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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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BEGIN:VTIMEZONE
TZID:Europe/Prague
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TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
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TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20251026T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250305T150000
DTEND;TZID=Europe/Prague:20250305T160000
DTSTAMP:20260419T190927
CREATED:20250205T094137Z
LAST-MODIFIED:20250205T094137Z
UID:2302-1741186800-1741190400@www.biomed.cas.cz
SUMMARY:Seminář Andrea Pauli
DESCRIPTION:“Fundamental principles during the egg-to-embryo transition” \nFertilization initiates the egg-to-embryo transition\, one of the most dramatic developmental transition resulting in the transformation of the egg from a dormant state into regulatorily and functionally distinct embryonic cells. While this transition has been studied extensively in respect to zygotic genome activation\, the molecular mechanisms that mediate sperm-egg binding and fusion during fertilization and regulate the maintenance of dormancy in the egg and re-activation in the embryo remain poorly understood. The vision of the Pauli lab is to gain mechanistic insights into the egg-to-embryo transition\, with a specific focus on the molecular control of fertilization and developmentally programmed dormancy and re-activation. \nAndrea (Andi) Pauli will talk about recent findings from her lab related to their work towards uncovering the mechanism of vertebrate fertilization and translational regulation during the egg-to-embryo transition. By combining genetic\, molecular\, cellular\, biochemical\, structural and genomics approaches in their main model organism\, the zebrafish\, the long-term vision of the Pauli lab is to unravel new concepts and molecular mechanisms governing this fascinating developmental transition that marks the beginning of life.
URL:https://www.biomed.cas.cz/event/seminar-andrea-pauli/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250312T150000
DTEND;TZID=Europe/Prague:20250312T160000
DTSTAMP:20260419T190927
CREATED:20250303T145647Z
LAST-MODIFIED:20250303T145647Z
UID:2315-1741791600-1741795200@www.biomed.cas.cz
SUMMARY:Seminář Jakub Onhajzer\, M.Sc.
DESCRIPTION:“Reactivation of oncofetal genes reveals cellular heterogeneity and zonation in intestinal tumors” \nColorectal cancer is one of the most common malignancies. Recent studies have shown that tumor cells can reactivate so-called oncofetal genes — genes normally expressed during embryonic development but silenced in healthy adult intestinal tissue. These include Trop2 and Sca1\, both of which are reactivated during the development and progression of intestinal tumors. Using a mouse model\, we investigated the timing and molecular mechanisms driving the reactivation of these genes during the transformation of intestinal epithelial cells into tumor cells. By combining flow cytometry\, 3D microscopy\, and transcriptional profiling\, we demonstrate that the re-expression of oncofetal genes is not uniform. Instead\, it creates spatial heterogeneity — a phenomenon known as tumor zonation. This zonation is associated with the activation of fetal gene programs and the acquisition of stem cell-like properties. We also show that Sca1– and/or Trop2-positive tumor cells activate distinct molecular pathways and display unique biological properties. As several oncofetal genes (antigens) are already being explored as potential therapeutic targets\, understanding the mechanisms underlying their reactivation could contribute to the development of new targeted therapies for colorectal cancer.
URL:https://www.biomed.cas.cz/event/seminar-jakub-onhajzer-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250319T150000
DTEND;TZID=Europe/Prague:20250319T160000
DTSTAMP:20260419T190927
CREATED:20250310T081141Z
LAST-MODIFIED:20250310T081141Z
UID:2326-1742396400-1742400000@www.biomed.cas.cz
SUMMARY:Seminář Jakub Sumbal
DESCRIPTION:“Probing the functional heterogeneity and hierarchy in mammary gland fibroblasts” \nIn this talk\, I will focus on the heterogeneity and hierarchy of mouse mammary fibroblasts – the predominant cell type of mammary stroma. By single cell RNA sequencing\, genetic lineage tracing and microscopy we show that fibroblast transcriptomic clusters represent spatially differentiated populations with specific functions. Moreover\, we used the lineage tracing to show differentiation traits within fibroblast populations and other stromal cell types. Finally\, I will discuss how the regulation of fibroblast differentiation may be important for proper organ morphogenesis and cancer progression.
