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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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BEGIN:VTIMEZONE
TZID:Europe/Prague
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T010000
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TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20261025T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20261014T150000
DTEND;TZID=Europe/Prague:20261014T160000
DTSTAMP:20261018T231744
CREATED:20261008T083900Z
LAST-MODIFIED:20261008T083900Z
UID:2578-1791990000-1791993600@www.biomed.cas.cz
SUMMARY:Seminar Hynek Wichterle
DESCRIPTION:“Turning back the clock on neurodegeneration: transcriptional rejuvenation of motor neurons” \nTo paraphrase Dobzhansky’s famous aphorism: nothing in neuroscience makes sense except in the light of motor behavior. Our work focuses on spinal motor neurons – the final common path in motor control and the primary target of degeneration in amyotrophic lateral sclerosis (ALS). Leveraging developmental insights from human and mouse stem-cell models\, we aim to divert motor neurons from vulnerable\, disease-sensitive states into resilient phenotypes while preserving their physiological function. To achieve this\, we pursue a dual strategy:\n1) Targeted Pharmacology: We developed novel kinase inhibitors that counteract motor neuron vulnerability to endoplasmic reticulum (ER) and proteostatic stress; shared pathogenic drivers across ALS\, Parkinson’s\, Huntington’s\, and Alzheimer’s diseases.\n2) Transcriptional Reprogramming: We established approaches to rejuvenate motor neurons\, bolstering their capacity to clear misfolded proteins\, and methods to reprogram them toward subtype identities naturally resistant to ALS pathology. By dissecting the genetic programs governing neuronal specification and maturation\, we seek to establish conceptually novel therapeutic paradigms to halt neurodegeneration.
URL:https://www.biomed.cas.cz/event/seminar-hynek-wichterle/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20261012T150000
DTEND;TZID=Europe/Prague:20261012T160000
DTSTAMP:20261018T231744
CREATED:20261008T083740Z
LAST-MODIFIED:20261008T083940Z
UID:2576-1791817200-1791820800@www.biomed.cas.cz
SUMMARY:Lecture André Marques
DESCRIPTION:“Sex without crossovers produces clonal-like offspring in Rhynchospora tenuis“ \nMeiotic recombination ensures accurate chromosome segregation and promotes genetic diversity by generating crossovers between homologous chromosomes. Although essential in most sexually reproducing organisms\, recombination is variably regulated and can be absent in some lineages\, a condition known as achiasmy. However\, obligate achiasmy in both sexes of a sexual species has not been documented. Here we investigate Rhynchospora tenuis\, a flowering plant with the lowest known chromosome number and inverted meiosis. Combining genomics with molecular experiments\, we show that R. tenuis undergoes obligate\, genome-wide achiasmy in both male and female meiosis. Despite normal early meiotic axis formation\, synapsis fails\, crossovers are undetectable cytologically and genetically\, and univalents persist at metaphase I. Haplotype-specific accumulation of transposable elements generates segregation distortion favouring the transmission of larger\, repeat-rich chromosomes. Sexual reproduction is nevertheless retained: fertilization yields viable seeds only when translocation-compatible gametes meet\, indicating strong post-meiotic selection against incompatible homozygous combinations. As a result\, all surviving offspring are genetically identical\, effectively maintaining heterozygosity by sexual reproduction with parental genotype restitution mimicking clonal reproduction. We propose that recombination loss\, a low chromosome number\, inverted meiosis and selection for compatible gamete combinations together enable faithful segregation and clonal-like inheritance despite sexual reproduction. These findings blur the boundary between sex and clonality\, linking genome architecture\, recombination loss and transmission bias.
URL:https://www.biomed.cas.cz/event/lecture-andre-marques/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20261012T140000
DTEND;TZID=Europe/Prague:20261012T150000
DTSTAMP:20261018T231744
CREATED:20260910T104440Z
LAST-MODIFIED:20260910T104440Z
UID:2563-1791813600-1791817200@www.biomed.cas.cz
SUMMARY:ELIXIR IMPACT Webinar: Discover Agentic AI in Life Sciences
DESCRIPTION:Join us for an introductory webinar exploring how agentic AI is being applied in the life sciences\, presented by members of the ELIXIR IMPACT project\, a Czech–Swiss collaboration (funded by the Swiss Czech Cooperation Programme) building new solutions that connect molecular\, pathogen and clinical data through cutting-edge AI technologies.\n\nIn this session\, colleagues from across the project will share their perspectives on the technological side of agentic AI: how autonomous research agents\, APIs\, hosting infrastructure\, and secure handling of sensitive data all come together to support biomedical research.