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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240307T140000
DTEND;TZID=Europe/Prague:20240307T150000
DTSTAMP:20260427T001848
CREATED:20240122T091559Z
LAST-MODIFIED:20240207T112651Z
UID:773-1709820000-1709823600@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 03/2024
DESCRIPTION:Subpopulations of NG2 glia in the adult mouse brain after focal cerebral ischemia.\nLecturer: Mgr. Tomáš Knotek / Department of Cellular Neurophysiology \nAnnotation: Glia expressing NG2 antigen are known predominantly as precursors of oligodendrocytes. However\, their differentiation potential in tissue affected by ischemic injury has not yet been fully explored. To further our understanding of these cells\, we employed single-cell RNA sequencing\, immunohistochemical staining\, RT-qPCR\, and patch-clamp technique on NG2-expressing cells in healthy tissue and in tissue affected by focal cerebral ischemia (FCI). Single-cell RNA sequencing data revealed that NG2 glia form distinct subpopulations\, some of which can be ascribed to the proliferation of NG2 glia and their progression in the oligodendrocyte lineage. However\, we also observed previously described astrocyte-like NG2 glia that appeared both in healthy and ischemic tissue. Interestingly\, this subpopulation also shared properties with neural progenitor cells. Expression of genes linked to neurogenesis was confirmed by immunohistochemical staining and changed at different time points after FCI. Of note\, 28 days after the stroke\, we observed NG2-expressing cells positive for NeuN. Together\, these results provide new insight into the plasticity of NG2 glia following ischemic injury. \nThe seminar will take place on 7. 3. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-03-2024/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240306T150000
DTEND;TZID=Europe/Prague:20240306T160000
DTSTAMP:20260427T001848
CREATED:20240228T082050Z
LAST-MODIFIED:20240228T082050Z
UID:800-1709737200-1709740800@www.biomed.cas.cz
SUMMARY:Seminář Simona Mikula Mršťáková\, M.Sc.
DESCRIPTION:“Role of pax6 genes in the eye during embryonal development of medaka” \nPax6 is remarkably conserved across a wide range of species\, from flies to humans\, signifying its fundamental role in the regulatory network governing eye formation. In this presentation\, we will delve into the functions of three pax6 genes – Pax6.1\, Pax6.2\, and Pax6.3 – and their specific contributions to eye development during the embryonic stages of the Japanese medaka fish (Oryzias latipes). We will explore how these genes orchestrate the complex process of eye formation\, underscoring their importance in developmental biology and evolutionary studies.
URL:https://www.biomed.cas.cz/event/seminar-simona-mikula-mrstakova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240304T150000
DTEND;TZID=Europe/Prague:20240304T160000
DTSTAMP:20260427T001848
CREATED:20240115T114730Z
LAST-MODIFIED:20240115T114730Z
UID:762-1709564400-1709568000@www.biomed.cas.cz
SUMMARY:Lecture "AMPA glutamate receptor signaling – auxiliary subunits and beyond"
DESCRIPTION:Dr. Ingo Greger\, Neurobiology Division MRC Laboratory of Molecular Biology\, Cambridge\, UK
URL:https://www.biomed.cas.cz/event/lecture-ampa-glutamate-receptor-signaling-auxiliary-subunits-and-beyond/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240228T150000
DTEND;TZID=Europe/Prague:20240228T160000
DTSTAMP:20260427T001848
CREATED:20240228T081937Z
LAST-MODIFIED:20240228T081937Z
UID:798-1709132400-1709136000@www.biomed.cas.cz
SUMMARY:Seminář Prasoon Kumar Thakur\, M.Sc.
DESCRIPTION:“Splicing in the world of marine diplonemids” \nRecent surveys of marine biodiversity have revealed the abundance and diversity of planktonic diplonemids. By sequencing the genomes and transcriptomes of six marine diplonemids and performing comprehensive splice site analyses\, we identified numerous non-canonical introns and mapped their common features\, shedding light on the evolution of RNA splicing in these abundant unicellular organisms.
