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X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
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TZID:Europe/Prague
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
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DTSTART:20241027T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240625T130000
DTEND;TZID=Europe/Prague:20240625T140000
DTSTAMP:20260426T230129
CREATED:20240917T083708Z
LAST-MODIFIED:20240917T083708Z
UID:2140-1719320400-1719324000@www.biomed.cas.cz
SUMMARY:IEM CAS μLectures: Checklists for Publishing Images and Introduction to Image Archives
DESCRIPTION:μLectures is a monthly seminar series designed to enhance researchers‘ understanding of microscopy’s fundamental workings and principles. Each session\, lasting 30 minutes\, focuses on a specific concept or topic within microscopy. The practical information presented aims to deepen researchers‘ comprehension of their microscopy experiments\, giving them a better overview of the options available and enabling them to improve their experimental design and more effectively identify and resolve potential issues. \nAnnotation\nThanks to speedy technological developments\, microscopy images document a significant part of scientific discoveries in this data-intensive era. It is becoming increasingly important to ensure that images are presented in a transparent and reproducible manner. However\, there are only a few guidelines available for publishing terabytes to petabytes of image data\, while research funding agencies require data to be published in open repositories. The objective of this seminar is to provide an overview of the key aspects of data publication\, with a particular focus on image data. In addition\, the seminar will offer a brief introduction to repositories and other relevant resources. \nThe seminar will take place on 25. 6. 2024 from 1 p.m. in the Turquoise Auditorium of the IEM CAS. It will also be possible to join online using this link. \nRegistration\nRegistration is not required\, but we will be happy if you let us know (in person or at iva.svecova@iem.cas.cz) and if we have an idea of how many people are planning to come.
URL:https://www.biomed.cas.cz/event/iem-cas-%ce%bclectures-checklists-for-publishing-images-and-introduction-to-image-archives/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240620T100000
DTEND;TZID=Europe/Prague:20240620T113000
DTSTAMP:20260426T230129
CREATED:20240605T102859Z
LAST-MODIFIED:20240605T102859Z
UID:927-1718877600-1718883000@www.biomed.cas.cz
SUMMARY:Představení kandidáta na předsedu AV ČR pro funkční období 2025–2029 - Ing. Jiří Plešek\, CSc.
DESCRIPTION:Dne 24. 3. 2025 skončí druhé čtyřleté období ve funkci předsedkyně AV ČR\nprof. RNDr. Evě Zažímalové\, CSc. Volba kandidáta na předsedu AV ČR pro následné funkční období proběhne na zasedání sněmu AV ČR dne 10. 12. 2024. \n\n\n\nJedním z kandidátů na předsedu AV ČR je Ing. Jiří Plešek\, CSc.
URL:https://www.biomed.cas.cz/event/predstaveni-kandidata-na-predsedu-av-cr-pro-funkcni-obdobi-2025-2029-ing-jiri-plesek-csc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240619T150000
DTEND;TZID=Europe/Prague:20240619T160000
DTSTAMP:20260426T230129
CREATED:20240611T060610Z
LAST-MODIFIED:20240611T060610Z
UID:930-1718809200-1718812800@www.biomed.cas.cz
SUMMARY:Seminář Josef Novák\, Ph.D.
DESCRIPTION:“Switch of ADP/ATP translocase isoforms in cellular senescence and malignancy” \nFour isoforms of human ATD/ADP translocators (ANTs) have poorly understood functional differences. Due to their high sequence similarity\, antibody-based detection of these proteins is challenging. We\, therefore\, developed a sensitive proteomic method for detecting ATD/ADP translocator isoforms and their relative ratio. Using this technique\, we observed a switch of ANT isoforms during senescence establishment associated with changes in cellular energy metabolism. The switch of ANT protein isoforms was not correlated with the change of ANT transcripts. Similarly\, we found a non-correlation of ANT transcripts with corresponding proteins in patients‘ glioblastoma and lung cancer samples. We concluded that protein levels of ANT isoforms are regulated on multiple levels and are tightly linked to mitochondria biogenesis.
