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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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TZID:Europe/Prague
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DTSTART:20260329T010000
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DTSTART:20261025T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20260421
DTEND;VALUE=DATE:20260424
DTSTAMP:20260417T171616
CREATED:20260223T091341Z
LAST-MODIFIED:20260223T091341Z
UID:2489-1776729600-1776988799@www.biomed.cas.cz
SUMMARY:Innovation Days in Bioscience Imaging – Vision for Life
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/innovation-days-in-bioscience-imaging-vision-for-life/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260422T150000
DTEND;TZID=Europe/Prague:20260422T160000
DTSTAMP:20260417T171616
CREATED:20260414T123612Z
LAST-MODIFIED:20260414T123612Z
UID:2522-1776870000-1776873600@www.biomed.cas.cz
SUMMARY:Seminář Karolina Kowalska
DESCRIPTION:“Mechanisms of MICAL regulation in actin filament disassembly” \nActin oxidation at specific methionine residues is a distinctive mechanism that drives actin filament disassembly. This process is mediated by the cytoskeletal effector MICAL\, which selectively associates with and oxidizes actin filaments\, thereby promoting their disassembly. MICAL-dependent actin oxidation is essential for axon guidance and also contributes to other biological processes\, including angiogenesis\, vesicle trafficking\, and cytokinesis. Despite its broad biological importance\, the molecular basis of MICAL regulation has remained unclear. In this talk\, I will show how structural biology approaches\, particularly cryo-EM\, combined with biochemical assays\, provide mechanistic insight into MICAL autoinhibition and its activation by Rab GTPases.
URL:https://www.biomed.cas.cz/event/seminar-karolina-kowalska/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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DTSTART;TZID=Europe/Prague:20260428T100000
DTEND;TZID=Europe/Prague:20260428T113000
DTSTAMP:20260417T171616
CREATED:20260416T061641Z
LAST-MODIFIED:20260416T061941Z
UID:2524-1777370400-1777375800@www.biomed.cas.cz
SUMMARY:Lecture Jonathan W. Yewdell
DESCRIPTION:„How MHC I Peptides Are Generated for Viral and Cancer Immunosurveillance“ \nThe talk focuses on peptide generation from DRiPs (defective ribosomal products)\, ribosomal generated polypeptides that don’t achieve folded stable forms and are proteolytically converted into peptides presented by MHC I molecules for CD8+ T cell immunosurveillance. Influenza A virus DRiPs will occupy center stage. I will discuss dozens of novel influenza virus gene products we discovered in characterizing DRiPs. These include PB1-F2\, the granddaddy of flu alternative reading frame proteins\, UFOs generated from host mRNA start codons\, and most recently\, numerous open reading frames encoded by the negative strand. The talk will conclude with a brief discussion of DRiPs and cancer\, and the contribution of “immunoribosomes“ (subsets of ribosomes) to the cancer immuopeptidome.
URL:https://www.biomed.cas.cz/event/lecture-jonathan-w-yewdell/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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