URL:https://www.biomed.cas.cz/event/seminar-prasoon-kumar-thakur-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240227T130000
DTEND;TZID=Europe/Prague:20240227T140000
DTSTAMP:20260427T001848
CREATED:20240213T101009Z
LAST-MODIFIED:20240213T101009Z
UID:790-1709038800-1709042400@www.biomed.cas.cz
SUMMARY:IEM CAS μLectures: Microscope objectives
DESCRIPTION:μLectures is a new\, monthly seminar series designed to enhance researchers’ understanding of the fundamental workings and principles of microscopy. Each session\, lasting 30 minutes\, will focus on a specific concept or topic within microscopy. The practical information presented aims to deepen researchers’ comprehension of their microscopy experiments\, giving them better overview of the options available and enabling them to improve their experimental design\, and more effectively identify and resolve potential issues.  \nAnnotation\nThe first session will focus on objectives. It will introduce different types of objectives and their relevant parameters\, explore the interaction between immersion and medium/fixation methods\, and discuss how objective selection can impact image quality.  \nThe seminar will take place on 27. 2. 2024 from 1 p.m. in the Turquoise Auditorium of the IEM CAS. It will also be possible to join online using this link (opens in new window). \nIt will be held in English. \nRegistration\nRegistration is not required\, but if you are interested\, you can let us know (in person or on iva.svecova@iem.cas.cz) to give us an idea about how many people are planning to come. \nLecturer\nIva Švecová
URL:https://www.biomed.cas.cz/event/iem-cas-%ce%bclectures-microscope-objectives/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240222T093000
DTEND;TZID=Europe/Prague:20240222T150000
DTSTAMP:20260427T001848
CREATED:20240214T082352Z
LAST-MODIFIED:20240214T082352Z
UID:796-1708594200-1708614000@www.biomed.cas.cz
SUMMARY:Den fyziologie a medicíny pro vysokoškoláky
DESCRIPTION:Studujete vysokou školu přírodovědeckého nebo medicínského zaměření? Připravili jsme pro vás speciální den otevřených dveří s nabídkou zajímavých témat pro vaši bakalářskou či magisterskou práci i témata pro studium PhD. Vědci z FGÚ vás s nimi seznámí v dopoledním bloku (prezenční i online formou) a odpoledne budete mít možnost nahlédnout přímo do jejich laboratoří. Celý program je v angličtině. \nPřihlašování  a program: https://www.fgu.cas.cz/articles/1114-program-den-fyziologie-a-mediciny-pro-vysokoskolaky-2024 \n 
URL:https://www.biomed.cas.cz/event/den-fyziologie-a-mediciny-pro-vysokoskolaky/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240221T150000
DTEND;TZID=Europe/Prague:20240221T160000
DTSTAMP:20260427T001848
CREATED:20240213T114522Z
LAST-MODIFIED:20240213T114522Z
UID:792-1708527600-1708531200@www.biomed.cas.cz
SUMMARY:Seminář Ing. Eliška Gáliková
DESCRIPTION:“Knocking out spo11 in chicken arrests meiosis but does not prevent further development of germ cells” \nKnockout of the mouse spo11 prevents double-strand breaks and formation of synaptonemal complex during meiosis. As a result\, the development of spermatocytes is arrested at zygotene and the arrested cells undergo apoptosis. Not so in the chicken. Here\, although we also observe arrest of meiosis and impaired fertility\, diploid spermatocytes and oocytes continue to develop with interesting biological consequences.
URL:https://www.biomed.cas.cz/event/seminar-ing-eliska-galikova/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240220T140000
DTEND;TZID=Europe/Prague:20240220T150000
DTSTAMP:20260427T001848
CREATED:20240214T082128Z
LAST-MODIFIED:20240214T082128Z
UID:794-1708437600-1708441200@www.biomed.cas.cz
SUMMARY:Hodnocení výzkumu v Akademii věd ČR
DESCRIPTION:Přednášející:  prof. Ing. Jiří Homola\, CSc.\, DSc. \nOrganizace přednášky byla projednána a schválena na schůzi Rady areálu dne 15.1.2024. \nVzhledem k projednávanému tématu a v návaznosti na administraci procesu hodnocení\, se přednáška bude konat pouze v českém jazyce.