URL:https://www.biomed.cas.cz/event/seminar-josef-novak-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240617T163000
DTEND;TZID=Europe/Prague:20240617T173000
DTSTAMP:20260426T230129
CREATED:20240509T101609Z
LAST-MODIFIED:20240509T101609Z
UID:907-1718641800-1718645400@www.biomed.cas.cz
SUMMARY:Lecture "Obesity cannot be cured\, but increasingly better treated"
DESCRIPTION:Prof. Matthias Blüher\, Director of the Helmholtz Institute for Metabolism\, Obesity and Vasculature research at the Helmholtz Center Munich and the University of Leipzig\, Germany
URL:https://www.biomed.cas.cz/event/lecture-obesity-cannot-be-cured-but-increasingly-better-treated/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240612T150000
DTEND;TZID=Europe/Prague:20240612T160000
DTSTAMP:20260426T230129
CREATED:20240603T095411Z
LAST-MODIFIED:20240603T095411Z
UID:924-1718204400-1718208000@www.biomed.cas.cz
SUMMARY:Seminář Jiří Březina\, M.Sc.
DESCRIPTION:“How antigens get distributed in the thymus” \nThe presentation of self-antigens in the thymus by medullary thymic epithelial cells (mTECs) and dendritic cells (DCs) is crucial for the establishment of central tolerance. While mTECs produce and present self-antigens in an autonomous manner\, DCs acquire them from mTECs by cooperative antigen transfer (CAT). Although CAT represents a key process of central tolerance\, molecular determinants which define CAT’s effectivity as well as the the capacity of DCs to subsequently present highjacked antigens are largely unknown. To reveal the nature of these determinants\, we compared the transcriptomes of CAT-experienced and inexperienced DCs via scRNAseq. In this seminar\, we will focus on one such a determinant of CAT\, gene product encoding the tight junction protein\, CLAUDIN 1. A series of experiments demonstrated  that CLAUDIN 1 is a regulatory molecule which coordinates CAT and T cell selection processes. The comprehension of these processes will aid in the resolution of the current controversy concerning the role of DCs in central tolerance.
URL:https://www.biomed.cas.cz/event/seminar-jiri-brezina-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240612T130000
DTEND;TZID=Europe/Prague:20240612T140000
DTSTAMP:20260426T230129
CREATED:20240523T224952Z
LAST-MODIFIED:20240917T083407Z
UID:919-1718197200-1718200800@www.biomed.cas.cz
SUMMARY:IEM CAS μLectures Seminar Series: Digital Image Basics
DESCRIPTION:μLectures is a monthly seminar series designed to enhance researchers’ understanding of microscopy’s fundamental workings and principles. Each session\, lasting 30 minutes\, focuses on a specific concept or topic within microscopy. The practical information presented aims to deepen researchers’ comprehension of their microscopy experiments\, giving them a better overview of the options available and enabling them to improve their experimental design and more effectively identify and resolve potential issues. \nAnnotation\nThe seminar aims to provide participants with the basic knowledge and skills to work with graphics and digital images. The participants will be introduced to key concepts and techniques. For example\, they will learn how information is stored in a digital image or what bit depth is. Understanding these principles is essential for the proper processing of microscopic data. \nThe seminar will take place on 12.6.2024 from 1 p.m. in the Turquoise Auditorium of the IEM CAS. It will also be possible to join online using this link. \nRegistration\nRegistration is not required\, but we will be happy if you let us know (in person or at iva.svecova@iem.cas.cz) and if we have an idea of how many people are planning to come. \nLecturer\nJan Setnička
URL:https://www.biomed.cas.cz/event/919/
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20240612
DTEND;VALUE=DATE:20240615
DTSTAMP:20260426T230129
CREATED:20240507T075917Z
LAST-MODIFIED:20240507T075917Z
UID:893-1718150400-1718409599@www.biomed.cas.cz
SUMMARY:Practical course SUPER-RESOLUTION IN LIGHT MICROSCOPY
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/practical-course-super-resolution-in-light-microscopy/
LOCATION:IMG
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240606T140000
DTEND;TZID=Europe/Prague:20240606T150000
DTSTAMP:20260426T230129
CREATED:20240523T221435Z
LAST-MODIFIED:20240523T223848Z
UID:917-1717682400-1717686000@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 06/2024