\n\n    • When: 12 October 2026 at 14:00 CEST\n    • Duration: 1 hour\n    • Where: Online (link to follow upon registration)\n\nWhether you are curious about the possibilities of agentic AI or already working with these tools\, this session offers a practical\, grounded look at where the technology stands today\, and a preview of future webinars\, including an open call for project partners to present their own work.\n\nRegistration https://www.elixir-czech.cz/registration/elixir-impact-discover-agentic-ai-in-life-sciences-2026/registration.php\n\nProgramme\n\n14:00 – 14:05 (5 min)   – Welcome and ELIXIR IMPACT project overview (context\, partners\, goals)\n14:05 – 14:15 (10 min) – Michaela Liegertova (IMG): Autonomous research agents for life sciences (capabilities and the limits of reliance)\n14:15 – 14:25 (10 min) – Lukas Hejtmanek (MUNI-ICS): APIs and directly connected services: inference and hosting\n14:25 – 14:35 (10 min) – Vojtech Bystry (MUNI): Agentic AI and sensitive data\n14:35 – 14:45 (10 min) – Panayiotis Smeros (SIB): Agentic AI for biodata exploration\n14:45 – 14:57 (12 min) – Live Q&A (all speakers)\n14:57 – 15:00 (3 min)   – Wrap up and what’s next
URL:https://www.biomed.cas.cz/event/elixir-impact-webinar-discover-agentic-ai-in-life-sciences/
LOCATION:IMG
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20261012
DTEND;VALUE=DATE:20261017
DTSTAMP:20261018T231744
CREATED:20260616T064901Z
LAST-MODIFIED:20260616T064901Z
UID:2554-1791763200-1792195199@www.biomed.cas.cz
SUMMARY:Course “Microscopy Methods in Biomedicine”
DESCRIPTION:Dear Colleagues\, \n  \nThe Institute of Molecular Genetics CAS together with the research infrastructure Czech-BioImaging would like to invite you to attend the course “Microscopy methods in biomedicine”\, which will be held on 12. – 16. 10. 2026 in Prague. \nThe five-day theoretical course with practical demonstrations and exercises\, is devoted to modern methodologies of light and electron microscopy. The program of the course is updated every year to reflect new trends in microscopy. The course covers general methods and fundamental approaches in microscopy\, as well as cutting edge techniques like super-resolution light microscopy\, fast confocal spinning disc acquisition or light sheet microscopy and imaging of whole living organisms. \n  \nThe course is intended for PhD students and young researchers in the biomedical fields. \n  \nThe course is taught in English. \n  \nThe registration deadline is 25 September 2026 \n  \nFor more information and registration please visit the course’s webpage https://course.img.cas.cz/mmib/ \n  \nWe look forward to seeing you in Prague! \nBest regards\, \nOrganizers
URL:https://www.biomed.cas.cz/event/course-microscopy-methods-in-biomedicine/
LOCATION:IMG
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260626T140000
DTEND;TZID=Europe/Prague:20260626T153000
DTSTAMP:20261018T231744
CREATED:20260616T065046Z
LAST-MODIFIED:20260616T065046Z
UID:2557-1782482400-1782487800@www.biomed.cas.cz
SUMMARY:Lecture Liqun Luo
DESCRIPTION:Wiring Specificity of Neural Circuits \nDeveloping brains use a limited number of cell-surface proteins to instruct wiring specificity of a much larger number of neurons and synapses. How is this feat achieved? How do different cell-surface proteins work together to assemble a functional circuit? To address these questions\, I will first describe our work using the fly olfactory circuit\, focusing on a recent study in which we rewired the circuit by altering the combinatorial code of cell-surface proteins.\nI will then discuss functions of similar cell-surface proteins in instructing wiring specificity of neural circuits in the mouse brain.
URL:https://www.biomed.cas.cz/event/lecture-liqun-luo/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260625T160000
DTEND;TZID=Europe/Prague:20260625T200000
DTSTAMP:20261018T231744
CREATED:20260512T054355Z
LAST-MODIFIED:20260512T054355Z
UID:2534-1782403200-1782417600@www.biomed.cas.cz
SUMMARY:Photons\, Electrons\, and Sausages – User Meeting and BBQ 2026
DESCRIPTION:Dear colleagues\, \n  \nPhotons\, Electrons\, and Sausages – User Meeting and BBQ 2026 \n  \nThe beginning of summer is traditionally associated with an informal gathering of staff\, users\, industry partners\, colleagues\, friends\, and supporters of Prague microscopy facilities united within the Czech-BioImaging infrastructure and the Prague Node of Euro-BioImaging ERIC: \n\nLight Microscopy Core Facility\, IMG\nElectron Microscopy Core Facility\, IMG\nMicroscopy Service Center\, IEM\nBioimaging Facility\, IPHYS\nViničná Microscopy Core Facility\, Faculty of Science\, CUNI\nImaging Methods Core Facility\, BIOCEV – Faculty of Science\, CUNI\nLaboratory of Electron Microscopy\, BC\nImaging Facility\, IEB\n\nWe warmly invite you to join us for an afternoon and evening in an unusual setting\, away from the dark microscopy rooms. The event will offer discussions not only about microscopy\, but also entertainment\, good food\, and refreshing drinks. Together\, we will celebrate another successful year of collaboration and perhaps recharge for the year ahead. \nThe event is hosted by the Institute of Molecular Genetics of the Czech Academy of Sciences (IMG). \nWhat to expect\n\nDelicious barbecue and refreshing drinks\nFun microscopy-themed activities\nAnnouncement of the Picture of the Year award\, featuring stunning images produced at our core facilities\n\nSave the date\n\n25 June 2026\nFrom 4:00 PM\nIMG pond – BBQ area\n\nRegistration\nWe kindly ask everyone planning to attend to register in advance. This will help us estimate the required amount of food and drinks. After registering\, you will receive a confirmation e-mail\, which will also serve as your entry pass to the Krč campus at the main gate. \nREGISTRATION \nDeadline: 18 June 2026 \nDownload\nPoster (PDF\, 801kB) \n  \nOn behalf of organizers \nOndrej Horvath \n  \n****************************** \nOndrej Horváth M.D. \nLight Microscopy Core Facility \nInstitue of Molecular Genetics AS CR \nVideňská 1083 \n1220 Praha 4 \nCzech Republic \n  \ne-mail: ondrej.horvath@img.cas.cz \nTel. +420 24106 3168 \nMobile: +420 773 979 818