URL:https://www.biomed.cas.cz/event/hodnoceni-vyzkumu-v-akademii-ved-cr/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240219T150000
DTEND;TZID=Europe/Prague:20240219T160000
DTSTAMP:20260427T001848
CREATED:20240212T120433Z
LAST-MODIFIED:20240212T120433Z
UID:788-1708354800-1708358400@www.biomed.cas.cz
SUMMARY:Lecture "Microtubule associated proteins and their regulation - between brain development and disease"
DESCRIPTION:Martin Balaštík\, Ph.D.\, Laboratory of Molecular Neurobiology\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture-microtubule-associated-proteins-and-their-regulation-between-brain-development-and-disease/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240214T150000
DTEND;TZID=Europe/Prague:20240214T160000
DTSTAMP:20260427T001848
CREATED:20240130T112256Z
LAST-MODIFIED:20240130T112256Z
UID:778-1707922800-1707926400@www.biomed.cas.cz
SUMMARY:Seminář Miroslav Stoyanov\, M.Sc.
DESCRIPTION:“PPM1D activity promotes genome instability and cellular transformation” \nProtein phosphatase magnesium dependent 1 (PPM1D) is a negative regulator of the tumour suppressor p53 and is implicated in termination of DNA damage response. Increased PPM1D activity allows proliferation in the presence of DNA breaks caused by ionizing radiation or replication stress induced by expression of active RAS oncogene. Active PPM1D promotes cell growth in the soft agar and formation of tumours in nude mice confirming the oncogenic potential of PPM1D.
URL:https://www.biomed.cas.cz/event/seminar-miroslav-stoyanov-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240207T150000
DTEND;TZID=Europe/Prague:20240207T160000
DTSTAMP:20260427T001848
CREATED:20240123T082320Z
LAST-MODIFIED:20240206T070143Z
UID:776-1707318000-1707321600@www.biomed.cas.cz
SUMMARY:Seminář Dr. rer. nat. Leoš Shivaya Valášek\, DSc.
DESCRIPTION:“Ribosomal A-site interactions with near-cognate tRNAs drive stop codon readthrough” \nImagine a gene is a sentence starting with a capital letter and ending with a period\, and a genome as a book telling an entire story. In some protozoans\, extra periods infiltrated their sentences\, replacing specific letters of arbitrary words (namely E and W). As a r.sult\, r.aders (ribosom.s) are confus.d about .here these sentenc.s really .nd\, and the story b.comes disjoint.d. We described how these protozoans handled this mystery\, shedding a new light on (non)universality of the genetic code.
URL:https://www.biomed.cas.cz/event/seminar-prof-dr-reinhard-luhrmann/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240201T140000
DTEND;TZID=Europe/Prague:20240201T150000
DTSTAMP:20260427T001848
CREATED:20240122T091345Z
LAST-MODIFIED:20240122T091504Z
UID:771-1706796000-1706799600@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 02/2024
DESCRIPTION:The role of miR-20a in the injured CNS\nLecturer: Mgr. Ivan Arzhanov / Department of Neuroregeneration \nAnnotation: Spinal cord injury (SCI) involves damage to any part of the spinal cord\, leading to nervous cell death and disruption of conduction pathways. This damage results in the loss of motor and sensory function below the injury site\, potentially causing paralysis and\, in severe cases\, complete paralysis. Following SCI\, a myriad of genes undergo dysregulation\, accompanied by alterations in the expression of microRNAs (miRNAs). MiRNAs\, small non-coding RNA molecules\, play a pivotal regulatory role in various biological processes by interfering with mRNA. In our experiments\, the expression of miR-20a was significantly upregulated for at least one week post-trauma. MiR-20a targets numerous genes\, hindering the regenerative process of nervous tissue. However\, inhibiting miR-20a decreases pro-apoptotic gene expression while facilitating the expression of anti-apoptotic genes\, thereby diminishing neural cell death after injury. During this seminar\, we will summarise the data regarding changes in mRNAs\, miRNAs\, and protein expression following SCI. Subsequently\, we will specifically focus on miR-20a and its role in basic cellular processes following SCI. \nThe seminar will take place on 1. 2. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-02-2024/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240131T150000
DTEND;TZID=Europe/Prague:20240131T160000
DTSTAMP:20260427T001848
CREATED:20240117T065534Z
LAST-MODIFIED:20240117T065534Z
UID:767-1706713200-1706716800@www.biomed.cas.cz
SUMMARY:Seminář Maria Kuzmina\, M.Sc.
