BEGIN:VCALENDAR
VERSION:2.0
PRODID:-// - ECPv6.6.3//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Prague
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20241027T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240502T140000
DTEND;TZID=Europe/Prague:20240502T150000
DTSTAMP:20260501T101419
CREATED:20240419T143733Z
LAST-MODIFIED:20240426T132403Z
UID:881-1714658400-1714662000@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 05/2024
DESCRIPTION:Monitoring of telomeres through colorectal adenomas to advanced stages of colorectal cancer\nLecturer: Mgr. Kateřina Balounová / Department of the Molecular Biology of Cancer \nAnnotation: Telomeres\, repetitive sequences located at the ends of chromosomes\, naturally shorten with ageing. Disruption in telomere biology is closely associated with the onset and progression of cancers\, including colorectal carcinoma (CRC). Given that CRC is one of the most common cancer-related deaths\, we focus on studying telomeres and their potential use to characterise CRC subtypes\, as well as serving as a suitable prognostic biomarker for this disease. \nThe seminar will take place on 2. 5. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-05-2024/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240509T150000
DTEND;TZID=Europe/Prague:20240509T160000
DTSTAMP:20260501T101419
CREATED:20240509T101047Z
LAST-MODIFIED:20240509T101047Z
UID:899-1715266800-1715270400@www.biomed.cas.cz
SUMMARY:Lecture "Preclinical Drug Development for Epilepsy: Animal Models and New Horizons"
DESCRIPTION:Cameron S.Metcalf\, Dept.Pharmacology\, University of Utah\, Salt Lake City\, USA \nvenue: Conference room of Laboratory of Biomathematics in Krč areal (Vídeńská 1083) \n  \n  \n  \n  \n 
URL:https://www.biomed.cas.cz/event/lecture-preclinical-drug-development-for-epilepsy-animal-models-and-new-horizons/
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240513T150000
DTEND;TZID=Europe/Prague:20240513T160000
DTSTAMP:20260501T101419
CREATED:20240509T101313Z
LAST-MODIFIED:20240509T101313Z
UID:901-1715612400-1715616000@www.biomed.cas.cz
SUMMARY:Lectures of Laboratory of Developmental Cardiology
DESCRIPTION:Vevo 3100: The Short Story of a High-tech Upgrade \nJaroslav Hrdlička\, Laboratory of Developmental Cardiology\, IPHYS \n  \nCardioprotection: the role of HIF-1α and mitochondria \nPetra Alánová\, Laboratory of Developmental Cardiology\, IPHYS
URL:https://www.biomed.cas.cz/event/lectures-of-laboratory-of-developmental-cardiology/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240514T083000
DTEND;TZID=Europe/Prague:20240514T163000
DTSTAMP:20260501T101419
CREATED:20240507T075424Z
LAST-MODIFIED:20240507T075424Z
UID:891-1715675400-1715704200@www.biomed.cas.cz
SUMMARY:3rd 10x Genomics Experience Meeting 2024
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/3rd-10x-genomics-experience-meeting-2024/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240515T150000
DTEND;TZID=Europe/Prague:20240515T160000
DTSTAMP:20260501T101419
CREATED:20240506T070531Z
LAST-MODIFIED:20240506T070531Z
UID:888-1715785200-1715788800@www.biomed.cas.cz
SUMMARY:Seminář Milan Reiniš\, Ph.D.
DESCRIPTION:“Targeting the STAT3 signaling pathway in cancer and senescence” \nSTAT3 signaling pathway plays important roles in many cellular processes\, such as cell differentiation\, carcinogenesis\, cellular senescence or regulation of the immune responses. The STAT3 molecule thus represents an attractive therapeutic target. However\, its druggability is still questionable. We have tested a number of small molecules designed to inhibit STAT3 phosphorylation for their inhibitory capabilities and impacts on the tumor cell growth. Importantly\, we have documented that selected compounds with limited cytotoxicity were able to inhibit secretion of immunosuppressive cytokines by senescent cells. These results suggest that the STAT3 inhibitors could serve as senomodulatory agents.
URL:https://www.biomed.cas.cz/event/seminar-milan-reinis-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240520T150000
DTEND;TZID=Europe/Prague:20240520T160000
DTSTAMP:20260501T101419
CREATED:20240509T101413Z
LAST-MODIFIED:20240509T101413Z
UID:903-1716217200-1716220800@www.biomed.cas.cz
SUMMARY:Lecture "Single-particle tracking of neurotransmitter receptors as a window on synaptic organization and function"
DESCRIPTION:RNDr. Martin Zápotocký\, Ph.D.\, Laboratory of Computational Neuroscience\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture-single-particle-tracking-of-neurotransmitter-receptors-as-a-window-on-synaptic-organization-and-function/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20240522
DTEND;VALUE=DATE:20240525
DTSTAMP:20260501T101419
CREATED:20240409T092424Z
LAST-MODIFIED:20240409T092424Z
UID:871-1716336000-1716595199@www.biomed.cas.cz
SUMMARY:IEM CAS Entry Level Super-Resolution Microscopy
DESCRIPTION:Basic Information\nThe course covers theoretical and practical aspects of an “entry-level” super-resolution imaging methods based on the principle of Optical-Photon-Reassignment available in our facility at confocal microscopes Zeiss LSM880\nwith AiryScan and Olympus SpinSR10 with OSR. \nWhat is meant by “Entry-Level Super-Resolution Microscopy”? It is a group of methods that improve resolution by a factor of ~2 over diffraction-limited imaging and are very easy to use. While these methods cannot offer the resolution improvement of factor 5x-10x like STED or STROM/PALM\, they are fast\, easy to operate and require no special sample preparation or extra skills. They are also very suitable for live cell imaging. \n\nDuration: 3 days\nLanguage: English\nLocation: IEM library\, microscope rooms\n\nRegistration form and more information can be found on our website.
