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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Prague
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20261025T010000
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END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260107T150000
DTEND;TZID=Europe/Prague:20260107T160000
DTSTAMP:20260428T212747
CREATED:20251216T124552Z
LAST-MODIFIED:20251216T124552Z
UID:2469-1767798000-1767801600@www.biomed.cas.cz
SUMMARY:Seminář Veronika Niederlová
DESCRIPTION:“CD8+ T cells in infection: Orchestration of the effector and memory fates” \nIn infection\, naive CD8+ T cells differentiate into short-lived effector cells\, which provide immediate protection against the pathogen\, and long-lived memory cells\, which retain immunological information long after pathogen clearance. Using single-cell multiomics techniques and in vivo tracking of individual clonal families\, we show which factors drive the effector versus memory cell fate decision. \n 
URL:https://www.biomed.cas.cz/event/seminar-veronika-niederlova/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260114T150000
DTEND;TZID=Europe/Prague:20260114T160000
DTSTAMP:20260428T212747
CREATED:20260105T115716Z
LAST-MODIFIED:20260105T121039Z
UID:2471-1768402800-1768406400@www.biomed.cas.cz
SUMMARY:Seminář Viktor Bugajev
DESCRIPTION:“Multiple Layers of Control in Early Sphingolipid Biosynthesis” \nSphingolipids are fundamental components of cellular membranes and key mediators of intracellular signaling. Their de novo synthesis is initiated in the endoplasmic reticulum (ER) and is tightly regulated at the level of the serine palmitoyltransferase (SPT) complex. ORMDL proteins are established canonical negative regulators of SPT activity\, thereby maintaining sphingolipid homeostasis. In this seminar\, we demonstrate that ceramides act as major regulators of ORMDL expression levels and identify a previously unrecognized ORMDL interactor that establishes a novel relationship between ORMDL expression and sphingolipid abundance\, reminiscent of dysregulated sphingolipid metabolism observed in pathological conditions. These findings uncover an additional layer of control over the sphingolipid pathway and highlight unexpected flexibility in ORMDL-dependent regulation of de novo sphingolipid biosynthesis.
URL:https://www.biomed.cas.cz/event/seminar-viktor-bugajev/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260121T150000
DTEND;TZID=Europe/Prague:20260121T160000
DTSTAMP:20260428T212747
CREATED:20260112T143738Z
LAST-MODIFIED:20260112T143738Z
UID:2476-1769007600-1769011200@www.biomed.cas.cz
SUMMARY:Seminář Anna Koslová
DESCRIPTION:“Integration and reactivation of endogenous DNA viruses in unicellular eukaryotes” \nViruses infecting protists play important ecological and evolutionary roles by modulating microbial population dynamics and contributing to genome evolution through endogenization. Protist genomes contain tens to thousands of endogenous viral elements (EVEs)\, many of which appear intact and may represent functional viruses. Some EVEs are related to virophages—viruses that parasitize on larger “giant viruses” infecting eukaryotic hosts. Using an isolated virophage system\, we aim to uncover the molecular mechanisms underlying viral DNA integration and reactivation.
URL:https://www.biomed.cas.cz/event/seminar-anna-koslova/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260127T150000
DTEND;TZID=Europe/Prague:20260127T160000
DTSTAMP:20260428T212747
CREATED:20260113T133922Z
LAST-MODIFIED:20260113T133922Z
UID:2478-1769526000-1769529600@www.biomed.cas.cz
SUMMARY:Seminář Hanna-Mari Baldauf
DESCRIPTION:“From virus-host interactions to a novel protein delivery tool” \nThe VIIRAL lab has advanced the understanding of species-specific virus-host interactions against retroviruses. This advancement facilitates now the development of a rabbit model against HIV\, which is a long standing interest in the lab. We use virological\, cellular\, biochemical\, and evolutionary approaches to decipher motifs/pathways that might be important for virus-host interactions. Furthermore\, we have developed VICTORI\, a novel protein delivery platform that can be tailored for the delivery of therapeutic proteins for different purposes. \n 
URL:https://www.biomed.cas.cz/event/seminar-hanna-mari-baldauf/
LOCATION:Posluchárna 0.195 / Lecture room 0.195
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260128T150000
DTEND;TZID=Europe/Prague:20260128T160000
DTSTAMP:20260428T212747
CREATED:20260112T073717Z
LAST-MODIFIED:20260112T073717Z
UID:2474-1769612400-1769616000@www.biomed.cas.cz
SUMMARY:Seminář Lorena Arranz
DESCRIPTION:“Therapeutic targeting of stem cells and their niches in myeloid malignancies” \nOur research group “Stem Cells\, Ageing and Cancer” aims at providing insights into mechanisms of hematopoietic stem cell malignant transformation\, including interactions of this cell with its surrounding microenvironment\, and a focus on inflammation\, signaling oncometabolites and various cellular components of the stem cell niche. Our goal is the identification of novel therapeutic targets of potential clinical interest for myeloid malignancies. \nWe will give an overview of our research and present unpublished observations accepted in principle in Nature Communications\, where we have uncovered an important role for the metabolite succinate and its membrane receptor Succinate receptor (Sucnr1) in the regulation of hematopoiesis in health and malignancy. Our work suggests that Sucnr1 signaling restricts hematopoiesis at least partially via the hematopoietic stem and progenitor cell compartment and control of S100a9. The dysregulation of Sucnr1 emerges as contributor to malignancy\, accounting for SUCNR1 expression as a predictor of prognosis in acute myeloid leukemia (AML) patients and opening new potential therapeutic avenues for these patients.
