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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250602T150000
DTEND;TZID=Europe/Prague:20250602T160000
DTSTAMP:20260428T224836
CREATED:20250305T115745Z
LAST-MODIFIED:20250305T115745Z
UID:2319-1748876400-1748880000@www.biomed.cas.cz
SUMMARY:Přednáška pro nevědce a nevědkyně - V. Varga
DESCRIPTION:„Cesta do nitra buňky“ \nBěhem přednášky podnikneme cestu do nitra živé buňky. Ukážeme si\, jaké nástroje vědci používají\, aby odhalili její mikroskopické struktury\, a jak lze tyto detaily převést do podoby\, kterou můžeme spatřit\npouhým okem. Zároveň zjistíme něco překvapivého – naše buňky mají víc společného\, než byste čekali\, s buňkami nebezpečných parazitů\, například s původcem spavé nemoci. Jak moc jsme si podobní a co to pro nás znamená? To vše odhalíme v průběhu přednášky.
URL:https://www.biomed.cas.cz/event/prednaska-pro-nevedce-a-nevedkyne-v-varga/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250604T150000
DTEND;TZID=Europe/Prague:20250604T160000
DTSTAMP:20260428T224836
CREATED:20250423T100816Z
LAST-MODIFIED:20250423T100816Z
UID:2368-1749049200-1749052800@www.biomed.cas.cz
SUMMARY:Seminář Piergiorgio Percipalle
DESCRIPTION:“Chromatin Architecture and Gene Regulation by Actin and Myosin in Health and Disease” \nChromosomes are arranged in distinct chromosome territories\, within which chromatin is further organized into chromatin compartments and topologically associating domains (TADs). By orchestrating DNA loops and promoter-enhancer interactions\, this spatial organization of the genome plays a crucial role in gene expression and ultimately has a critical impact on cell identity. Disruptions in these hierarchical layers of genome organization can lead to aberrant expression of entire gene programs\, contributing to various diseases\, including metabolic and genetic disorders. Understanding these spatial features provides critical insights into genome function and potential therapeutic strategies. Architectural proteins such as CTCF and cohesin have been shown to play key roles in genome organization. In this talk\, I will primarily focus on the critical role of nuclear actin and myosin in regulating 3D genome organization at the chromatin level and how these mechanisms\, once impaired\, affect metabolic reprogramming in the context of tumorigenesis and differentiation\, including adipogenesis.
URL:https://www.biomed.cas.cz/event/seminar-piergiorgio-percipalle/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250615
DTEND;VALUE=DATE:20250623
DTSTAMP:20260428T224836
CREATED:20250321T112735Z
LAST-MODIFIED:20250321T112735Z
UID:2344-1749945600-1750636799@www.biomed.cas.cz
SUMMARY:EMBO Practical Course "Super-resolution in Light Microscopy"
DESCRIPTION:Dear Colleagues\, \n  \nWe are pleased to announce the upcoming EMBO Practical Course „Super-resolution in Light Microscopy\,“ \ntaking place from June 15–22\, 2025\, Institute of Molecular Genetics of the Czech Academy of Sciences (IMG) in Prague. \n  \nThis 8-day course combines theoretical talks\, lectures from leading experts in the field\, and practical demonstrations with hands-on sessions using advanced microscopy systems. \n  \nFollowing the introductory day\, the course is structured into three thematic 2-day blocks: \n\nConfocal-based super-resolution (optical/mathematical reassignment\, adaptive deconvolution\, and radial fluctuations)\nStructured Illumination Microscopy (SIM)\nNanoscopy techniques (Single-Molecule Localization Microscopy – SMLM\, and Stimulated Emission Depletion microscopy – STED)\n\nThe last day is focused on deconvolution of SR images and QC approaches. \n  \nFor the course\, we have gathered an outstanding group of international experts who will deliver lectures and keynotes and participate actively in practical demonstrations. Leading microscopy companies will provide their latest super-resolution systems\, with application specialists guiding dedicated hands-on sessions. \n  \nThe course is ideally suited for biologists\, microscopy facility staff\, and imaging specialists who wish to enhance their practical expertise and remain at the forefront of microscopy innovations. \n  \nThe registration deadline is April 14\, 2025. \nThe course is offered in a hybrid format: 20 in-person seats and 25 virtual participant slots are available.  \n  \nCourse in numbers: \n16 expert lectures and keynotes by global leaders in microscopy. \n38 intensive practical hours to master super-resolution techniques. \n12 advanced microscopy systems from industry-leading producers. \n4 interactive discussions exploring specialized microscopy topics. \n3 amazing social events for networking with experts \n  \nDetailed course information and registration are available at: \nhttps://meetings.embo.org/event/25-superres-light-microscopy \n  \nProgramme overview: \nhttps://meetings.embo.org/files/2025-03/embo-practical-course-srlm-2025-overview.pdf \n  \nYou can follow us on: \nInstagram: https://www.instagram.com/embo_pc_srlm/  \nFacebook: https://www.facebook.com/embopcsrlm/  \n  \nWe encourage you to apply soon and look forward to welcoming you to Prague! \n  \nBest regards\, \n  \nEMBO Organizing Team
URL:https://www.biomed.cas.cz/event/embo-practical-course-super-resolution-in-light-microscopy/
LOCATION:IMG
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250623T150000
DTEND;TZID=Europe/Prague:20250623T160000
DTSTAMP:20260428T224836
CREATED:20250319T134811Z
LAST-MODIFIED:20250319T135059Z
UID:2334-1750690800-1750694400@www.biomed.cas.cz
SUMMARY:Prof. Bradley Launikonis\, The University of Queensland\, Brisbane\, Australia
DESCRIPTION:Lecture „The role of ryanodine receptors in muscle function“ \nRyanodine receptors (RyR) are the Ca2+ release channel of skeletal muscle\, which are responsible for rapidly releasing a large amount of Ca2+ upon electrical stimulation to evoke contraction. In the resting muscle\, RyR leak Ca2+ and require the expenditure of energy to maintain steady state Ca2+ content of the intracellular Ca2+ store. It is this function that regulates multiple processes in the muscle\, including the regulation of Ca2+ permeability of the plasma membrane and distribution of Ca2+ across the intracellular compartments\, non-shivering thermogenesis and adaptation to changes in muscle activity. In this talk I will describe how RyR basal function controls the movements of Ca2+ between cellular compartments following changes in the RyR due to mutations\, intense exercise and changes in activity. To do this I will present novel techniques for measuring Ca2+ movements and heat generation within the fibre that we have used in conjunction with muscle from transgenic mice and fibres isolated from biopsies of human muscle.
