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X-ORIGINAL-URL:https://www.biomed.cas.cz
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TZID:Europe/Prague
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DTSTART:20250330T010000
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DTSTART:20251026T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20250331
DTEND;VALUE=DATE:20250405
DTSTAMP:20260419T230010
CREATED:20250120T104415Z
LAST-MODIFIED:20250120T104415Z
UID:2289-1743379200-1743811199@www.biomed.cas.cz
SUMMARY:Course Processing and Analysis of Microscopic Images in Biomedicine
DESCRIPTION:Dear Colleagues\, \nthe Institute of Molecular Genetics of the Czech Academy of Sciences would like to invite you to the 5-day course „Processing and analysis of microscopic images in biomedicine (PAMIB25)“ intended for PhD students and junior researchers. \nThe course will address fundamental aspects of image data acquisition\, processing\, and analysis\, encompassing techniques in stereology. Alongside theoretical principles\, the course will prioritize hands-on practical learning. Participants will gain proficiency in utilizing the freely available software package Fiji for both basic and advanced analyses. They will learn to assess co-localizations\, analyze data from FRAP and electron microscopy\, track particles\, segment objects in images\, and explore methods of employing artificial intelligence for image segmentation. \nAdditionally\, participants will master techniques to enhance data quality through deconvolution using Huygens software. An interactive session featuring Imaris software will be complemented by practical exercises. Furthermore\, this year introduces a session utilizing NIS-Elements\, a platform for image processing developed in Prague\, and a lecture about the publishing images in scientific journals. Independent practical tasks involving Fiji and Huygens will also constitute a significant component of the course. \nThe course will be held at the Institute of Molecular Genetics of the Czech Academy of Sciences in Prague in March 31 – April 4\, 2025. For more information and link to the registration form\, please\, visit the course website: https://course.img.cas.cz/pamib/. The registration deadline is March 17. \nWhile the course aligns with the Microscopy Methods in Biomedicine\, prior attendance is not a prerequisite for participation. \nThe course will be taught in English. \nOn behalf of the organizers\, \nMichaela Blažíková and Martin Čapek
URL:https://www.biomed.cas.cz/event/course-processing-and-analysis-of-microscopic-images-in-biomedicine/
LOCATION:IMG
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250402T150000
DTEND;TZID=Europe/Prague:20250402T160000
DTSTAMP:20260419T230010
CREATED:20250325T073011Z
LAST-MODIFIED:20250325T122550Z
UID:2346-1743606000-1743609600@www.biomed.cas.cz
SUMMARY:Seminář Diego F. Joseph\, M.Sc.
DESCRIPTION:“Life Through Colors: Single-cell fluorescence-based reporter system for monitoring gene expression” \nThe presentation will depict a long journey from decision to actual making a novel reporter system for RNA silencing\, which could also be adopted for studying other mechanisms manipulating gene expression. This development lead to production of two types of triple-color reporter HeLa lines where fluorescence reporters are inserted in frame in into endogenous genes encoding highly abundant soluble nuclear proteins. The system now allows for monitoring repression (loss of specific dluorescence) and derepression (appearence of previously silenced fluorescence) across the entire population of cultured cells and\, possibly\, for high throughput screening.
URL:https://www.biomed.cas.cz/event/seminar-diego-andre-florian-joseph-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250407
DTEND;VALUE=DATE:20250412
DTSTAMP:20260419T230010
CREATED:20250204T105021Z
LAST-MODIFIED:20250204T105021Z
UID:2297-1743984000-1744415999@www.biomed.cas.cz
SUMMARY:Euro-BioImaging Image Data Community Days 2025
DESCRIPTION:Dear imaging users\, \nwe would  like to inform you about the Image Data Community Days that will be happening from 7-11. April this year. \nThis free week-long online event will bring together Euro-BioImaging Node staff\, researchers and other experts from around the world to explore and exchange on the latest advances in image data through a mix of workshops\, lectures and interactive discussions. \nThe Euro-BioImaging Data Team is pleased to announce that as of now we have officially opened registrations for this event! Find out all about the event and the preliminary agenda here: \nhttps://www.eurobioimaging.eu/our-events/image-data-events/image-data-community-days/ \nWe are very much looking forward to your participation in the week! \nBest\, \nEuro-BioImaging Data Team
URL:https://www.biomed.cas.cz/event/euro-bioimaging-image-data-community-days-2025/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250409T150000
DTEND;TZID=Europe/Prague:20250409T160000
DTSTAMP:20260419T230010
CREATED:20250402T060558Z
LAST-MODIFIED:20250402T060558Z
UID:2349-1744210800-1744214400@www.biomed.cas.cz
SUMMARY:Seminář Jana Smolíková\, Ph.D.
