BEGIN:VCALENDAR
VERSION:2.0
PRODID:-// - ECPv6.6.3//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Prague
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20241027T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240522T150000
DTEND;TZID=Europe/Prague:20240522T160000
DTSTAMP:20260427T005010
CREATED:20240513T113032Z
LAST-MODIFIED:20240513T113032Z
UID:909-1716390000-1716393600@www.biomed.cas.cz
SUMMARY:Seminář Vadym Sulimenko\, Ph.D.
DESCRIPTION:“Differential roles of GIT1 and GIT2 adaptor proteins in regulating microtubule nucleation in glioblastoma cells” \nMicrotubules play a critical role in cell division and migration\, impacting the viability and invasiveness of malignant tumors. Although the reorganization of highly dynamic microtubules is central to these processes\, the precise mechanism underlying microtubule involvement in glioblastoma cell motility remains poorly understood. G protein-coupled receptor kinase-interacting proteins (GITs) are GTPase-activating proteins (GAPs) for ADP-ribosylation factor (Arf) small GTPases. GITs are structurally conserved multidomain scaffold/adaptor proteins that link Arf GTPases to other intracellular signaling events. Here we show that the signalling proteins GIT1 and GIT2 form complexes with γ-Tubulin ring complexes (γTuRCs)\, associate with centrosomes and differentially regulate microtubule nucleation and cell migration in glioblastoma cells.
URL:https://www.biomed.cas.cz/event/seminar-vadym-sulimenko-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20240522
DTEND;VALUE=DATE:20240525
DTSTAMP:20260427T005010
CREATED:20240409T092424Z
LAST-MODIFIED:20240409T092424Z
UID:871-1716336000-1716595199@www.biomed.cas.cz
SUMMARY:IEM CAS Entry Level Super-Resolution Microscopy
DESCRIPTION:Basic Information\nThe course covers theoretical and practical aspects of an “entry-level” super-resolution imaging methods based on the principle of Optical-Photon-Reassignment available in our facility at confocal microscopes Zeiss LSM880\nwith AiryScan and Olympus SpinSR10 with OSR. \nWhat is meant by “Entry-Level Super-Resolution Microscopy”? It is a group of methods that improve resolution by a factor of ~2 over diffraction-limited imaging and are very easy to use. While these methods cannot offer the resolution improvement of factor 5x-10x like STED or STROM/PALM\, they are fast\, easy to operate and require no special sample preparation or extra skills. They are also very suitable for live cell imaging. \n\nDuration: 3 days\nLanguage: English\nLocation: IEM library\, microscope rooms\n\nRegistration form and more information can be found on our website.
URL:https://www.biomed.cas.cz/event/iem-cas-entry-level-super-resolution-microscopy/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240520T150000
DTEND;TZID=Europe/Prague:20240520T160000
DTSTAMP:20260427T005010
CREATED:20240509T101413Z
LAST-MODIFIED:20240509T101413Z
UID:903-1716217200-1716220800@www.biomed.cas.cz
SUMMARY:Lecture "Single-particle tracking of neurotransmitter receptors as a window on synaptic organization and function"
DESCRIPTION:RNDr. Martin Zápotocký\, Ph.D.\, Laboratory of Computational Neuroscience\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture-single-particle-tracking-of-neurotransmitter-receptors-as-a-window-on-synaptic-organization-and-function/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240515T150000
DTEND;TZID=Europe/Prague:20240515T160000
DTSTAMP:20260427T005010
CREATED:20240506T070531Z
LAST-MODIFIED:20240506T070531Z
UID:888-1715785200-1715788800@www.biomed.cas.cz
SUMMARY:Seminář Milan Reiniš\, Ph.D.
