BEGIN:VCALENDAR
VERSION:2.0
PRODID:-// - ECPv6.6.3//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Prague
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20261025T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260107T150000
DTEND;TZID=Europe/Prague:20260107T160000
DTSTAMP:20260418T104438
CREATED:20251216T124552Z
LAST-MODIFIED:20251216T124552Z
UID:2469-1767798000-1767801600@www.biomed.cas.cz
SUMMARY:Seminář Veronika Niederlová
DESCRIPTION:“CD8+ T cells in infection: Orchestration of the effector and memory fates” \nIn infection\, naive CD8+ T cells differentiate into short-lived effector cells\, which provide immediate protection against the pathogen\, and long-lived memory cells\, which retain immunological information long after pathogen clearance. Using single-cell multiomics techniques and in vivo tracking of individual clonal families\, we show which factors drive the effector versus memory cell fate decision. \n 
URL:https://www.biomed.cas.cz/event/seminar-veronika-niederlova/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260114T150000
DTEND;TZID=Europe/Prague:20260114T160000
DTSTAMP:20260418T104438
CREATED:20260105T115716Z
LAST-MODIFIED:20260105T121039Z
UID:2471-1768402800-1768406400@www.biomed.cas.cz
SUMMARY:Seminář Viktor Bugajev
DESCRIPTION:“Multiple Layers of Control in Early Sphingolipid Biosynthesis” \nSphingolipids are fundamental components of cellular membranes and key mediators of intracellular signaling. Their de novo synthesis is initiated in the endoplasmic reticulum (ER) and is tightly regulated at the level of the serine palmitoyltransferase (SPT) complex. ORMDL proteins are established canonical negative regulators of SPT activity\, thereby maintaining sphingolipid homeostasis. In this seminar\, we demonstrate that ceramides act as major regulators of ORMDL expression levels and identify a previously unrecognized ORMDL interactor that establishes a novel relationship between ORMDL expression and sphingolipid abundance\, reminiscent of dysregulated sphingolipid metabolism observed in pathological conditions. These findings uncover an additional layer of control over the sphingolipid pathway and highlight unexpected flexibility in ORMDL-dependent regulation of de novo sphingolipid biosynthesis.
URL:https://www.biomed.cas.cz/event/seminar-viktor-bugajev/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260121T150000
DTEND;TZID=Europe/Prague:20260121T160000
DTSTAMP:20260418T104438
CREATED:20260112T143738Z
LAST-MODIFIED:20260112T143738Z
UID:2476-1769007600-1769011200@www.biomed.cas.cz
SUMMARY:Seminář Anna Koslová
DESCRIPTION:“Integration and reactivation of endogenous DNA viruses in unicellular eukaryotes” \nViruses infecting protists play important ecological and evolutionary roles by modulating microbial population dynamics and contributing to genome evolution through endogenization. Protist genomes contain tens to thousands of endogenous viral elements (EVEs)\, many of which appear intact and may represent functional viruses. Some EVEs are related to virophages—viruses that parasitize on larger “giant viruses” infecting eukaryotic hosts. Using an isolated virophage system\, we aim to uncover the molecular mechanisms underlying viral DNA integration and reactivation.
URL:https://www.biomed.cas.cz/event/seminar-anna-koslova/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260127T150000
DTEND;TZID=Europe/Prague:20260127T160000
DTSTAMP:20260418T104438
CREATED:20260113T133922Z
LAST-MODIFIED:20260113T133922Z
UID:2478-1769526000-1769529600@www.biomed.cas.cz
SUMMARY:Seminář Hanna-Mari Baldauf
DESCRIPTION:“From virus-host interactions to a novel protein delivery tool” \nThe VIIRAL lab has advanced the understanding of species-specific virus-host interactions against retroviruses. This advancement facilitates now the development of a rabbit model against HIV\, which is a long standing interest in the lab. We use virological\, cellular\, biochemical\, and evolutionary approaches to decipher motifs/pathways that might be important for virus-host interactions. Furthermore\, we have developed VICTORI\, a novel protein delivery platform that can be tailored for the delivery of therapeutic proteins for different purposes. \n 
URL:https://www.biomed.cas.cz/event/seminar-hanna-mari-baldauf/
LOCATION:Posluchárna 0.195 / Lecture room 0.195
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260128T150000
DTEND;TZID=Europe/Prague:20260128T160000
DTSTAMP:20260418T104438
CREATED:20260112T073717Z
LAST-MODIFIED:20260112T073717Z
UID:2474-1769612400-1769616000@www.biomed.cas.cz
SUMMARY:Seminář Lorena Arranz
DESCRIPTION:“Therapeutic targeting of stem cells and their niches in myeloid malignancies” \nOur research group “Stem Cells\, Ageing and Cancer” aims at providing insights into mechanisms of hematopoietic stem cell malignant transformation\, including interactions of this cell with its surrounding microenvironment\, and a focus on inflammation\, signaling oncometabolites and various cellular components of the stem cell niche. Our goal is the identification of novel therapeutic targets of potential clinical interest for myeloid malignancies. \nWe will give an overview of our research and present unpublished observations accepted in principle in Nature Communications\, where we have uncovered an important role for the metabolite succinate and its membrane receptor Succinate receptor (Sucnr1) in the regulation of hematopoiesis in health and malignancy. Our work suggests that Sucnr1 signaling restricts hematopoiesis at least partially via the hematopoietic stem and progenitor cell compartment and control of S100a9. The dysregulation of Sucnr1 emerges as contributor to malignancy\, accounting for SUCNR1 expression as a predictor of prognosis in acute myeloid leukemia (AML) patients and opening new potential therapeutic avenues for these patients.
URL:https://www.biomed.cas.cz/event/seminar-lorena-arranz/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
END:VCALENDAR