URL:https://www.biomed.cas.cz/event/seminar-jakub-sumbal/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250324T140000
DTEND;TZID=Europe/Prague:20250324T150000
DTSTAMP:20260419T190927
CREATED:20250305T115621Z
LAST-MODIFIED:20250305T115621Z
UID:2317-1742824800-1742828400@www.biomed.cas.cz
SUMMARY:Přednáška pro nevědce a nevědkyně - V. Hořejší
DESCRIPTION:Poučení z covidové epidemie – co dělat příště jinak \nCovidová krize v letech 2020-2022 výrazně zasáhla do životů nás všech. Co se udělalo dobře a co naopak špatně? Jak obstáli občané\, politici\, vědci a zdravotníci? Jak je možné\, že se americkým ministrem zdravotnictví stává výrazný antivaxer a šiřitel „fejků“? Pochází covidový virus z přírody nebo z laboratoře? Pomohou nám získané zkušenosti při příští epidemii\, která jistě někdy přijde? \nZajímavých otázek je mnoho… \n 
URL:https://www.biomed.cas.cz/event/prednaska-pro-nevedce-a-nevedkyne-v-horejsi/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250324T150000
DTEND;TZID=Europe/Prague:20250324T160000
DTSTAMP:20260419T190927
CREATED:20250319T135232Z
LAST-MODIFIED:20250319T135232Z
UID:2341-1742828400-1742832000@www.biomed.cas.cz
SUMMARY:Lectures – Laboratory of Experimental Hypertension\, IPHYS
DESCRIPTION:Silvie Hojná: Anorexigenic neuropeptides in the treatment of obesity \nObesity and its complications have reached epidemic proportions. Therefore\, finding new\, more effective drugs for the treatment of obesity without side effects is a major challenge. Natural anorexigenic neuropeptides have this potential\, but their major disadvantage is their low stability in plasma and inability to cross the blood-brain barrier (BBB) after peripheral administration. One strategy to develop peptidic drugs is based on peptide lipidization. This modification leads to increased stability and half-life of the peptide in the organism and allows its application in the periphery because lipidized peptides are able to cross the BBB. In Monday’s seminar\, you will hear the full story of the development of anorexigenic analogs of prolactin-releasing peptide (PrRP)\, including their implications not only for the treatment of obesity\, but also for their other potential applications. \nMahak Arora: Role of mTOR in cardiometabolic dysfunction \nCardiometabolic disorders (CMDs) such as hypertension\, diabetes and obesity are associated with damage to key organs such as the heart\, liver and kidneys. The mammalian target of rapamycin (mTOR) signaling pathway\, which is critical for cell metabolism and growth\, is often dysregulated in these diseases. In a mouse model of steatohepatitis\, the mTOR inhibitor KU-0063794 ameliorated oxidative stress\, reduced liver triglycerides and downregulated TNF-alpha mRNA by altering mTOR signaling. Recent pilot studies in high-fat fed SHR rats treated with empagliflozin and salt-sensitive Dahl rats exposed to high or low salt diet showed significant changes in mTOR-related genes such as mtor\, akt\, pgc1a\, srebp\, etc. in liver and kidney. These results suggest that mTOR plays a key role in the regulation of cardiometabolic functions
URL:https://www.biomed.cas.cz/event/lectures-laboratory-of-experimental-hypertension-iphys/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250326T160000
DTEND;TZID=Europe/Prague:20250326T170000
DTSTAMP:20260419T190927
CREATED:20250313T075437Z
LAST-MODIFIED:20250313T075437Z
UID:2330-1743004800-1743008400@www.biomed.cas.cz
SUMMARY:Seminář Jakub Gemperle\, Ph.D.