DESCRIPTION:“Targeting the STAT3 signaling pathway in cancer and senescence” \nSTAT3 signaling pathway plays important roles in many cellular processes\, such as cell differentiation\, carcinogenesis\, cellular senescence or regulation of the immune responses. The STAT3 molecule thus represents an attractive therapeutic target. However\, its druggability is still questionable. We have tested a number of small molecules designed to inhibit STAT3 phosphorylation for their inhibitory capabilities and impacts on the tumor cell growth. Importantly\, we have documented that selected compounds with limited cytotoxicity were able to inhibit secretion of immunosuppressive cytokines by senescent cells. These results suggest that the STAT3 inhibitors could serve as senomodulatory agents.
URL:https://www.biomed.cas.cz/event/seminar-milan-reinis-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240514T083000
DTEND;TZID=Europe/Prague:20240514T163000
DTSTAMP:20260427T005010
CREATED:20240507T075424Z
LAST-MODIFIED:20240507T075424Z
UID:891-1715675400-1715704200@www.biomed.cas.cz
SUMMARY:3rd 10x Genomics Experience Meeting 2024
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/3rd-10x-genomics-experience-meeting-2024/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240513T150000
DTEND;TZID=Europe/Prague:20240513T160000
DTSTAMP:20260427T005010
CREATED:20240509T101313Z
LAST-MODIFIED:20240509T101313Z
UID:901-1715612400-1715616000@www.biomed.cas.cz
SUMMARY:Lectures of Laboratory of Developmental Cardiology
DESCRIPTION:Vevo 3100: The Short Story of a High-tech Upgrade \nJaroslav Hrdlička\, Laboratory of Developmental Cardiology\, IPHYS \n  \nCardioprotection: the role of HIF-1α and mitochondria \nPetra Alánová\, Laboratory of Developmental Cardiology\, IPHYS
URL:https://www.biomed.cas.cz/event/lectures-of-laboratory-of-developmental-cardiology/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240509T150000
DTEND;TZID=Europe/Prague:20240509T160000
DTSTAMP:20260427T005010
CREATED:20240509T101047Z
LAST-MODIFIED:20240509T101047Z
UID:899-1715266800-1715270400@www.biomed.cas.cz
SUMMARY:Lecture "Preclinical Drug Development for Epilepsy: Animal Models and New Horizons"
DESCRIPTION:Cameron S.Metcalf\, Dept.Pharmacology\, University of Utah\, Salt Lake City\, USA \nvenue: Conference room of Laboratory of Biomathematics in Krč areal (Vídeńská 1083) \n  \n  \n  \n  \n 
URL:https://www.biomed.cas.cz/event/lecture-preclinical-drug-development-for-epilepsy-animal-models-and-new-horizons/
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240502T140000
DTEND;TZID=Europe/Prague:20240502T150000
DTSTAMP:20260427T005010
CREATED:20240419T143733Z
LAST-MODIFIED:20240426T132403Z
UID:881-1714658400-1714662000@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 05/2024
DESCRIPTION:Monitoring of telomeres through colorectal adenomas to advanced stages of colorectal cancer\nLecturer: Mgr. Kateřina Balounová / Department of the Molecular Biology of Cancer \nAnnotation: Telomeres\, repetitive sequences located at the ends of chromosomes\, naturally shorten with ageing. Disruption in telomere biology is closely associated with the onset and progression of cancers\, including colorectal carcinoma (CRC). Given that CRC is one of the most common cancer-related deaths\, we focus on studying telomeres and their potential use to characterise CRC subtypes\, as well as serving as a suitable prognostic biomarker for this disease. \nThe seminar will take place on 2. 5. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-05-2024/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240430T130000
DTEND;TZID=Europe/Prague:20240430T140000
DTSTAMP:20260427T005010
CREATED:20240409T091950Z
LAST-MODIFIED:20240409T092125Z
UID:868-1714482000-1714485600@www.biomed.cas.cz
SUMMARY:IEM CAS μLectures Seminar Series: Confocal Microscopy
DESCRIPTION:μLectures is a monthly seminar series designed to enhance researchers’ understanding of microscopy’s fundamental workings and principles. Each session\, lasting 30 minutes\, focuses on a specific concept or topic within microscopy. The practical information presented aims to deepen researchers’ comprehension of their microscopy experiments\, giving them a better overview of the options available and enabling them to improve their experimental design and more effectively identify and resolve potential issues. \nAnnotation\nThis session will focus on confocal microscopy. We will talk about the basic principles of confocal microscopy\, its practical implications and the difference between different confocal microscopy techniques (scanning vs spinning disk). \nThe seminar will take place on 30. 4. 2024 from 1 p.m. in the Turquoise Auditorium of the IEM CAS. It will also be possible to join online using this link (open in a new window). \nRegistration\nRegistration is not required\, but we will be happy if you let us know (in person or at iva.svecova@iem.cas.cz) and if we have an idea of how many people are planning to come. \nLecturer\nBarbora Hyklová\, PhD.