DESCRIPTION:“Analysis of a novel chicken Pax6 mutant” \n Pax6 is known as the „master control gene“ for eye formation\, playing a crucial role in the development of the lens\, retina\, and other ocular structures. It drives the formation of the eye field\, initiates lens differentiation\, and helps establish the retina—all vital for vision. \nWhile the role of Pax6 in eye development is well-studied in other species\, there has been little research on Pax6 in chickens specifically. This gap in knowledge presents an exciting opportunity to understand how the mutation of Pax6 impacts eye formation in birds. \nIn this seminar we’ll explore the role of the Pax6 transcription factor in chicken eye development and this could provide valuable insights into vertebrate eye development.
URL:https://www.biomed.cas.cz/event/seminar-jana-smolikova-ph-d-2/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250416T150000
DTEND;TZID=Europe/Prague:20250416T160000
DTSTAMP:20260419T230010
CREATED:20250407T122503Z
LAST-MODIFIED:20250407T122503Z
UID:2351-1744815600-1744819200@www.biomed.cas.cz
SUMMARY:Seminář Goncalo Oliveira\, Ph.D.
DESCRIPTION:“Deciphering PNKP Functions in Neurological Disorders” \nHereditary mutations in polynucleotide kinase-phosphatase (PNKP)\, a key enzyme in DNA strand break repair\, result in a broad spectrum of neurological disorders\, ranging from mild neurodegeneration to severe neurodevelopmental defects. PNKP has dual phosphatase and kinase activities essential for DNA break repair\, but their specific contributions to preventing neuropathology remains unclear. In this seminar\, we will present findings from mouse genetic models that highlight the crucial role of the PNKP phosphatase domain in neurodevelopment. Additionally\, we will introduce a novel cell-based system to investigate the immediate effects of acute PNKP depletion and explore how this model helps identify key sources of DNA damage and the molecular mechanisms underlying PNKP-related disease pathology.
URL:https://www.biomed.cas.cz/event/seminar-goncalo-oliveira-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250423T150000
DTEND;TZID=Europe/Prague:20250423T160000
DTSTAMP:20260419T230010
CREATED:20250416T064325Z
LAST-MODIFIED:20250416T064325Z
UID:2353-1745420400-1745424000@www.biomed.cas.cz
SUMMARY:Seminář Irena Adkins\, Ph.D.
DESCRIPTION:“Preclinical development of IL-15-based immunocytokine SOT201 and antibody-drug conjugate SOT106 for treatment of solid tumors” \nSOT201 is a novel cis-acting immunocytokine consisting of an antibody against PD-1 genetically fused to a sushi+ domain of IL-15Ra and IL-15 mutein. SOT201 targets PD-1+ TILs with a balanced cytokine potency to revive exhausted T cells in tumor microenvironment. SOT201 is currently being evaluated in Phase I clinical study VICTORIA-01 (NCT06163391) in metastatic advanced cancer patients.SOT106 is a novel antibody-drug conjugate (ADC) targeting LRRC15\, comprised of a proprietary humanized monoclonal antibody conjugated to monomethyl auristatin E (MMAE) via a beta-glucuronidase (GUSB) cleavable linker. SOT106 anti-tumor efficacy was confirmed in soft tissue sarcoma and pediatric osteosarcoma models with moderate to low LRRC15 expression supporting its clinical development as a novel therapy for sarcomas. Combined with its superior performance over a clinical benchmark ADC\, these results underscore the potential of SOT106 as a best-in-class targeted treatment for these challenging malignancies.
