Akce

“Genetic architecture of Prdm9-driven reproductive isolation between mouse subspecies” Hybrid incompatibility, the inviability or infertility of species hybrids, has played a central role in speciation research since Darwin's Origin of Species. However, the search for genes controlling hybrid sterility, mainly using Drosophila species hybrids, has been largely unsuccessful, revealing a polygenic control with complex epistatic…
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ABC transporter blood-brain barrier function in neurodegenerative and neuroinflammatory diseases – from basic research to treatment Lecturer: Prof. Jens Pahnke, M.D., Ph.D., E.F.N./ University of Oslo, Faculty of Medicine / Oslo University Hospital, Department of Pathology, Norway The seminar will take place on 20. 11. 2023 from 2:30 p.m. in the Turquoise Auditorium of the IEM CAS. Annotation: The current understanding of…
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Laboratory of Developmental Epileptology, IPHYS

“A chance for fertility despite bad DNA breaks (AKA The effect of crossing-over rate on fertility)” Programmed meiotic DNA breaks are essential for mammalian fertility but dangerous for genome integrity. DNA-binding H3-lysine-trimethyltransferase PRDM9 determines the positions of the meiotic DNA breaks, which can be repaired as crossovers or noncrossovers. The crossover/noncrossover decision is regulated by many…
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Dear Colleagues, We are pleased to announce the annual Mini-Symposium BIOCEV Regeneration III, which will be held on 23-24th November 2023 in BIOCEV, Vestec. Our symposium aims to exchange knowledge in regenerative medicine, tissue engineering, 3D in vitro modelling, organoid research, new tools and technologies in cell culture, and many more. Along with several lectures given by…
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"Studying the eukaryotic cilium by a single organelle approach" Cilia are present on the surface of many eukaryotic cells and have critical motility, sensory, and signalling functions. Yet, many fundamental aspects of their biology are poorly understood. Taking advantage of the fact, that the cilia are experimentally well accessible, I have been developing approaches for…
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Sensorineural hearing loss in mice lacking GABAB receptor-associated KCTD12 protein Lecturer: Mgr. Adolf Melichar / Department of Auditory Neuroscience Annotation: KCTD12 protein is the auxiliary subunit of the G-protein coupled receptor for γ-aminobutyric acid (GABA-B). KCTD12 constitutively binds to the intracellular portion of GABA-B receptor and significantly modulates its structural and functional properties. KCTD12/GABA-B complexes are characterized by…
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“Canonical RNAi in vivo in mice” Canonical RNAi, i.e. long dsRNA-induced mRNA degradation, is essentially not operating in vivo in mammalian somatic cells. Low efficiency of dsRNA conversion into small interfering RNA by Dicer was identified as key limiting factor for canonical RNAi in mammals. We have genetically engineered mice to express a more active…
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"The impact of FAM84B in retinal homeostasis" Fam84b is an incompletely characterised protein. Its aberrant expression has been associated with various human cancers, with a possible reported role in endosomal trafficking. We genetically ablated Fam84b expression in mice, and extensively characterised the subsequent age-related, degenerative phenotype in the retinas of knockout animals. The aim of…
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Improvement of healing of bone defects by new approaches of regenerative medicine Lecturer: Mgr. Eva Šebová / Department of Tissue Engineering Annotation: The PLA and PCL block copolymer combined with hydroxyapatite nanoparticles is a promising material for bone tissue engineering. We expect a high ability to seamlessly interact with bone cells and promote bone growth, which is at the…
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“The novel sphingolipid synthesis regulators in cell life” Sphingolipids are bioactive lipids and critical structural components of cell membranes. Regulation of their de novo synthesis is critical for normal mammalian development and physiology. Although the ORMDL family has been identified as the gatekeeper of the serine palmitoyl transferase (SPT) activity, our new data suggest that…
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Lsp1 partially substitutes Pil1 function in eisosome assembly under stress conditions Lecturer: Ing. Petra Veselá, Ph.D. / Department of Functional Organisation of Biomembranes Annotation: Eisosomes are large hemitubular structures that underlie the invaginated microdomains in the plasma membrane of various organisms and take part in the cellular stress response. In the yeast Saccharomyces cerevisiae, they are organised by BAR-domain containing…
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