URL:https://www.biomed.cas.cz/event/%ce%bclectures-seminar-series-confocal-microscopy/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240430T100000
DTEND;TZID=Europe/Prague:20240430T120000
DTSTAMP:20260427T005010
CREATED:20240409T091410Z
LAST-MODIFIED:20240409T091453Z
UID:865-1714471200-1714478400@www.biomed.cas.cz
SUMMARY:IEM CAS Distinguished Guest Seminar Series - Cyril Hanus
DESCRIPTION:The dendrite’s sweet spot: Atypical glycosylation of the neuronal surface and impact on synaptic receptor trafficking\, structure and function\nLecturer: Cyril Hanus\, PhD. / The Institute of Psychiatry and Neuroscience of Paris \nThe seminar will take place on 30. 04. 2024 from 10:00 p.m. in the Turquoise Auditorium of the IEM CAS. \nAnnotation: \nLike 75% of membrane proteins\, neurotransmitter receptors and synaptic adhesion molecules are literally covered by covalently linked sugars\, N-glycans. Despite a general awareness that N-glycans may have a strong impact on protein structure and function and are altered in a number of brain pathologies\, we know surprisingly little about N-glycosylation in the brain. Our work indicates that a substantial fraction of neuronal surface proteins\, notably glutamate AMPA receptors\, are locally synthesized in dendrites and use unconventional Golgi-independent pathways to reach the neuronal surface. This local processing modifies protein N-glycosylation states and hence regulates receptor chemical composition and function\, unravelling a previously unrecognized mechanism controlling the sensing properties and plasticity of the neuronal membrane. \nKeywords: cell-biology\, neurotransmitter receptors\, synaptic plasticity\, cell type-specific gene knockout\, electrophysiology\, mass spectrometry\, molecular dynamics\, structural biology \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/distinguished-guest-seminar-series-cyril-hanus/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240429T150000
DTEND;TZID=Europe/Prague:20240429T160000
DTSTAMP:20260427T005010
CREATED:20240320T090148Z
LAST-MODIFIED:20240320T090148Z
UID:829-1714402800-1714406400@www.biomed.cas.cz
SUMMARY:Lecture "Redox mechanisms of insulin secretion"
DESCRIPTION:RNDr. Petr Ježek\, DrSc.\, Laboratory of Mitochondrial Physiology\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture-redox-mechanisms-of-insulin-secretion/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240424T150000
DTEND;TZID=Europe/Prague:20240424T160000
DTSTAMP:20260427T005010
CREATED:20240415T071711Z
LAST-MODIFIED:20240415T071711Z
UID:878-1713970800-1713974400@www.biomed.cas.cz
SUMMARY:Seminář Farahdokht Nourisanami\, M.Sc.
