Akce

Improvement of healing of bone defects by new approaches of regenerative medicine Lecturer: Mgr. Eva Šebová / Department of Tissue Engineering Annotation: The PLA and PCL block copolymer combined with hydroxyapatite nanoparticles is a promising material for bone tissue engineering. We expect a high ability to seamlessly interact with bone cells and promote bone growth, which is at the…
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“The novel sphingolipid synthesis regulators in cell life” Sphingolipids are bioactive lipids and critical structural components of cell membranes. Regulation of their de novo synthesis is critical for normal mammalian development and physiology. Although the ORMDL family has been identified as the gatekeeper of the serine palmitoyl transferase (SPT) activity, our new data suggest that…
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Lsp1 partially substitutes Pil1 function in eisosome assembly under stress conditions Lecturer: Ing. Petra Veselá, Ph.D. / Department of Functional Organisation of Biomembranes Annotation: Eisosomes are large hemitubular structures that underlie the invaginated microdomains in the plasma membrane of various organisms and take part in the cellular stress response. In the yeast Saccharomyces cerevisiae, they are organised by BAR-domain containing…
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“The cell biology and molecular genetics of avian gonadal development” I am interested in investigating the regulatory mechanisms governing sex differentiation in avian species, with a specific focus on utilizing the chicken as a model organism. In the course of my presentation, I will explore the cellular foundations and molecular components dictating the development of…
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Topic: Spatial metabolomics Program: https://www.fgu.cas.cz/significant/event/495  

“HSCs in inflammation: go extramedullary or go home” Hematopoietic stem cells (HSCs) are a rare cell type residing in the bone marrow and giving rise to all hematopoietic cells. Despite their quiescence, HSCs respond to extracellular signals which regulate their fate. In this presentation, we will determine how of chronic inflammation affects HSC location and…
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The role of miR-20a in the injured CNS Lecturer: Mgr. Ivan Arzhanov / Department of Neuroregeneration Annotation: Spinal cord injury (SCI) involves damage to any part of the spinal cord, leading to nervous cell death and disruption of conduction pathways. This damage results in the loss of motor and sensory function below the injury site, potentially causing paralysis and,…
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“Ribosomal A-site interactions with near-cognate tRNAs drive stop codon readthrough” Imagine a gene is a sentence starting with a capital letter and ending with a period, and a genome as a book telling an entire story. In some protozoans, extra periods infiltrated their sentences, replacing specific letters of arbitrary words (namely E and W). As…
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“PPM1D activity promotes genome instability and cellular transformation” Protein phosphatase magnesium dependent 1 (PPM1D) is a negative regulator of the tumour suppressor p53 and is implicated in termination of DNA damage response. Increased PPM1D activity allows proliferation in the presence of DNA breaks caused by ionizing radiation or replication stress induced by expression of active…
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Martin Balaštík, Ph.D., Laboratory of Molecular Neurobiology, IPHYS

Přednášející:  prof. Ing. Jiří Homola, CSc., DSc. Organizace přednášky byla projednána a schválena na schůzi Rady areálu dne 15.1.2024. Vzhledem k projednávanému tématu a v návaznosti na administraci procesu hodnocení, se přednáška bude konat pouze v českém jazyce.

“Knocking out spo11 in chicken arrests meiosis but does not prevent further development of germ cells” Knockout of the mouse spo11 prevents double-strand breaks and formation of synaptonemal complex during meiosis. As a result, the development of spermatocytes is arrested at zygotene and the arrested cells undergo apoptosis. Not so in the chicken. Here, although…
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