URL:https://www.biomed.cas.cz/event/photons-electrons-and-sausages-user-meeting-and-bbq-2026/
LOCATION:IMG
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260625T100000
DTEND;TZID=Europe/Prague:20260625T110000
DTSTAMP:20261018T231744
CREATED:20260612T110011Z
LAST-MODIFIED:20260612T110011Z
UID:2548-1782381600-1782385200@www.biomed.cas.cz
SUMMARY:Lecture Pascal Mayer
DESCRIPTION:Pluridisciplinarity at work: from next generation DNA sequencing to next generation therapeutics \nScientific breakthroughs often emerge at the intersection of disciplines. This presentation explores how transdisciplinary thinking contributed to the conceptual inception of Next Generation Sequencing (NGS) and now inspires a new generation of therapeutics. \nAfter revisiting key innovations behind the emergence of NGS and the often-overlooked Lemanic roots of its development\, the talk focuses on a novel AI-driven approach to drug discovery developed at Alphanosos. Based on network polypharmacology\, this strategy uses synergistic mixes of edible botanical extracts to discover safe\, effective\, and sustainable therapeutic solutions against infectious agents and oncological and complex disease conditions. \nBy connecting biophysics\, genomics\, artificial intelligence\, and systems biology\, this presentation highlights how cross-disciplinary innovation may help rethink drug development and pave the way toward safer and more effective medicines\, and potentially a fast therapeutic response to emerging infectious threats.
URL:https://www.biomed.cas.cz/event/lecture-pascal-mayer/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260624T150000
DTEND;TZID=Europe/Prague:20260624T160000
DTSTAMP:20261018T231744
CREATED:20260622T062816Z
LAST-MODIFIED:20260622T062816Z
UID:2559-1782313200-1782316800@www.biomed.cas.cz
SUMMARY:Seminar - Kriti Attri
DESCRIPTION:„Deciphering contractile fibroblasts in the developing mammary gland“ \nMammary gland development relies on coordinated interactions between the epithelium and its surrounding stroma. Although fibroblasts are key regulators of tissue morphogenesis\, their diversity and specific functions during mammary development remain poorly understood. We recently uncovered previously unrecognized heterogeneity among mammary fibroblasts and identified a transient\, niche-forming population of specialized contractile fibroblasts that localize around the tips of the growing epithelium (TEBs). These peri-TEB fibroblasts arise from preadipocytes. In this talk\, I will present our ongoing efforts to define the molecular mechanisms governing peri-TEB fibroblast specification. Our preliminary data implicate WNT signaling and hormonal cues in regulating the peri-TEB fibroblast state\, revealing new links between systemic developmental signals\, local stromal regulation\, and epithelial morphogenesis\, with broader implications for fibroblast plasticity in breast disease and cancer.
URL:https://www.biomed.cas.cz/event/seminar-kriti-attri/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260622
DTEND;VALUE=DATE:20260626
DTSTAMP:20261018T231744
CREATED:20260506T092853Z
LAST-MODIFIED:20260506T092853Z
UID:2532-1782086400-1782431999@www.biomed.cas.cz
SUMMARY:Flow Cytometry Summer School
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/flow-cytometry-summer-school/
LOCATION:IMG
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260619T100000
DTEND;TZID=Europe/Prague:20260619T113000
DTSTAMP:20261018T231744
CREATED:20260615T072703Z
LAST-MODIFIED:20260615T072703Z
UID:2551-1781863200-1781868600@www.biomed.cas.cz
SUMMARY:Special Guest Lecture on Nuclear actin dynamics
DESCRIPTION:Dear colleagues\, \nWe would like to invite you to a special lecture by Prof. Robert Grosse (University of Freiburg)\, a leading expert in actin dynamics whose pioneering work and innovative tools have helped uncover the dynamic roles of actin within the cell nucleus. \nThe role of actin microfilaments in shaping cells\, driving migration\, and orchestrating cell division is among the best-established principles of cell biology. Yet beyond this familiar cytoplasmic cytoskeleton lies the emerging and still enigmatic world of nuclear actin\, whose functions have only begun to come into focus in recent years. Nuclear actin is now recognized as an important regulator of chromatin organization\, transcriptional machinery\, and genome function. These discoveries challenge the oversimplified views of actin biology and raise fundamental questions about how dynamic actin structures contribute to nuclear processes. \nJoin us on Friday\, June 19\, at 10:00 a.m. in the Milan Hašek Auditorium\, Institute of Molecular Genetics (IMG)\, for an exciting seminar on the emerging roles of nuclear actin in gene regulation and nuclear organization. \nWe look forward to seeing you there. \nKind regards \nLibor \n— \n\n\n\n \n\n\nLibor Macůrek\, M.D.\, Ph.D. | Laboratory of Cancer Cell Biology\nHead\n\n\n+420 296 443 210\n\n\n libor.macurek@img.cas.cz \n\n\nwww.img.cas.cz\n\n\nInstitute of Molecular Genetics of the Czech Academy of Sciences\n\n\nVídeňská 1083\, 142 00 Prague 4\, Czech Republic\n\n\nID: 68378050 | VAT ID: CZ68378050