DESCRIPTION:“Molecular mechanisms of proteoglycan-mediated semaphorin signaling in axon guidance” \nThe precise assembly of a functional nervous system relies on axon guidance cues. Beyond engaging their cognate receptors and initiating signaling cascades that modulate cytoskeletal dynamics\, guidance cues also bind components of the extracellular matrix\, notably proteoglycans\, yet the role and mechanisms of these interactions remain poorly understood. We found that Drosophila secreted semaphorins bind specifically to glycosaminoglycan (GAG) chains of proteoglycans\, showing a preference based on the degree of sulfation. Structural analysis of Sema2b unveiled multiple GAG binding sites positioned outside canonical plexin-binding site\, with the highest affinity binding site located at the C-terminal tail\, characterized by a lysine-rich helical arrangement that appears to be conserved across secreted semaphorins. In vivo studies revealed a crucial role of the Sema2b C-terminal tail in specifying the trajectory of olfactory receptor neurons. We propose that secreted semaphorins tether to the cell surface through interactions with GAG chains of proteoglycans\, facilitating their presentation to cognate receptors on passing axons.
URL:https://www.biomed.cas.cz/event/seminar-farahdokht-nourisanami-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240423T140000
DTEND;TZID=Europe/Prague:20240423T150000
DTSTAMP:20260427T005010
CREATED:20240115T114856Z
LAST-MODIFIED:20240320T090026Z
UID:764-1713880800-1713884400@www.biomed.cas.cz
SUMMARY:Lecture "Epoxylipids from biological actions to therapies for cardiovascular\, kidney\, and metabolic diseases"
DESCRIPTION:Prof. John D. Imig\, University of Arkansas for Medical Sciences\, USA
URL:https://www.biomed.cas.cz/event/lecture-epoxylipids-from-biological-actions-to-therapies-for-cardiovascular-kidney-and-metabolic-diseases/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240417T150000
DTEND;TZID=Europe/Prague:20240417T160000
DTSTAMP:20260427T005010
CREATED:20240410T072013Z
LAST-MODIFIED:20240410T072013Z
UID:876-1713366000-1713369600@www.biomed.cas.cz
SUMMARY:Seminář Kristýna Hrychová\, M.Sc.
DESCRIPTION:“Chromatin ADP-ribosylation in neurodegenerative disease” \nADP-ribosylation is a common protein post-translational modification that regulates numerous cellular processes\, including transcription\, cell proliferation and differentiation\, immune and stress responses\, aging\, and cell death. One of its most extensively studied roles is in DNA damage response and subsequent DNA repair. Moreover\, deregulation of ADP-ribose metabolism is linked to neurological and neurodevelopmental disorders. Interestingly\, our recent work reveals that serine ADP-ribosylation is largely dispensable for DNA repair. We propose that deregulated serine ADP-ribosylation might instead lead to alterations in other histone modifications\, changes in chromatin remodeling and gene expression\, and consequently could contribute to the development of neurological diseases.
URL:https://www.biomed.cas.cz/event/seminar-kristyna-hrychova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240415T150000
DTEND;TZID=Europe/Prague:20240415T160000
DTSTAMP:20260427T005010
CREATED:20240320T085807Z
LAST-MODIFIED:20240320T085807Z
UID:827-1713193200-1713196800@www.biomed.cas.cz
SUMMARY:Lecture "How Foxk1 and Foxk2 Regulate Aerobic Glycolysis – Implications for Systemic Energy Homeostasis and Type 2 Diabetes"
DESCRIPTION:Prof. Sven Enerbäck\, Department of Medical Biochemistry and Cell Biology\, Institute of Biomedicine\, University of Gothenburg\, Sweden.
URL:https://www.biomed.cas.cz/event/lecture-how-foxk1-and-foxk2-regulate-aerobic-glycolysis-implications-for-systemic-energy-homeostasis-and-type-2-diabetes/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240410T150000
DTEND;TZID=Europe/Prague:20240410T160000
DTSTAMP:20260427T005010
CREATED:20240320T082325Z
LAST-MODIFIED:20240320T082325Z
UID:818-1712761200-1712764800@www.biomed.cas.cz
SUMMARY:Seminář Takashi Akera\, Ph.D.
DESCRIPTION:“The impact of genetic cheating on mammalian reproduction and speciation” \n Selfish DNA violate Mendel’s Law of Segregation by biased segregation to the egg cell. This genetic cheating\, meiotic drive\, is a widespread phenomenon across eukaryotes with associated fitness costs such as fertility issues. I will discuss our recent work on the cell biological mechanism of meiotic drive and how it can impact mammalian reproduction and speciation.