URL:https://www.biomed.cas.cz/event/seminar-lorena-arranz/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260204T150000
DTEND;TZID=Europe/Prague:20260204T160000
DTSTAMP:20260428T212747
CREATED:20260115T104013Z
LAST-MODIFIED:20260115T104013Z
UID:2480-1770217200-1770220800@www.biomed.cas.cz
SUMMARY:Seminář Susana Minguet
DESCRIPTION:“Harnessing TCR Discoveries for the Next Generation of Immunotherapies” \nRecent advances in synthetic immunology and CAR T cell engineering have highlighted the critical importance of signaling diversity for optimizing anti-tumor responses. Our work outlines the design of innovative cell-based cancer immunotherapies rooted in a molecular understanding of T cell activation via the T cell receptor complex (TCR–CD3). I will discuss how modulating receptor signaling interfaces and precisely recruiting kinases and adaptors can advance both fundamental immunology and translational therapies. Key noncanonical interactions between specific components of the TCR–CD3 complex and the Src-kinase Lck fine-tune T cell activation; when implemented in chimeric antigen receptors (CARs)\, these mechanisms improved in vivo tumor control and reduced T cell exhaustion. Supporting our rational design of next-generation CAR T cells\, we demonstrated that harnessing CD3 chain diversity\, rather than simply increasing signaling strength\, enabled the generation of CAR T cells with enhanced anti-tumor efficacy and safety profiles.
URL:https://www.biomed.cas.cz/event/seminar-susana-minguet/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260211T150000
DTEND;TZID=Europe/Prague:20260211T160000
DTSTAMP:20260428T212747
CREATED:20260129T104523Z
LAST-MODIFIED:20260129T104523Z
UID:2482-1770822000-1770825600@www.biomed.cas.cz
SUMMARY:Seminář Lucie Janečková
DESCRIPTION:“NG2-lineage cell plasticity in ischemic brain repair: Roles of Wnt signaling” \nFocal cerebral ischemia (FCI) leads to neuronal loss followed by extensive tissue remodeling\, in which glial and vascular cell populations play indispensable roles. Among these\, NG2 glia and perivascular NG2⁺ cells represent highly plastic cell types that actively participate in post-ischemic responses\, yet their functional heterogeneity and regulatory mechanisms remain poorly understood. In this lecture\, I will present our work investigating how these cell populations respond to ischemic injury and how modulation of Wnt/β-catenin signaling reshapes their cellular states and functions. By combining lineage tracing\, transcriptomic analyses\, and imaging approaches\, we uncover changes in oligodendrocyte differentiation\, perivascular cell behavior\, and their contributions to tissue repair and regeneration. Finally\, I will introduce an ongoing spatial transcriptomics study aimed at mapping cellular organization in the ischemic periphery and glial scar\, highlighting emerging spatial patterns and open questions in brain regeneration.