URL:https://www.biomed.cas.cz/event/lecture-the-role-of-ryanodine-receptors-in-muscle-function/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250623T150000
DTEND;TZID=Europe/Prague:20250623T160000
DTSTAMP:20260428T224836
CREATED:20250423T073953Z
LAST-MODIFIED:20250423T073953Z
UID:2366-1750690800-1750694400@www.biomed.cas.cz
SUMMARY:Lecture „The role of ryanodine receptors in muscle function“
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/lecture-the-role-of-ryanodine-receptors-in-muscle-function-2/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250625T150000
DTEND;TZID=Europe/Prague:20250625T160000
DTSTAMP:20260428T224836
CREATED:20250617T070133Z
LAST-MODIFIED:20250617T070133Z
UID:2386-1750863600-1750867200@www.biomed.cas.cz
SUMMARY:Seminář Rositsa Maystorova\, M.Sc.
DESCRIPTION:“Ontogeny of zebrafish erythropoietic waves” \nHematopoiesis is the process of blood formation\, which occurs in multiple waves during vertebrate development. In zebrafish\, the first wave initiates before 24 hours post-fertilization with the generation of primitive myeloid cells from cephalic mesoderm and primitive erythrocytes in the intermediate cell mass. The first definitive wave is transient\, and it produces erythro-myeloid progenitors in the posterior blood island at 26-30hpf. The next definitive wave forms hematopoietic stem cells from the aortic endothelium\, which migrate to the caudal hematopoietic tissue\, and later colonize the kidneys and thymus. Despite the importance of zebrafish as a model organism\, it has been challenging to study the erythroid waves in fish in detail\, and our knowledge about these processes is limited and predominantly focused on their emergence. Through our work\, we are providing more information on the dynamics of the erythroid waves\, as well as globin gene expression patterns in the primitive and definitive populations. Additionally\, we have managed to identify novel factors playing a role in the globin switch from larval to adult globins.
URL:https://www.biomed.cas.cz/event/seminar-rositsa-maystorova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250703T150000
DTEND;TZID=Europe/Prague:20250703T163000
DTSTAMP:20260428T224836
CREATED:20250619T071834Z
LAST-MODIFIED:20250619T071834Z
UID:2389-1751554800-1751560200@www.biomed.cas.cz
SUMMARY:Seminar "Adoptive cell therapy with Treg cells obtained from thymic tissue (thyTreg): from a clinical trial using autologous cells to preclinical research exploring allogeneic applications"
DESCRIPTION:We would like to invite you to the seminar \n********************************** \nDr. Marjorie Pion\n \n„Adoptive cell therapy with Treg cells obtained from thymic tissue (thyTreg): from a clinical trial using autologous cells to preclinical research exploring allogeneic applications“ \nThe seminar will be held on 3rd July 2025 at 15:00 in the Lecture room (0.195) at IMG. \nFor more information see: https://www.img.cas.cz/2025/06/86929-seminar-marjorie-pion/
URL:https://www.biomed.cas.cz/event/seminar-adoptive-cell-therapy-with-treg-cells-obtained-from-thymic-tissue-thytreg-from-a-clinical-trial-using-autologous-cells-to-preclinical-research-exploring-allogeneic-applications/
LOCATION:Posluchárna 0.195 / Lecture room 0.195
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250911
DTEND;VALUE=DATE:20250913
DTSTAMP:20260428T224836
CREATED:20250729T101758Z
LAST-MODIFIED:20250729T101758Z
UID:2401-1757548800-1757721599@www.biomed.cas.cz
SUMMARY:7th Annual CCP Phenogenomics Conference
DESCRIPTION:Dear colleagues and members of the research community\, \nIt is my great pleasure to invite you to the 7th Annual CCP Phenogenomics Conference\, taking place on September 11–12\, 2025 at the Institute of Molecular Genetics in Prague. \nContinuing a tradition of scientific excellence\, this hybrid conference offers a unique forum to exchange knowledge and advance research in the fields of rare diseases\, gene and cell therapy development\, and preclinical modeling with animal systems. \nWe are proud to host a lineup of distinguished speakers\, including leading international experts and innovators\, who will present groundbreaking findings and cutting-edge technologies. Highlights include keynote lectures on in vivo gene function studies\, \nadvanced genotype-phenotype integration via bioinformatics\, and the rapidly evolving field of genome programming for tailored therapeutic solutions. \nA special focus will be placed on bottom-up approaches to gene therapy development\, integrating basic research with clinical perspectives through sessions featuring not only scientists but also representatives from patient advocacy groups and rare disease foundations. \nThis interdisciplinary dialogue aims to foster collaboration and accelerate translation from bench to bedside. \nParticipation in the scientific sessions is offered free of charge for all academic attendees\, underlining our commitment to supporting the scientific community and encouraging broad engagement. \nFor detailed information on the full conference programme\, featured speakers\, and registration\, please visit our website at https://www.ccp-conference.cz/. \nPlease feel free to share this invitation with colleagues and students who may be interested. \nThank you very much\, and I look forward to seeing you in Prague this September. \nBest regards\, \n  \nRadislav Sedláček \nDirector of the Czech Centre for Phenogenomics \nInstitute of Molecular Genetics of the Czech Academy of Sciences