URL:https://www.biomed.cas.cz/event/seminar-takashi-akera-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240408T150000
DTEND;TZID=Europe/Prague:20240408T160000
DTSTAMP:20260427T005010
CREATED:20240320T085651Z
LAST-MODIFIED:20240320T085651Z
UID:825-1712588400-1712592000@www.biomed.cas.cz
SUMMARY:Lecture "Cancer metabolism"
DESCRIPTION:RNDr. Katarína Smolková\, Ph.D.\, Laboratory of Mitochondrial Physiology\, IPHYS \n 
URL:https://www.biomed.cas.cz/event/lecture-cancer-metabolism/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240404T140000
DTEND;TZID=Europe/Prague:20240404T143000
DTSTAMP:20260427T005010
CREATED:20240207T113012Z
LAST-MODIFIED:20240402T080600Z
UID:784-1712239200-1712241000@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 04/2024
DESCRIPTION:Maternal diet quality and health status of newborns\nLecturer: Mgr. Jitka Pavlíková\, Ph.D. / Department of Toxicology a Molecular Epidemiology \nAnnotation: Persistent organic pollutants are compounds of mostly anthropogenic origin that persist in the environment for a long time\, become part of food chains\, and some of them accumulate in living organisms. These substances are being monitored for their adverse effects on organisms\, and the use of some of them has already been banned or at least significantly restricted. In our study\, we analyzed possible associations between the health status of newborns (birth weight\, oxidative damage levels) and maternal diet. We obtained information about diet quantity and quality from the maternal diet records and determined the concentrations of 67 different persistent organic pollutants in the collected samples. \nThe seminar will take place on 4. 4. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-04-2024/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240403T150000
DTEND;TZID=Europe/Prague:20240403T160000
DTSTAMP:20260427T005010
CREATED:20240320T082234Z
LAST-MODIFIED:20240320T082234Z
UID:816-1712156400-1712160000@www.biomed.cas.cz
SUMMARY:Seminář Jose Ordovas-Montanes\, M.Sc.\, Ph.D.
DESCRIPTION:“Single-cell to tissue-scale memory of infection and inflammation” \nThe role of epithelial and stromal cells in driving inflammation\, together with immune cells\, is being increasingly appreciated. However\, we currently lack tissue-scale frameworks to define and test how inflammation collectively impacts epithelial\, stromal\, and immune cells. This poses a fundamental challenge for understanding the cellular mechanisms that drive or sustain health and disease within\, and across\, barriers such as the skin\, airway\, and intestine. Our lab is addressing this challenge by quantifying and controlling how inflammation changes the ecology of barrier tissues. Our central hypothesis is that inflammation is distributed and stored in multiple cell types\, with the capacity to form tissue-level collective cellular networks. Starting from our human single-cell RNA-sequencing data collected from infectious and inflammatory diseases\, we are developing quantitative approaches to define how static cellular ecosystems are arranged in barrier tissues. These studies are informing time-series modeling of murine inflammatory models focused on Type 1\, 2 and 17 inflammation to understand how the same pressure applied to epithelial\, stromal\, and immune cell subsets shifts functional states and interactions in distinct barrier tissues. We anticipate to identify the gradual inflammatory transitions which maintain essential tissue functionality and critical “tipping points” in tissue state that compromise barrier functions.
URL:https://www.biomed.cas.cz/event/seminar-jose-ordovas-montanes-m-sc-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240327T150000
DTEND;TZID=Europe/Prague:20240327T160000
DTSTAMP:20260427T005010
CREATED:20240318T080719Z
LAST-MODIFIED:20240318T080719Z
UID:807-1711551600-1711555200@www.biomed.cas.cz
SUMMARY:Seminář Veronika Zimolová\, M.Sc.