URL:https://www.biomed.cas.cz/event/seminar-lucie-janeckova/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260218T150000
DTEND;TZID=Europe/Prague:20260218T160000
DTSTAMP:20260428T212747
CREATED:20260209T151442Z
LAST-MODIFIED:20260209T151442Z
UID:2484-1771426800-1771430400@www.biomed.cas.cz
SUMMARY:Seminář Pranav Gulati
DESCRIPTION:“Initiating Mechanisms of Autoinflammatory Osteomyelitis: dysregulated neutrophil recruitment and tyrosine kinase signaling” \nAutoinflammatory diseases result from inappropriate activation of the innate immune system in the absence of infection. Loss of PSTPIP2\, a membrane adaptor protein\, leads to the development of one such disease Chronic Multifocal Osteomyelitis (CMO)\, an autoinflammatory disease in mice which serves as a model for Chronic Recurrent Multifocal Osteomyelitis (CRMO) in humans. Neutrophils are essential for murine CMO initiation and contribute to tissue damage\, but the early events that trigger their pathogenic activity remain poorly defined. Our work shows that early alterations in neutrophil signaling and migration precede both classical inflammatory cytokine responses and the appearance of overt disease symptoms. Pharmacological inhibition of some of these early pathways reduces disease severity and neutrophil activation. Together\, these findings identify the initiating mechanisms of sterile bone inflammation in the mouse model of autoinflammatory osteomyelitis and provide potential targets for therapeutic intervention.
URL:https://www.biomed.cas.cz/event/seminar-pranav-gulati/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260225T150000
DTEND;TZID=Europe/Prague:20260225T160000
DTSTAMP:20260428T212747
CREATED:20260216T074449Z
LAST-MODIFIED:20260216T074449Z
UID:2486-1772031600-1772035200@www.biomed.cas.cz
SUMMARY:Seminář Poulami Banik
DESCRIPTION:“Characterization and targeted rescue of a novel PRPF31 mutation in retinitis pigmentosa” \nRetinitis pigmentosa (RP) is an inherited retinal disease characterized by photoreceptor loss. Mutations in the PRPF31 gene cause approximately 10% of cases of autosomal dominant RP. In this project\, we characterize a novel intronic pathogenic variant in the PRPF31 gene. We provide evidence that the novel RP mutation activates a cryptic splice site\, inducing the expression of an abnormal transcript. The resulting protein is unstable\, and patient cells exhibit lower expression of PRPF31 and other splicing factors. To correct aberrant RNA splicing\, we applied modified antisense oligonucleotides (ASOs) to improve PRPF31 splicing in patient cells. We differentiated the patients‘ induced pluripotent stem cells (iPSCs) into retinal pigment epithelium (RPE) cells and demonstrated that ASO treatment improves PRPF31 splicing and increases PRPF31 protein levels in patient’s RPE cells. These findings suggest that ASO-based splicing correction is a promising therapy for this currently untreatable disease.
URL:https://www.biomed.cas.cz/event/seminar-poulami-banik/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260303
DTEND;VALUE=DATE:20260304
DTSTAMP:20260428T212747
CREATED:20260223T091618Z
LAST-MODIFIED:20260223T091618Z
UID:2491-1772496000-1772582399@www.biomed.cas.cz
SUMMARY:BD Biosciences – Lunch and Learn Seminar
DESCRIPTION:Dear colleagues\, \nWe would like to invite you to join Lunch & Learn seminar focused on Panel Design Strategy in Flow Cytometry. This session is designed to support anyone involved in planning\, optimizing\, or performing multicolor flow cytometry experiments by providing both conceptual guidance and practical demonstrations. \n  \nMore information and registration. \nFlyer \n  \nRegistration is free. \n  \nBest regards \n  \n— \n\n\n\n\n\n\nMatyáš Šíma\, Ph.D.
URL:https://www.biomed.cas.cz/event/bd-biosciences-lunch-and-learn-seminar/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260304T150000
DTEND;TZID=Europe/Prague:20260304T160000
DTSTAMP:20260428T212747
CREATED:20260225T130603Z
LAST-MODIFIED:20260225T130603Z
UID:2494-1772636400-1772640000@www.biomed.cas.cz
SUMMARY:Seminář Vladimír Varga
DESCRIPTION:“Towards understanding life cycle of Trypanosoma brucei” \nTrypanosoma brucei is a unicellular eukaryotic parasite of mammals causing sleeping sickness in humans. T. brucei is transmitted by the tsetse fly. In the fly trypanosomes migrate from the gut to salivary glands\, which is associated with a defined sequence of changes to cells of the parasite. We have established an in vitro approach enabling us for the first time to study these life cycle transitions during initial stages of trypanosome migration. Hence\, we were able to describe associated changes to trypanosome morphology\, cell cycle\, motility as well as to its proteome and metabolome. This revealed that the initial life cycle transitions represent a continuous plastic process rather than a sequence of irreversible decisions. Furthermore\, it let to identification of a molecule in the trypanosome environment\, which is critical for triggering cell cycle arrest during these transitions. Thus\, our work opens new possibilities to understand complex biology of this important human parasite.