URL:https://www.biomed.cas.cz/event/7th-annual-ccp-phenogenomics-conference/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251001T150000
DTEND;TZID=Europe/Prague:20251001T160000
DTSTAMP:20260428T224836
CREATED:20250922T140000Z
LAST-MODIFIED:20250922T140000Z
UID:2408-1759330800-1759334400@www.biomed.cas.cz
SUMMARY:Seminář Vadym Sulimenko
DESCRIPTION:“Regulation of microtubule organization in glioblastoma cells by GIT2 phosphorylation” \nGlioblastoma\, the most aggressive common type of brain cancer in humans\, carries a very poor prognosis for patient survival. Microtubules are critical for cell division and mesenchymal migration\, processes that strongly influence tumor viability and invasiveness. While the reorganization of highly dynamic microtubules is central to these events\, the mechanisms by which microtubules contribute to glioblastoma cell motility remain poorly understood. We previously demonstrated that ARF GTPase-activating proteins (GITs) associate with γ-tubulin ring complex (γTuRC) proteins. Here\, we show that GIT2 localizes to centrosomes\, regulates microtubule organization and cell motility. Our findings indicate that the ArfGAP domain of GIT2 and protein kinase C (PKC) are essential for controlling microtubule nucleation. Furthermore\, we demonstrate that glioblastoma cells can be effectively treated with newly developed functionalized upconverting nanoparticles (UCNPs)\, which represent a promising new approach for photodynamic therapy of glioblastoma.
URL:https://www.biomed.cas.cz/event/seminar-vadym-sulimenko/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251008T150000
DTEND;TZID=Europe/Prague:20251008T160000
DTSTAMP:20260428T224836
CREATED:20250924T150118Z
LAST-MODIFIED:20250924T150118Z
UID:2414-1759935600-1759939200@www.biomed.cas.cz
SUMMARY:Seminář Katarína Ondrušková
DESCRIPTION:“How Cells Keep DNA Replication in Check” \nAccurate DNA replication is the foundation of genome stability and cell survival. Our study uncovers a key “gatekeeper” complex that ensures the molecular machinery starting DNA replication is properly assembled and regulated. When this control breaks down\, replication becomes uncoordinated\, leading to stress\, genetic instability\, and changes often seen in cancer cells. By revealing this hidden layer of replication control\, our work opens new opportunities to understand how cells protect their genomes and how these mechanisms could be exploited in cancer therapy. \n 
URL:https://www.biomed.cas.cz/event/seminar-katarina-ondruskova/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251015T150000
DTEND;TZID=Europe/Prague:20251015T160000
DTSTAMP:20260428T224836
CREATED:20251008T123139Z
LAST-MODIFIED:20251008T123139Z
UID:2418-1760540400-1760544000@www.biomed.cas.cz
SUMMARY:Seminář Kihyuck Kwak
DESCRIPTION:Department of Microbiology\, College of Medicine\, Yonsei University\, Seoul\, South Korea \n“Intrinsic mechanisms governing B cell discrimination between self and non-self antigens”
URL:https://www.biomed.cas.cz/event/seminar-kihyuck-kwak/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251023T130000
DTEND;TZID=Europe/Prague:20251023T160000
DTSTAMP:20260428T224836
CREATED:20251013T071221Z
LAST-MODIFIED:20251013T071221Z
UID:2423-1761224400-1761235200@www.biomed.cas.cz
SUMMARY:100th anniversary of the birth of Prof. Milan Hašek
DESCRIPTION:Dear colleagues and friends\, \nThis year marks the 100th anniversary of the birth of Prof. Milan Hašek (October 4\, 1925)\,\na giant of Czech immunology. He was not only an outstanding scientist\, immunologist\,\nbiologist\, and physician\, but also an inspiring mentor to an entire generation of researchers\,\nmany of whom emigrated after 1968 and became respected ambassadors of Czech immunology\nabroad. His insatiable curiosity\, innovative spirit\, and experimental precision\, often bordering\non genius\, earned him worldwide recognition as a co-discoverer of immune tolerance.\nWhen this year’s Nobel laureate in Physiology or Medicine\, Prof. Shimon Sakaguchi\, was\ninvited to Prague\, his response was clear: “I would be delighted to visit the country that gave\nthe world Milan Hašek.” \nWe are pleased to invite you to a mini-conference dedicated to the centennial of Prof. Milan\nHašek’s birth.\n📅 October 23\, 2025\n📍 Hašek Lecture Hall\, Institute of Molecular Genetics\, Czech Academy of Sciences\n🕐 1:00–4:00 PM (followed by refreshments) \nInvited speakers include:\n• Prof. MUDr. Juraj Ivanyi\, Emeritus Professor of Immunology of Infectious Diseases\,\nKing’s College London\, long-term collaborator and close friend of Prof. Hašek\n• Prof. RNDr. Vladimír Holáň\, DrSc.