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METHOD:PUBLISH
X-ORIGINAL-URL:https://www.biomed.cas.cz
X-WR-CALDESC:Akce na 
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Prague
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231120T150000
DTEND;TZID=Europe/Prague:20231120T160000
DTSTAMP:20260427T083231
CREATED:20231030T111926Z
LAST-MODIFIED:20231030T111926Z
UID:700-1700492400-1700496000@www.biomed.cas.cz
SUMMARY:Lecture
DESCRIPTION:Laboratory of Developmental Epileptology\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231120T143000
DTEND;TZID=Europe/Prague:20231120T160000
DTSTAMP:20260427T083231
CREATED:20231115T140331Z
LAST-MODIFIED:20231115T140803Z
UID:718-1700490600-1700496000@www.biomed.cas.cz
SUMMARY:IEM CAS Distinguished Guest Seminar Series - Prof. Jens Pahnke
DESCRIPTION:ABC transporter blood-brain barrier function in neurodegenerative and neuroinflammatory diseases – from basic research to treatment\nLecturer: Prof. Jens Pahnke\, M.D.\, Ph.D.\, E.F.N./ University of Oslo\, Faculty of Medicine / Oslo University Hospital\, Department of Pathology\, Norway \nThe seminar will take place on 20. 11. 2023 from 2:30 p.m. in the Turquoise Auditorium of the IEM CAS. \nAnnotation: \nThe current understanding of neurodegenerative diseases focusses on the deposition of toxic peptide species as larger aggregates in the brain of effected individuals. However\, patients with sporadic neurodegenerative diseases do not overexpress these peptides. Moreover\, they are hampered in removing the physiologically produced peptides\, e.g. Aβ and α-synuclein. The blood-brain barrier plays a prominent role in the active and effective removal of metabolites and in the efflux of toxic peptides from the brain into the blood stream. \nHere\, ABC transporters were discovered by us and others to have a fundamental role in the homeostasis of the brain’s environment. In 2011\, we described a new ABC transporter (ABCC1) that increases Aβ in the brain of knock-out animals by 12-14fold. Since then\, we could show that the activation of ABC transporters can be used as a diagnostic tool and a new treatment option in elderly with Alzheimer’s disease and other neurodegenerative diseases\, such as Huntington’s disease. \n1 Pahnke\, J. et al. Free Neuropathol 2\, 33\, (2021)\n2 Pahnke\, J. et al. Neurobiol Dis 72 Pt A\, 54-60\, (2014)\n3 Pahnke\, J. et al. Curr Alzheimer Res 5\, 396-405\, (2008) \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-distinguished-guest-seminar-series-prof-jens-pahnke/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231115T150000
DTEND;TZID=Europe/Prague:20231115T160000
DTSTAMP:20260427T083231
CREATED:20231107T122449Z
LAST-MODIFIED:20231108T090525Z
UID:711-1700060400-1700064000@www.biomed.cas.cz
SUMMARY:Seminář - Prof. Jiří Forejt\, M.D.\, Ph.D.\, DSc.
DESCRIPTION:“Genetic architecture of Prdm9-driven reproductive isolation between mouse subspecies” \nHybrid incompatibility\, the inviability or infertility of species hybrids\, has played a central role in speciation research since Darwin’s Origin of Species. However\, the search for genes controlling hybrid sterility\, mainly using Drosophila species hybrids\, has been largely unsuccessful\, revealing a polygenic control with complex epistatic interactions. Fifty years ago\, we identified the first hybrid sterility locus\, Hst1\, in the house mouse genome\, and 14 years ago\, we positionally cloned Prdm9 as the gene responsible for Hst1-controlled hybrid sterility. \nIn this talk\, I will summarize our current understanding of the molecular genetic mechanisms that control this unique model of mammalian hybrid sterility.
URL:https://www.biomed.cas.cz/event/seminar-prof-jiri-forejt-m-d-ph-d-dsc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231114T090000
DTEND;TZID=Europe/Prague:20231114T150000
DTSTAMP:20260427T083231
CREATED:20231107T075453Z
LAST-MODIFIED:20231107T075453Z
UID:704-1699952400-1699974000@www.biomed.cas.cz
SUMMARY:Den otevřených dveří ÚMG / IMG Open House Day
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/den-otevrenych-dveri-umg-img-open-house-day/
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231113T150000
DTEND;TZID=Europe/Prague:20231113T160000
DTSTAMP:20260427T083231
CREATED:20231030T111844Z
LAST-MODIFIED:20231030T111844Z
UID:697-1699887600-1699891200@www.biomed.cas.cz
SUMMARY:Lecture "Gliflozins in the treatment of non-diabetic cardiovascular diseases"
DESCRIPTION:RNDr. Ivana Vaněčková\, DSc.\, Laboratory of Experimental Hypertension\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture-gliflozins-in-the-treatment-of-non-diabetic-cardiovascular-diseases/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20231110
DTEND;VALUE=DATE:20231111
DTSTAMP:20260427T083231
CREATED:20231027T104223Z
LAST-MODIFIED:20231027T104417Z
UID:683-1699574400-1699660799@www.biomed.cas.cz
SUMMARY:IEM CAS Open House Day / Week of the Czech Academy of Sciences Festival
DESCRIPTION:Week of the Czech Academy of Sciences is a science festival that follows the previous Week of Science and Technology of the CAS. The festival offers scientific lectures\, exhibitions\, events at institutes\, documentary films\, workshops and many other activities across the Czech Republic and all scientific disciplines. As part of the festival\, the IEM CAS traditionally organises an Open House Day\, which includes individual and group excursions around the research departments\, as well as a cycle of lectures which presents the latest discoveries and achievements of the IEM CAS to the public. The morning programme is focused primarily on high school students. \nRegistration
URL:https://www.biomed.cas.cz/event/open-house-day-of-the-iem-cas-week-of-the-czech-academy-of-sciences-festival/
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20231109
DTEND;VALUE=DATE:20231110
DTSTAMP:20260427T083231
CREATED:20231004T074439Z
LAST-MODIFIED:20231004T074439Z
UID:670-1699488000-1699574399@www.biomed.cas.cz
SUMMARY:Den otevřených dveří - FGÚ
DESCRIPTION:Začátek v 9\,00 hod a ve 13\,00 hod.