URL:https://www.biomed.cas.cz/event/seminar-irena-adkins-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250428T100000
DTEND;TZID=Europe/Prague:20250428T110000
DTSTAMP:20260419T230010
CREATED:20250424T060007Z
LAST-MODIFIED:20250424T060007Z
UID:2370-1745834400-1745838000@www.biomed.cas.cz
SUMMARY:Seminar: "The unfolded protein sensor IRE1 as a regulator of homeostatic dendritic cell maturation"
DESCRIPTION:Dear friends and colleagues\, \nit is my pleasure to invite you to a special seminar given by \n\n \n                      Prof. Sophie Janssens\, PhD. \nVIB-UGent Center for Inflammation Research\, Belgium \nTitle: The unfolded protein sensor IRE1 as a regulator of homeostatic dendritic cell maturation  \n  \nMonday\, April 28\, 2025 at 10 am\, in Hasek’s lecture hall\, Institute of Molecular Genetics (Videnska 1083) \nThen\, after the seminar you are invited to join us for an informal post-seminar hangout with the speaker\, 🍕 A PIZZA TALK 🍕🎤 Open Q&A on science\, careers\, life in academia\, women in science & more.👩‍🔬 For students & early-career scientists.🍕 Yes\, there will be pizza. \nProf. Sofie Janssens’s research team focuses on the role of the unfolded protein response (UPR) in several immune cell types. Their recent work has shown that the UPR is an important component in the functioning of the immune system. In CD8α conventional dendritic cells (DCs) the UPR sensor IRE-1α and its downstream transcription factor XBP-1s is constitutively active and deficiency of XBP-1s leads to defects in cross-presentation of dead cell-derived antigens. \nExamples of recent publications: \nStriking a balance: new perspectives on homeostatic dendritic cell maturation.\nBosteels Victor\, Janssens Sophie \nNATURE REVIEWS. IMMUNOLOGY\, 125-140\, 25\, 2025 \nDOI: 10.1038/s41577-024-01079-5 \nPaneth cell TNF signaling induces gut bacterial translocation and sepsis.\nWallaeys Charlotte\, Garcia Gonzalez Natalia\, Timmermans Steven\, Vandewalle Jolien\, Vanderhaeghen Tineke\, De Beul Somara\, Dufoor Hester\, Eggermont Melanie\, Moens Elise\, Bosteels Victor Show more \nCELL HOST & MICROBE\, 1-19\, 32\, 2024 \nDOI: 10.1016/j.chom.2024.08.007 \nActivation of goblet-cell stress sensor IRE1ß is controlled by the mucin chaperone AGR2.\nCloots Eva\, Guilbert Phaedra\, Provost Mathias\, Neidhardt Lisa\, Van De Velde Evelien\, Fayazpour Farzaneh\, De Sutter Delphine\, Savvides Savvas\, Eyckerman Sven\, Janssens Sophie \nTHE EMBO JOURNAL\, 695-718\, 43\, 2024 \nDOI: 10.1038/s44318-023-00015-y \nThe IRE1ß-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells.\nNeidhardt Lisa\, Cloots Eva\, Friemel Natalie\, Weiss Caroline A\, Harding Heather\, Mclaughlin Stephen\, Janssens Sophie\, Ron David \nTHE EMBO JOURNAL\, 719-753\, 43\, 2024 \nDOI: 10.1038/s44318-023-00014-z \nCanonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection.\nVetters Jessica\, Van Helden Mary\, De Nolf Clint\, Rennen Sofie\, Cloots Eva\, Van De Velde Evelien\, Fayazpour Farzaneh\, Van Moorleghem Justine\, Vanheerswynghels Manon\, Vergote Karl Show more \nISCIENCE\, 108570\, 26\, 2023 \nDOI: 10.1016/j.isci.2023.108570 \nLXR signaling controls homeostatic dendritic cell maturation.\nBosteels Victor\, Marechal Sandra\, De Nolf Clint\, Rennen Sofie\, Maelfait Jonathan\, Tavernier Simon\, Vetters Jessica\, Van De Velde Evelien\, Fayazpour Farzaneh\, Deswarte Kim Show more \nSCIENCE IMMUNOLOGY\, eadd3955\, 8\, 2023 \nDOI: 10.1126/sciimmunol.add3955 \n— Dominik Filipp\, PhD Laboratory of Immunobiology Institute of Molecular Genetics AS CR Videnska 1083 CZ-142 20 Prague 4 Czech Republic
URL:https://www.biomed.cas.cz/event/seminar-the-unfolded-protein-sensor-ire1-as-a-regulator-of-homeostatic-dendritic-cell-maturation/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250430T150000
DTEND;TZID=Europe/Prague:20250430T160000
DTSTAMP:20260419T230010
CREATED:20250422T105138Z
LAST-MODIFIED:20250422T105138Z
UID:2361-1746025200-1746028800@www.biomed.cas.cz
SUMMARY:Seminář Mohamed Elgendy\, Ph.D.
DESCRIPTION:„SHOULD CANCER PATIENTS EAT DIFFERENTLY? Metabolomics-guided dietary intervention for optimal clinical use of anti-cancer MCL1 inhibitors.” \nDiet is the major source of nutrients for tumors. However\, dietary interventions in cancer patients lack personalization. One of our active research areas is aimed at tailoring metabolomics-guided strategies to enhance the therapeutic effects of anti-cancer agents and/or ameliorate their toxicity. A new class of anti-cancer agents targeting Myeloid Cell Leukemia 1 (MCL1) protein is MCL1 is upregulated in around 10% of all tumors and contributes to tumorigenersis by allowing tumors to evade apoptosis. However\, our recent findings (Gui et al.\, In revision in Nature Comm.) have identified unexpected functions for MCL1 in regulating cellular metabolism positioning MCL1 as a hinge linking the two hallmarks of cancer of “deregulated energetics” and “evading cell death”. Using these novel insights and exploiting state-of-the-art humanized Mcl-1 mice\, we devised dietary approaches to optimize the clinical use of MCL1 inhibitors currently under clinical testing.
URL:https://www.biomed.cas.cz/event/seminar-mohamed-elgendy-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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