URL:https://www.biomed.cas.cz/event/special-guest-lecture-on-nuclear-actin-dynamics/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260608T140000
DTEND;TZID=Europe/Prague:20260608T150000
DTSTAMP:20261018T231744
CREATED:20260601T062837Z
LAST-MODIFIED:20260601T062837Z
UID:2546-1780927200-1780930800@www.biomed.cas.cz
SUMMARY:Přednáška pro nevědce a nevědkyně Lucie Láníková
DESCRIPTION:Lucie Láníková \nKrev je tekutina\, bez které nemůžeme žít – a přesto o ní většinou víme překvapivě málo. Jak vlastně vznikla během evoluce? Proč je červená? Kolik kyslíku dokáže přenést? A co se stane\, když se její jemně vyladěný systém porouchá? \nPřednáška vás provede příběhem krve od prvních jednoduchých organismů bez oběhového systému až po moderního člověka. Dozvíte se\, jak fungují červené krvinky a hemoglobin\, proč existují různé krevní skupiny\, jak se naše tělo přizpůsobuje nedostatku kyslíku ve vysokých horách a jak se dnes krev vyšetřuje pomocí moderních laboratorních metod. \nSpolečně nahlédneme také do světa poruch červených krvinek – od anémií\, kdy tělu chybí dostatek zdravých červených krvinek nebo hemoglobinu a orgány tak nedostávají potřebné množství kyslíku\, až po erytrocytózy\, tedy opačný stav\, kdy je červených krvinek nadbytek. Ukážeme si\, proč tyto nerovnováhy vznikají\, jak mohou souviset s genetikou i prostředím a kde končí přirozená reakce organismu a začíná umělé zvyšování výkonnosti pomocí dopingu.
URL:https://www.biomed.cas.cz/event/prednaska-pro-nevedce-a-nevedkyne-lucie-lanikova/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260608
DTEND;VALUE=DATE:20260611
DTSTAMP:20261018T231744
CREATED:20260316T081803Z
LAST-MODIFIED:20260316T081803Z
UID:2507-1780876800-1781135999@www.biomed.cas.cz
SUMMARY:Super-Resolution in Light Microscopy - practical course
DESCRIPTION:Dear colleagues\, \n  \nwe would like to announce the upcoming practical course Super-Resolution in Light Microscopy (SLM 2026)\, which will take place June 8–10\, 2026 at the Institute of Molecular Genetics of the Czech Academy of Sciences in Prague. \n  \nSome of you may know our EMBO Practical Course on Super-Resolution Microscopy\, which we bi-annually organize at IMG. The SLM course is a complementary event focused primarily on extended hands-on training\, allowing participants to spend more time working directly with the methods and data processing workflows. \n  \nThe three-day course combines short theoretical introductions with practical sessions in small groups. Participants will work with several super-resolution approaches including SIM\, SMLM\, STED and optical reassignment methods – Airyscan and SoRa. \n  \nThe practical sessions are organized in collaboration with the Microscopy unit at the Institute of Experimental Medicine (IEM CAS). \n  \nThe course is open to an international audience and the number of participants is limited to 15 to ensure an intensive training format. \n  \nMore information\, programme and registration details are available here: \nhttps://course.img.cas.cz/slm/ \n  \nRegistration deadline: May 5\, 2026 \n  \nPlease feel free to share this announcement with colleagues who might be interested. \n  \n  \nBest regards\, \n  \nIvan Novotny & Michaela Blazikova \n  \n  \n  \n\n\n\n\n\n\nIvan Novotny\, Ph.D. | Light Microscopy Core Facility\n\n\n+420 296 44 3192\, 3168\n\n\n+420 777 270 279\n\n\nivan.novotny@img.cas.cz \n\n\nwww.img.cas.cz
URL:https://www.biomed.cas.cz/event/super-resolution-in-light-microscopy-practical-course/
LOCATION:IMG
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260603T150000
DTEND;TZID=Europe/Prague:20260603T160000
DTSTAMP:20261018T231744
CREATED:20260528T111940Z
LAST-MODIFIED:20260528T111940Z
UID:2540-1780498800-1780502400@www.biomed.cas.cz
SUMMARY:Seminar Michaela Šímová
DESCRIPTION:“Where Blood Begins: Decoding Early Embryonic Hematopoiesis” \nDespite the central role of bone marrow in postnatal hematopoiesis\, the first blood cells in mammalian development arise in the yolk sac\, and their activity is essential for successful embryonic development. Progenitors of all three hematopoietic waves coexist in overlapping temporal and spatial windows and share many molecular markers\, which makes their discrimination and study challenging. As a result\, key aspects of early hematopoietic development remain unresolved. This presentation will focus on early embryonic hematopoiesis\, particularly yolk sac–derived waves and their contribution to the developing immune system. Using a combination of single-cell RNA sequencing\, flow cytometry\, and novel lineage-tracing approaches based on the Split-Cre system\, we aim to identify regulatory pathways\, discover new progenitor markers\, and refine strategies for tracking their developmental fate.