\, leading Czech immunologist specializing in\ntransplant immunology and immunoregulation\, former researcher at the Institute of\nExperimental Medicine of the CAS and Prof. Hašek’s last PhD student\n• RNDr. Jiří Hejnar\, CSc.\, Head of the Laboratory of Viral and Cellular Genetics\, IMG\nCAS\, expert in endogenous retroviruses\, viral receptors\, and gene editing in poultry\n• Mgr. Ondřej Štěpánek\, Ph.D.\, Head of the Laboratory of Adaptive Immunity\, holder\nof the EMBO Installation and ERC Starting Grants\, and Horizon Europe Grant\, focused\non fundamental aspects of T-cell biology in infection\, cancer\, and autoimmunity\n• Mgr. Jan Dobeš\, Ph.D.\, Head of the Laboratory of Microbial Immunity\, Department\nof Cell Biology\, Faculty of Science\, Charles University; recipient of the Česká hlava\n“Invence” Award (2023)\, “ACTERIA Early Career Research Prize”\, and grants Junior\nStar\, Primus\, and ERC.CZ\, focused on peripheral tolerance and gut immunity\n• Mgr. Matouš Vobořil\, Ph.D.\, Head of the newly established Laboratory of Viral\nImmunology\, Department of Cell Biology\, Faculty of Science\, Charles University;\nlaureate of the Česká hlava “Doctorandus” Award (2020) and holder of Junior Star and\nPrimus grants\, focused on immune tolerance and antiviral immunity\n• Mgr. Jiří Březina\, Ph.D.\, Postdoctoral researcher at VIB Ghent\, Belgium – studying\nnovel mechanisms underlying the establishment of central tolerance \nWe warmly look forward to seeing you and celebrating the scientific legacy of Prof. Milan\nHašek together. \nRNDr. Petr Dráber\, DrSc.\, MUDr. Luca Vannucci\, PhD.\, RNDr. Dominik Filipp\, CSc. \n  \n 
URL:https://www.biomed.cas.cz/event/100th-anniversary-of-the-birth-of-prof-milan-hasek/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251029T150000
DTEND;TZID=Europe/Prague:20251029T160000
DTSTAMP:20260428T224836
CREATED:20251013T073543Z
LAST-MODIFIED:20251013T073543Z
UID:2426-1761750000-1761753600@www.biomed.cas.cz
SUMMARY:Seminář Rositsa Maystorova
DESCRIPTION:“Ontogeny of zebrafish erythropoietic waves” \nHematopoiesis is the process of blood formation\, which occurs in multiple waves during vertebrate development. In zebrafish\, the first wave initiates before 24 hours post-fertilization with the generation of primitive myeloid cells from cephalic mesoderm and primitive erythrocytes in the intermediate cell mass. The first definitive wave is transient\, and it produces erythro-myeloid progenitors in the posterior blood island at 26-30hpf. The next definitive wave forms hematopoietic stem cells from the aortic endothelium\, which migrate to the caudal hematopoietic tissue\, and later colonize the kidneys and thymus. Despite the importance of zebrafish as a model organism\, it has been challenging to study the erythroid waves in fish in detail\, and our knowledge about these processes is limited and predominantly focused on their emergence. Through our work\, we are providing more information on the dynamics of the erythroid waves\, as well as globin gene expression patterns in the primitive and definitive populations. Additionally\, we have managed to identify novel factors playing a role in the globin switch from larval to adult globins.
URL:https://www.biomed.cas.cz/event/seminar-rositsa-maystorova/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20251031
DTEND;VALUE=DATE:20251101
DTSTAMP:20260428T224836
CREATED:20250306T130439Z
LAST-MODIFIED:20250306T130439Z
UID:2322-1761868800-1761955199@www.biomed.cas.cz
SUMMARY:RNA Club
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/rna-club/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20251103
DTEND;VALUE=DATE:20251115
DTSTAMP:20260428T224836
CREATED:20250912T070739Z
LAST-MODIFIED:20250912T070739Z
UID:2406-1762128000-1763164799@www.biomed.cas.cz
SUMMARY:49th Advances in Molecular Biology & Genetics
DESCRIPTION:Dear colleagues\, \n\nI would like to invite you to register online for the seminar course Advances in Molecular Biology and Genetics and share news concerning the course. The program of the 49th course is available here:\n\nhttps://pokroky.img.cas.cz/programme/\n\nThe course is a two week lecture series and is particularly suitable for individual study plans (ISPs) of the first year PhD students in biomedicine as lectures cover broad area of molecular biology and biomedical research. The course is accredited at the Charles University as MPGS0034 (https://is.cuni.cz/studium/eng/predmety/index.php?do=predmet&kod=MPGS0034). Therefore\, attending the seminar course is recognized as a fulfilled study requirement in PhD programs in biomedicine at the Charles University. In the past\, some students came from the University of Chemistry and Technology (VSCHT) and the Czech University of Life Sciences (CZU). The course is held in English and will take place in Hasek lecture hall at IMG from November 3rd until 14th\, 2025.\n\nFor attending the course\, we kindly (but firmly) ask all participants to register at the site of the course:\n\nhttps://event.img.cas.cz/registration/advances2025/\n\nThe course is for free\, i.e. there is no registration fee. Please\, note that this registration is in addition to the course registrations/recordings at universities in PhD programs. It is for us and it is necessary\, so we can have a list of all attending students before the meeting starts. Then we can make sure that there is enough cakes during coffee breaks and can keep track of attendance\, which is needed for the credit.\n\nFurther details can be found at the website of the course: https://pokroky.img.cas.cz/\n\nIf you have any questions\, please\, contact: pokroky@img.cas.cz\n\nWith kind regards \nPetr Svoboda & Jiri Jonak on behalf of the organizing team