DESCRIPTION:“HSCs in inflammation: go extramedullary or go home” \nHematopoietic stem cells (HSCs) are a rare cell type residing in the bone marrow and giving rise to all hematopoietic cells. Despite their quiescence\, HSCs respond to extracellular signals which regulate their fate. In this presentation\, we will determine how of chronic inflammation affects HSC location and function.
URL:https://www.biomed.cas.cz/event/seminar-maria-kuzmina-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240129T150000
DTEND;TZID=Europe/Prague:20240129T160000
DTSTAMP:20260427T001848
CREATED:20240115T114433Z
LAST-MODIFIED:20240115T114433Z
UID:759-1706540400-1706544000@www.biomed.cas.cz
SUMMARY:BioCEV-Krč Methodological Seminar
DESCRIPTION:Topic: Spatial metabolomics \nProgram: https://www.fgu.cas.cz/significant/event/495 \n 
URL:https://www.biomed.cas.cz/event/biocev-krc-methodological-seminar/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240124T150000
DTEND;TZID=Europe/Prague:20240124T160000
DTSTAMP:20260427T001848
CREATED:20240111T072555Z
LAST-MODIFIED:20240111T072555Z
UID:755-1706108400-1706112000@www.biomed.cas.cz
SUMMARY:Seminář Martin Estermann\, Ph.D.
DESCRIPTION:“The cell biology and molecular genetics of avian gonadal development” \nI am interested in investigating the regulatory mechanisms governing sex differentiation in avian species\, with a specific focus on utilizing the chicken as a model organism. In the course of my presentation\, I will explore the cellular foundations and molecular components dictating the development of ovarian and testicular fate in avian species. Employing comparative approaches\, I will scrutinize the distinctive attributes of the ZZ and ZW chromosome sex determination system\, elucidating its role in cell-autonomous sex determination. Lastly\, I will share my recent postdoctoral findings particularly the metabolic regulation of sex differentiation.
URL:https://www.biomed.cas.cz/event/seminar-martin-estermann-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240118T140000
DTEND;TZID=Europe/Prague:20240118T150000
DTSTAMP:20260427T001848
CREATED:20231208T124440Z
LAST-MODIFIED:20240122T091240Z
UID:741-1705586400-1705590000@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series (replacement date from 10/2023)
DESCRIPTION:Lsp1 partially substitutes Pil1 function in eisosome assembly under stress conditions\nLecturer: Ing. Petra Veselá\, Ph.D. / Department of Functional Organisation of Biomembranes \nAnnotation: Eisosomes are large hemitubular structures that underlie the invaginated microdomains in the plasma membrane of various organisms and take part in the cellular stress response. In the yeast Saccharomyces cerevisiae\, they are organised by BAR-domain containing proteins Pil1 and Lsp1. While under normal laboratory conditions\, deletion of the PIL1 gene results in the inability of cells to assemble eisosomes\, deletion of LSP1 shows no apparent phenotype. We show that under stress conditions\, Lsp1 takes over the Pil1 function and forms eisosomes even in the absence of Pil1. \nThe seminar will take place on 18. 1. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/institutional-seminar-series-alternative-date-from-10-2023/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240117T150000
DTEND;TZID=Europe/Prague:20240117T160000
DTSTAMP:20260427T001848
CREATED:20240108T074737Z
LAST-MODIFIED:20240108T074823Z
UID:752-1705503600-1705507200@www.biomed.cas.cz
SUMMARY:Seminář Viktor Bugajev\, Ph.D.
DESCRIPTION:“The novel sphingolipid synthesis regulators in cell life” \nSphingolipids are bioactive lipids and critical structural components of cell membranes. Regulation of their de novo synthesis is critical for normal mammalian development and physiology. Although the ORMDL family has been identified as the gatekeeper of the serine palmitoyl transferase (SPT) activity\, our new data suggest that other components are also involved. We will present our results on new regulators of the SPT complex based on their interaction with members of the ORMDL family using genetic\, immunogenetic and mass spectrometry approaches. Our data indicate that SPT regulatory circuits are more complex than previously thought.
