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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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BEGIN:VTIMEZONE
TZID:Europe/Prague
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
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TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20251026T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250507T150000
DTEND;TZID=Europe/Prague:20250507T160000
DTSTAMP:20260420T152300
CREATED:20250416T073223Z
LAST-MODIFIED:20250416T073223Z
UID:2355-1746630000-1746633600@www.biomed.cas.cz
SUMMARY:Seminář César Nombela-Arrieta
DESCRIPTION:“Structural and functional remodeling of the bone marrow stromal microenv. during tissue regeneration and acute myeloid leukemia” \nBone marrow (BM) tissues are the prime sites for hematopoietic cell production\, long-term reservoirs for immunological memory and hubs in which bone metabolism is orchestrated. The BM is comprised of a complex hematopoietic compartment\, as well as a heterogeneous stromal fraction made of endothelial\, mesenchymal and neural cells\, which beyond proving the necessary tissue infrastructure\, play fundamental regulatory roles in fine-tuning hematopoietic cell production. Stromal cells have also been shown to crucially contribute to hematological disease and marrow regeneration post-myeloablative damage. We combine 3D quantitative microscopy (3D-QM) techniques pioneered in our lab\, novel reporter mouse models and single cell sequencing to analyze the compositional and structural organization of BM stroma in murine and human marrow samples. In this talk I will describe our findings on the dynamic spatial reorganization of major stromal components\, and the localization of HSCs during the remodeling process that leads to the regeneration of normal marrow tissues following myeloablation. I will also present our latest work on the detailed single cell analysis of the human BM microenvironment and the alterations presented during aging as well as in patients with Acute Myeloid Leukemia.
URL:https://www.biomed.cas.cz/event/seminar-cesar-nombela-arrieta/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250512T100000
DTEND;TZID=Europe/Prague:20250512T160000
DTSTAMP:20260420T152300
CREATED:20250422T100158Z
LAST-MODIFIED:20250422T100158Z
UID:2358-1747044000-1747065600@www.biomed.cas.cz
SUMMARY:4th 10x Genomics Experience Meeting 2025
DESCRIPTION:Dear Colleagues\,\n\nWe are pleased to invite you to the 4th 10x Genomics Experience Meeting\, taking place on May 12\, 2025\, from 10:00 AM to 4:00 PM at IMG (Hašek's Auditorium).\n\nPlease find the detailed workshop program attached and join us for discussions on the current advancements in single-cell and spatial technologies.\n\nTo ensure your participation please register at https://10xgen.com/1Ls\n\nWe look forward to seeing you there!\n\nWarm regards\,\n\nMichal Kolář\n\n—\nLaboratory of Genomics and Bioinformatics\nInstitute of Molecular Genetics of the Czech Academy of Sciences
URL:https://www.biomed.cas.cz/event/4th-10x-genomics-experience-meeting-2025/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250513
DTEND;VALUE=DATE:20250515
DTSTAMP:20260420T152300
CREATED:20250306T093941Z
LAST-MODIFIED:20250306T093941Z
UID:2324-1747094400-1747267199@www.biomed.cas.cz
SUMMARY:AI-BASED SEGMENTATION AND TRACKING
DESCRIPTION:Dear all! \nIf you wish to analyze your microscopy image data efficiently using techniques of artificial intelligence\,\nYOU ARE INVITED to the practical course:\nAI-BASED SEGMENTATION AND TRACKING \nThis intensive 2-day course takes place on May 13-14\, 2025\, at the Institute of Molecular Genetics of the Czech Academy of Sciences and focuses intensively on image data segmentation\, cell tracking and denoising using state-of-the-art deep learning methods. Detailed information can be found at:\nhttps://course.img.cas.cz/aist/ \nThe deadline for registration is April 30. \nBest regards\, Martin Čapek\, Michaela Blažíková\, Jan Valečka and Pavel Krist (Zeiss)
URL:https://www.biomed.cas.cz/event/ai-based-segmentation-and-tracking/
LOCATION:IMG
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250514T150000
DTEND;TZID=Europe/Prague:20250514T160000
DTSTAMP:20260420T152300
CREATED:20250512T055543Z
LAST-MODIFIED:20250512T055543Z
UID:2372-1747234800-1747238400@www.biomed.cas.cz
SUMMARY:Seminář Jacobus van Grootel\, B.Sc.