URL:https://www.biomed.cas.cz/event/seminar-vladimir-varga/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260311T150000
DTEND;TZID=Europe/Prague:20260311T160000
DTSTAMP:20260428T212747
CREATED:20260302T081531Z
LAST-MODIFIED:20260302T081531Z
UID:2496-1773241200-1773244800@www.biomed.cas.cz
SUMMARY:Seminář Diego André Florian Joseph
DESCRIPTION:“The Fall of the Helicase of Dicer” \nDicer is an RNase III endoribonuclease that processes pre-miRNAs and dsRNAs into small RNAs of ~21–28 nt\, serving the miRNA and RNAi pathways. In mammals\, Dicer’s ability to process long dsRNA is constrained by its helicase domain. Consequently\, the miRNA pathway predominates\, and RNAi is considered vestigial. This constraint comes from a crucial interaction between the HEL1 subdomain of Dicer and its catalytic domain\, which maintains Dicer in a “closed” conformation\, making it highly selective. In the absence of HEL1\, Dicer adopts an “open” conformation that reduces substrate selectivity and activates RNAi. Until now\, this was the only interaction known to confer substrate selectivity and restrict RNAi activity. Here\, we show that Dicer contains an additional region within its helicase that contributes to substrate selectivity. Analysis of Dicer’s AlphaFold structure revealed four major intrinsically disordered regions (IDRs) adopting loop-like conformations. IDR1 is enriched in negatively charged residues and is predicted to interact with the positively charged RNA substrate channel of Dicer. Removal of IDR1 recapitulates the phenotype observed in the absence of HEL1\, suggesting that HEL1 subdomain is not the only region in Dicer responsible for substrate selectivity.
URL:https://www.biomed.cas.cz/event/seminar-diego-andre-florian-joseph/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260318T150000
DTEND;TZID=Europe/Prague:20260318T160000
DTSTAMP:20260428T212747
CREATED:20260305T070841Z
LAST-MODIFIED:20260408T101238Z
UID:2499-1773846000-1773849600@www.biomed.cas.cz
SUMMARY:Seminář Srikant Ojha
DESCRIPTION:“Plectin Loss Disrupts Mechanotransduction and Attenuates\nHepatic Stellate Cell Activation” \nLiver fibrosis\, a hallmark of fibroproliferative disorders that contribute to nearly 45% of global mortality\, is primarily driven by the activation of hepatic stellate cells (HSCs). In response to injury-induced tissue stiffening\, HSCs undergo mechanosignaling-dependent activation and deposit excessive extracellular matrix (ECM)\, perpetuating a self-sustaining fibrotic loop. We sought to disrupt this process by targeting plectin\, a cytolinker protein central to mechanotransduction. Using an HSC-specific plectin knockout (KO) mouse model\, we observed significantly reduced ECM accumulation following carbon tetrachloride–induced injury. In vitro\, plectin-deficient HSCs displayed impaired proliferation\, migration\, and focal adhesion formation. Single-cell transcriptomics further revealed attenuated activation signatures in KO HSCs. Together\, our findings establish plectin as a key regulator of HSC mechanosignaling and highlight its potential as a therapeutic target to alleviate liver fibrosis.
URL:https://www.biomed.cas.cz/event/seminar-srikant-ojha/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260325T150000
DTEND;TZID=Europe/Prague:20260325T160000
DTSTAMP:20260428T212747
CREATED:20260316T072314Z
LAST-MODIFIED:20260408T101231Z
UID:2501-1774450800-1774454400@www.biomed.cas.cz
SUMMARY:Seminář Michael Sixt
DESCRIPTION:“Mechanic and energetic principles of leukocyte locomotion” \nDuring metazoan development\, immune surveillance and cancer dissemination\, cells migrate in complex three-dimensional (3D) microenvironments. These are crowded by cells and extracellular matrix\, generating mazes of differently sized spaces typically smaller than the diameter of the migrating cell. Most mesenchymal and epithelial cells actively generate their migratory path using pericellular tissue proteolysis and transmit traction forces via specific adhesion receptors. On the contrary\, amoeboid cells such as leukocytes employ non-destructive strategies of locomotion and do not hold on to extracellular substrates. This raises the question how these extremely fast cells negotiate dense tissues. We discovered that leukocytes are able to migrate in the total absence of transmembrane force coupling. Instead\, active deformations of the cell body can impose normal forces on the substrate and thereby generate propulsion. We are actively investigating how these normal forces are triggered and generated by the collective activity of the actin and microtuble cytoskeleton and develop new approaches to measure the energetic demands of the process.
