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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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TZID:Europe/Prague
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TZOFFSETFROM:+0100
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TZNAME:CEST
DTSTART:20260329T010000
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DTSTART:20261025T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260415T150000
DTEND;TZID=Europe/Prague:20260415T160000
DTSTAMP:20260415T022554
CREATED:20260408T101152Z
LAST-MODIFIED:20260408T101152Z
UID:2516-1776265200-1776268800@www.biomed.cas.cz
SUMMARY:Seminář Despoina Giamaki
DESCRIPTION:“A hidden layer of chromatin regulation in neurological disease” \nGenome stability and DNA repair are essential for human health. ADP-ribosylation is a key post-translational modification in the DNA damage response\, regulated by PARP enzymes. Our research focuses on ARH3\, an enzyme that removes mono-ADP-ribose from proteins\, as its deficiency is linked to rare neurological disease. Using patient-derived cells\, 3D brain organoids and mouse models\, we show that loss of ARH3 leads to accumulation of mono-ADP-ribose on chromatin. Genome-wide analyses (CUT&Tag\, spatial transcriptomic and RNA-seq) reveal that these changes alter gene expression and modulate other histone modifications. We further explore how these chromatin alterations affect responses to stress\, including viral infections\, potentially contributing to neuropathology. Our findings provide new insights into disease mechanisms and highlight ADP-ribosylation as a potential therapeutic target in neurological disorders.
URL:https://www.biomed.cas.cz/event/seminar-despoina-giamaki/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20260421
DTEND;VALUE=DATE:20260424
DTSTAMP:20260415T022554
CREATED:20260223T091341Z
LAST-MODIFIED:20260223T091341Z
UID:2489-1776729600-1776988799@www.biomed.cas.cz
SUMMARY:Innovation Days in Bioscience Imaging – Vision for Life
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/innovation-days-in-bioscience-imaging-vision-for-life/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260422T150000
DTEND;TZID=Europe/Prague:20260422T160000
DTSTAMP:20260415T022554
CREATED:20260414T123612Z
LAST-MODIFIED:20260414T123612Z
UID:2522-1776870000-1776873600@www.biomed.cas.cz
SUMMARY:Seminář Karolina Kowalska
DESCRIPTION:“Mechanisms of MICAL regulation in actin filament disassembly” \nActin oxidation at specific methionine residues is a distinctive mechanism that drives actin filament disassembly. This process is mediated by the cytoskeletal effector MICAL\, which selectively associates with and oxidizes actin filaments\, thereby promoting their disassembly. MICAL-dependent actin oxidation is essential for axon guidance and also contributes to other biological processes\, including angiogenesis\, vesicle trafficking\, and cytokinesis. Despite its broad biological importance\, the molecular basis of MICAL regulation has remained unclear. In this talk\, I will show how structural biology approaches\, particularly cryo-EM\, combined with biochemical assays\, provide mechanistic insight into MICAL autoinhibition and its activation by Rab GTPases.
URL:https://www.biomed.cas.cz/event/seminar-karolina-kowalska/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260519
DTEND;VALUE=DATE:20260522
DTSTAMP:20260415T022554
CREATED:20260316T081510Z
LAST-MODIFIED:20260316T081510Z
UID:2504-1779148800-1779407999@www.biomed.cas.cz
SUMMARY:AI-based Segmentation and Tracking
DESCRIPTION:Learn practical workflows for image segmentation\, cell tracking\, and denoising using modern deep-learning tools (StarDist\, Cellpose\, Omnipose\, Noise2Void\, DeepImageJ\, TrackMate\, Delta2\, ZeroCostDL4MIc\, Zeiss arivis Cloud). \nMore information & registration:\nhttps://course.img.cas.cz/aist/ \nRegistration deadline: May 4 \nBest regards\,\nMartin Čapek\, Michaela Blažíková\, Jan Valečka and Pavel Krist (Zeiss)
URL:https://www.biomed.cas.cz/event/ai-based-segmentation-and-tracking-2/
LOCATION:IMG
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260608
DTEND;VALUE=DATE:20260611
DTSTAMP:20260415T022554
CREATED:20260316T081803Z
LAST-MODIFIED:20260316T081803Z
UID:2507-1780876800-1781135999@www.biomed.cas.cz
SUMMARY:Super-Resolution in Light Microscopy - practical course
DESCRIPTION:Dear colleagues\, \n  \nwe would like to announce the upcoming practical course Super-Resolution in Light Microscopy (SLM 2026)\, which will take place June 8–10\, 2026 at the Institute of Molecular Genetics of the Czech Academy of Sciences in Prague. \n  \nSome of you may know our EMBO Practical Course on Super-Resolution Microscopy\, which we bi-annually organize at IMG. The SLM course is a complementary event focused primarily on extended hands-on training\, allowing participants to spend more time working directly with the methods and data processing workflows. \n  \nThe three-day course combines short theoretical introductions with practical sessions in small groups. Participants will work with several super-resolution approaches including SIM\, SMLM\, STED and optical reassignment methods – Airyscan and SoRa. \n  \nThe practical sessions are organized in collaboration with the Microscopy unit at the Institute of Experimental Medicine (IEM CAS). \n  \nThe course is open to an international audience and the number of participants is limited to 15 to ensure an intensive training format. \n  \nMore information\, programme and registration details are available here: \nhttps://course.img.cas.cz/slm/ \n  \nRegistration deadline: May 5\, 2026 \n  \nPlease feel free to share this announcement with colleagues who might be interested. \n  \n  \nBest regards\, \n  \nIvan Novotny & Michaela Blazikova \n  \n  \n  \n\n\n\n\n\n\nIvan Novotny\, Ph.D. | Light Microscopy Core Facility\n\n\n+420 296 44 3192\, 3168\n\n\n+420 777 270 279\n\n\nivan.novotny@img.cas.cz \n\n\nwww.img.cas.cz
URL:https://www.biomed.cas.cz/event/super-resolution-in-light-microscopy-practical-course/
LOCATION:IMG
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