URL:https://www.biomed.cas.cz/event/49th-advances-in-molecular-biology-genetics/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251105T150000
DTEND;TZID=Europe/Prague:20251105T160000
DTSTAMP:20260428T224836
CREATED:20250925T102537Z
LAST-MODIFIED:20250925T102537Z
UID:2416-1762354800-1762358400@www.biomed.cas.cz
SUMMARY:Seminář Ludger Klein
DESCRIPTION:“Role of B cells in central T cell tolerance” \nTolerance to self-antigens is a fundamental property of the immune system. During central tolerance induction in the thymus\, autoreactive T cells are either eliminated or diverted into the regulatory T cell lineage. Both processes are dependent on the presentation of self-antigens by thymic antigen presenting cells (APCs). Commonly\, dendritic cells and medullary thymic epithelial cells are believed to represent the key APCs for central T cell tolerance. The thymus also harbours a distinct population of B cells\, raising the possibility that thymic B cells serve a non-redundant APC function in central T cell tolerance induction. I will discuss our ongoing work to test this hypothesis through large scale comparisons of the TCR composition of ‘normally’ selected T cell repertoires versus repertoires selected in the absence of B cells or Dendritic cells or both.
URL:https://www.biomed.cas.cz/event/seminar-ludger-klein/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251112T150000
DTEND;TZID=Europe/Prague:20251112T160000
DTSTAMP:20260428T224836
CREATED:20251103T081947Z
LAST-MODIFIED:20251103T081947Z
UID:2433-1762959600-1762963200@www.biomed.cas.cz
SUMMARY:Seminář Igor Adameyko
DESCRIPTION:“The atlas of placodal development helps to decipher their evolutionary origin” \nIn this talk I will present our single cell and spatial transcriptomics data\, which I will place into the light of the current ideas about the placodal evolution. Neurogenic placodes are specialized embryonic ectodermal thickenings in the head that give rise to sensory neurons\, sensory receptor and glial cell\, and endocrine tissues. They\, together with the neural crest\, form the basis of the vertebrate cranial sensory and neurosecretory systems. Placodes are unique to vertebrates and represent a major evolutionary innovation that allowed the elaboration of the vertebrate „new head“ – the complex sensory apparatus and associated ganglia that support the information flows necessary for effective predation and movement. They may have evolved from ancestral epidermal sensory cell fields present in protochordates (like tunicates or amphioxus).
URL:https://www.biomed.cas.cz/event/seminar-igor-adameyko/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20251118
DTEND;VALUE=DATE:20251122
DTSTAMP:20260428T224836
CREATED:20250923T132640Z
LAST-MODIFIED:20250923T132716Z
UID:2411-1763424000-1763769599@www.biomed.cas.cz
SUMMARY:Single-cell course – laboratory methods
DESCRIPTION:Dear Colleagues\,\n\nWe are excited to invite you to an intensive introductory three-day course on Single-cell analysis - from qPCR to sequencing\, organised by the Institute of Biotechnology (Radek Šindelka) and the Institute of Molecular Genetics (Michal Kolář).\n\nDates: November 18\, 19\, and 21\nTime: 9:00 AM – 3:00 PM\nLocation: Krč Campus (IMG Lecture room 0.195 – Jágr’s hall)\n\nThis course will provide valuable insights and practical skills in the rapidly evolving field of laboratory methods for single-cell analyses and spatial transcriptomics. With a maximum of 25 participants\, you’ll receive personalised attention and the opportunity to engage deeply with the subject.\n\nIn early December\, a course on bioinformatical analysis will follow up with particular focus on single-cell RNA-seq data.\n\nIf you’re interested in joining us\, please respond via email to sindelka@ibt.cas.cz as soon as possible\, as space is limited.\n\nWe look forward to an enriching experience together!\n\nBest regards\,\n\nRadek Šindelka & Michal Kolář
URL:https://www.biomed.cas.cz/event/single-cell-course-laboratory-methods/
LOCATION:Posluchárna 0.195 / Lecture room 0.195
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251118T093000
DTEND;TZID=Europe/Prague:20251118T123000
DTSTAMP:20260428T224836
CREATED:20251013T070142Z
LAST-MODIFIED:20251013T070142Z
UID:2421-1763458200-1763469000@www.biomed.cas.cz