URL:https://www.biomed.cas.cz/event/seminar-michaela-simova/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260602T103000
DTEND;TZID=Europe/Prague:20260602T160000
DTSTAMP:20261018T231744
CREATED:20260512T054722Z
LAST-MODIFIED:20260512T054722Z
UID:2536-1780396200-1780416000@www.biomed.cas.cz
SUMMARY:5th 10x Genomics Experience Meeting (2026)
DESCRIPTION:Dear Colleagues\,\n\nWe are pleased to invite you to the 5th 10x Genomics Experience Meeting\, taking place on June 2\, 2026\, from 10:30 AM to 4:00 PM at IMG (Hašek's Auditorium).\n\nPlease find the detailed workshop program attached and join us for discussions on the current advancements in single-cell and spatial technologies.\n\nTo ensure your participation please register at https://qrfy.io/wDpU5HDZF8\n\nWe look forward to seeing you there!\n\nWarm regards\,\n\nMichal Kolář\n\n—\nLaboratory of Genomics and Bioinformatics\nInstitute of Molecular Genetics of the Czech Academy of Sciences
URL:https://www.biomed.cas.cz/event/5th-10x-genomics-experience-meeting-2026/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260527T150000
DTEND;TZID=Europe/Prague:20260527T160000
DTSTAMP:20261018T231744
CREATED:20260528T112054Z
LAST-MODIFIED:20260528T112054Z
UID:2542-1779894000-1779897600@www.biomed.cas.cz
SUMMARY:Seminar Olha Ivashchenko
DESCRIPTION:“Primary Cilia in Bone Marrow Niche Regulation” \nPrimary cilia are small sensory organelles that regulate cellular signaling\, but their role in the bone marrow mesenchymal stromal cell (MSC) niche is still not well understood. Here\, we show that MSCs possess primary cilia both in vivo and in vitro and are mainly located around blood vessels in the bone marrow. Interestingly\, the number of ciliated MSCs decreases with age\, suggesting that ciliation changes over time. To study the role of MSC cilia in bone marrow homeostasis\, we generated mice lacking the cilia-associated protein IFT88 specifically in MSCs using an Ocn-Cre driver. Loss of MSC cilia caused mild changes in bone structure\, particularly in females. Under normal conditions\, hematopoiesis remained largely unaffected\, although females showed modest increases in hematopoietic stem cells and reduced lymphoid progenitors. Under hematopoietic stress\, induced by lipopolysaccharide treatment or 5-fluorouracil administration\, mice lacking MSC cilia showed mild but reproducible alterations in hematopoietic responses\, with differences between males and females. To better understand the molecular mechanisms involved\, we are currently analyzing single-cell RNA sequencing data from bone marrow stromal cells to identify signaling pathways regulated by ciliary function within the niche.
URL:https://www.biomed.cas.cz/event/seminar-olha-ivashchenko/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260519
DTEND;VALUE=DATE:20260522
DTSTAMP:20261018T231744
CREATED:20260316T081510Z
LAST-MODIFIED:20260316T081510Z
UID:2504-1779148800-1779407999@www.biomed.cas.cz
SUMMARY:AI-based Segmentation and Tracking
DESCRIPTION:Learn practical workflows for image segmentation\, cell tracking\, and denoising using modern deep-learning tools (StarDist\, Cellpose\, Omnipose\, Noise2Void\, DeepImageJ\, TrackMate\, Delta2\, ZeroCostDL4MIc\, Zeiss arivis Cloud). \nMore information & registration:\nhttps://course.img.cas.cz/aist/ \nRegistration deadline: May 4 \nBest regards\,\nMartin Čapek\, Michaela Blažíková\, Jan Valečka and Pavel Krist (Zeiss)
URL:https://www.biomed.cas.cz/event/ai-based-segmentation-and-tracking-2/
LOCATION:IMG
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260513T150000
DTEND;TZID=Europe/Prague:20260513T160000
DTSTAMP:20261018T231744
CREATED:20260528T112200Z
LAST-MODIFIED:20260528T112200Z
UID:2544-1778684400-1778688000@www.biomed.cas.cz
SUMMARY:Seminar Ondřej Ballek
DESCRIPTION:“An Intimate Dance of Two: Revealing Membrane Morphology in Early Immunological Synapse” \nT cells are central to how the immune system recognizes and responds to threats\, yet the physical organization of their surface during activation is not fully understood. In this lecture\, we use advanced imaging techniques to explore how T cells interact with antigen-presenting cells. Using high-pressure freezing combined with TEM and FIB-SEM microscopy\, we show that\, at the contact site\, known as the immunological synapse\, the cell membrane forms\na highly dynamic and complex structure\, increasing its surface area through fine protrusions. This architecture creates an optimal environment for signaling and antigen recognition. These findings provide new insight into the earliest steps of immune activation and highlight how cell structure supports immune function.
