 Regulate Aerobic Glycolysis – Implications for Systemic Energy Homeostasis and Type 2 Diabetes"
DESCRIPTION:Prof. Sven Enerbäck\, Department of Medical Biochemistry and Cell Biology\, Institute of Biomedicine\, University of Gothenburg\, Sweden.
URL:https://www.biomed.cas.cz/event/lecture-how-foxk1-and-foxk2-regulate-aerobic-glycolysis-implications-for-systemic-energy-homeostasis-and-type-2-diabetes/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240417T150000
DTEND;TZID=Europe/Prague:20240417T160000
DTSTAMP:20260731T155736
CREATED:20240410T072013Z
LAST-MODIFIED:20240410T072013Z
UID:876-1713366000-1713369600@www.biomed.cas.cz
SUMMARY:Seminář Kristýna Hrychová\, M.Sc.
DESCRIPTION:“Chromatin ADP-ribosylation in neurodegenerative disease” \nADP-ribosylation is a common protein post-translational modification that regulates numerous cellular processes\, including transcription\, cell proliferation and differentiation\, immune and stress responses\, aging\, and cell death. One of its most extensively studied roles is in DNA damage response and subsequent DNA repair. Moreover\, deregulation of ADP-ribose metabolism is linked to neurological and neurodevelopmental disorders. Interestingly\, our recent work reveals that serine ADP-ribosylation is largely dispensable for DNA repair. We propose that deregulated serine ADP-ribosylation might instead lead to alterations in other histone modifications\, changes in chromatin remodeling and gene expression\, and consequently could contribute to the development of neurological diseases.
URL:https://www.biomed.cas.cz/event/seminar-kristyna-hrychova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240423T140000
DTEND;TZID=Europe/Prague:20240423T150000
DTSTAMP:20260731T155736
CREATED:20240115T114856Z
LAST-MODIFIED:20240320T090026Z
UID:764-1713880800-1713884400@www.biomed.cas.cz
SUMMARY:Lecture "Epoxylipids from biological actions to therapies for cardiovascular\, kidney\, and metabolic diseases"
DESCRIPTION:Prof. John D. Imig\, University of Arkansas for Medical Sciences\, USA
URL:https://www.biomed.cas.cz/event/lecture-epoxylipids-from-biological-actions-to-therapies-for-cardiovascular-kidney-and-metabolic-diseases/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240424T150000
DTEND;TZID=Europe/Prague:20240424T160000
DTSTAMP:20260731T155736
CREATED:20240415T071711Z
LAST-MODIFIED:20240415T071711Z
UID:878-1713970800-1713974400@www.biomed.cas.cz
SUMMARY:Seminář Farahdokht Nourisanami\, M.Sc.
DESCRIPTION:“Molecular mechanisms of proteoglycan-mediated semaphorin signaling in axon guidance” \nThe precise assembly of a functional nervous system relies on axon guidance cues. Beyond engaging their cognate receptors and initiating signaling cascades that modulate cytoskeletal dynamics\, guidance cues also bind components of the extracellular matrix\, notably proteoglycans\, yet the role and mechanisms of these interactions remain poorly understood. We found that Drosophila secreted semaphorins bind specifically to glycosaminoglycan (GAG) chains of proteoglycans\, showing a preference based on the degree of sulfation. Structural analysis of Sema2b unveiled multiple GAG binding sites positioned outside canonical plexin-binding site\, with the highest affinity binding site located at the C-terminal tail\, characterized by a lysine-rich helical arrangement that appears to be conserved across secreted semaphorins. In vivo studies revealed a crucial role of the Sema2b C-terminal tail in specifying the trajectory of olfactory receptor neurons. We propose that secreted semaphorins tether to the cell surface through interactions with GAG chains of proteoglycans\, facilitating their presentation to cognate receptors on passing axons.
URL:https://www.biomed.cas.cz/event/seminar-farahdokht-nourisanami-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240429T150000
DTEND;TZID=Europe/Prague:20240429T160000
DTSTAMP:20260731T155736
CREATED:20240320T090148Z
LAST-MODIFIED:20240320T090148Z
UID:829-1714402800-1714406400@www.biomed.cas.cz
SUMMARY:Lecture "Redox mechanisms of insulin secretion"
DESCRIPTION:RNDr. Petr Ježek\, DrSc.\, Laboratory of Mitochondrial Physiology\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture-redox-mechanisms-of-insulin-secretion/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240430T100000
DTEND;TZID=Europe/Prague:20240430T120000
DTSTAMP:20260731T155736
CREATED:20240409T091410Z
LAST-MODIFIED:20240409T091453Z
UID:865-1714471200-1714478400@www.biomed.cas.cz
SUMMARY:IEM CAS Distinguished Guest Seminar Series - Cyril Hanus
DESCRIPTION:The dendrite’s sweet spot: Atypical glycosylation of the neuronal surface and impact on synaptic receptor trafficking\, structure and function\nLecturer: Cyril Hanus\, PhD. / The Institute of Psychiatry and Neuroscience of Paris \nThe seminar will take place on 30. 04. 2024 from 10:00 p.m. in the Turquoise Auditorium of the IEM CAS. \nAnnotation: \nLike 75% of membrane proteins\, neurotransmitter receptors and synaptic adhesion molecules are literally covered by covalently linked sugars\, N-glycans. Despite a general awareness that N-glycans may have a strong impact on protein structure and function and are altered in a number of brain pathologies\, we know surprisingly little about N-glycosylation in the brain. Our work indicates that a substantial fraction of neuronal surface proteins\, notably glutamate AMPA receptors\, are locally synthesized in dendrites and use unconventional Golgi-independent pathways to reach the neuronal surface. This local processing modifies protein N-glycosylation states and hence regulates receptor chemical composition and function\, unravelling a previously unrecognized mechanism controlling the sensing properties and plasticity of the neuronal membrane. \nKeywords: cell-biology\, neurotransmitter receptors\, synaptic plasticity\, cell type-specific gene knockout\, electrophysiology\, mass spectrometry\, molecular dynamics\, structural biology \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/distinguished-guest-seminar-series-cyril-hanus/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240430T130000
DTEND;TZID=Europe/Prague:20240430T140000
DTSTAMP:20260731T155736
CREATED:20240409T091950Z
LAST-MODIFIED:20240409T092125Z
UID:868-1714482000-1714485600@www.biomed.cas.cz
SUMMARY:IEM CAS μLectures Seminar Series: Confocal Microscopy
DESCRIPTION:μLectures is a monthly seminar series designed to enhance researchers’ understanding of microscopy’s fundamental workings and principles. Each session\, lasting 30 minutes\, focuses on a specific concept or topic within microscopy. The practical information presented aims to deepen researchers’ comprehension of their microscopy experiments\, giving them a better overview of the options available and enabling them to improve their experimental design and more effectively identify and resolve potential issues. \nAnnotation\nThis session will focus on confocal microscopy. We will talk about the basic principles of confocal microscopy\, its practical implications and the difference between different confocal microscopy techniques (scanning vs spinning disk). \nThe seminar will take place on 30. 4. 2024 from 1 p.m. in the Turquoise Auditorium of the IEM CAS. It will also be possible to join online using this link (open in a new window). \nRegistration\nRegistration is not required\, but we will be happy if you let us know (in person or at iva.svecova@iem.cas.cz) and if we have an idea of how many people are planning to come. \nLecturer\nBarbora Hyklová\, PhD.
URL:https://www.biomed.cas.cz/event/%ce%bclectures-seminar-series-confocal-microscopy/
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