SUMMARY:FlowJo™ 11 training
DESCRIPTION:Dear colleagues\, \non November 18th 2025 we will organize FlowJo™ 11 training with Ioannis Panetas\, Ph.D.- application specialist from BD. \nFlowJo is a powerful cytometry data analysis software available to users of our Flow Cytometry Core Facility. \nMore information about FlowJo: https://www.flowjo.com/solutions/flowjo \nThis year\, the training will focus on the new version 11\, which\, in terms of the user interface and some features\, is quite different from the previous version. This training is therefore also suitable for more experienced FlowJo users who have not yet become familiar with version 11. \n  \nTuesday November 18th 2025\, 9:30 am — 12:30pm \nInstitute of Molecular Genetics of the Czech Academy of Sciences \nVídeňská 1083\n142 20 Prague 4\, Czech Republic \nHašek Auditorium \n  \n9:30 AM – 10:15 AM | Unveiling FlowJo 11\, the future of data analysis\nCome hear about the newest version of FlowJo Software! We’ll tour the new immersive workbench and discuss features unique to this version such as the Metadata Manager\, Graph Gallery\, virtual concatenation\, charts\, and integrated algorithms. \n10:30 AM – 12:30 PM | Hands-on training for FlowJo 11\nAttendees will be guided through the analysis of a shared data set. To participate\, users are expected to bring their own laptop\, complete all downloads and installs\, and have an active FlowJo Portal license. Please follow the instructions here \n  \nIf you don‘ have license on your laptop\, please check yes in the related question in registration form and BD will send you temporary license. \n  \nThere is no fee for the training. \n  \nIf you want to attend\, please fill the registration form: https://forms.gle/23UrU6fmdn7TxSxCA \nBest regards \nMatyáš Šíma
URL:https://www.biomed.cas.cz/event/flowjo-11-training/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251119T150000
DTEND;TZID=Europe/Prague:20251119T160000
DTSTAMP:20260428T224836
CREATED:20251113T085932Z
LAST-MODIFIED:20251113T085932Z
UID:2459-1763564400-1763568000@www.biomed.cas.cz
SUMMARY:Seminář Nándor Nagy
DESCRIPTION:“Understanding the enteric nervous system development through the avian embryo model: implications for regenerative biology” \nIn this presentation\, I will provide an overview of enteric nervous system (ENS) development from the perspective of the avian embryo. The ENS\, often referred to as the “second brain\,” originates from vagal neural crest cells that migrate into the developing gut and differentiate into neuronal and glial networks that regulate intestinal function. \nAvian species\, particularly chicken and quail\, have long served as powerful model organisms for studying the cellular and molecular mechanisms regulating ENS formation\, because their embryos are easily accessible\, rapidly developing\, and highly suitable for experimental manipulation. Today\, with new tools such as in ovo electroporation\, retroviral gene transfer\, and CRISPR-based editing\, the avian model again provides unique opportunities to study enteric neurogenesis in vivo. \nIntegrating classical embryonic manipulation approaches with single-cell and spatial transcriptomic analyses now provides a comprehensive framework for understanding enteric neurogenesis\, lineage diversification\, and the evolutionary conservation of neural crest–derived systems across vertebrates.
URL:https://www.biomed.cas.cz/event/seminar-nandor-nagy/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251126T150000
DTEND;TZID=Europe/Prague:20251126T160000
DTSTAMP:20260428T224836
CREATED:20251118T072631Z
LAST-MODIFIED:20251118T072631Z
UID:2461-1764169200-1764172800@www.biomed.cas.cz
SUMMARY:Seminář Tomas Paulenda
DESCRIPTION:“The immunoregulatory properties of the metabolite itaconate” \nIn this talk I will present my latest findings of the function of immunoregulatory metabolite itaconate. Itaconate accumulates in innate immune cells upon Toll-like receptor stimulation. In response to macrophage activation by lipopolysaccharide\, itaconate inhibits inflammasome activation and boosts type I interferon signalling; however\, the molecular mechanism of this immunoregulation remained unclear. Here\, we show that the enhancement of type I interferon secretion by itaconate depends on the inhibition of peroxiredoxin 5 and on mitochondrial reactive oxygen species. We find that itaconate non-covalently inhibits peroxiredoxin 5\, leading to the modulation of mitochondrial peroxide in activating macrophages. Through genetic manipulation\, we confirm that peroxiredoxin 5 modulates  type I interferon secretion in macrophages. The non-electrophilic itaconate mimetic 2-methylsuccinate inhibits peroxiredoxin 5 and phenocopies immunoregulatory action of itaconate on type I interferon and inflammasome activation\, providing further support for a non-covalent inhibition of peroxiredoxin 5 by itaconate. Our work shows Peroxiredoxin 5 as a novel Type I interferon regulator with big potential to future research of redox regulation of immune responses.
