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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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BEGIN:VTIMEZONE
TZID:Europe/Prague
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TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
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TZOFFSETFROM:+0200
TZOFFSETTO:+0100
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DTSTART:20241027T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20241203
DTEND;VALUE=DATE:20241206
DTSTAMP:20260418T232821
CREATED:20241101T112749Z
LAST-MODIFIED:20241101T112841Z
UID:2242-1733184000-1733443199@www.biomed.cas.cz
SUMMARY:Live Cell Imaging Course 2024
DESCRIPTION:The course is very practically-oriented\, theoretical lectures are followed by 6 hours of hands-on session every day in small groups. You will learn widefield\, confocal\, and advanced methods including super-resolution\, photomanipulation\, and FLIM. You will have a chance to work on high-end microscopes and compare wide variety of approaches and instrumentation. \nFor detailed program and overview of taught methods and microscopes please check course webpage: https://course.img.cas.cz/lci/ \nLooking forward to seeing you! \nJan Valečka and Helena Chmelová
URL:https://www.biomed.cas.cz/event/live-cell-imaging-course-2024/
LOCATION:IMG
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241204T150000
DTEND;TZID=Europe/Prague:20241204T160000
DTSTAMP:20260418T232821
CREATED:20241126T132009Z
LAST-MODIFIED:20241126T132009Z
UID:2263-1733324400-1733328000@www.biomed.cas.cz
SUMMARY:Seminář Marie Zelená\, M.Sc.
DESCRIPTION:“Every stick has two ends – Using high resolution imaging to characterize both ends of the eukaryotic flagellum” \nThe eukaryotic flagellum is important for cell motility. The microtubule-based axoneme generating the flagellar beating has been extensively studied. However\, additional structures are associated with the proximal and distal end of the flagellum\, with their composition and processes of their formation being poorly understood. \nTo gain an insigth into these structures we have studied them in the protozoan parasite Trypanosoma brucei\, which is experimentally highly tractable. First\, we focused on the flagellar pocket around the proximal end of the flagellum\, which is the exclusive site for endocytosis and exocytosis of the parasite. Using expansion microscopy we were able to define discrete stages of the flagellar pocket division and formation of the flagellar pocket collar\, which seals the pocket. Second\, we took advantage of our knowledge of the flagellum distal-end proteome and combined it with expansion microscopy and cryo-electron tomography to characterize the enigmatic microtubule plugs at the distal end of the flagellum. \nOur work elucidates aspects of the flagellar biology of an important parasite. Moreover\, given the conserved nature of the organelle\, our results have also implications for flagella across eukaryotes.
URL:https://www.biomed.cas.cz/event/seminar-marie-zelena-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241209T150000
DTEND;TZID=Europe/Prague:20241209T163000
DTSTAMP:20260418T232821
CREATED:20241021T123023Z
LAST-MODIFIED:20241021T123023Z
UID:2217-1733756400-1733761800@www.biomed.cas.cz
SUMMARY:19th BioCEV-Krč Methodological Seminar
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/19th-biocev-krc-methodological-seminar/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20241210
DTEND;VALUE=DATE:20241212
DTSTAMP:20260418T232821
CREATED:20241107T124538Z
LAST-MODIFIED:20241107T124639Z
UID:2251-1733788800-1733961599@www.biomed.cas.cz
SUMMARY:IDP – Image Data Presentation
DESCRIPTION:The human eye is our primary tool for interpreting images\, so scientific images should be adjusted with this perception in mind. However\, display and print transfer characteristics often degrade images\, making them differ from reality. This course offers a unique approach\, focusing on preparing image data for presentation. \nWe’ll cover essential topics like gamma correction and print preparation to ensure your posters and figures appear as true-to-life as possible. \nDay 1: Lectures with scientific colleagues and the opportunity to consult with top experts in advanced graphic displays (Antonin Charvat\, EIZO) and professional photo preparation for print (Karel Pones\, ITF). \nDay 2: Hands-on practice with image processing software and figure-making techniques (Adobe CS and freeware alternatives). \nYou’re welcome to attend the lectures without registration\, but registration is required for the practical sessions. \nWe look forward to seeing you! \nThe Organizing Team \n Oldrich Benada\, MBU & Ivan Novotny\, IMG
URL:https://www.biomed.cas.cz/event/idp-image-data-presentation/
LOCATION:IMG
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241211T080000
DTEND;TZID=Europe/Prague:20241211T170000
DTSTAMP:20260418T232821
CREATED:20241126T132105Z
LAST-MODIFIED:20241126T132105Z
UID:2265-1733904000-1733936400@www.biomed.cas.cz
SUMMARY:Seminář Nenad Radivojević\, M.Sc.