DESCRIPTION:Open Access Publishing & Green Open Access\nLecturer: Arzuv Caryjeva\, Ph.D. / Data Manager / Director’s Secretariat \nAnnotation: The Open Science requirements of project funders and available options and tools to satisfy these requirements will be introduced. Mainly\, Open access publishing and the green route to ensure open access to Scientific articles will be discussed. Moreover\, there will be an introduction to the Institutional data repository and how researchers can use it. This seminar is particularly important for lab leaders and grant holders. \nThe seminar will take place on 6. 6. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-06-2024/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240605T150000
DTEND;TZID=Europe/Prague:20240605T160000
DTSTAMP:20260426T230129
CREATED:20240528T080600Z
LAST-MODIFIED:20240528T080600Z
UID:922-1717599600-1717603200@www.biomed.cas.cz
SUMMARY:Seminář Subhadip Chakraborty\, M.Sc.
DESCRIPTION:“Understanding the mechanochemical transitions that underlie early embryo development” \nDuring embryogenesis a single fertilized oocyte develops into an adult organism via tightly controlled patterns of cell division\, cell polarization and cell movements. These mechanical processes depend on the actomyosin cortex\, a thin 2D layer that resides underneath the plasma membrane. Importantly\, for normal development the actomyosin cortex in rapidly dividing embryonic cells needs to transition between contractile and non-contractile phases. Surprisingly little is known about how these mechanical transitions are regulated in a developing embryo. To understand mechanical transitions during embryogenesis\, I use C. elegans early embryos as a model\, and perform quantitative live imaging of the actomyosin cortex as it transitions between contractile and non-contractile phases. In the IMG seminar I will present my recent results in which we demonstrate how two major signaling cascades\, Cdc42 and RhoA\, affect distinct mechanical phases and the transitions between them.
URL:https://www.biomed.cas.cz/event/seminar-subhadip-chakraborty-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240603T150000
DTEND;TZID=Europe/Prague:20240603T160000
DTSTAMP:20260426T230129
CREATED:20240509T101513Z
LAST-MODIFIED:20240509T101513Z
UID:905-1717426800-1717430400@www.biomed.cas.cz
SUMMARY:Lecture "How are the epilepsy molecular clocks ticking?"
DESCRIPTION:Cristina Reschke\, RCSI University of Medicine and Health Sciences\, School of Pharmacy and Biomolecular Sciences\, Dublin\, Ireland
URL:https://www.biomed.cas.cz/event/lecture-how-are-the-epilepsy-molecular-clocks-ticking-2/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240529T150000
DTEND;TZID=Europe/Prague:20240529T160000
DTSTAMP:20260426T230129
CREATED:20240513T113146Z
LAST-MODIFIED:20240513T113146Z
UID:911-1716994800-1716998400@www.biomed.cas.cz
SUMMARY:Seminář Prof. Dominique Bonnet
DESCRIPTION:“Dissecting the cross-talk between normal\, leukaemic stem cells and the bone marrow microenvironment” \nHaematopoietic stem cells (HSC) sustain the life-long maintenance of mature blood cells. Over the last decade progress has been made in our understanding of the contribution of the different stroma cells in the regulation of normal HSCs. Our current knowledge is predominantly derived from mouse studies. In humans\, the cellular and molecular composition of the bone marrow (BM) niche\, its functional organisation remains largely unknown. In recent years\, deregulation of the BM microenvironment has emerged to be an important factor in the development of myeloid malignancies. Indeed\, like normal HSC\, leukaemic stem cells (LSCs) remain dependent on signals from the BM niche for survival and proliferation\, and niche factors serves as a sanctuary for their chemoresistance. Thus\, targeting BM niche factors represents a promising avenue for therapeutic interventions. Determining the niche associated alterations in the composition/ organisation along with dissecting the interactome of LSCs and their niche is thus fundamental\, which will ultimately enable us to understand the mechanism of leukaemia initiation\, evolution and resistance. \nI will summarise some of the recent published data from the lab\, showing the alterations of endothelial cells by AML as well as described the development of our new humanised scaffold system that is allowing us to better study the cross-talk between normal and malignant HSPCs and their bone marrow niche in a human/human context. I will show the utility of this model to study MDS and their dependence to the human niche components. Lastly\, I will also discuss new un/published data on the effect of pre-leukaemic mutation on haematopoieisis.