URL:https://www.biomed.cas.cz/event/seminar-tomas-paulenda/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20251201
DTEND;VALUE=DATE:20251204
DTSTAMP:20260428T224836
CREATED:20251107T103704Z
LAST-MODIFIED:20251107T103704Z
UID:2438-1764547200-1764806399@www.biomed.cas.cz
SUMMARY:Course on scRNA-seq Data Analysis - IMG
DESCRIPTION:Single-cell RNA sequencing (scRNA-seq) allows researchers to study gene expression at the level of individual cells. This approach can\, for example\, help to identify different cell populations in a complex sample and describe their expression patterns. To generate and analyse scRNA-seq data\, several methods are available\, all with their strengths and weaknesses depending on the researchers’ needs. This 3-day course will cover the main technologies as well as the main aspects to consider while designing an scRNA-seq experiment. In particular\, it will combine the theoretical background of analytical methods with hands-on data analysis sessions focused on data generated by droplet-based platforms.\n\nBy the end of the course\, participants will possess the following abilities:\n   • Distinguish advantages and pitfalls of scRNA-seq.\n   • Design their own scRNA-seq experiment\, using common technologies like 10× Genomics.\n   • Apply quality control (QC) measures and utilise analysis tools to preprocess scRNA-seq data.\n   • Apply normalisation\, scaling\, dimensionality reduction\, integration and clustering on scRNA-seq data using R.\n   • Differentiate between cell annotation techniques to identify and characterise cell populations.\n   • Use differential gene expression analysis methods on scRNA-seq data to gain biological insights.\n   • Select enrichment analysis methods appropriate to the biological question and data.\n   • Develop an scRNA-seq data analysis workflow from raw count matrix to differential gene expression with peer support and light guidance.\n\nMore information and registration at https://www.elixir-czech.cz/events/course-on-scrna-seq-data-analysis-2025\n\nOn behalf of the organisers\,\n\nMichal Kolář\n\n—\nLaboratory of Genomics and Bioinformatics\nInstitute of Molecular Genetics of the Czech Academy of Sciences\nVidenska 1083\n142 20 Prague 4\nCzech Republic\n\nPhone +420 241 063 412\nEmail kolarmi@img.cas.cz <mailto:kolarmi@img.cas.cz>
URL:https://www.biomed.cas.cz/event/course-on-scrna-seq-data-analysis-img/
LOCATION:Posluchárna 0.195 / Lecture room 0.195
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251201T150000
DTEND;TZID=Europe/Prague:20251201T150000
DTSTAMP:20260428T224836
CREATED:20251020T111027Z
LAST-MODIFIED:20251020T111314Z
UID:2429-1764601200-1764601200@www.biomed.cas.cz
SUMMARY:Metabolomics and lipidomics: platforms\, pitfalls\, and practical tips
DESCRIPTION:Doc. Ing. Tomáš Čajka Ph.D.\, Fyziologický ústav AV ČR\, bude zajišťovat  21 th Metodologický seminář Krč – Biocev na téma: \n„Metabolomics and lipidomics: platforms\, pitfalls\, and practical tips“\, který se bude konat 1.12.2025 od 15\,00 hodin v Kinosále FGÚ. \nAnotace: \nMetabolomics and lipidomics are rapidly advancing fields that have transformed our understanding of biological processes at the molecular level. Yet\, designing an appropriate workflow and selecting from the many available analytical options can be challenging [1]. Since 2018\, the Metabolomics Core Facility at the Institute of Physiology CAS (https://metabolomics.fgu.cas.cz) has offered fee-based services for analyzing polar metabolites\, complex lipids\, and exposome compounds (including drugs) in biological materials [2]. The scope of these services has steadily expanded\, with approximately 5\,000 samples analyzed annually using a multiplatform liquid chromatography–mass spectrometry (LC–MS) approach. This lecture will present the current untargeted LC–MS platforms (LIMeX workflow) and introduce upcoming platforms. We will also discuss common pitfalls related to study design\, metabolome coverage\, and statistical analysis. \n[1] Rakusanova & Cajka\, Trends Anal Chem 180 (2024) 117940 (doi: 10.1016/j.trac.2024.117940) \n[2] Cajka et al.\, Int J Mol Sci 324 (2023) 1987 (doi: 10.3390/ijms24031987)
URL:https://www.biomed.cas.cz/event/metabolomics-and-lipidomics-platforms-pitfalls-and-practical-tips/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251203T150000
DTEND;TZID=Europe/Prague:20251203T160000
DTSTAMP:20260428T224836
CREATED:20251124T135541Z
LAST-MODIFIED:20251124T135541Z
UID:2463-1764774000-1764777600@www.biomed.cas.cz
SUMMARY:Seminář Tomáš Venit
DESCRIPTION:“Nuclear myosin 1 – from gene to function” \nMitochondria play a vital role in cellular metabolism by generating energy through oxidative phosphorylation (OXPHOS) in most somatic cells. However\, highly proliferative\, undifferentiated pluripotent stem cells and cancer cells mainly rely on aerobic glycolysis for energy production. Recently\, we reported that nuclear myosin 1 (NM1) functions as a tumor suppressor and a key regulator of cellular metabolism\, directly controlling the expression of the mitochondrial transcription factors TFAM and Pgc1α. Its deletion alters mitochondrial structure\, reduces OXPHOS gene expression\, induces a metabolic shift toward aerobic glycolysis\, and promotes tumor formation in mice. In this talk\, I will move from tumor development to somatic tissues and share our latest findings from phenotyping NM1 knockout mice.
URL:https://www.biomed.cas.cz/event/seminar-tomas-venit/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251210T150000
DTEND;TZID=Europe/Prague:20251210T160000
DTSTAMP:20260428T224836
CREATED:20251202T071927Z
LAST-MODIFIED:20251202T071927Z
UID:2465-1765378800-1765382400@www.biomed.cas.cz
SUMMARY:Seminář Jakub Rídl
DESCRIPTION:“Enigmatic germline-restricted chromosome of songbirds has different centromere compared to regular chromosomes” \nCentromeres are an important part of chromosomes which direct chromosome segregation during cell division. Their modifications can therefore explain the unusual mitotic and meiotic behaviour of certain chromosomes\, such as the germline-restricted chromosome (GRC) of songbirds. This chromosome is eliminated from somatic cells during early embryogenesis and later also from male germ cells during spermatogenesis. We used a combination of cytogenetic and genomic approaches to identify the centromeric sequences of two closely related songbird species\, the common nightingale (Luscinia megarhynchos) and the thrush nightingale (L. luscinia). We found a 436-bp satellite repeat present in the centromeric regions of all regular chromosomes (i.e.\, autosomes and sex chromosomes). Interestingly\, hybridization of the probe to this repeat on meiotic spreads suggested that this repeat is missing on the GRC. Our results indicate that the change of the centromeric sequence may underlie the unusual inheritance and programmed DNA elimination of the GRC in songbirds.
