Akce

Seminář povedou Eva Oliva a Gabriela Langhammerová z NKC - gender a věda. Na semináři se dozvíte: - jaké jsou požadavky evropských i domácích grantových agentur - co je genderová dimenze a proč je důležité ji zohlednit - jaká je souvislost s ins􀀃tucionální změnou a plány genderové rovnos􀀃 - v čem spočívají koncepty intersekcionality a inkluzivity…
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“PIP2-RNA-protein interactions in phase separation of Pol II transcription” The RNA Polymerase II transcription is a multifaceted process crucial for gene expression in eukaryotic cells. Over the last decade, liquid-liquid phase separation (LLPS) was shown to be crucial in regulation of RNA pol II transcription. We have shown that nuclear phosphoinositides are pivotal for regulating biological…
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“Analysis of a novel chicken Pax6 mutant” Pax6 is known as the "master control gene" for eye formation, playing a crucial role in the development of the lens, retina, and other ocular structures. It drives the formation of the eye field, initiates lens differentiation, and helps establish the retina—all vital for vision. While the role of Pax6 in…
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“Transmembrane adaptor protein WBP1L: searching for its binding partners to understand its role in hematopoiesis” Transmembrane adaptor protein WBP1L, also known as Outcome Predictor of Acute Leukemia 1 (OPAL1) was identified nearly 20 years ago as a positive prognostic marker in childhood acute lymphoblastic leukemia. More recently, elevated WBP1L expression has also been linked to…
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“Fundamental principles during the egg-to-embryo transition” Fertilization initiates the egg-to-embryo transition, one of the most dramatic developmental transition resulting in the transformation of the egg from a dormant state into regulatorily and functionally distinct embryonic cells. While this transition has been studied extensively in respect to zygotic genome activation, the molecular mechanisms that mediate sperm-egg…
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“Reactivation of oncofetal genes reveals cellular heterogeneity and zonation in intestinal tumors” Colorectal cancer is one of the most common malignancies. Recent studies have shown that tumor cells can reactivate so-called oncofetal genes — genes normally expressed during embryonic development but silenced in healthy adult intestinal tissue. These include Trop2 and Sca1, both of which…
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“Probing the functional heterogeneity and hierarchy in mammary gland fibroblasts” In this talk, I will focus on the heterogeneity and hierarchy of mouse mammary fibroblasts - the predominant cell type of mammary stroma. By single cell RNA sequencing, genetic lineage tracing and microscopy we show that fibroblast transcriptomic clusters represent spatially differentiated populations with specific…
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Poučení z covidové epidemie – co dělat příště jinak Covidová krize v letech 2020-2022 výrazně zasáhla do životů nás všech. Co se udělalo dobře a co naopak špatně? Jak obstáli občané, politici, vědci a zdravotníci? Jak je možné, že se americkým ministrem zdravotnictví stává výrazný antivaxer a šiřitel „fejků“? Pochází covidový virus z přírody nebo z laboratoře? Pomohou nám…
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Silvie Hojná: Anorexigenic neuropeptides in the treatment of obesity Obesity and its complications have reached epidemic proportions. Therefore, finding new, more effective drugs for the treatment of obesity without side effects is a major challenge. Natural anorexigenic neuropeptides have this potential, but their major disadvantage is their low stability in plasma and inability to cross…
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“Live-cell magnetic micromanipulation of recycling endosomes reveals their direct effect on actin-based protrusions to promote invasive migration” Endocytic recycling pathways play key roles in the re-routing of cargoes through the cell to control a broad range of cellular processes, and many vesicle trafficking regulators are implicated in progression of disease such as cancer. The Rab11…
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„Etika a integrita vědeckého výzkumu a právní otázky“ Seminář se zaměří na témata: testy vědecké integrity; kdy zapojovat etické komise při řešení deliktů na pracovišti; význam závěrů etických komisí v právních přístupech; autorský zákon v praxi a z hlediska práva. JUDr. Ján Matejka, Ph.D. ředitel Ústavu státu a práva AV ČR, v. v. i.