DESCRIPTION:“Janus Kinase 2 (JAK2) mutations: implications for blood diseases” \nThe project aims to elucidate the impact of the germline Jak2 R1063H variant on myeloproliferative disorders and its potential implication in myeloid malignancy predisposition. Utilizing a mouse model harboring the Jak2 R1063H mutation\, we observed higher mortality rate\, elevated D-dimer levels indicative of thrombotic events\, and increased platelets counts. Furthermore\, metabolic profiling revealed alterations in platelet bioenergetics and gene expression patterns associated with fatty acid metabolism. Additionally\, we showed aberrations in hematopoietic stem cell functionality\, manifesting as a skewed myeloid progenitor cell expansion and bone marrow remodeling. These findings collectively suggest that Jak2 R1063H variant represents risk factor in the pathogenesis of myeloid cell transformation.
URL:https://www.biomed.cas.cz/event/seminar-veronika-zimolova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240326T130000
DTEND;TZID=Europe/Prague:20240326T140000
DTSTAMP:20260427T005010
CREATED:20240409T093101Z
LAST-MODIFIED:20240409T121238Z
UID:873-1711458000-1711461600@www.biomed.cas.cz
SUMMARY:IEM CAS μLectures Seminar Series: Cameras and Detectors
DESCRIPTION:μLectures is a new monthly seminar series designed to enhance researchers’ understanding of microscopy’s fundamental workings and principles. Each session\, lasting 30 minutes\, will focus on a specific concept or topic within microscopy. The practical information presented aims to deepen researchers’ comprehension of their microscopy experiments\, giving them a better overview of the options available and enabling them to improve their experimental design and more effectively identify and resolve potential issues. \nAnnotation\nThe second session will focus on cameras and detectors. We will talk about the difference between cameras and detectors\, and what parameters are important for which kind of experiments.\n \nThe seminar will take place on 26. 3. 2024 from 1 p.m. in the Turquoise Auditorium of the IEM CAS. It will also be possible to join online using this link (open in a new window). \nRegistration\nRegistration is not required\, but we will be happy if you let us know (in person or at iva.svecova@iem.cas.cz) and if we have an idea of how many people are planning to come. \nLecturer\nŠtěpán Kortus\, PhD.
URL:https://www.biomed.cas.cz/event/%ce%bclectures-cameras-and-detectors/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240325T150000
DTEND;TZID=Europe/Prague:20240325T160000
DTSTAMP:20260427T005010
CREATED:20240320T085512Z
LAST-MODIFIED:20240320T085512Z
UID:823-1711378800-1711382400@www.biomed.cas.cz
SUMMARY:Lecture "Hemodynamic mechanisms initiating salt-sensitive hypertension: Prevention options"
DESCRIPTION:Ing. Michal Pravenec\, DrSc.\, Laboratory of Genetics of Model Diseases\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture-hemodynamic-mechanisms-initiating-salt-sensitive-hypertension-prevention-options/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240320T150000
DTEND;TZID=Europe/Prague:20240320T160000
DTSTAMP:20260427T005010
CREATED:20240306T080948Z
LAST-MODIFIED:20240306T080948Z
UID:805-1710946800-1710950400@www.biomed.cas.cz
SUMMARY:Seminář  Zuzana Outlá\, M.Sc.
DESCRIPTION:„Targeting plectin-mediated cytoskeletal crosstalk in hepatocellular carcinoma“ \nAnotace: The study’s findings indicate that the elevation of plectin in tumor hepatocytes is associated with the progression of hepatocellular carcinoma (HCC). This progression can be inhibited through genetic or pharmacological targeting of plectin. The oncogenic and invasive potentials of HCC cells are attenuated through plectin ablation\, suggesting that plectin contributes to HCC’s metastatic capacity. These results identify plectin as a potential therapeutic target in HCC.
URL:https://www.biomed.cas.cz/event/seminar-zuzana-outla-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240313T150000
DTEND;TZID=Europe/Prague:20240313T160000
DTSTAMP:20260427T005010
CREATED:20240306T080743Z
LAST-MODIFIED:20240306T080743Z
UID:803-1710342000-1710345600@www.biomed.cas.cz
SUMMARY:Seminář Imtissal Krayem\, Ph.D.