URL:https://www.biomed.cas.cz/event/seminar-michael-sixt/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260401T150000
DTEND;TZID=Europe/Prague:20260401T160000
DTSTAMP:20260428T212747
CREATED:20260324T121133Z
LAST-MODIFIED:20260408T101222Z
UID:2510-1775055600-1775059200@www.biomed.cas.cz
SUMMARY:Seminář Anna Zitová
DESCRIPTION:“Amphioxus point of view” \nLight\, a crucial environmental signal\, that drives lives of myriad creatures upon the Earth\, regulating processes such as circadian rhythms\, reproductive cycles\, and visually guided behaviors. We all perceive light through specialized cells called photoreceptors. Behold Amphioxus\, who possesses several distinct types of photoreceptors. It is also considered one of the closest living likenesses to the last common ancestor of all vertebrates. Although it lacks many vertebrate-specific innovations\, it has a simple body plan and homologous structures shared with vertebrates. In this discourse\, we shall cast our gaze more narrowly upon these photoreceptors of Amphioxus\, to unravel their function and inquire whether they may reveal some glimmer of the origins whence the vertebrate visual systems first took its light.
URL:https://www.biomed.cas.cz/event/seminar-anna-zitova/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260408T150000
DTEND;TZID=Europe/Prague:20260408T160000
DTSTAMP:20260428T212747
CREATED:20260331T120116Z
LAST-MODIFIED:20260408T101210Z
UID:2512-1775660400-1775664000@www.biomed.cas.cz
SUMMARY:Seminář Lumír Krejčí
DESCRIPTION:“Homologous Recombination – From repair of DSBs to processing stalled replication forks and human diseases” \nHomologous recombination (HR) is a central genome maintenance pathway that safeguards DNA integrity during both double-strand break (DSB) repair and replication stress. A key intermediate of HR is the nucleoprotein filament formed by RAD51 on single-stranded DNA\, which mediates homology search and strand invasion. During DSB repair RAD51 filament assembly is tightly regulated by mediator proteins\, including BRCA2\, and RAD51 paralogs\, ensuring accurate repair using a homologous template and preventing genome instability. Beyond canonical DSB repair\, HR plays a crucial role at stalled replication forks\, where RAD51 stabilises nascent DNA\, protects forks from nucleolytic degradation\, and promotes fork reversal and restart. The dynamic regulation of RAD51 filament formation and disassembly at replication forks is essential for balancing protection and timely recovery of DNA synthesis. Dysregulation of these processes leads to pathological outcomes\, including chromosomal instability and tumourigenesis. Defects in HR factors\, particularly those controlling RAD51 filament dynamics\, are strongly linked to human diseases such as cancer predisposition syndromes. Understanding how RAD51 orchestrates HR across different DNA damage contexts provides critical insights into genome stability mechanisms and offers therapeutic opportunities\, including synthetic lethality-based cancer treatments.
URL:https://www.biomed.cas.cz/event/seminar-lumir-krejci/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260415T150000
DTEND;TZID=Europe/Prague:20260415T160000
DTSTAMP:20260428T212747
CREATED:20260408T101152Z
LAST-MODIFIED:20260408T101152Z
UID:2516-1776265200-1776268800@www.biomed.cas.cz
SUMMARY:Seminář Despoina Giamaki
DESCRIPTION:“A hidden layer of chromatin regulation in neurological disease” \nGenome stability and DNA repair are essential for human health. ADP-ribosylation is a key post-translational modification in the DNA damage response\, regulated by PARP enzymes. Our research focuses on ARH3\, an enzyme that removes mono-ADP-ribose from proteins\, as its deficiency is linked to rare neurological disease. Using patient-derived cells\, 3D brain organoids and mouse models\, we show that loss of ARH3 leads to accumulation of mono-ADP-ribose on chromatin. Genome-wide analyses (CUT&Tag\, spatial transcriptomic and RNA-seq) reveal that these changes alter gene expression and modulate other histone modifications. We further explore how these chromatin alterations affect responses to stress\, including viral infections\, potentially contributing to neuropathology. Our findings provide new insights into disease mechanisms and highlight ADP-ribosylation as a potential therapeutic target in neurological disorders.