URL:https://www.biomed.cas.cz/event/seminar-jakub-ridl/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20251217T150000
DTEND;TZID=Europe/Prague:20251217T160000
DTSTAMP:20260428T224836
CREATED:20251202T073428Z
LAST-MODIFIED:20251202T073428Z
UID:2467-1765983600-1765987200@www.biomed.cas.cz
SUMMARY:Seminář  Mehak Nihal Shaikh
DESCRIPTION:“ALDH1A1 inhibition as a therapeutic target in Acute Myeloid Leukemia” \nAcute Myeloid Leukemia (AML) is a hematological malignancy leading to differentiation arrest of the myeloid compartment in the bone marrow. It is reported that high levels of ALDH1A1 inhibition promote chemoresistance in AML. Therefore\, in my project we are studying the role of ALDH1A1 inhibition in AML using AML cell lines\, mouse models\, and AML patient samples. And lastly\, we will show the effect of ALDH1A1 inhibition in combination with standard of care chemotherapeutic drugs as a potential treatment strategy for AML. \n 
URL:https://www.biomed.cas.cz/event/seminar-mehak-nihal-shaikh/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260107T150000
DTEND;TZID=Europe/Prague:20260107T160000
DTSTAMP:20260428T224836
CREATED:20251216T124552Z
LAST-MODIFIED:20251216T124552Z
UID:2469-1767798000-1767801600@www.biomed.cas.cz
SUMMARY:Seminář Veronika Niederlová
DESCRIPTION:“CD8+ T cells in infection: Orchestration of the effector and memory fates” \nIn infection\, naive CD8+ T cells differentiate into short-lived effector cells\, which provide immediate protection against the pathogen\, and long-lived memory cells\, which retain immunological information long after pathogen clearance. Using single-cell multiomics techniques and in vivo tracking of individual clonal families\, we show which factors drive the effector versus memory cell fate decision. \n 
URL:https://www.biomed.cas.cz/event/seminar-veronika-niederlova/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260114T150000
DTEND;TZID=Europe/Prague:20260114T160000
DTSTAMP:20260428T224836
CREATED:20260105T115716Z
LAST-MODIFIED:20260105T121039Z
UID:2471-1768402800-1768406400@www.biomed.cas.cz
SUMMARY:Seminář Viktor Bugajev
DESCRIPTION:“Multiple Layers of Control in Early Sphingolipid Biosynthesis” \nSphingolipids are fundamental components of cellular membranes and key mediators of intracellular signaling. Their de novo synthesis is initiated in the endoplasmic reticulum (ER) and is tightly regulated at the level of the serine palmitoyltransferase (SPT) complex. ORMDL proteins are established canonical negative regulators of SPT activity\, thereby maintaining sphingolipid homeostasis. In this seminar\, we demonstrate that ceramides act as major regulators of ORMDL expression levels and identify a previously unrecognized ORMDL interactor that establishes a novel relationship between ORMDL expression and sphingolipid abundance\, reminiscent of dysregulated sphingolipid metabolism observed in pathological conditions. These findings uncover an additional layer of control over the sphingolipid pathway and highlight unexpected flexibility in ORMDL-dependent regulation of de novo sphingolipid biosynthesis.
URL:https://www.biomed.cas.cz/event/seminar-viktor-bugajev/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260121T150000
DTEND;TZID=Europe/Prague:20260121T160000
DTSTAMP:20260428T224836
CREATED:20260112T143738Z
LAST-MODIFIED:20260112T143738Z
UID:2476-1769007600-1769011200@www.biomed.cas.cz
SUMMARY:Seminář Anna Koslová
DESCRIPTION:“Integration and reactivation of endogenous DNA viruses in unicellular eukaryotes” \nViruses infecting protists play important ecological and evolutionary roles by modulating microbial population dynamics and contributing to genome evolution through endogenization. Protist genomes contain tens to thousands of endogenous viral elements (EVEs)\, many of which appear intact and may represent functional viruses. Some EVEs are related to virophages—viruses that parasitize on larger “giant viruses” infecting eukaryotic hosts. Using an isolated virophage system\, we aim to uncover the molecular mechanisms underlying viral DNA integration and reactivation.
URL:https://www.biomed.cas.cz/event/seminar-anna-koslova/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260127T150000
DTEND;TZID=Europe/Prague:20260127T160000
DTSTAMP:20260428T224836
CREATED:20260113T133922Z
LAST-MODIFIED:20260113T133922Z
UID:2478-1769526000-1769529600@www.biomed.cas.cz
SUMMARY:Seminář Hanna-Mari Baldauf
DESCRIPTION:“From virus-host interactions to a novel protein delivery tool” \nThe VIIRAL lab has advanced the understanding of species-specific virus-host interactions against retroviruses. This advancement facilitates now the development of a rabbit model against HIV\, which is a long standing interest in the lab. We use virological\, cellular\, biochemical\, and evolutionary approaches to decipher motifs/pathways that might be important for virus-host interactions. Furthermore\, we have developed VICTORI\, a novel protein delivery platform that can be tailored for the delivery of therapeutic proteins for different purposes. \n 
URL:https://www.biomed.cas.cz/event/seminar-hanna-mari-baldauf/
LOCATION:Posluchárna 0.195 / Lecture room 0.195
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
END:VCALENDAR