URL:https://www.biomed.cas.cz/event/seminar-prof-dominique-bonnet/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240527T150000
DTEND;TZID=Europe/Prague:20240527T160000
DTSTAMP:20260426T230129
CREATED:20240516T085615Z
LAST-MODIFIED:20240516T085741Z
UID:913-1716822000-1716825600@www.biomed.cas.cz
SUMMARY:BioCEV-Krč Methodological Seminar
DESCRIPTION:BioCEV-Krč Methodological Seminar\nTopic: Campus Animal Facility \n27. 5. 2024\, start: 15:00 \nvenue: Milan Hašek lecture hall\, IMG CAS \nThe Animal facility methodological seminar will include a series of presentations by representatives of individual institutions located on the campus. Each institution will briefly present its local or detached animal facility and the services it provides
URL:https://www.biomed.cas.cz/event/biocev-krc-methodological-seminar-2/
LOCATION:IMG
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240522T150000
DTEND;TZID=Europe/Prague:20240522T160000
DTSTAMP:20260426T230129
CREATED:20240513T113032Z
LAST-MODIFIED:20240513T113032Z
UID:909-1716390000-1716393600@www.biomed.cas.cz
SUMMARY:Seminář Vadym Sulimenko\, Ph.D.
DESCRIPTION:“Differential roles of GIT1 and GIT2 adaptor proteins in regulating microtubule nucleation in glioblastoma cells” \nMicrotubules play a critical role in cell division and migration\, impacting the viability and invasiveness of malignant tumors. Although the reorganization of highly dynamic microtubules is central to these processes\, the precise mechanism underlying microtubule involvement in glioblastoma cell motility remains poorly understood. G protein-coupled receptor kinase-interacting proteins (GITs) are GTPase-activating proteins (GAPs) for ADP-ribosylation factor (Arf) small GTPases. GITs are structurally conserved multidomain scaffold/adaptor proteins that link Arf GTPases to other intracellular signaling events. Here we show that the signalling proteins GIT1 and GIT2 form complexes with γ-Tubulin ring complexes (γTuRCs)\, associate with centrosomes and differentially regulate microtubule nucleation and cell migration in glioblastoma cells.
URL:https://www.biomed.cas.cz/event/seminar-vadym-sulimenko-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20240522
DTEND;VALUE=DATE:20240525
DTSTAMP:20260426T230129
CREATED:20240409T092424Z
LAST-MODIFIED:20240409T092424Z
UID:871-1716336000-1716595199@www.biomed.cas.cz
SUMMARY:IEM CAS Entry Level Super-Resolution Microscopy
DESCRIPTION:Basic Information\nThe course covers theoretical and practical aspects of an “entry-level” super-resolution imaging methods based on the principle of Optical-Photon-Reassignment available in our facility at confocal microscopes Zeiss LSM880\nwith AiryScan and Olympus SpinSR10 with OSR. \nWhat is meant by “Entry-Level Super-Resolution Microscopy”? It is a group of methods that improve resolution by a factor of ~2 over diffraction-limited imaging and are very easy to use. While these methods cannot offer the resolution improvement of factor 5x-10x like STED or STROM/PALM\, they are fast\, easy to operate and require no special sample preparation or extra skills. They are also very suitable for live cell imaging. \n\nDuration: 3 days\nLanguage: English\nLocation: IEM library\, microscope rooms\n\nRegistration form and more information can be found on our website.
