Akce

"Studying the eukaryotic cilium by a single organelle approach" Cilia are present on the surface of many eukaryotic cells and have critical motility, sensory, and signalling functions. Yet, many fundamental aspects of their biology are poorly understood. Taking advantage of the fact, that the cilia are experimentally well accessible, I have been developing approaches for…
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Sensorineural hearing loss in mice lacking GABAB receptor-associated KCTD12 protein Lecturer: Mgr. Adolf Melichar / Department of Auditory Neuroscience Annotation: KCTD12 protein is the auxiliary subunit of the G-protein coupled receptor for γ-aminobutyric acid (GABA-B). KCTD12 constitutively binds to the intracellular portion of GABA-B receptor and significantly modulates its structural and functional properties. KCTD12/GABA-B complexes are characterized by…
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“Canonical RNAi in vivo in mice” Canonical RNAi, i.e. long dsRNA-induced mRNA degradation, is essentially not operating in vivo in mammalian somatic cells. Low efficiency of dsRNA conversion into small interfering RNA by Dicer was identified as key limiting factor for canonical RNAi in mammals. We have genetically engineered mice to express a more active…
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"The impact of FAM84B in retinal homeostasis" Fam84b is an incompletely characterised protein. Its aberrant expression has been associated with various human cancers, with a possible reported role in endosomal trafficking. We genetically ablated Fam84b expression in mice, and extensively characterised the subsequent age-related, degenerative phenotype in the retinas of knockout animals. The aim of…
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Improvement of healing of bone defects by new approaches of regenerative medicine Lecturer: Mgr. Eva Šebová / Department of Tissue Engineering Annotation: The PLA and PCL block copolymer combined with hydroxyapatite nanoparticles is a promising material for bone tissue engineering. We expect a high ability to seamlessly interact with bone cells and promote bone growth, which is at the…
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“The novel sphingolipid synthesis regulators in cell life” Sphingolipids are bioactive lipids and critical structural components of cell membranes. Regulation of their de novo synthesis is critical for normal mammalian development and physiology. Although the ORMDL family has been identified as the gatekeeper of the serine palmitoyl transferase (SPT) activity, our new data suggest that…
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Lsp1 partially substitutes Pil1 function in eisosome assembly under stress conditions Lecturer: Ing. Petra Veselá, Ph.D. / Department of Functional Organisation of Biomembranes Annotation: Eisosomes are large hemitubular structures that underlie the invaginated microdomains in the plasma membrane of various organisms and take part in the cellular stress response. In the yeast Saccharomyces cerevisiae, they are organised by BAR-domain containing…
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“The cell biology and molecular genetics of avian gonadal development” I am interested in investigating the regulatory mechanisms governing sex differentiation in avian species, with a specific focus on utilizing the chicken as a model organism. In the course of my presentation, I will explore the cellular foundations and molecular components dictating the development of…
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Topic: Spatial metabolomics Program: https://www.fgu.cas.cz/significant/event/495  

“HSCs in inflammation: go extramedullary or go home” Hematopoietic stem cells (HSCs) are a rare cell type residing in the bone marrow and giving rise to all hematopoietic cells. Despite their quiescence, HSCs respond to extracellular signals which regulate their fate. In this presentation, we will determine how of chronic inflammation affects HSC location and…
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The role of miR-20a in the injured CNS Lecturer: Mgr. Ivan Arzhanov / Department of Neuroregeneration Annotation: Spinal cord injury (SCI) involves damage to any part of the spinal cord, leading to nervous cell death and disruption of conduction pathways. This damage results in the loss of motor and sensory function below the injury site, potentially causing paralysis and,…
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“Ribosomal A-site interactions with near-cognate tRNAs drive stop codon readthrough” Imagine a gene is a sentence starting with a capital letter and ending with a period, and a genome as a book telling an entire story. In some protozoans, extra periods infiltrated their sentences, replacing specific letters of arbitrary words (namely E and W). As…
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