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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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TZID:Europe/Prague
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TZOFFSETFROM:+0100
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TZNAME:CEST
DTSTART:20240331T010000
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DTSTART:20241027T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241002T150000
DTEND;TZID=Europe/Prague:20241002T160000
DTSTAMP:20260418T231710
CREATED:20240919T063219Z
LAST-MODIFIED:20240919T104402Z
UID:2151-1727881200-1727884800@www.biomed.cas.cz
SUMMARY:Seminář Marharyta Klianitskaya\, Ing.
DESCRIPTION:“Human Endogenous Retroviruses: Role in Negative Selection of T cells in the Thymus and Pathogenesis of Psoriasis” \nOur research elucidates the role of human endogenous retroviruses (HERVs) in biological processes related to T cell immunity\, autoimmunity\, and the pathogenesis of psoriasis. HERVs are ancient viral elements integrated into the human genome. While most of these elements are rendered non-functional due to mutations and epigenetic silencing\, some retain the ability to express themselves. Despite their foreign origin\, the expression of these endogenous retroviruses does not typically trigger autoimmune disease. \nThe study employed single-cell RNA sequencing data from thymic tissues\, revealing that a wide range of HERVs is expressed in thymic cells responsible for presenting autoantigens to T cells and for their subsequent negative selection. This suggests that some HERVs may be perceived by the immune system as autoantigens\, and disruptions in the negative selection process could potentially lead to autoimmune diseases. \nPsoriasis is a T cell-mediated chronic inflammatory skin disease that occurs in predisposed individuals carrying specific HLA-C alleles\, which are crucial for presenting small peptides to T cells that survey for non-self peptides. RNA-seq data from psoriasis-affected tissues highlighted a significant correlation between elevated HERV expression and the development of the disease. These findings emphasize the potential role of HERVs in T cell-mediated conditions and offer new insights into the molecular mechanisms underlying psoriasis.
URL:https://www.biomed.cas.cz/event/seminar-marharyta-klianitskaya-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241003T140000
DTEND;TZID=Europe/Prague:20241003T150000
DTSTAMP:20260418T231710
CREATED:20240917T082247Z
LAST-MODIFIED:20240917T082612Z
UID:2110-1727964000-1727967600@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 10/2024
DESCRIPTION:Single-particle tracking of NMDA receptors at hippocampal synapses\nLecturer: Mgr. Petra Zahumenská / Department of Neurochemistry \nAnnotation: N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors essential for excitatory neurotransmission. These heterotetrameric complexes consist of two obligatory GluN1 subunits combined with two GluN2 (GluN2A-GluN2D) or GluN3 (GluN3A-GluN3B) subunits. The surface expression and subtype composition of NMDARs are tightly regulated through externalization\, internalization\, and lateral diffusion between synaptic and extrasynaptic regions. \nIn our study\, we utilized the uPAINT (Universal Point Accumulation Imaging in Nanoscale Topography) microscopy technique to examine the surface dynamics of different NMDAR subtypes. uPAINT enables the tracking of individual NMDARs with a high spatial and temporal resolution by labelling them with fluorescent probes. This allows us to observe the distinct patterns of synaptic and extrasynaptic localization of GluN2A- and GluN2B-containing NMDARs in hippocampal neurons. Our approach combines the use of a small anti-GFP nanobody derived from a llama conjugated with an Atto647N fluorophore\, along with the tdTomato-Homer1c marker\, to define synaptic regions. This allows us to gain insights into the mobility and distribution of NMDAR subtypes at the synaptic level. \nThe seminar will take place on 3. 10. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-10-2024/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241009T150000
DTEND;TZID=Europe/Prague:20241009T160000
DTSTAMP:20260418T231710
CREATED:20241001T064659Z
LAST-MODIFIED:20241001T064659Z
UID:2166-1728486000-1728489600@www.biomed.cas.cz
SUMMARY:Seminář Kristína Jamrichová\, M.Sc.
DESCRIPTION:“Investigating the Impact of Cullin-Dependent Degradation on Protein Homeostasis” \nCullin-dependent ligases (CRLs) regulate cellular homeostasis by targeting proteins for degradation. Mutations and alterations in the CRL substrate receptor FBXO38 have been linked to distal muscular atrophy\, chronic obstructive pulmonary disease\, and gender dysphoria. In our previous research\, we demonstrated that FBXO38 controls centromeric chromatin density during spermatogenesis. We will present our progress in deciphering FBXO38 function\, particularly in the context of protein homeostasis and ribosomal activity. \n 
URL:https://www.biomed.cas.cz/event/seminar-kristina-jamrichova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20241011
DTEND;VALUE=DATE:20241012
DTSTAMP:20260418T231710
CREATED:20241001T074244Z
LAST-MODIFIED:20241001T074244Z
UID:2168-1728604800-1728691199@www.biomed.cas.cz
SUMMARY:17th IMG PhD conference
DESCRIPTION:Dear colleagues\, \nWe would like to invite you to the 17th IMG PhD conference that will be on the 11th of October.  \nThis year we will be hosting two international speakers: Mileidys Perez Alea\, who will have a talk about ¨How to build a Start-up¨ and Elodie Chabrol\, who will be talking about the world of ¨Science Communication¨. \nWe are opening the registration for everyone who is interested in attending the sessions we organized. You can find the program as well as information about the conference at the IMG website and the registration link below. \nWe are looking forward to seeing all of you and enjoying with us the up-coming conference. \nBest regards\, \nAnton & Irina
URL:https://www.biomed.cas.cz/event/17th-img-phd-conference/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241016T093000
DTEND;TZID=Europe/Prague:20241016T103000
DTSTAMP:20260418T231710
CREATED:20241008T073612Z
LAST-MODIFIED:20241008T073612Z
UID:2172-1729071000-1729074600@www.biomed.cas.cz
SUMMARY:Představení kandidáta na předsedu AV ČR - prof. RNDr. Radomír Pánek\, Ph.D.