URL:https://www.biomed.cas.cz/event/seminar-despoina-giamaki/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260421
DTEND;VALUE=DATE:20260424
DTSTAMP:20260428T212747
CREATED:20260223T091341Z
LAST-MODIFIED:20260223T091341Z
UID:2489-1776729600-1776988799@www.biomed.cas.cz
SUMMARY:Innovation Days in Bioscience Imaging – Vision for Life
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/innovation-days-in-bioscience-imaging-vision-for-life/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260422T150000
DTEND;TZID=Europe/Prague:20260422T160000
DTSTAMP:20260428T212747
CREATED:20260414T123612Z
LAST-MODIFIED:20260422T074024Z
UID:2522-1776870000-1776873600@www.biomed.cas.cz
SUMMARY:Seminář Karolina Kowalska
DESCRIPTION:“Mechanisms of MICAL regulation in actin filament disassembly” \nActin oxidation at specific methionine residues is a distinctive mechanism that drives actin filament disassembly. This process is mediated by the cytoskeletal effector MICAL\, which selectively associates with and oxidizes actin filaments\, thereby promoting their disassembly. MICAL-dependent actin oxidation is essential for axon guidance and also contributes to other biological processes\, including angiogenesis\, vesicle trafficking\, and cytokinesis. Despite its broad biological importance\, the molecular basis of MICAL regulation has remained unclear. In this talk\, I will show how structural biology approaches\, particularly cryo-EM\, combined with biochemical assays\, provide mechanistic insight into MICAL autoinhibition and its activation by Rab GTPases.
URL:https://www.biomed.cas.cz/event/seminar-karolina-kowalska/
LOCATION:Posluchárna 0.195 / Lecture room 0.195
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260428T100000
DTEND;TZID=Europe/Prague:20260428T113000
DTSTAMP:20260428T212747
CREATED:20260416T061641Z
LAST-MODIFIED:20260416T061941Z
UID:2524-1777370400-1777375800@www.biomed.cas.cz
SUMMARY:Lecture Jonathan W. Yewdell
DESCRIPTION:„How MHC I Peptides Are Generated for Viral and Cancer Immunosurveillance“ \nThe talk focuses on peptide generation from DRiPs (defective ribosomal products)\, ribosomal generated polypeptides that don’t achieve folded stable forms and are proteolytically converted into peptides presented by MHC I molecules for CD8+ T cell immunosurveillance. Influenza A virus DRiPs will occupy center stage. I will discuss dozens of novel influenza virus gene products we discovered in characterizing DRiPs. These include PB1-F2\, the granddaddy of flu alternative reading frame proteins\, UFOs generated from host mRNA start codons\, and most recently\, numerous open reading frames encoded by the negative strand. The talk will conclude with a brief discussion of DRiPs and cancer\, and the contribution of “immunoribosomes“ (subsets of ribosomes) to the cancer immuopeptidome.
URL:https://www.biomed.cas.cz/event/lecture-jonathan-w-yewdell/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260429T150000
DTEND;TZID=Europe/Prague:20260429T160000
DTSTAMP:20260428T212747
CREATED:20260422T074033Z
LAST-MODIFIED:20260422T074033Z
UID:2526-1777474800-1777478400@www.biomed.cas.cz
SUMMARY:Seminář Joe Howard
DESCRIPTION:“How molecular motors drive the motility of cilia and flagella” \nCilia and flagella are thin\, rod-like organelles whose snake-like beating patterns drive cells through fluids and move fluids across cellular surfaces. They play essential roles in locomotion\, sensory reception\, and signaling. The core structure within the cilium\, known as the axoneme\, consists of nine pairs of doublet microtubules\, a central pair of single microtubules\, and a myriad of other proteins\, including the axonemal dynein motor proteins\, which generate the shear forces that slide adjacent doublets. A key question is how dynein activity is coordinated to produce the characteristic sinusoidal beating patterns. We are addressing this question through reconstitution and modeling\, leveraging the genetics of the unicellular alga Chlamydomonas reinhardtii.