URL:https://www.biomed.cas.cz/event/iem-cas-entry-level-super-resolution-microscopy/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240520T150000
DTEND;TZID=Europe/Prague:20240520T160000
DTSTAMP:20260426T230129
CREATED:20240509T101413Z
LAST-MODIFIED:20240509T101413Z
UID:903-1716217200-1716220800@www.biomed.cas.cz
SUMMARY:Lecture "Single-particle tracking of neurotransmitter receptors as a window on synaptic organization and function"
DESCRIPTION:RNDr. Martin Zápotocký\, Ph.D.\, Laboratory of Computational Neuroscience\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture-single-particle-tracking-of-neurotransmitter-receptors-as-a-window-on-synaptic-organization-and-function/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240515T150000
DTEND;TZID=Europe/Prague:20240515T160000
DTSTAMP:20260426T230129
CREATED:20240506T070531Z
LAST-MODIFIED:20240506T070531Z
UID:888-1715785200-1715788800@www.biomed.cas.cz
SUMMARY:Seminář Milan Reiniš\, Ph.D.
DESCRIPTION:“Targeting the STAT3 signaling pathway in cancer and senescence” \nSTAT3 signaling pathway plays important roles in many cellular processes\, such as cell differentiation\, carcinogenesis\, cellular senescence or regulation of the immune responses. The STAT3 molecule thus represents an attractive therapeutic target. However\, its druggability is still questionable. We have tested a number of small molecules designed to inhibit STAT3 phosphorylation for their inhibitory capabilities and impacts on the tumor cell growth. Importantly\, we have documented that selected compounds with limited cytotoxicity were able to inhibit secretion of immunosuppressive cytokines by senescent cells. These results suggest that the STAT3 inhibitors could serve as senomodulatory agents.
URL:https://www.biomed.cas.cz/event/seminar-milan-reinis-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240514T083000
DTEND;TZID=Europe/Prague:20240514T163000
DTSTAMP:20260426T230129
CREATED:20240507T075424Z
LAST-MODIFIED:20240507T075424Z
UID:891-1715675400-1715704200@www.biomed.cas.cz
SUMMARY:3rd 10x Genomics Experience Meeting 2024
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/3rd-10x-genomics-experience-meeting-2024/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240513T150000
DTEND;TZID=Europe/Prague:20240513T160000
DTSTAMP:20260426T230129
CREATED:20240509T101313Z
LAST-MODIFIED:20240509T101313Z
UID:901-1715612400-1715616000@www.biomed.cas.cz
SUMMARY:Lectures of Laboratory of Developmental Cardiology
DESCRIPTION:Vevo 3100: The Short Story of a High-tech Upgrade \nJaroslav Hrdlička\, Laboratory of Developmental Cardiology\, IPHYS \n  \nCardioprotection: the role of HIF-1α and mitochondria \nPetra Alánová\, Laboratory of Developmental Cardiology\, IPHYS
URL:https://www.biomed.cas.cz/event/lectures-of-laboratory-of-developmental-cardiology/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240509T150000
DTEND;TZID=Europe/Prague:20240509T160000
DTSTAMP:20260426T230129
CREATED:20240509T101047Z
LAST-MODIFIED:20240509T101047Z
UID:899-1715266800-1715270400@www.biomed.cas.cz
SUMMARY:Lecture "Preclinical Drug Development for Epilepsy: Animal Models and New Horizons"
DESCRIPTION:Cameron S.Metcalf\, Dept.Pharmacology\, University of Utah\, Salt Lake City\, USA \nvenue: Conference room of Laboratory of Biomathematics in Krč areal (Vídeńská 1083) \n  \n  \n  \n  \n 
URL:https://www.biomed.cas.cz/event/lecture-preclinical-drug-development-for-epilepsy-animal-models-and-new-horizons/
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240502T140000
DTEND;TZID=Europe/Prague:20240502T150000
DTSTAMP:20260426T230129