URL:https://www.biomed.cas.cz/event/seminar-viktor-bugajev-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20240104T140000
DTEND;TZID=Europe/Prague:20240104T150000
DTSTAMP:20260427T001848
CREATED:20231208T123949Z
LAST-MODIFIED:20231208T123949Z
UID:739-1704376800-1704380400@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 01/2024
DESCRIPTION:Improvement of healing of bone defects by new approaches of regenerative medicine\nLecturer: Mgr. Eva Šebová / Department of Tissue Engineering \nAnnotation: The PLA and PCL block copolymer combined with hydroxyapatite nanoparticles is a promising material for bone tissue engineering. We expect a high ability to seamlessly interact with bone cells and promote bone growth\, which is at the core of our research. By exploring electrospun nanofibers\, we aim to uncover the potential of copolymer with hydroxyapatite in new bone healing strategies\, offering promising avenues for more effective and efficient bone regeneration therapies. \nThe seminar will take place on 4. 1. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-01-2024/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231220T150000
DTEND;TZID=Europe/Prague:20231220T160000
DTSTAMP:20260427T001848
CREATED:20231211T123835Z
LAST-MODIFIED:20231213T135507Z
UID:744-1703084400-1703088000@www.biomed.cas.cz
SUMMARY:Seminář - Miles Joseph Raishbrook\, M.Sc.
DESCRIPTION:„The impact of FAM84B in retinal homeostasis“ \nFam84b is an incompletely characterised protein. Its aberrant expression has been associated with various human cancers\, with a possible reported role in endosomal trafficking. We genetically ablated Fam84b expression in mice\, and extensively characterised the subsequent age-related\, degenerative phenotype in the retinas of knockout animals. The aim of the project is to explain how the lack of Fam84b unsettles retinal homeostasis and induces the presented phenotype.
URL:https://www.biomed.cas.cz/event/seminar-miles-joseph-raishbrook/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231213T150000
DTEND;TZID=Europe/Prague:20231213T160000
DTSTAMP:20260427T001848
CREATED:20231204T124646Z
LAST-MODIFIED:20231204T152228Z
UID:732-1702479600-1702483200@www.biomed.cas.cz
SUMMARY:Seminář - Valeria Buccheri\, M.Sc.
DESCRIPTION:“Canonical RNAi in vivo in mice” \nCanonical RNAi\, i.e. long dsRNA-induced mRNA degradation\, is essentially not operating in vivo in mammalian somatic cells. Low efficiency of dsRNA conversion into small interfering RNA by Dicer was identified as key limiting factor for canonical RNAi in mammals. We have genetically engineered mice to express a more active Dicer variant and investigated how this impacts mouse development and RNAi activity in vivo.
URL:https://www.biomed.cas.cz/event/seminar-valeria-buccheri-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231207T140000
DTEND;TZID=Europe/Prague:20231207T150000
DTSTAMP:20260427T001848
CREATED:20231115T140644Z
LAST-MODIFIED:20231205T085824Z
UID:720-1701957600-1701961200@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 12/2023
DESCRIPTION:Sensorineural hearing loss in mice lacking GABAB receptor-associated KCTD12 protein\nLecturer: Mgr. Adolf Melichar / Department of Auditory Neuroscience \nAnnotation: KCTD12 protein is the auxiliary subunit of the G-protein coupled receptor for γ-aminobutyric acid (GABA-B). KCTD12 constitutively binds to the intracellular portion of GABA-B receptor and significantly modulates its structural and functional properties. KCTD12/GABA-B complexes are characterized by high expression levels in the mammalian peripheral and central auditory system\, suggesting their important role in auditory function. In this presentation\, we summarize our results showing that deletion of the KCTD12 gene in mice leads to hearing loss and behavioral manifestations of hyperacusis and tinnitus. \nThe seminar will take place on 7. 12. 2023 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-12-2023/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231206T150000
DTEND;TZID=Europe/Prague:20231206T160000
DTSTAMP:20260427T001848
CREATED:20231204T124305Z
LAST-MODIFIED:20231204T124400Z
UID:729-1701874800-1701878400@www.biomed.cas.cz
SUMMARY:Seminář - Mgr. Luděk Štěpánek\, Ph.D.