URL:https://www.biomed.cas.cz/event/seminar-ondrej-ballek/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260504T150000
DTEND;TZID=Europe/Prague:20260504T163000
DTSTAMP:20261018T231744
CREATED:20260428T063031Z
LAST-MODIFIED:20260428T063031Z
UID:2529-1777906800-1777912200@www.biomed.cas.cz
SUMMARY:Methodological Seminar BIOCEV-Krč - Campus Animal Facility
DESCRIPTION:Dear all\, \nwe would like to invite you to the seminar as part of the „BIOCEV-Krč  Methodological Seminar“: \nTopic: „CAMPUS ANIMAL FACILITY“ \nSeminar program: \nAnimal Facility FGÚ: Martin Blažka\nAnimal Facility MBÚ: Alexandra Bartelik / Martin Schwarzer\nAnimal Facility ÚŽFG: Jiří Klíma\nAnimal Facility ÚEM: Andrej Litvinec\nAnimal Facility ÚMG: Libor Kopkan / Jan Honetschläger \nThe Animal facility methodological seminar will include a series of presentations by representatives of individual institutions located on the campus. Each institution will briefly present its local or detached animal facility and the services it provides.
URL:https://www.biomed.cas.cz/event/methodological-seminar-biocev-krc-campus-animal-facility/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260429T150000
DTEND;TZID=Europe/Prague:20260429T160000
DTSTAMP:20261018T231744
CREATED:20260422T074033Z
LAST-MODIFIED:20260422T074033Z
UID:2526-1777474800-1777478400@www.biomed.cas.cz
SUMMARY:Seminář Joe Howard
DESCRIPTION:“How molecular motors drive the motility of cilia and flagella” \nCilia and flagella are thin\, rod-like organelles whose snake-like beating patterns drive cells through fluids and move fluids across cellular surfaces. They play essential roles in locomotion\, sensory reception\, and signaling. The core structure within the cilium\, known as the axoneme\, consists of nine pairs of doublet microtubules\, a central pair of single microtubules\, and a myriad of other proteins\, including the axonemal dynein motor proteins\, which generate the shear forces that slide adjacent doublets. A key question is how dynein activity is coordinated to produce the characteristic sinusoidal beating patterns. We are addressing this question through reconstitution and modeling\, leveraging the genetics of the unicellular alga Chlamydomonas reinhardtii.
URL:https://www.biomed.cas.cz/event/seminar-joe-howard/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260428T100000
DTEND;TZID=Europe/Prague:20260428T113000
DTSTAMP:20261018T231744
CREATED:20260416T061641Z
LAST-MODIFIED:20260416T061941Z
UID:2524-1777370400-1777375800@www.biomed.cas.cz
SUMMARY:Lecture Jonathan W. Yewdell
DESCRIPTION:„How MHC I Peptides Are Generated for Viral and Cancer Immunosurveillance“ \nThe talk focuses on peptide generation from DRiPs (defective ribosomal products)\, ribosomal generated polypeptides that don’t achieve folded stable forms and are proteolytically converted into peptides presented by MHC I molecules for CD8+ T cell immunosurveillance. Influenza A virus DRiPs will occupy center stage. I will discuss dozens of novel influenza virus gene products we discovered in characterizing DRiPs. These include PB1-F2\, the granddaddy of flu alternative reading frame proteins\, UFOs generated from host mRNA start codons\, and most recently\, numerous open reading frames encoded by the negative strand. The talk will conclude with a brief discussion of DRiPs and cancer\, and the contribution of “immunoribosomes“ (subsets of ribosomes) to the cancer immuopeptidome.
URL:https://www.biomed.cas.cz/event/lecture-jonathan-w-yewdell/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260422T150000
DTEND;TZID=Europe/Prague:20260422T160000
DTSTAMP:20261018T231744
CREATED:20260414T123612Z
LAST-MODIFIED:20260422T074024Z
UID:2522-1776870000-1776873600@www.biomed.cas.cz
SUMMARY:Seminář Karolina Kowalska
DESCRIPTION:“Mechanisms of MICAL regulation in actin filament disassembly” \nActin oxidation at specific methionine residues is a distinctive mechanism that drives actin filament disassembly. This process is mediated by the cytoskeletal effector MICAL\, which selectively associates with and oxidizes actin filaments\, thereby promoting their disassembly. MICAL-dependent actin oxidation is essential for axon guidance and also contributes to other biological processes\, including angiogenesis\, vesicle trafficking\, and cytokinesis. Despite its broad biological importance\, the molecular basis of MICAL regulation has remained unclear. In this talk\, I will show how structural biology approaches\, particularly cryo-EM\, combined with biochemical assays\, provide mechanistic insight into MICAL autoinhibition and its activation by Rab GTPases.
URL:https://www.biomed.cas.cz/event/seminar-karolina-kowalska/
LOCATION:Posluchárna 0.195 / Lecture room 0.195
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260421
DTEND;VALUE=DATE:20260424
DTSTAMP:20261018T231744
CREATED:20260223T091341Z
LAST-MODIFIED:20260223T091341Z
UID:2489-1776729600-1776988799@www.biomed.cas.cz
SUMMARY:Innovation Days in Bioscience Imaging – Vision for Life
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/innovation-days-in-bioscience-imaging-vision-for-life/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260415T150000
DTEND;TZID=Europe/Prague:20260415T160000
DTSTAMP:20261018T231744
CREATED:20260408T101152Z
LAST-MODIFIED:20260408T101152Z
UID:2516-1776265200-1776268800@www.biomed.cas.cz
SUMMARY:Seminář Despoina Giamaki
DESCRIPTION:“A hidden layer of chromatin regulation in neurological disease” \nGenome stability and DNA repair are essential for human health. ADP-ribosylation is a key post-translational modification in the DNA damage response\, regulated by PARP enzymes. Our research focuses on ARH3\, an enzyme that removes mono-ADP-ribose from proteins\, as its deficiency is linked to rare neurological disease. Using patient-derived cells\, 3D brain organoids and mouse models\, we show that loss of ARH3 leads to accumulation of mono-ADP-ribose on chromatin. Genome-wide analyses (CUT&Tag\, spatial transcriptomic and RNA-seq) reveal that these changes alter gene expression and modulate other histone modifications. We further explore how these chromatin alterations affect responses to stress\, including viral infections\, potentially contributing to neuropathology. Our findings provide new insights into disease mechanisms and highlight ADP-ribosylation as a potential therapeutic target in neurological disorders.
