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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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BEGIN:VTIMEZONE
TZID:Europe/Prague
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
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DTSTART:20251026T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250205T150000
DTEND;TZID=Europe/Prague:20250205T160000
DTSTAMP:20260419T165240
CREATED:20250122T070222Z
LAST-MODIFIED:20250122T070222Z
UID:2292-1738767600-1738771200@www.biomed.cas.cz
SUMMARY:Seminář Lenka Ungrová\, M.Sc.
DESCRIPTION:“Birds do it their way: avian interferon regulatory factors (almost) resolved” \nInterferon regulatory factors (IRFs) are transcription factors that play a key role in vertebrate innate antiviral immunity. IRF3 and IRF7 activate the expression of IFN-β\, which in response induces the assembly of STAT1\, STAT2 and IRF9 into the ISGF3 complex. Subsequently\, this complex activates the expression of interferon-stimulated genes (ISGs) mounting the antiviral state of the cell. Interestingly\, IRF9 and IRF3 have been reported to be missing in birds. As part of our efforts to search for hidden genes in avian genomes\, we have identified IRF3 in paleognathous birds and IRF9 in most bird orders with the notable exception of the chicken. We focus on the experimental characterization of IRF9 in a duck cell line and also look for a possible substitute for IRF9 in chickens.
URL:https://www.biomed.cas.cz/event/seminar-lenka-ungrova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250206T140000
DTEND;TZID=Europe/Prague:20250206T150000
DTSTAMP:20260419T165240
CREATED:20250204T105313Z
LAST-MODIFIED:20250204T105353Z
UID:2299-1738850400-1738854000@www.biomed.cas.cz
SUMMARY:Seminář - Prof. Cheng Zhu - "Mechanotransduction through immunoreceptors"
DESCRIPTION:Dear colleagues\, \nI am delighted to invite you to a seminar by Prof. Cheng Zhu (Georgia Institute of Technology\, USA) at the Institute of Molecular Genetics on February 6 at 14:00 (Hasek Lecture Hall). Prof. Zhu is a recognized leader and pioneer at the interface of immunology\, structural biology\, and mechanosensing with groundbreaking contributions that have advanced our understanding of how immune receptors work at the cell-cell contacts. \nInvitation: https://www.img.cas.cz/files/2025/01/20250206_Cheng_Zhu.pdf \nPublication profile: https://scholar.google.com/citations?user=_tPv2wEAAAAJ&hl=en&oi=ao \nWith best regards\, \nOndrej Stepanek
URL:https://www.biomed.cas.cz/event/seminar-mechanotransduction-through-immunoreceptors/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250211T090000
DTEND;TZID=Europe/Prague:20250211T120000
DTSTAMP:20260419T165240
CREATED:20250116T105835Z
LAST-MODIFIED:20250116T105835Z
UID:2286-1739264400-1739275200@www.biomed.cas.cz
SUMMARY:Školení Genderová dimenze v obsahu výzkumu
DESCRIPTION:Seminář povedou Eva Oliva a Gabriela Langhammerová z NKC – gender a věda. \nNa semináři se dozvíte:\n– jaké jsou požadavky evropských i domácích grantových agentur\n– co je genderová dimenze a proč je důležité ji zohlednit\n– jaká je souvislost s ins􀀃tucionální změnou a plány genderové rovnos􀀃\n– v čem spočívají koncepty intersekcionality a inkluzivity\n– a jak vše začlenit do obsahu výzkumu
URL:https://www.biomed.cas.cz/event/skoleni-genderova-dimenze-v-obsahu-vyzkumu/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250212T150000
DTEND;TZID=Europe/Prague:20250212T160000
DTSTAMP:20260419T165240
CREATED:20250203T151725Z
LAST-MODIFIED:20250203T151725Z
UID:2294-1739372400-1739376000@www.biomed.cas.cz
SUMMARY:Seminář Ludovica Antiga\, M.Sc.