CREATED:20240419T143733Z
LAST-MODIFIED:20240426T132403Z
UID:881-1714658400-1714662000@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 05/2024
DESCRIPTION:Monitoring of telomeres through colorectal adenomas to advanced stages of colorectal cancer\nLecturer: Mgr. Kateřina Balounová / Department of the Molecular Biology of Cancer \nAnnotation: Telomeres\, repetitive sequences located at the ends of chromosomes\, naturally shorten with ageing. Disruption in telomere biology is closely associated with the onset and progression of cancers\, including colorectal carcinoma (CRC). Given that CRC is one of the most common cancer-related deaths\, we focus on studying telomeres and their potential use to characterise CRC subtypes\, as well as serving as a suitable prognostic biomarker for this disease. \nThe seminar will take place on 2. 5. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-05-2024/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240430T130000
DTEND;TZID=Europe/Prague:20240430T140000
DTSTAMP:20260426T230129
CREATED:20240409T091950Z
LAST-MODIFIED:20240409T092125Z
UID:868-1714482000-1714485600@www.biomed.cas.cz
SUMMARY:IEM CAS μLectures Seminar Series: Confocal Microscopy
DESCRIPTION:μLectures is a monthly seminar series designed to enhance researchers’ understanding of microscopy’s fundamental workings and principles. Each session\, lasting 30 minutes\, focuses on a specific concept or topic within microscopy. The practical information presented aims to deepen researchers’ comprehension of their microscopy experiments\, giving them a better overview of the options available and enabling them to improve their experimental design and more effectively identify and resolve potential issues. \nAnnotation\nThis session will focus on confocal microscopy. We will talk about the basic principles of confocal microscopy\, its practical implications and the difference between different confocal microscopy techniques (scanning vs spinning disk). \nThe seminar will take place on 30. 4. 2024 from 1 p.m. in the Turquoise Auditorium of the IEM CAS. It will also be possible to join online using this link (open in a new window). \nRegistration\nRegistration is not required\, but we will be happy if you let us know (in person or at iva.svecova@iem.cas.cz) and if we have an idea of how many people are planning to come. \nLecturer\nBarbora Hyklová\, PhD.
URL:https://www.biomed.cas.cz/event/%ce%bclectures-seminar-series-confocal-microscopy/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240430T100000
DTEND;TZID=Europe/Prague:20240430T120000
DTSTAMP:20260426T230129
CREATED:20240409T091410Z
LAST-MODIFIED:20240409T091453Z
UID:865-1714471200-1714478400@www.biomed.cas.cz
SUMMARY:IEM CAS Distinguished Guest Seminar Series - Cyril Hanus
DESCRIPTION:The dendrite’s sweet spot: Atypical glycosylation of the neuronal surface and impact on synaptic receptor trafficking\, structure and function\nLecturer: Cyril Hanus\, PhD. / The Institute of Psychiatry and Neuroscience of Paris \nThe seminar will take place on 30. 04. 2024 from 10:00 p.m. in the Turquoise Auditorium of the IEM CAS. \nAnnotation: \nLike 75% of membrane proteins\, neurotransmitter receptors and synaptic adhesion molecules are literally covered by covalently linked sugars\, N-glycans. Despite a general awareness that N-glycans may have a strong impact on protein structure and function and are altered in a number of brain pathologies\, we know surprisingly little about N-glycosylation in the brain. Our work indicates that a substantial fraction of neuronal surface proteins\, notably glutamate