DESCRIPTION:“Transmembrane adaptor protein OPAL1 regulates leukocyte hematopoiesis and thymus development” \nExpression of transmembrane adaptor protein Outcome predictor of acute leukemia 1 (OPAL1)\, has been linked to the ETV6-RUNX1 translocation and favorable prognosis in childhood leukemia. Our research also suggests that it has an important role in leukocyte development. We show that in mice with germline deletion of OPAL1\, hematopoiesis is dysregulated early on\, affecting mainly hematopoietic stem cells and early progenitors. Dysregulations in this compartment also contribute to more efficient engraftment of OPAL1-deficient cells following hematopoietic stem and progenitor cell transplantations. In addition\, the thymi of OPAL1-deficient mice are enlarged\, housing increased numbers of thymocytes across all subsets. This phenomenon may be attributed to the elevated generation of MPP4/LMPP progenitors in the bone marrow\, which subsequently give rise to thymus-seeding progenitors. In summary\, WBP1L emerges as a key player in leukocyte homeostasis\, maintaining leukocyte numbers during steady-state conditions and after bone marrow transplantation.
URL:https://www.biomed.cas.cz/event/seminar-imtissal-krayem-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240307T140000
DTEND;TZID=Europe/Prague:20240307T150000
DTSTAMP:20260427T005010
CREATED:20240122T091559Z
LAST-MODIFIED:20240207T112651Z
UID:773-1709820000-1709823600@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 03/2024
DESCRIPTION:Subpopulations of NG2 glia in the adult mouse brain after focal cerebral ischemia.\nLecturer: Mgr. Tomáš Knotek / Department of Cellular Neurophysiology \nAnnotation: Glia expressing NG2 antigen are known predominantly as precursors of oligodendrocytes. However\, their differentiation potential in tissue affected by ischemic injury has not yet been fully explored. To further our understanding of these cells\, we employed single-cell RNA sequencing\, immunohistochemical staining\, RT-qPCR\, and patch-clamp technique on NG2-expressing cells in healthy tissue and in tissue affected by focal cerebral ischemia (FCI). Single-cell RNA sequencing data revealed that NG2 glia form distinct subpopulations\, some of which can be ascribed to the proliferation of NG2 glia and their progression in the oligodendrocyte lineage. However\, we also observed previously described astrocyte-like NG2 glia that appeared both in healthy and ischemic tissue. Interestingly\, this subpopulation also shared properties with neural progenitor cells. Expression of genes linked to neurogenesis was confirmed by immunohistochemical staining and changed at different time points after FCI. Of note\, 28 days after the stroke\, we observed NG2-expressing cells positive for NeuN. Together\, these results provide new insight into the plasticity of NG2 glia following ischemic injury. \nThe seminar will take place on 7. 3. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-03-2024/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240306T150000
DTEND;TZID=Europe/Prague:20240306T160000
DTSTAMP:20260427T005010
CREATED:20240228T082050Z
LAST-MODIFIED:20240228T082050Z
UID:800-1709737200-1709740800@www.biomed.cas.cz
SUMMARY:Seminář Simona Mikula Mršťáková\, M.Sc.
DESCRIPTION:“Role of pax6 genes in the eye during embryonal development of medaka” \nPax6 is remarkably conserved across a wide range of species\, from flies to humans\, signifying its fundamental role in the regulatory network governing eye formation. In this presentation\, we will delve into the functions of three pax6 genes – Pax6.1\, Pax6.2\, and Pax6.3 – and their specific contributions to eye development during the embryonic stages of the Japanese medaka fish (Oryzias latipes). We will explore how these genes orchestrate the complex process of eye formation\, underscoring their importance in developmental biology and evolutionary studies.