DESCRIPTION:“Quality control in snRNP biogenesis” \nBefore being assembled into spliceosomes\, small nuclear ribonucleoprotein particles (snRNPs) undergo a complex and regulated maturation pathway. Cajal bodies (CBs) have been shown to monitor the final stage of this process by sequestering immature or misassembled particles through a yet unknown quality control mechanism. Here\, we have identified coilin\, a CB marker protein\, as the quality control factor. We further characterize coilin domains interacting with snRNPs and elucidate the molecular mechanism how coilin recognize immature snRNPs. \n 
URL:https://www.biomed.cas.cz/event/seminar-nenad-radivojevic-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241217T100000
DTEND;TZID=Europe/Prague:20241217T110000
DTSTAMP:20260418T232821
CREATED:20241205T094751Z
LAST-MODIFIED:20241205T094751Z
UID:2273-1734429600-1734433200@www.biomed.cas.cz
SUMMARY:Lecture „Unlocking the secrets of the heart – toward an understanding of molecular sex differences in cardiac health and disease“
DESCRIPTION:Lukáš Chmátal\, Ph.D.\, Whitehead Institute for Biomedical Research\, MIT\, USA \nHeart disease is the leading cause of death worldwide\, but its effects are far from uniform. Men and women experience striking differences in symptoms\, prevalence\, and outcomes – yet the molecular mechanisms underlying these differences remain poorly understood. In this lecture\, I will reveal how male and female hearts fundamentally differ in their energy metabolism\, which is driven by mitochondria\, the cell’s powerhouse. I will also outline innovative experimental approaches to uncover the role of sex chromosomes in regulating these differences – insights that will shape the research agenda of my own laboratory. Please\, join me to explore how understanding these mechanisms could transform the way we approach cardiac health for both sexes. \nMore: https://fgu.cas.cz/udalost/lukas-chmatal-ph-d/
URL:https://www.biomed.cas.cz/event/lecture-unlocking-the-secrets-of-the-heart-toward-an-understanding-of-molecular-sex-differences-in-cardiac-health-and-disease/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241218T150000
DTEND;TZID=Europe/Prague:20241218T160000
DTSTAMP:20260418T232821
CREATED:20241204T070320Z
LAST-MODIFIED:20241204T070320Z
UID:2270-1734534000-1734537600@www.biomed.cas.cz
SUMMARY:Seminář Karolina Kowalska\, M.Sc.
DESCRIPTION:“Structural basis of MICAL autoinhibition and activation” \nIn this talk\, we will explore the role of MICAL proteins in cellular dynamics\, focusing on their ability to disassemble actin filaments and their implications for processes like axon guidance\, cytokinesis\, and cell morphology. We will present our recent findings based on the cryoEM structure of human MICAL1\, which reveal the molecular mechanisms underlying MICAL1 autoinhibition. Specifically\, we will discuss how an intramolecular interaction between the N-terminal catalytic and C-terminal coiled-coil domains blocks F-actin interaction\, and how structural changes and domain interactions mediate activation. These findings highlight evolutionarily conserved mechanisms within the MICAL family\, shedding light on their broader functional relevance.
URL:https://www.biomed.cas.cz/event/seminar-karolina-kowalska-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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