DESCRIPTION:“Evolutionary diversification of actomyosin-driven early embryo morphogenesis” \nThe shape of an animal arises during embryo morphogenesis and involves rotatory movements of\ncells relative to eachother. These movements are driven by forces that arise in the actomyosin\ncytoskeleton. Biophysical studies in C. elegans have unraveled many of the physcial mechanisms\nunderlying morphogenetic cell rotations. However\, little is known about whether and how these\nphysical mechanisms diversified. We set out to study this by analyzing actomyosin-driven\nmorphogenesis in a panel of nematode species that covers more than 100 million years of\nevolutionary distance. Although the overall pattern of cell orientations displays little variability in\nthese nematodes\, we find striking differences in the actomyosin behavior. This indicates that\ndifferent force-generating mechanisms underlie similar types of morphogenetic cell rotations.\nAltogether\, these results are indicative of developmental systems drift\, where different physical\nmechanisms give rise to a similar developmental outcome.
URL:https://www.biomed.cas.cz/event/seminar-jacobus-van-grootel-b-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250521T150000
DTEND;TZID=Europe/Prague:20250521T160000
DTSTAMP:20260420T152300
CREATED:20250513T060824Z
LAST-MODIFIED:20250513T060824Z
UID:2380-1747839600-1747843200@www.biomed.cas.cz
SUMMARY:Seminář David Machač\, M.Sc.
DESCRIPTION:“RORγt⁺ Regulatory T Cells establish a memory footprint for the primary microbiota” \nA balanced immune system relies on regulatory T cells (Tregs) to prevent excessive immune responses. While thymus-derived Tregs are well known\, a unique subset of microbiota-specific\, peripherally induced RORγt⁺ Tregs has emerged as a critical regulator of intestinal immunity and crosstalk with microbial communities. Our data suggests that RORγt⁺ Tregs function as an immunological “memory\,” safeguarding beneficial primordial microbiota\, thus offering a novel paradigm for gut immune homeostasis.
URL:https://www.biomed.cas.cz/event/seminar-david-machac-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250526T150000
DTEND;TZID=Europe/Prague:20250526T160000
DTSTAMP:20260420T152300
CREATED:20250423T073816Z
LAST-MODIFIED:20250423T073816Z
UID:2364-1748271600-1748275200@www.biomed.cas.cz
SUMMARY:Lectures „Thermoneutrality and thermogenesis“ and „Thermogenesis: by which means?“
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/lectures-thermoneutrality-and-thermogenesis-and-thermogenesis-by-which-means/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250528T150000
DTEND;TZID=Europe/Prague:20250528T160000
DTSTAMP:20260420T152300
CREATED:20250519T133610Z
LAST-MODIFIED:20250519T133610Z
UID:2384-1748444400-1748448000@www.biomed.cas.cz
SUMMARY:Seminář Alexandra Urbančoková\, M.Sc.
DESCRIPTION:“PML nucleolar association: What is it and what does it do?” \nPromyelocytic leukemia protein (PML) is a multivalent stress response protein that\, upon specific genotoxic stress\, can organize into a unique structure that encloses nucleolar material\, termed the PML-nucleolar association (PNA). PNAs were described in both senescent cells and cells harboring DNA damage. We investigated the origin\, dynamics\, and signaling pathways leading to PNA formation. Our recent findings suggest that PNAs are involved in ribosomal DNA (rDNA) damage response by sequestration of persistent rDNA lesions and promote cellular senescence. Further analysis of PNA-associated proteins reinforces their involvement in the rDNA damage response. Together\, these insights contribute to a more comprehensive understanding of the functional relevance of PNAs in rDNA maintenance and cellular genotoxic stress response.
URL:https://www.biomed.cas.cz/event/seminar-alexandra-urbancokova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
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