DESCRIPTION:“PIP2-RNA-protein interactions in phase separation of Pol II transcription” \nThe RNA Polymerase II transcription is a multifaceted process crucial for gene expression in eukaryotic cells. Over the last decade\, liquid-liquid phase separation (LLPS) was shown to be crucial in regulation of RNA pol II transcription. We have shown that nuclear phosphoinositides are pivotal for regulating biological processes and PIP2 has been shown to localize with RNA Pol II machinery and nascent RNA\, linking it to the initiation step of transcription. Here\, by using lipid-interacting RNA sequencing (LIPRNAseq) and confocal microscopy\, we found a PIP2-binding AU-rich RNA motif and identified the long non-coding RNA HANR (lncHANR) in complex with PIP2 as a part of oncogenic super-enhancers in perinucleolar region of the nucleus.Furthermore\, we used PIP2-pull down coupled with mass spectrometry to identify RNA-dependent PIP2 interactome associated with nuclear processes emphasizing the role of PIP2 in liquid-liquid phase separation of RNA Pol II transcription machinery. \n 
URL:https://www.biomed.cas.cz/event/seminar-ludovica-antiga-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250217T150000
DTEND;TZID=Europe/Prague:20250217T160000
DTSTAMP:20260419T165240
CREATED:20250207T135500Z
LAST-MODIFIED:20250207T135500Z
UID:2306-1739804400-1739808000@www.biomed.cas.cz
SUMMARY:Lecture „Sleep\, synuclein and microbiome“
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/lecture-sleep-synuclein-and-microbiome/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250219T150000
DTEND;TZID=Europe/Prague:20250219T160000
DTSTAMP:20260419T165240
CREATED:20250210T070500Z
LAST-MODIFIED:20250218T081223Z
UID:2308-1739977200-1739980800@www.biomed.cas.cz
SUMMARY:Seminář Jana Smolíková\, Ph.D. - ZRUŠENO
DESCRIPTION:“Analysis of a novel chicken Pax6 mutant” \nPax6 is known as the „master control gene“ for eye formation\, playing a crucial role in the development of the lens\, retina\, and other ocular structures. It drives the formation of the eye field\, initiates lens differentiation\, and helps establish the retina—all vital for vision. \nWhile the role of Pax6 in eye development is well-studied in other species\, there has been little research on Pax6 in chickens specifically. This gap in knowledge presents an exciting opportunity to understand how the mutation of Pax6 impacts eye formation in birds. \nIn this seminar we’ll explore the role of the Pax6 transcription factor in chicken eye development and this could provide valuable insights into vertebrate eye development.
URL:https://www.biomed.cas.cz/event/seminar-jana-smolikova-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250226T150000
DTEND;TZID=Europe/Prague:20250226T160000
DTSTAMP:20260419T165240
CREATED:20250218T115219Z
LAST-MODIFIED:20250218T115219Z
UID:2312-1740582000-1740585600@www.biomed.cas.cz
SUMMARY:Seminář Iris Durić
DESCRIPTION:“Transmembrane adaptor protein WBP1L: searching for its binding partners to understand its role in hematopoiesis” \nTransmembrane adaptor protein WBP1L\, also known as Outcome Predictor of Acute Leukemia 1 (OPAL1) was identified nearly 20 years ago as a positive prognostic marker in childhood acute lymphoblastic leukemia. More recently\, elevated WBP1L expression has also been linked to positive outcomes in ovarian cancer. Despite these clinical associations\, the physiological function of WBP1L has long remained unclear. Recently we demonstrated its involvement in the regulation of hematopoiesis\, hematopoietic stem cell functionality and hematopoietic stem cell performance during transplantation. As an adaptor protein\, WBP1L’s activity depends on its interacting partners. This presentation will describe our efforts to identify these proteins and understand their contributions to WBP1L function\, focusing on two novel interactions: one with the receptor for interferon gamma and the other with the SCFβ-TRCP1 ubiquitin ligase complex.
URL:https://www.biomed.cas.cz/event/seminar-iris-duric/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
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