URL:https://www.biomed.cas.cz/event/iem-cas-entry-level-super-resolution-microscopy/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240522T150000
DTEND;TZID=Europe/Prague:20240522T160000
DTSTAMP:20260501T101419
CREATED:20240513T113032Z
LAST-MODIFIED:20240513T113032Z
UID:909-1716390000-1716393600@www.biomed.cas.cz
SUMMARY:Seminář Vadym Sulimenko\, Ph.D.
DESCRIPTION:“Differential roles of GIT1 and GIT2 adaptor proteins in regulating microtubule nucleation in glioblastoma cells” \nMicrotubules play a critical role in cell division and migration\, impacting the viability and invasiveness of malignant tumors. Although the reorganization of highly dynamic microtubules is central to these processes\, the precise mechanism underlying microtubule involvement in glioblastoma cell motility remains poorly understood. G protein-coupled receptor kinase-interacting proteins (GITs) are GTPase-activating proteins (GAPs) for ADP-ribosylation factor (Arf) small GTPases. GITs are structurally conserved multidomain scaffold/adaptor proteins that link Arf GTPases to other intracellular signaling events. Here we show that the signalling proteins GIT1 and GIT2 form complexes with γ-Tubulin ring complexes (γTuRCs)\, associate with centrosomes and differentially regulate microtubule nucleation and cell migration in glioblastoma cells.
URL:https://www.biomed.cas.cz/event/seminar-vadym-sulimenko-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240527T150000
DTEND;TZID=Europe/Prague:20240527T160000
DTSTAMP:20260501T101419
CREATED:20240516T085615Z
LAST-MODIFIED:20240516T085741Z
UID:913-1716822000-1716825600@www.biomed.cas.cz
SUMMARY:BioCEV-Krč Methodological Seminar
DESCRIPTION:BioCEV-Krč Methodological Seminar\nTopic: Campus Animal Facility \n27. 5. 2024\, start: 15:00 \nvenue: Milan Hašek lecture hall\, IMG CAS \nThe Animal facility methodological seminar will include a series of presentations by representatives of individual institutions located on the campus. Each institution will briefly present its local or detached animal facility and the services it provides
URL:https://www.biomed.cas.cz/event/biocev-krc-methodological-seminar-2/
LOCATION:IMG
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240529T150000
DTEND;TZID=Europe/Prague:20240529T160000
DTSTAMP:20260501T101419
CREATED:20240513T113146Z
LAST-MODIFIED:20240513T113146Z
UID:911-1716994800-1716998400@www.biomed.cas.cz
SUMMARY:Seminář Prof. Dominique Bonnet
DESCRIPTION:“Dissecting the cross-talk between normal\, leukaemic stem cells and the bone marrow microenvironment” \nHaematopoietic stem cells (HSC) sustain the life-long maintenance of mature blood cells. Over the last decade progress has been made in our understanding of the contribution of the different stroma cells in the regulation of normal HSCs. Our current knowledge is predominantly derived from mouse studies. In humans\, the cellular and molecular composition of the bone marrow (BM) niche\, its functional organisation remains largely unknown. In recent years\, deregulation of the BM microenvironment has emerged to be an important factor in the development of myeloid malignancies. Indeed\, like normal HSC\, leukaemic stem cells (LSCs) remain dependent on signals from the BM niche for survival and proliferation\, and niche factors serves as a sanctuary for their chemoresistance. Thus\, targeting BM niche factors represents a promising avenue for therapeutic interventions. Determining the niche associated alterations in the composition/ organisation along with dissecting the interactome of LSCs and their niche is thus fundamental\, which will ultimately enable us to understand the mechanism of leukaemia initiation\, evolution and resistance. \nI will summarise some of the recent published data from the lab\, showing the alterations of endothelial cells by AML as well as described the development of our new humanised scaffold system that is allowing us to better study the cross-talk between normal and malignant HSPCs and their bone marrow niche in a human/human context. I will show the utility of this model to study MDS and their dependence to the human niche components. Lastly\, I will also discuss new un/published data on the effect of pre-leukaemic mutation on haematopoieisis.
URL:https://www.biomed.cas.cz/event/seminar-prof-dominique-bonnet/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
END:VCALENDAR