DESCRIPTION:„Studying the eukaryotic cilium by a single organelle approach“ \nCilia are present on the surface of many eukaryotic cells and have critical motility\, sensory\, and signalling functions. Yet\, many fundamental aspects of their biology are poorly understood. Taking advantage of the fact\, that the cilia are experimentally well accessible\, I have been developing approaches for imaging and manipulation of individual cilia. These include correlative light and electron microscopy\, blocking transport within the cilia by physical and chemical means\, as well as in vitro reconstitution approaches. In this talk\, I will discuss the development of such methods and present the advancements in our understanding of processes responsible for building and maintenance of the cilia these approaches have enabled.
URL:https://www.biomed.cas.cz/event/seminar-mgr-ludek-stepanek-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20231123
DTEND;VALUE=DATE:20231125
DTSTAMP:20260427T001848
CREATED:20231027T104549Z
LAST-MODIFIED:20231115T140958Z
UID:687-1700697600-1700870399@www.biomed.cas.cz
SUMMARY:IEM CAS Mini-Symposium BIOCEV Regeneration III.
DESCRIPTION:Dear Colleagues\, \nWe are pleased to announce the annual Mini-Symposium BIOCEV Regeneration III\, which will be held on 23-24th November 2023 in BIOCEV\, Vestec. \nOur symposium aims to exchange knowledge in regenerative medicine\, tissue engineering\, 3D in vitro modelling\, organoid research\, new tools and technologies in cell culture\, and many more. \nAlong with several lectures given by well-known experts in the fields\, this year\, we encourage early career researchers to contribute to our symposium and share research achievements\, exchange opinions\, or find new contacts and cooperations. To achieve the best welcoming atmosphere during the event\, our organising team comprises PhD students of Charles University working in the Institute of Experimental Medicine of the CAS\, v. v. i. and the Institute of Physiology of the CAS\, v. v. i. \nIn a student-to-student format\, we would like to invite our colleagues (PhD students\, early post-doctoral scientists) to submit the abstracts and share their research via an oral presentation or a poster combined with a short pitch talk. Additionally\, the active participants will benefit from a specially organised Student Workshop on the 24th of November\, where our colleagues from research organisations and companies will share their knowledge in 3D culture\, tissue engineering tools and methods\, advise on the commercialisation of the research or the translation of the results into clinical applications. The Symposium will be held in English. \nThe main topics of the mini-symposium: \n\nTissue engineering\nRegenerative medicine\nIn vitro models\n3D cultures\nOrganoids\nNew tools and technologies in regenerative medicine and tissue engineering\n\nRegistration for the event is free of charge. To register as a delegate as well as an active participant with the abstract submission\, please fill out the registration form here: \n\nRegistration and abstract submission: https://forms.gle/YhLqptsLwnzYuTTj8 (open in a new window)\nThe abstract submission deadline is 24.10. 2023.\nThe registration deadline is 10.11.2023\n\nWe are looking forward to seeing you in November! \nSincerely\, Organising team \n\n\n\n\n\n\n\n\n\n\n\n\nLecturers and Committee Members\n\nPre-confirmed invited lecturers\n\nNatalia Rozwadowska\, PhD (The Institute of Human Genetics of the PAS\, Poznan\, Poland)\nDasa Bohaciaková\, PhD (Masaryk University\, Brno\, Czech Republic)\nOleg Lunov\, PhD (Institute of Physics of the CAS\, Prague\, Czech Republic)\nTomasz Kolanowski\, PhD (The Institute of Human Genetics of the PAS\, Poznan\, Poland)\nLukas Valihrach\, PhD (Institute of Biotechnology of the CAS\, BIOCEV\, Vestec\, Czech Republic)\n\nOrganising committee\n\nJarmila Havelkova\, MSc (Institute of Physiology of the CAS\, v. v. i. & Institute of Experimental Medicine of the CAS\, v. v. i.\, BIOCEV\, Charles University)\nKristyna Sintakova\, MSc (Institute of Experimental Medicine of the CAS\, v. v. i.\, BIOCEV\, Charles University)\nEliska Vavrinova\, MSc (Institute of Experimental Medicine of the CAS\, v. v. i.\, BIOCEV\, Charles University)\n\nScientific committee\n\nAssoc. Prof. Lucie Bacakova\, MD\, PhD (Institute of Physiology of the CAS\, v. v. i.)\nAssoc. Prof. Pavla Jendelova\, PhD (Institute of Experimental Medicine of the CAS\, v. v. i.)\nYuriy Petrenko\, PhD (Institute of Experimental Medicine of the CAS\, v. v. i. & Institute of Physiology of the CAS\, v. v. i.\, BIOCEV)\nOlena Rohulska\, PhD (Institute of Experimental Medicine of the CAS\, v. v. i. & Institute of Physiology of the CAS\, v. v. i.\, BIOCEV)\nNataliya Romanyuk\, PhD (Institute of Experimental Medicine of the CAS\, v. v. i.)\n\n\n\n\n\n\n\n\n\n\n\nOur sponsors\n\n\n\n\n\nEast Port Life Science \nElmarco \nSchoeller Instruments \nSVEN Biolabs \nTATAA Biocenter 