DESCRIPTION:Dne 24. 3. 2025 skončí druhé čtyřleté období ve funkci předsedkyně AV ČR prof. RNDr. Evě Zažímalové\, CSc. Volba kandidátky/kandidáta na předsedu AV ČR pro následné funkční období proběhne na zasedání sněmu AV ČR dne 10. 12. 2024.\n \nJedním z kandidátů na předsedu AV ČR je prof. RNDr. Radomír Pánek\, Ph.D.\, který představí zaměstnancům krčského kampusu svou vizi o řízení AV ČR na jednání ve středu 16. 10. 2024 od 9:30 hod. v sále Milana Haška na ÚMG.
URL:https://www.biomed.cas.cz/event/predstaveni-kandidata-na-predsedu-av-cr-prof-rndr-radomir-panek-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241021T150000
DTEND;TZID=Europe/Prague:20241021T160000
DTSTAMP:20260418T231710
CREATED:20241021T122316Z
LAST-MODIFIED:20241021T122403Z
UID:2206-1729522800-1729526400@www.biomed.cas.cz
SUMMARY:Lecture „Metabolic dysfunction-associated steatotic liver disease: its modeling in mice and the effect of n-3 fatty acids“
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/lecture-metabolic-dysfunction-associated-steatotic-liver-disease-its-modeling-in-mice-and-the-effect-of-n-3-fatty-acids/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241022T103000
DTEND;TZID=Europe/Prague:20241022T113000
DTSTAMP:20260418T231710
CREATED:20241014T061308Z
LAST-MODIFIED:20241014T061308Z
UID:2174-1729593000-1729596600@www.biomed.cas.cz
SUMMARY:Představení kandidáta na předsedu AV ČR - prof. RNDr. Libor Grubhoffer\, CSc.\, dr. h. c. mult.
DESCRIPTION:Dne 24. 3. 2025 skončí druhé čtyřleté období ve funkci předsedkyně AV ČR prof. RNDr. Evě Zažímalové\, CSc. Volba kandidátky/kandidáta na předsedu AV ČR pro následné funkční období proběhne na zasedání sněmu AV ČR dne 10. 12. 2024.\n \nJedním z kandidátů na předsedu AV ČR je prof. RNDr. Libor Grubhoffer\, CSc.\, dr. h. c. mult.\, který představí zaměstnancům krčského kampusu svou vizi o řízení AV ČR na jednání v úterý 22. 10. 2024 od 10:30 hod. v posluchárně Milana Haška na ÚMG.
URL:https://www.biomed.cas.cz/event/predstaveni-kandidata-na-predsedu-av-cr-prof-rndr-libor-grubhoffer-csc-dr-h-c-mult/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241023T150000
DTEND;TZID=Europe/Prague:20241023T160000
DTSTAMP:20260418T231710
CREATED:20241016T085332Z
LAST-MODIFIED:20241016T085332Z
UID:2196-1729695600-1729699200@www.biomed.cas.cz
SUMMARY:Seminář Prof. Dr. Daniel Sauter
DESCRIPTION:“Viral Influencers: How endogenous retroviruses regulate innate immunity and senescence” \nThe human genome harbors a significant number of endogenous retroviral elements\, remnants of ancient viral integration events. While often referred to as “genomic fossils“ and “dark matter of the genome” many of these elements function as promoters or enhancers for cellular genes. This presentation will show how a specific subset of endogenous retroviruses is activated during infection\, orchestrating the expression of genes involved antiviral immunity and cell cycle regulation.
URL:https://www.biomed.cas.cz/event/seminar-prof-dr-daniel-sauter/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241030T150000
DTEND;TZID=Europe/Prague:20241030T160000
DTSTAMP:20260418T231710
CREATED:20241016T094609Z
LAST-MODIFIED:20241030T074419Z
UID:2198-1730300400-1730304000@www.biomed.cas.cz
SUMMARY:Seminář Martina Zíková\, Ph.D. - ZRUŠENO
DESCRIPTION:“Impact of Medulloblastoma-Derived Extracellular Vesicles on Neural Stem/Progenitor Cells” \nMedulloblastoma is the most common malignant brain tumor in children. Recent advances in understanding its genetic and molecular heterogeneity have uncovered at least four distinct subgroups\, each characterized by unique transcriptional profiles\, DNA alterations and clinical outcomes. Extracellular vesicle secretion has emerged as a critical mediator of communication within the tumor microenvironment. In this presentation\, we will discuss our progress in deciphering the effects of extracellular vesicles derived and purified from medulloblastoma cells on neural stem/progenitor cell gene expressions.
URL:https://www.biomed.cas.cz/event/seminar-martina-zikova-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
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