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TZID:Europe/Prague
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DTSTART:20230326T010000
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DTSTART:20231029T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231102T140000
DTEND;TZID=Europe/Prague:20231102T144500
DTSTAMP:20260501T213451
CREATED:20231027T103432Z
LAST-MODIFIED:20231027T103844Z
UID:681-1698933600-1698936300@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 11/2023
DESCRIPTION:Single-cell gene expression analysis of developing craniofacial region\nLecturer: Erika Hudáčová\, M.Sc. / Department of Developmental Biology \nThe seminar will take place on 2. 11. 2023 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nAnnotation: In vertebrates\, the skull is composed of various skeletal elements originating from cranial neural crest cells (CNCCs). CNCCs are responsible for the formation of the cranium vault\, frontonasal prominence\, upper and lower jaw\, hyoid bone\, external ear and middle ear. The morphogenesis of the craniofacial region encompasses a number of processes\, from epithelial-mesenchymal induction and mesenchymal condensation to endochondral or intramembranous ossification. However\, the molecular and genetic pathways regulating cranial cartilage shaping and growth during embryogenesis are poorly understood. \nIn our research\, we present Wnt1-Cre2\, Meis2 conditional knock-out (cKO) mice with several craniofacial bone abnormalities resembling severe human pathologies due to improper molecular mechanisms guiding mesenchymal condensation. Using single-cell RNA sequencing\, we further focus on describing the Meis2-dependent gene regulatory network involved in mesenchymal condensation. Comparison of wild-type and Meis2 cKO embryonic stages E12.5 and E13.5 reveals multiple mesenchymal cell types responsible for craniofacial formation. We have identified markers for cell type specification and positional cues in developing craniofacial regions. Furthermore\, differences identified in specific cell types governing mesenchymal condensation and endochondral ossification correlate with the phenotype present in Meis2 cKO mice. Our transcriptomics data in Meis2 cKO show elevated expression of the genes involved in ossification\, cell-cell adhesion and cell-extracellular matrix contact. Altogether\, the identification of hitherto unknown factors controlling the growth and shape of cranial bones may potentially contribute to the mitigation or prevention of human craniofacial abnormalities. \nWe look forward to your participation. \n  \n 
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-11-2023/
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231023T150000
DTEND;TZID=Europe/Prague:20231023T160000
DTSTAMP:20260501T213451
CREATED:20231004T074255Z
LAST-MODIFIED:20231004T074255Z
UID:666-1698073200-1698076800@www.biomed.cas.cz
SUMMARY:Lecture "Understanding the molecular mechanisms of thermoTRP ion channel activation"
DESCRIPTION:Mgr. Lucie Zímová\, Ph.D.\, Laboratory of Cellular Neurophysiology
URL:https://www.biomed.cas.cz/event/lecture-understanding-the-molecular-mechanisms-of-thermotrp-ion-channel-activation/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231016T150000
DTEND;TZID=Europe/Prague:20231016T160000
DTSTAMP:20260501T213451
CREATED:20231004T074139Z
LAST-MODIFIED:20231004T074139Z
UID:662-1697468400-1697472000@www.biomed.cas.cz
SUMMARY:Lecture "Parvalbumin interneurons: A hothouse flower in the brain?"
DESCRIPTION:RNDr. Jan Svoboda Ph.D. – Laboratory of Neurophysiology of Memory
URL:https://www.biomed.cas.cz/event/lecture-parvalbumin-interneurons-a-hothouse-flower-in-the-brain/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231009T150000
DTEND;TZID=Europe/Prague:20231009T163000
DTSTAMP:20260501T213451
CREATED:20231004T071247Z
LAST-MODIFIED:20231004T073916Z
UID:657-1696863600-1696869000@www.biomed.cas.cz
SUMMARY:Bureš lecture series "Skeletal muscle function in the context of the neuromuscular\, musculoskeletal and metabolic system"
DESCRIPTION:Prof. Stefano Schiaffino\, Venetian Institute of Molecular Medicine\, Padova\, Italy
URL:https://www.biomed.cas.cz/event/bures-lecture-series-skeletal-muscle-function-in-the-context-of-the-neuromuscular-musculoskeletal-and-metabolic-system/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231004T150000
DTEND;TZID=Europe/Prague:20231004T160000
DTSTAMP:20260501T213451
CREATED:20230822T085825Z
LAST-MODIFIED:20230822T112804Z
UID:633-1696431600-1696435200@www.biomed.cas.cz
SUMMARY:Pravidelný středeční seminář / Regular Wednesday Seminar
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/pravidelny-stredecni-seminar/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231002T123000
DTEND;TZID=Europe/Prague:20231002T150000
DTSTAMP:20260501T213451
CREATED:20230908T101722Z
LAST-MODIFIED:20230908T101817Z
UID:640-1696249800-1696258800@www.biomed.cas.cz
SUMMARY:Miloš Pěkný - Astrocytes as a treatment target in neurological diseases  Marcela Pěkná - Novel therapeutic strategy to promote recovery after stroke
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/640/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20230821
DTEND;VALUE=DATE:20230822
DTSTAMP:20260501T213451
CREATED:20230721T104647Z
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UID:617-1692576000-1692662399@www.biomed.cas.cz
SUMMARY:NIVB Networking Meeting
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/nivb-networking-meeting/
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
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