URL:https://www.biomed.cas.cz/event/seminar-despoina-giamaki/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260408T150000
DTEND;TZID=Europe/Prague:20260408T160000
DTSTAMP:20261018T231744
CREATED:20260331T120116Z
LAST-MODIFIED:20260408T101210Z
UID:2512-1775660400-1775664000@www.biomed.cas.cz
SUMMARY:Seminář Lumír Krejčí
DESCRIPTION:“Homologous Recombination – From repair of DSBs to processing stalled replication forks and human diseases” \nHomologous recombination (HR) is a central genome maintenance pathway that safeguards DNA integrity during both double-strand break (DSB) repair and replication stress. A key intermediate of HR is the nucleoprotein filament formed by RAD51 on single-stranded DNA\, which mediates homology search and strand invasion. During DSB repair RAD51 filament assembly is tightly regulated by mediator proteins\, including BRCA2\, and RAD51 paralogs\, ensuring accurate repair using a homologous template and preventing genome instability. Beyond canonical DSB repair\, HR plays a crucial role at stalled replication forks\, where RAD51 stabilises nascent DNA\, protects forks from nucleolytic degradation\, and promotes fork reversal and restart. The dynamic regulation of RAD51 filament formation and disassembly at replication forks is essential for balancing protection and timely recovery of DNA synthesis. Dysregulation of these processes leads to pathological outcomes\, including chromosomal instability and tumourigenesis. Defects in HR factors\, particularly those controlling RAD51 filament dynamics\, are strongly linked to human diseases such as cancer predisposition syndromes. Understanding how RAD51 orchestrates HR across different DNA damage contexts provides critical insights into genome stability mechanisms and offers therapeutic opportunities\, including synthetic lethality-based cancer treatments.
URL:https://www.biomed.cas.cz/event/seminar-lumir-krejci/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260401T150000
DTEND;TZID=Europe/Prague:20260401T160000
DTSTAMP:20261018T231744
CREATED:20260324T121133Z
LAST-MODIFIED:20260408T101222Z
UID:2510-1775055600-1775059200@www.biomed.cas.cz
SUMMARY:Seminář Anna Zitová
DESCRIPTION:“Amphioxus point of view” \nLight\, a crucial environmental signal\, that drives lives of myriad creatures upon the Earth\, regulating processes such as circadian rhythms\, reproductive cycles\, and visually guided behaviors. We all perceive light through specialized cells called photoreceptors. Behold Amphioxus\, who possesses several distinct types of photoreceptors. It is also considered one of the closest living likenesses to the last common ancestor of all vertebrates. Although it lacks many vertebrate-specific innovations\, it has a simple body plan and homologous structures shared with vertebrates. In this discourse\, we shall cast our gaze more narrowly upon these photoreceptors of Amphioxus\, to unravel their function and inquire whether they may reveal some glimmer of the origins whence the vertebrate visual systems first took its light.
URL:https://www.biomed.cas.cz/event/seminar-anna-zitova/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260325T150000
DTEND;TZID=Europe/Prague:20260325T160000
DTSTAMP:20261018T231744
CREATED:20260316T072314Z
LAST-MODIFIED:20260408T101231Z
UID:2501-1774450800-1774454400@www.biomed.cas.cz
SUMMARY:Seminář Michael Sixt
DESCRIPTION:“Mechanic and energetic principles of leukocyte locomotion” \nDuring metazoan development\, immune surveillance and cancer dissemination\, cells migrate in complex three-dimensional (3D) microenvironments. These are crowded by cells and extracellular matrix\, generating mazes of differently sized spaces typically smaller than the diameter of the migrating cell. Most mesenchymal and epithelial cells actively generate their migratory path using pericellular tissue proteolysis and transmit traction forces via specific adhesion receptors. On the contrary\, amoeboid cells such as leukocytes employ non-destructive strategies of locomotion and do not hold on to extracellular substrates. This raises the question how these extremely fast cells negotiate dense tissues. We discovered that leukocytes are able to migrate in the total absence of transmembrane force coupling. Instead\, active deformations of the cell body can impose normal forces on the substrate and thereby generate propulsion. We are actively investigating how these normal forces are triggered and generated by the collective activity of the actin and microtuble cytoskeleton and develop new approaches to measure the energetic demands of the process.