URL:https://www.biomed.cas.cz/event/mini-symposium-biocev-regeneration-iii/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231122T150000
DTEND;TZID=Europe/Prague:20231122T160000
DTSTAMP:20260427T001848
CREATED:20231115T123407Z
LAST-MODIFIED:20231115T134822Z
UID:714-1700665200-1700668800@www.biomed.cas.cz
SUMMARY:Seminář - RNDr. Ondřej Mihola\, Ph.D.
DESCRIPTION:“A chance for fertility despite bad DNA breaks (AKA The effect of crossing-over rate on fertility)” \nProgrammed meiotic DNA breaks are essential for mammalian fertility but dangerous for genome integrity. DNA-binding H3-lysine-trimethyltransferase PRDM9 determines the positions of the meiotic DNA breaks\, which can be repaired as crossovers or noncrossovers. The crossover/noncrossover decision is regulated by many factors that include RING-domain E3 ligase RNF212. The dosage of the Rnf212 gene in mouse affects the crossover rate per meiotic cell and variants in the human RNF212 gene are associated with crossover rates. Deficiency for RNF212 leads to complete arrest of meiosis at the metaphase stage. The deficiency for human and rodent PRDM9 causes partial to complete pachytene arrest\, depending on unknown genetic factors. We will present results demonstrating that the dosage of Rnf212 (and thus crossover rate) affects meiotic progression and germ cell counts of semisterile Prdm9-deficient mice. Our findings offer an insight into the mechanisms and treatment possibilities of some cases of infertility. \n 
URL:https://www.biomed.cas.cz/event/seminar-ondrej-mihola-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231120T150000
DTEND;TZID=Europe/Prague:20231120T160000
DTSTAMP:20260427T001848
CREATED:20231030T111926Z
LAST-MODIFIED:20231030T111926Z
UID:700-1700492400-1700496000@www.biomed.cas.cz
SUMMARY:Lecture
DESCRIPTION:Laboratory of Developmental Epileptology\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231120T143000
DTEND;TZID=Europe/Prague:20231120T160000
DTSTAMP:20260427T001848
CREATED:20231115T140331Z
LAST-MODIFIED:20231115T140803Z
UID:718-1700490600-1700496000@www.biomed.cas.cz
SUMMARY:IEM CAS Distinguished Guest Seminar Series - Prof. Jens Pahnke
DESCRIPTION:ABC transporter blood-brain barrier function in neurodegenerative and neuroinflammatory diseases – from basic research to treatment\nLecturer: Prof. Jens Pahnke\, M.D.\, Ph.D.\, E.F.N./ University of Oslo\, Faculty of Medicine / Oslo University Hospital\, Department of Pathology\, Norway \nThe seminar will take place on 20. 11. 2023 from 2:30 p.m. in the Turquoise Auditorium of the IEM CAS. \nAnnotation: \nThe current understanding of neurodegenerative diseases focusses on the deposition of toxic peptide species as larger aggregates in the brain of effected individuals. However\, patients with sporadic neurodegenerative diseases do not overexpress these peptides. Moreover\, they are hampered in removing the physiologically produced peptides\, e.g. Aβ and α-synuclein. The blood-brain barrier plays a prominent role in the active and effective removal of metabolites and in the efflux of toxic peptides from the brain into the blood stream. \nHere\, ABC transporters were discovered by us and others to have a fundamental role in the homeostasis of the brain’s environment. In 2011\, we described a new ABC transporter (ABCC1) that increases Aβ in the brain of knock-out animals by 12-14fold. Since then\, we could show that the activation of ABC transporters can be used as a diagnostic tool and a new treatment option in elderly with Alzheimer’s disease and other neurodegenerative diseases\, such as Huntington’s disease. \n1 Pahnke\, J. et al. Free Neuropathol 2\, 33\, (2021)\n2 Pahnke\, J. et al. Neurobiol Dis 72 Pt A\, 54-60\, (2014)\n3 Pahnke\, J. et al. Curr Alzheimer Res 5\, 396-405\, (2008) \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-distinguished-guest-seminar-series-prof-jens-pahnke/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231115T150000
DTEND;TZID=Europe/Prague:20231115T160000
DTSTAMP:20260427T001848
CREATED:20231107T122449Z
LAST-MODIFIED:20231108T090525Z
UID:711-1700060400-1700064000@www.biomed.cas.cz
SUMMARY:Seminář - Prof. Jiří Forejt\, M.D.\, Ph.D.\, DSc.