DESCRIPTION:“Live-cell magnetic micromanipulation of recycling endosomes reveals their direct effect on actin-based protrusions to promote invasive migration” \nEndocytic recycling pathways play key roles in the re-routing of cargoes through the cell to control a broad range of cellular processes\, and many vesicle trafficking regulators are implicated in progression of disease such as cancer. The Rab11 family (Rab11a\, Rab11b\, and Rab25) control return of internalised cargoes to the plasma membrane\, and Rab25 has been implicated in the aggressiveness of cancer by promoting invasive migration. However\, whilst Rab25 vesicles distribute to the leading of edge of moving cells\, how directly they contribute to cell protrusion is not clear. Here we adopt a magnetogenetic approach that allows direct manipulation of Rab25 positioning to show that localisation to the cell periphery drives the formation of F-actin protrusions. We demonstrate that endogenous Rab25 vesicles coordinate the positioning of key cargoes\, including the actin regulator FMNL1 and integrin β1\, with the activation of Rho GTPases at the plasma membrane to generate and maintain F-actin rich filopodial protrusions and promote cancer cell invasive migration in 3D matrix.
URL:https://www.biomed.cas.cz/event/seminar-jakub-gemperle-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250331
DTEND;VALUE=DATE:20250405
DTSTAMP:20260419T190927
CREATED:20250120T104415Z
LAST-MODIFIED:20250120T104415Z
UID:2289-1743379200-1743811199@www.biomed.cas.cz
SUMMARY:Course Processing and Analysis of Microscopic Images in Biomedicine
DESCRIPTION:Dear Colleagues\, \nthe Institute of Molecular Genetics of the Czech Academy of Sciences would like to invite you to the 5-day course „Processing and analysis of microscopic images in biomedicine (PAMIB25)“ intended for PhD students and junior researchers. \nThe course will address fundamental aspects of image data acquisition\, processing\, and analysis\, encompassing techniques in stereology. Alongside theoretical principles\, the course will prioritize hands-on practical learning. Participants will gain proficiency in utilizing the freely available software package Fiji for both basic and advanced analyses. They will learn to assess co-localizations\, analyze data from FRAP and electron microscopy\, track particles\, segment objects in images\, and explore methods of employing artificial intelligence for image segmentation. \nAdditionally\, participants will master techniques to enhance data quality through deconvolution using Huygens software. An interactive session featuring Imaris software will be complemented by practical exercises. Furthermore\, this year introduces a session utilizing NIS-Elements\, a platform for image processing developed in Prague\, and a lecture about the publishing images in scientific journals. Independent practical tasks involving Fiji and Huygens will also constitute a significant component of the course. \nThe course will be held at the Institute of Molecular Genetics of the Czech Academy of Sciences in Prague in March 31 – April 4\, 2025. For more information and link to the registration form\, please\, visit the course website: https://course.img.cas.cz/pamib/. The registration deadline is March 17. \nWhile the course aligns with the Microscopy Methods in Biomedicine\, prior attendance is not a prerequisite for participation. \nThe course will be taught in English. \nOn behalf of the organizers\, \nMichaela Blažíková and Martin Čapek
URL:https://www.biomed.cas.cz/event/course-processing-and-analysis-of-microscopic-images-in-biomedicine/
LOCATION:IMG
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250331T150000
DTEND;TZID=Europe/Prague:20250331T160000
DTSTAMP:20260419T190928
CREATED:20250313T075257Z
LAST-MODIFIED:20250313T075257Z
UID:2328-1743433200-1743436800@www.biomed.cas.cz
SUMMARY:20. Metodický seminář BIOCEV-Krč
DESCRIPTION:„Etika a integrita vědeckého výzkumu a právní otázky“ \nSeminář se zaměří na témata: testy vědecké integrity; kdy zapojovat etické komise při řešení deliktů na pracovišti; význam závěrů etických komisí v právních přístupech; autorský zákon v praxi a z hlediska práva. \nJUDr. Ján Matejka\, Ph.D.\nředitel Ústavu státu a práva AV ČR\, v. v. i.
URL:https://www.biomed.cas.cz/event/20-metodicky-seminar-biocev-krc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
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