AMPA receptors\, are locally synthesized in dendrites and use unconventional Golgi-independent pathways to reach the neuronal surface. This local processing modifies protein N-glycosylation states and hence regulates receptor chemical composition and function\, unravelling a previously unrecognized mechanism controlling the sensing properties and plasticity of the neuronal membrane. \nKeywords: cell-biology\, neurotransmitter receptors\, synaptic plasticity\, cell type-specific gene knockout\, electrophysiology\, mass spectrometry\, molecular dynamics\, structural biology \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/distinguished-guest-seminar-series-cyril-hanus/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240429T150000
DTEND;TZID=Europe/Prague:20240429T160000
DTSTAMP:20260426T230129
CREATED:20240320T090148Z
LAST-MODIFIED:20240320T090148Z
UID:829-1714402800-1714406400@www.biomed.cas.cz
SUMMARY:Lecture "Redox mechanisms of insulin secretion"
DESCRIPTION:RNDr. Petr Ježek\, DrSc.\, Laboratory of Mitochondrial Physiology\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture-redox-mechanisms-of-insulin-secretion/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240424T150000
DTEND;TZID=Europe/Prague:20240424T160000
DTSTAMP:20260426T230129
CREATED:20240415T071711Z
LAST-MODIFIED:20240415T071711Z
UID:878-1713970800-1713974400@www.biomed.cas.cz
SUMMARY:Seminář Farahdokht Nourisanami\, M.Sc.
DESCRIPTION:“Molecular mechanisms of proteoglycan-mediated semaphorin signaling in axon guidance” \nThe precise assembly of a functional nervous system relies on axon guidance cues. Beyond engaging their cognate receptors and initiating signaling cascades that modulate cytoskeletal dynamics\, guidance cues also bind components of the extracellular matrix\, notably proteoglycans\, yet the role and mechanisms of these interactions remain poorly understood. We found that Drosophila secreted semaphorins bind specifically to glycosaminoglycan (GAG) chains of proteoglycans\, showing a preference based on the degree of sulfation. Structural analysis of Sema2b unveiled multiple GAG binding sites positioned outside canonical plexin-binding site\, with the highest affinity binding site located at the C-terminal tail\, characterized by a lysine-rich helical arrangement that appears to be conserved across secreted semaphorins. In vivo studies revealed a crucial role of the Sema2b C-terminal tail in specifying the trajectory of olfactory receptor neurons. We propose that secreted semaphorins tether to the cell surface through interactions with GAG chains of proteoglycans\, facilitating their presentation to cognate receptors on passing axons.
URL:https://www.biomed.cas.cz/event/seminar-farahdokht-nourisanami-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240423T140000
DTEND;TZID=Europe/Prague:20240423T150000
DTSTAMP:20260426T230129
CREATED:20240115T114856Z
LAST-MODIFIED:20240320T090026Z
UID:764-1713880800-1713884400@www.biomed.cas.cz
SUMMARY:Lecture "Epoxylipids from biological actions to therapies for cardiovascular\, kidney\, and metabolic diseases"
DESCRIPTION:Prof. John D. Imig\, University of Arkansas for Medical Sciences\, USA
URL:https://www.biomed.cas.cz/event/lecture-epoxylipids-from-biological-actions-to-therapies-for-cardiovascular-kidney-and-metabolic-diseases/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240417T150000
DTEND;TZID=Europe/Prague:20240417T160000
DTSTAMP:20260426T230129
CREATED:20240410T072013Z
LAST-MODIFIED:20240410T072013Z
UID:876-1713366000-1713369600@www.biomed.cas.cz
SUMMARY:Seminář Kristýna Hrychová\, M.Sc.