URL:https://www.biomed.cas.cz/event/seminar-joe-howard/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20260504T150000
DTEND;TZID=Europe/Prague:20260504T163000
DTSTAMP:20260428T212747
CREATED:20260428T063031Z
LAST-MODIFIED:20260428T063031Z
UID:2529-1777906800-1777912200@www.biomed.cas.cz
SUMMARY:Methodological Seminar BIOCEV-Krč - Campus Animal Facility
DESCRIPTION:Dear all\, \nwe would like to invite you to the seminar as part of the „BIOCEV-Krč  Methodological Seminar“: \nTopic: „CAMPUS ANIMAL FACILITY“ \nSeminar program: \nAnimal Facility FGÚ: Martin Blažka\nAnimal Facility MBÚ: Alexandra Bartelik / Martin Schwarzer\nAnimal Facility ÚŽFG: Jiří Klíma\nAnimal Facility ÚEM: Andrej Litvinec\nAnimal Facility ÚMG: Libor Kopkan / Jan Honetschläger \nThe Animal facility methodological seminar will include a series of presentations by representatives of individual institutions located on the campus. Each institution will briefly present its local or detached animal facility and the services it provides.
URL:https://www.biomed.cas.cz/event/methodological-seminar-biocev-krc-campus-animal-facility/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260519
DTEND;VALUE=DATE:20260522
DTSTAMP:20260428T212747
CREATED:20260316T081510Z
LAST-MODIFIED:20260316T081510Z
UID:2504-1779148800-1779407999@www.biomed.cas.cz
SUMMARY:AI-based Segmentation and Tracking
DESCRIPTION:Learn practical workflows for image segmentation\, cell tracking\, and denoising using modern deep-learning tools (StarDist\, Cellpose\, Omnipose\, Noise2Void\, DeepImageJ\, TrackMate\, Delta2\, ZeroCostDL4MIc\, Zeiss arivis Cloud). \nMore information & registration:\nhttps://course.img.cas.cz/aist/ \nRegistration deadline: May 4 \nBest regards\,\nMartin Čapek\, Michaela Blažíková\, Jan Valečka and Pavel Krist (Zeiss)
URL:https://www.biomed.cas.cz/event/ai-based-segmentation-and-tracking-2/
LOCATION:IMG
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260608
DTEND;VALUE=DATE:20260611
DTSTAMP:20260428T212747
CREATED:20260316T081803Z
LAST-MODIFIED:20260316T081803Z
UID:2507-1780876800-1781135999@www.biomed.cas.cz
SUMMARY:Super-Resolution in Light Microscopy - practical course
DESCRIPTION:Dear colleagues\, \n  \nwe would like to announce the upcoming practical course Super-Resolution in Light Microscopy (SLM 2026)\, which will take place June 8–10\, 2026 at the Institute of Molecular Genetics of the Czech Academy of Sciences in Prague. \n  \nSome of you may know our EMBO Practical Course on Super-Resolution Microscopy\, which we bi-annually organize at IMG. The SLM course is a complementary event focused primarily on extended hands-on training\, allowing participants to spend more time working directly with the methods and data processing workflows. \n  \nThe three-day course combines short theoretical introductions with practical sessions in small groups. Participants will work with several super-resolution approaches including SIM\, SMLM\, STED and optical reassignment methods – Airyscan and SoRa. \n  \nThe practical sessions are organized in collaboration with the Microscopy unit at the Institute of Experimental Medicine (IEM CAS). \n  \nThe course is open to an international audience and the number of participants is limited to 15 to ensure an intensive training format. \n  \nMore information\, programme and registration details are available here: \nhttps://course.img.cas.cz/slm/ \n  \nRegistration deadline: May 5\, 2026 \n  \nPlease feel free to share this announcement with colleagues who might be interested. \n  \n  \nBest regards\, \n  \nIvan Novotny & Michaela Blazikova \n  \n  \n  \n\n\n\n\n\n\nIvan Novotny\, Ph.D. | Light Microscopy Core Facility\n\n\n+420 296 44 3192\, 3168\n\n\n+420 777 270 279\n\n\nivan.novotny@img.cas.cz \n\n\nwww.img.cas.cz
URL:https://www.biomed.cas.cz/event/super-resolution-in-light-microscopy-practical-course/
LOCATION:IMG
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END:VCALENDAR