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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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TZID:Europe/Prague
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T010000
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DTSTART:20261025T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260504T150000
DTEND;TZID=Europe/Prague:20260504T163000
DTSTAMP:20260602T114356
CREATED:20260428T063031Z
LAST-MODIFIED:20260428T063031Z
UID:2529-1777906800-1777912200@www.biomed.cas.cz
SUMMARY:Methodological Seminar BIOCEV-Krč - Campus Animal Facility
DESCRIPTION:Dear all\, \nwe would like to invite you to the seminar as part of the „BIOCEV-Krč  Methodological Seminar“: \nTopic: „CAMPUS ANIMAL FACILITY“ \nSeminar program: \nAnimal Facility FGÚ: Martin Blažka\nAnimal Facility MBÚ: Alexandra Bartelik / Martin Schwarzer\nAnimal Facility ÚŽFG: Jiří Klíma\nAnimal Facility ÚEM: Andrej Litvinec\nAnimal Facility ÚMG: Libor Kopkan / Jan Honetschläger \nThe Animal facility methodological seminar will include a series of presentations by representatives of individual institutions located on the campus. Each institution will briefly present its local or detached animal facility and the services it provides.
URL:https://www.biomed.cas.cz/event/methodological-seminar-biocev-krc-campus-animal-facility/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260513T150000
DTEND;TZID=Europe/Prague:20260513T160000
DTSTAMP:20260602T114356
CREATED:20260528T112200Z
LAST-MODIFIED:20260528T112200Z
UID:2544-1778684400-1778688000@www.biomed.cas.cz
SUMMARY:Seminar Ondřej Ballek
DESCRIPTION:“An Intimate Dance of Two: Revealing Membrane Morphology in Early Immunological Synapse” \nT cells are central to how the immune system recognizes and responds to threats\, yet the physical organization of their surface during activation is not fully understood. In this lecture\, we use advanced imaging techniques to explore how T cells interact with antigen-presenting cells. Using high-pressure freezing combined with TEM and FIB-SEM microscopy\, we show that\, at the contact site\, known as the immunological synapse\, the cell membrane forms\na highly dynamic and complex structure\, increasing its surface area through fine protrusions. This architecture creates an optimal environment for signaling and antigen recognition. These findings provide new insight into the earliest steps of immune activation and highlight how cell structure supports immune function.
URL:https://www.biomed.cas.cz/event/seminar-ondrej-ballek/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20260519
DTEND;VALUE=DATE:20260522
DTSTAMP:20260602T114356
CREATED:20260316T081510Z
LAST-MODIFIED:20260316T081510Z
UID:2504-1779148800-1779407999@www.biomed.cas.cz
SUMMARY:AI-based Segmentation and Tracking
DESCRIPTION:Learn practical workflows for image segmentation\, cell tracking\, and denoising using modern deep-learning tools (StarDist\, Cellpose\, Omnipose\, Noise2Void\, DeepImageJ\, TrackMate\, Delta2\, ZeroCostDL4MIc\, Zeiss arivis Cloud). \nMore information & registration:\nhttps://course.img.cas.cz/aist/ \nRegistration deadline: May 4 \nBest regards\,\nMartin Čapek\, Michaela Blažíková\, Jan Valečka and Pavel Krist (Zeiss)
URL:https://www.biomed.cas.cz/event/ai-based-segmentation-and-tracking-2/
LOCATION:IMG
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260527T150000
DTEND;TZID=Europe/Prague:20260527T160000
DTSTAMP:20260602T114356
CREATED:20260528T112054Z
LAST-MODIFIED:20260528T112054Z
UID:2542-1779894000-1779897600@www.biomed.cas.cz
SUMMARY:Seminar Olha Ivashchenko
DESCRIPTION:“Primary Cilia in Bone Marrow Niche Regulation” \nPrimary cilia are small sensory organelles that regulate cellular signaling\, but their role in the bone marrow mesenchymal stromal cell (MSC) niche is still not well understood. Here\, we show that MSCs possess primary cilia both in vivo and in vitro and are mainly located around blood vessels in the bone marrow. Interestingly\, the number of ciliated MSCs decreases with age\, suggesting that ciliation changes over time. To study the role of MSC cilia in bone marrow homeostasis\, we generated mice lacking the cilia-associated protein IFT88 specifically in MSCs using an Ocn-Cre driver. Loss of MSC cilia caused mild changes in bone structure\, particularly in females. Under normal conditions\, hematopoiesis remained largely unaffected\, although females showed modest increases in hematopoietic stem cells and reduced lymphoid progenitors. Under hematopoietic stress\, induced by lipopolysaccharide treatment or 5-fluorouracil administration\, mice lacking MSC cilia showed mild but reproducible alterations in hematopoietic responses\, with differences between males and females. To better understand the molecular mechanisms involved\, we are currently analyzing single-cell RNA sequencing data from bone marrow stromal cells to identify signaling pathways regulated by ciliary function within the niche.
URL:https://www.biomed.cas.cz/event/seminar-olha-ivashchenko/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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