DESCRIPTION:“Chromatin ADP-ribosylation in neurodegenerative disease” \nADP-ribosylation is a common protein post-translational modification that regulates numerous cellular processes\, including transcription\, cell proliferation and differentiation\, immune and stress responses\, aging\, and cell death. One of its most extensively studied roles is in DNA damage response and subsequent DNA repair. Moreover\, deregulation of ADP-ribose metabolism is linked to neurological and neurodevelopmental disorders. Interestingly\, our recent work reveals that serine ADP-ribosylation is largely dispensable for DNA repair. We propose that deregulated serine ADP-ribosylation might instead lead to alterations in other histone modifications\, changes in chromatin remodeling and gene expression\, and consequently could contribute to the development of neurological diseases.
URL:https://www.biomed.cas.cz/event/seminar-kristyna-hrychova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240415T150000
DTEND;TZID=Europe/Prague:20240415T160000
DTSTAMP:20260426T230129
CREATED:20240320T085807Z
LAST-MODIFIED:20240320T085807Z
UID:827-1713193200-1713196800@www.biomed.cas.cz
SUMMARY:Lecture "How Foxk1 and Foxk2 Regulate Aerobic Glycolysis – Implications for Systemic Energy Homeostasis and Type 2 Diabetes"
DESCRIPTION:Prof. Sven Enerbäck\, Department of Medical Biochemistry and Cell Biology\, Institute of Biomedicine\, University of Gothenburg\, Sweden.
URL:https://www.biomed.cas.cz/event/lecture-how-foxk1-and-foxk2-regulate-aerobic-glycolysis-implications-for-systemic-energy-homeostasis-and-type-2-diabetes/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240410T150000
DTEND;TZID=Europe/Prague:20240410T160000
DTSTAMP:20260426T230129
CREATED:20240320T082325Z
LAST-MODIFIED:20240320T082325Z
UID:818-1712761200-1712764800@www.biomed.cas.cz
SUMMARY:Seminář Takashi Akera\, Ph.D.
DESCRIPTION:“The impact of genetic cheating on mammalian reproduction and speciation” \n Selfish DNA violate Mendel’s Law of Segregation by biased segregation to the egg cell. This genetic cheating\, meiotic drive\, is a widespread phenomenon across eukaryotes with associated fitness costs such as fertility issues. I will discuss our recent work on the cell biological mechanism of meiotic drive and how it can impact mammalian reproduction and speciation.
URL:https://www.biomed.cas.cz/event/seminar-takashi-akera-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240408T150000
DTEND;TZID=Europe/Prague:20240408T160000
DTSTAMP:20260426T230129
CREATED:20240320T085651Z
LAST-MODIFIED:20240320T085651Z
UID:825-1712588400-1712592000@www.biomed.cas.cz
SUMMARY:Lecture "Cancer metabolism"
DESCRIPTION:RNDr. Katarína Smolková\, Ph.D.\, Laboratory of Mitochondrial Physiology\, IPHYS \n 
URL:https://www.biomed.cas.cz/event/lecture-cancer-metabolism/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240404T140000
DTEND;TZID=Europe/Prague:20240404T143000
DTSTAMP:20260426T230129
CREATED:20240207T113012Z
LAST-MODIFIED:20240402T080600Z
UID:784-1712239200-1712241000@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 04/2024
DESCRIPTION:Maternal diet quality and health status of newborns\nLecturer: Mgr. Jitka Pavlíková\, Ph.D. / Department of Toxicology a Molecular Epidemiology \nAnnotation: Persistent organic pollutants are compounds of mostly anthropogenic origin that persist in the environment for a long time\, become part of food chains\, and some of them accumulate in living organisms. These substances are being monitored for their adverse effects on organisms\, and the use of some of them has already been banned or at least significantly restricted. In our study\, we analyzed possible associations between the health status of newborns (birth weight\, oxidative damage levels) and maternal diet. We obtained information about diet quantity and quality from the maternal diet records and determined the concentrations of 67 different persistent organic pollutants in the collected samples. \nThe seminar will take place on 4. 4. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-04-2024/
END:VEVENT
END:VCALENDAR