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X-ORIGINAL-URL:https://www.biomed.cas.cz
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20251103
DTEND;VALUE=DATE:20251115
DTSTAMP:20260419T025504
CREATED:20250912T070739Z
LAST-MODIFIED:20250912T070739Z
UID:2406-1762128000-1763164799@www.biomed.cas.cz
SUMMARY:49th Advances in Molecular Biology & Genetics
DESCRIPTION:Dear colleagues\, \n\nI would like to invite you to register online for the seminar course Advances in Molecular Biology and Genetics and share news concerning the course. The program of the 49th course is available here:\n\nhttps://pokroky.img.cas.cz/programme/\n\nThe course is a two week lecture series and is particularly suitable for individual study plans (ISPs) of the first year PhD students in biomedicine as lectures cover broad area of molecular biology and biomedical research. The course is accredited at the Charles University as MPGS0034 (https://is.cuni.cz/studium/eng/predmety/index.php?do=predmet&kod=MPGS0034). Therefore\, attending the seminar course is recognized as a fulfilled study requirement in PhD programs in biomedicine at the Charles University. In the past\, some students came from the University of Chemistry and Technology (VSCHT) and the Czech University of Life Sciences (CZU). The course is held in English and will take place in Hasek lecture hall at IMG from November 3rd until 14th\, 2025.\n\nFor attending the course\, we kindly (but firmly) ask all participants to register at the site of the course:\n\nhttps://event.img.cas.cz/registration/advances2025/\n\nThe course is for free\, i.e. there is no registration fee. Please\, note that this registration is in addition to the course registrations/recordings at universities in PhD programs. It is for us and it is necessary\, so we can have a list of all attending students before the meeting starts. Then we can make sure that there is enough cakes during coffee breaks and can keep track of attendance\, which is needed for the credit.\n\nFurther details can be found at the website of the course: https://pokroky.img.cas.cz/\n\nIf you have any questions\, please\, contact: pokroky@img.cas.cz\n\nWith kind regards \nPetr Svoboda & Jiri Jonak on behalf of the organizing team
URL:https://www.biomed.cas.cz/event/49th-advances-in-molecular-biology-genetics/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251105T150000
DTEND;TZID=Europe/Prague:20251105T160000
DTSTAMP:20260419T025504
CREATED:20250925T102537Z
LAST-MODIFIED:20250925T102537Z
UID:2416-1762354800-1762358400@www.biomed.cas.cz
SUMMARY:Seminář Ludger Klein
DESCRIPTION:“Role of B cells in central T cell tolerance” \nTolerance to self-antigens is a fundamental property of the immune system. During central tolerance induction in the thymus\, autoreactive T cells are either eliminated or diverted into the regulatory T cell lineage. Both processes are dependent on the presentation of self-antigens by thymic antigen presenting cells (APCs). Commonly\, dendritic cells and medullary thymic epithelial cells are believed to represent the key APCs for central T cell tolerance. The thymus also harbours a distinct population of B cells\, raising the possibility that thymic B cells serve a non-redundant APC function in central T cell tolerance induction. I will discuss our ongoing work to test this hypothesis through large scale comparisons of the TCR composition of ‘normally’ selected T cell repertoires versus repertoires selected in the absence of B cells or Dendritic cells or both.
URL:https://www.biomed.cas.cz/event/seminar-ludger-klein/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251112T150000
DTEND;TZID=Europe/Prague:20251112T160000
DTSTAMP:20260419T025504
CREATED:20251103T081947Z
LAST-MODIFIED:20251103T081947Z
UID:2433-1762959600-1762963200@www.biomed.cas.cz
SUMMARY:Seminář Igor Adameyko
DESCRIPTION:“The atlas of placodal development helps to decipher their evolutionary origin” \nIn this talk I will present our single cell and spatial transcriptomics data\, which I will place into the light of the current ideas about the placodal evolution. Neurogenic placodes are specialized embryonic ectodermal thickenings in the head that give rise to sensory neurons\, sensory receptor and glial cell\, and endocrine tissues. They\, together with the neural crest\, form the basis of the vertebrate cranial sensory and neurosecretory systems. Placodes are unique to vertebrates and represent a major evolutionary innovation that allowed the elaboration of the vertebrate „new head“ – the complex sensory apparatus and associated ganglia that support the information flows necessary for effective predation and movement. They may have evolved from ancestral epidermal sensory cell fields present in protochordates (like tunicates or amphioxus).