URL:https://www.biomed.cas.cz/event/seminar-simona-mikula-mrstakova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240304T150000
DTEND;TZID=Europe/Prague:20240304T160000
DTSTAMP:20260427T005010
CREATED:20240115T114730Z
LAST-MODIFIED:20240115T114730Z
UID:762-1709564400-1709568000@www.biomed.cas.cz
SUMMARY:Lecture "AMPA glutamate receptor signaling – auxiliary subunits and beyond"
DESCRIPTION:Dr. Ingo Greger\, Neurobiology Division MRC Laboratory of Molecular Biology\, Cambridge\, UK
URL:https://www.biomed.cas.cz/event/lecture-ampa-glutamate-receptor-signaling-auxiliary-subunits-and-beyond/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240228T150000
DTEND;TZID=Europe/Prague:20240228T160000
DTSTAMP:20260427T005010
CREATED:20240228T081937Z
LAST-MODIFIED:20240228T081937Z
UID:798-1709132400-1709136000@www.biomed.cas.cz
SUMMARY:Seminář Prasoon Kumar Thakur\, M.Sc.
DESCRIPTION:“Splicing in the world of marine diplonemids” \nRecent surveys of marine biodiversity have revealed the abundance and diversity of planktonic diplonemids. By sequencing the genomes and transcriptomes of six marine diplonemids and performing comprehensive splice site analyses\, we identified numerous non-canonical introns and mapped their common features\, shedding light on the evolution of RNA splicing in these abundant unicellular organisms.
URL:https://www.biomed.cas.cz/event/seminar-prasoon-kumar-thakur-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240227T130000
DTEND;TZID=Europe/Prague:20240227T140000
DTSTAMP:20260427T005010
CREATED:20240213T101009Z
LAST-MODIFIED:20240213T101009Z
UID:790-1709038800-1709042400@www.biomed.cas.cz
SUMMARY:IEM CAS μLectures: Microscope objectives
DESCRIPTION:μLectures is a new\, monthly seminar series designed to enhance researchers’ understanding of the fundamental workings and principles of microscopy. Each session\, lasting 30 minutes\, will focus on a specific concept or topic within microscopy. The practical information presented aims to deepen researchers’ comprehension of their microscopy experiments\, giving them better overview of the options available and enabling them to improve their experimental design\, and more effectively identify and resolve potential issues.  \nAnnotation\nThe first session will focus on objectives. It will introduce different types of objectives and their relevant parameters\, explore the interaction between immersion and medium/fixation methods\, and discuss how objective selection can impact image quality.  \nThe seminar will take place on 27. 2. 2024 from 1 p.m. in the Turquoise Auditorium of the IEM CAS. It will also be possible to join online using this link (opens in new window). \nIt will be held in English. \nRegistration\nRegistration is not required\, but if you are interested\, you can let us know (in person or on iva.svecova@iem.cas.cz) to give us an idea about how many people are planning to come. \nLecturer\nIva Švecová
URL:https://www.biomed.cas.cz/event/iem-cas-%ce%bclectures-microscope-objectives/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240222T093000
DTEND;TZID=Europe/Prague:20240222T150000
DTSTAMP:20260427T005010
CREATED:20240214T082352Z
LAST-MODIFIED:20240214T082352Z
UID:796-1708594200-1708614000@www.biomed.cas.cz
SUMMARY:Den fyziologie a medicíny pro vysokoškoláky
DESCRIPTION:Studujete vysokou školu přírodovědeckého nebo medicínského zaměření? Připravili jsme pro vás speciální den otevřených dveří s nabídkou zajímavých témat pro vaši bakalářskou či magisterskou práci i témata pro studium PhD. Vědci z FGÚ vás s nimi seznámí v dopoledním bloku (prezenční i online formou) a odpoledne budete mít možnost nahlédnout přímo do jejich laboratoří. Celý program je v angličtině. \nPřihlašování  a program: https://www.fgu.cas.cz/articles/1114-program-den-fyziologie-a-mediciny-pro-vysokoskolaky-2024 \n 
URL:https://www.biomed.cas.cz/event/den-fyziologie-a-mediciny-pro-vysokoskolaky/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
END:VCALENDAR