URL:https://www.biomed.cas.cz/event/seminar-michael-sixt/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260318T150000
DTEND;TZID=Europe/Prague:20260318T160000
DTSTAMP:20261018T231744
CREATED:20260305T070841Z
LAST-MODIFIED:20260408T101238Z
UID:2499-1773846000-1773849600@www.biomed.cas.cz
SUMMARY:Seminář Srikant Ojha
DESCRIPTION:“Plectin Loss Disrupts Mechanotransduction and Attenuates\nHepatic Stellate Cell Activation” \nLiver fibrosis\, a hallmark of fibroproliferative disorders that contribute to nearly 45% of global mortality\, is primarily driven by the activation of hepatic stellate cells (HSCs). In response to injury-induced tissue stiffening\, HSCs undergo mechanosignaling-dependent activation and deposit excessive extracellular matrix (ECM)\, perpetuating a self-sustaining fibrotic loop. We sought to disrupt this process by targeting plectin\, a cytolinker protein central to mechanotransduction. Using an HSC-specific plectin knockout (KO) mouse model\, we observed significantly reduced ECM accumulation following carbon tetrachloride–induced injury. In vitro\, plectin-deficient HSCs displayed impaired proliferation\, migration\, and focal adhesion formation. Single-cell transcriptomics further revealed attenuated activation signatures in KO HSCs. Together\, our findings establish plectin as a key regulator of HSC mechanosignaling and highlight its potential as a therapeutic target to alleviate liver fibrosis.
URL:https://www.biomed.cas.cz/event/seminar-srikant-ojha/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260311T150000
DTEND;TZID=Europe/Prague:20260311T160000
DTSTAMP:20261018T231744
CREATED:20260302T081531Z
LAST-MODIFIED:20260302T081531Z
UID:2496-1773241200-1773244800@www.biomed.cas.cz
SUMMARY:Seminář Diego André Florian Joseph
DESCRIPTION:“The Fall of the Helicase of Dicer” \nDicer is an RNase III endoribonuclease that processes pre-miRNAs and dsRNAs into small RNAs of ~21–28 nt\, serving the miRNA and RNAi pathways. In mammals\, Dicer’s ability to process long dsRNA is constrained by its helicase domain. Consequently\, the miRNA pathway predominates\, and RNAi is considered vestigial. This constraint comes from a crucial interaction between the HEL1 subdomain of Dicer and its catalytic domain\, which maintains Dicer in a “closed” conformation\, making it highly selective. In the absence of HEL1\, Dicer adopts an “open” conformation that reduces substrate selectivity and activates RNAi. Until now\, this was the only interaction known to confer substrate selectivity and restrict RNAi activity. Here\, we show that Dicer contains an additional region within its helicase that contributes to substrate selectivity. Analysis of Dicer’s AlphaFold structure revealed four major intrinsically disordered regions (IDRs) adopting loop-like conformations. IDR1 is enriched in negatively charged residues and is predicted to interact with the positively charged RNA substrate channel of Dicer. Removal of IDR1 recapitulates the phenotype observed in the absence of HEL1\, suggesting that HEL1 subdomain is not the only region in Dicer responsible for substrate selectivity.
URL:https://www.biomed.cas.cz/event/seminar-diego-andre-florian-joseph/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260304T150000
DTEND;TZID=Europe/Prague:20260304T160000
DTSTAMP:20261018T231744
CREATED:20260225T130603Z
LAST-MODIFIED:20260225T130603Z
UID:2494-1772636400-1772640000@www.biomed.cas.cz
SUMMARY:Seminář Vladimír Varga
DESCRIPTION:“Towards understanding life cycle of Trypanosoma brucei” \nTrypanosoma brucei is a unicellular eukaryotic parasite of mammals causing sleeping sickness in humans. T. brucei is transmitted by the tsetse fly. In the fly trypanosomes migrate from the gut to salivary glands\, which is associated with a defined sequence of changes to cells of the parasite. We have established an in vitro approach enabling us for the first time to study these life cycle transitions during initial stages of trypanosome migration. Hence\, we were able to describe associated changes to trypanosome morphology\, cell cycle\, motility as well as to its proteome and metabolome. This revealed that the initial life cycle transitions represent a continuous plastic process rather than a sequence of irreversible decisions. Furthermore\, it let to identification of a molecule in the trypanosome environment\, which is critical for triggering cell cycle arrest during these transitions. Thus\, our work opens new possibilities to understand complex biology of this important human parasite.
URL:https://www.biomed.cas.cz/event/seminar-vladimir-varga/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260303
DTEND;VALUE=DATE:20260304
DTSTAMP:20261018T231744
CREATED:20260223T091618Z
LAST-MODIFIED:20260223T091618Z
UID:2491-1772496000-1772582399@www.biomed.cas.cz
SUMMARY:BD Biosciences – Lunch and Learn Seminar
DESCRIPTION:Dear colleagues\, \nWe would like to invite you to join Lunch & Learn seminar focused on Panel Design Strategy in Flow Cytometry. This session is designed to support anyone involved in planning\, optimizing\, or performing multicolor flow cytometry experiments by providing both conceptual guidance and practical demonstrations. \n  \nMore information and registration. \nFlyer \n  \nRegistration is free. \n  \nBest regards \n  \n— \n\n\n\n\n\n\nMatyáš Šíma\, Ph.D.
URL:https://www.biomed.cas.cz/event/bd-biosciences-lunch-and-learn-seminar/
END:VEVENT
END:VCALENDAR