URL:https://www.biomed.cas.cz/event/seminar-igor-adameyko/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20251118
DTEND;VALUE=DATE:20251122
DTSTAMP:20260419T025504
CREATED:20250923T132640Z
LAST-MODIFIED:20250923T132716Z
UID:2411-1763424000-1763769599@www.biomed.cas.cz
SUMMARY:Single-cell course – laboratory methods
DESCRIPTION:Dear Colleagues\,\n\nWe are excited to invite you to an intensive introductory three-day course on Single-cell analysis - from qPCR to sequencing\, organised by the Institute of Biotechnology (Radek Šindelka) and the Institute of Molecular Genetics (Michal Kolář).\n\nDates: November 18\, 19\, and 21\nTime: 9:00 AM – 3:00 PM\nLocation: Krč Campus (IMG Lecture room 0.195 – Jágr’s hall)\n\nThis course will provide valuable insights and practical skills in the rapidly evolving field of laboratory methods for single-cell analyses and spatial transcriptomics. With a maximum of 25 participants\, you’ll receive personalised attention and the opportunity to engage deeply with the subject.\n\nIn early December\, a course on bioinformatical analysis will follow up with particular focus on single-cell RNA-seq data.\n\nIf you’re interested in joining us\, please respond via email to sindelka@ibt.cas.cz as soon as possible\, as space is limited.\n\nWe look forward to an enriching experience together!\n\nBest regards\,\n\nRadek Šindelka & Michal Kolář
URL:https://www.biomed.cas.cz/event/single-cell-course-laboratory-methods/
LOCATION:Posluchárna 0.195 / Lecture room 0.195
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251118T093000
DTEND;TZID=Europe/Prague:20251118T123000
DTSTAMP:20260419T025504
CREATED:20251013T070142Z
LAST-MODIFIED:20251013T070142Z
UID:2421-1763458200-1763469000@www.biomed.cas.cz
SUMMARY:FlowJo™ 11 training
DESCRIPTION:Dear colleagues\, \non November 18th 2025 we will organize FlowJo™ 11 training with Ioannis Panetas\, Ph.D.- application specialist from BD. \nFlowJo is a powerful cytometry data analysis software available to users of our Flow Cytometry Core Facility. \nMore information about FlowJo: https://www.flowjo.com/solutions/flowjo \nThis year\, the training will focus on the new version 11\, which\, in terms of the user interface and some features\, is quite different from the previous version. This training is therefore also suitable for more experienced FlowJo users who have not yet become familiar with version 11. \n  \nTuesday November 18th 2025\, 9:30 am — 12:30pm \nInstitute of Molecular Genetics of the Czech Academy of Sciences \nVídeňská 1083\n142 20 Prague 4\, Czech Republic \nHašek Auditorium \n  \n9:30 AM – 10:15 AM | Unveiling FlowJo 11\, the future of data analysis\nCome hear about the newest version of FlowJo Software! We’ll tour the new immersive workbench and discuss features unique to this version such as the Metadata Manager\, Graph Gallery\, virtual concatenation\, charts\, and integrated algorithms. \n10:30 AM – 12:30 PM | Hands-on training for FlowJo 11\nAttendees will be guided through the analysis of a shared data set. To participate\, users are expected to bring their own laptop\, complete all downloads and installs\, and have an active FlowJo Portal license. Please follow the instructions here \n  \nIf you don‘ have license on your laptop\, please check yes in the related question in registration form and BD will send you temporary license. \n  \nThere is no fee for the training. \n  \nIf you want to attend\, please fill the registration form: https://forms.gle/23UrU6fmdn7TxSxCA \nBest regards \nMatyáš Šíma
URL:https://www.biomed.cas.cz/event/flowjo-11-training/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251119T150000
DTEND;TZID=Europe/Prague:20251119T160000
DTSTAMP:20260419T025504
CREATED:20251113T085932Z
LAST-MODIFIED:20251113T085932Z
UID:2459-1763564400-1763568000@www.biomed.cas.cz
SUMMARY:Seminář Nándor Nagy
DESCRIPTION:“Understanding the enteric nervous system development through the avian embryo model: implications for regenerative biology” \nIn this presentation\, I will provide an overview of enteric nervous system (ENS) development from the perspective of the avian embryo. The ENS\, often referred to as the “second brain\,” originates from vagal neural crest cells that migrate into the developing gut and differentiate into neuronal and glial networks that regulate intestinal function. \nAvian species\, particularly chicken and quail\, have long served as powerful model organisms for studying the cellular and molecular mechanisms regulating ENS formation\, because their embryos are easily accessible\, rapidly developing\, and highly suitable for experimental manipulation. Today\, with new tools such as in ovo electroporation\, retroviral gene transfer\, and CRISPR-based editing\, the avian model again provides unique opportunities to study enteric neurogenesis in vivo. \nIntegrating classical embryonic manipulation approaches with single-cell and spatial transcriptomic analyses now provides a comprehensive framework for understanding enteric neurogenesis\, lineage diversification\, and the evolutionary conservation of neural crest–derived systems across vertebrates.
URL:https://www.biomed.cas.cz/event/seminar-nandor-nagy/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251126T150000
DTEND;TZID=Europe/Prague:20251126T160000
DTSTAMP:20260419T025504
CREATED:20251118T072631Z
LAST-MODIFIED:20251118T072631Z
UID:2461-1764169200-1764172800@www.biomed.cas.cz
SUMMARY:Seminář Tomas Paulenda
DESCRIPTION:“The immunoregulatory properties of the metabolite itaconate” \nIn this talk I will present my latest findings of the function of immunoregulatory metabolite itaconate. Itaconate accumulates in innate immune cells upon Toll-like receptor stimulation. In response to macrophage activation by lipopolysaccharide\, itaconate inhibits inflammasome activation and boosts type I interferon signalling; however\, the molecular mechanism of this immunoregulation remained unclear. Here\, we show that the enhancement of type I interferon secretion by itaconate depends on the inhibition of peroxiredoxin 5 and on mitochondrial reactive oxygen species. We find that itaconate non-covalently inhibits peroxiredoxin 5\, leading to the modulation of mitochondrial peroxide in activating macrophages. Through genetic manipulation\, we confirm that peroxiredoxin 5 modulates  type I interferon secretion in macrophages. The non-electrophilic itaconate mimetic 2-methylsuccinate inhibits peroxiredoxin 5 and phenocopies immunoregulatory action of itaconate on type I interferon and inflammasome activation\, providing further support for a non-covalent inhibition of peroxiredoxin 5 by itaconate. Our work shows Peroxiredoxin 5 as a novel Type I interferon regulator with big potential to future research of redox regulation of immune responses.
URL:https://www.biomed.cas.cz/event/seminar-tomas-paulenda/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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