DESCRIPTION:“Genetic architecture of Prdm9-driven reproductive isolation between mouse subspecies” \nHybrid incompatibility\, the inviability or infertility of species hybrids\, has played a central role in speciation research since Darwin’s Origin of Species. However\, the search for genes controlling hybrid sterility\, mainly using Drosophila species hybrids\, has been largely unsuccessful\, revealing a polygenic control with complex epistatic interactions. Fifty years ago\, we identified the first hybrid sterility locus\, Hst1\, in the house mouse genome\, and 14 years ago\, we positionally cloned Prdm9 as the gene responsible for Hst1-controlled hybrid sterility. \nIn this talk\, I will summarize our current understanding of the molecular genetic mechanisms that control this unique model of mammalian hybrid sterility.
URL:https://www.biomed.cas.cz/event/seminar-prof-jiri-forejt-m-d-ph-d-dsc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231114T090000
DTEND;TZID=Europe/Prague:20231114T150000
DTSTAMP:20260427T001848
CREATED:20231107T075453Z
LAST-MODIFIED:20231107T075453Z
UID:704-1699952400-1699974000@www.biomed.cas.cz
SUMMARY:Den otevřených dveří ÚMG / IMG Open House Day
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/den-otevrenych-dveri-umg-img-open-house-day/
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231113T150000
DTEND;TZID=Europe/Prague:20231113T160000
DTSTAMP:20260427T001848
CREATED:20231030T111844Z
LAST-MODIFIED:20231030T111844Z
UID:697-1699887600-1699891200@www.biomed.cas.cz
SUMMARY:Lecture "Gliflozins in the treatment of non-diabetic cardiovascular diseases"
DESCRIPTION:RNDr. Ivana Vaněčková\, DSc.\, Laboratory of Experimental Hypertension\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture-gliflozins-in-the-treatment-of-non-diabetic-cardiovascular-diseases/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20231110
DTEND;VALUE=DATE:20231111
DTSTAMP:20260427T001848
CREATED:20231027T104223Z
LAST-MODIFIED:20231027T104417Z
UID:683-1699574400-1699660799@www.biomed.cas.cz
SUMMARY:IEM CAS Open House Day / Week of the Czech Academy of Sciences Festival
DESCRIPTION:Week of the Czech Academy of Sciences is a science festival that follows the previous Week of Science and Technology of the CAS. The festival offers scientific lectures\, exhibitions\, events at institutes\, documentary films\, workshops and many other activities across the Czech Republic and all scientific disciplines. As part of the festival\, the IEM CAS traditionally organises an Open House Day\, which includes individual and group excursions around the research departments\, as well as a cycle of lectures which presents the latest discoveries and achievements of the IEM CAS to the public. The morning programme is focused primarily on high school students. \nRegistration
URL:https://www.biomed.cas.cz/event/open-house-day-of-the-iem-cas-week-of-the-czech-academy-of-sciences-festival/
END:VEVENT
END:VCALENDAR