URL:https://www.biomed.cas.cz/event/den-otevrenych-dveri-fgu/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231108T150000
DTEND;TZID=Europe/Prague:20231108T160000
DTSTAMP:20260427T083231
CREATED:20231107T075625Z
LAST-MODIFIED:20231107T075625Z
UID:706-1699455600-1699459200@www.biomed.cas.cz
SUMMARY:Seminář – Assoc. Prof. Pavel Plevka
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/seminar-assoc-prof-pavel-plevka/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231106T150000
DTEND;TZID=Europe/Prague:20231106T160000
DTSTAMP:20260427T083231
CREATED:20231030T111804Z
LAST-MODIFIED:20231030T111804Z
UID:694-1699282800-1699286400@www.biomed.cas.cz
SUMMARY:Lecture "Clocks in our body – how do they synchronize to shape our physiology?"
DESCRIPTION:Prof. PharmDr. Alena Sumová\, DSc.\, Laboratory of Biological Rhythms\, IPHYS
URL:https://www.biomed.cas.cz/event/lecture-clocks-in-our-body-how-do-they-synchronize-to-shape-our-physiology/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231102T140000
DTEND;TZID=Europe/Prague:20231102T144500
DTSTAMP:20260427T083231
CREATED:20231027T103432Z
LAST-MODIFIED:20231027T103844Z
UID:681-1698933600-1698936300@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 11/2023
DESCRIPTION:Single-cell gene expression analysis of developing craniofacial region\nLecturer: Erika Hudáčová\, M.Sc. / Department of Developmental Biology \nThe seminar will take place on 2. 11. 2023 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nAnnotation: In vertebrates\, the skull is composed of various skeletal elements originating from cranial neural crest cells (CNCCs). CNCCs are responsible for the formation of the cranium vault\, frontonasal prominence\, upper and lower jaw\, hyoid bone\, external ear and middle ear. The morphogenesis of the craniofacial region encompasses a number of processes\, from epithelial-mesenchymal induction and mesenchymal condensation to endochondral or intramembranous ossification. However\, the molecular and genetic pathways regulating cranial cartilage shaping and growth during embryogenesis are poorly understood. \nIn our research\, we present Wnt1-Cre2\, Meis2 conditional knock-out (cKO) mice with several craniofacial bone abnormalities resembling severe human pathologies due to improper molecular mechanisms guiding mesenchymal condensation. Using single-cell RNA sequencing\, we further focus on describing the Meis2-dependent gene regulatory network involved in mesenchymal condensation. Comparison of wild-type and Meis2 cKO embryonic stages E12.5 and E13.5 reveals multiple mesenchymal cell types responsible for craniofacial formation. We have identified markers for cell type specification and positional cues in developing craniofacial regions. Furthermore\, differences identified in specific cell types governing mesenchymal condensation and endochondral ossification correlate with the phenotype present in Meis2 cKO mice. Our transcriptomics data in Meis2 cKO show elevated expression of the genes involved in ossification\, cell-cell adhesion and cell-extracellular matrix contact. Altogether\, the identification of hitherto unknown factors controlling the growth and shape of cranial bones may potentially contribute to the mitigation or prevention of human craniofacial abnormalities. \nWe look forward to your participation. \n  \n 
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-11-2023/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231023T150000
DTEND;TZID=Europe/Prague:20231023T160000
DTSTAMP:20260427T083231
CREATED:20231004T074255Z
LAST-MODIFIED:20231004T074255Z
UID:666-1698073200-1698076800@www.biomed.cas.cz
SUMMARY:Lecture "Understanding the molecular mechanisms of thermoTRP ion channel activation"
DESCRIPTION:Mgr. Lucie Zímová\, Ph.D.\, Laboratory of Cellular Neurophysiology
URL:https://www.biomed.cas.cz/event/lecture-understanding-the-molecular-mechanisms-of-thermotrp-ion-channel-activation/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231016T150000
DTEND;TZID=Europe/Prague:20231016T160000
DTSTAMP:20260427T083231
CREATED:20231004T074139Z
LAST-MODIFIED:20231004T074139Z
UID:662-1697468400-1697472000@www.biomed.cas.cz
SUMMARY:Lecture "Parvalbumin interneurons: A hothouse flower in the brain?"
DESCRIPTION:RNDr. Jan Svoboda Ph.D. – Laboratory of Neurophysiology of Memory
URL:https://www.biomed.cas.cz/event/lecture-parvalbumin-interneurons-a-hothouse-flower-in-the-brain/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231009T150000
DTEND;TZID=Europe/Prague:20231009T163000
DTSTAMP:20260427T083231
CREATED:20231004T071247Z
LAST-MODIFIED:20231004T073916Z
UID:657-1696863600-1696869000@www.biomed.cas.cz
SUMMARY:Bureš lecture series "Skeletal muscle function in the context of the neuromuscular\, musculoskeletal and metabolic system"
DESCRIPTION:Prof. Stefano Schiaffino\, Venetian Institute of Molecular Medicine\, Padova\, Italy
URL:https://www.biomed.cas.cz/event/bures-lecture-series-skeletal-muscle-function-in-the-context-of-the-neuromuscular-musculoskeletal-and-metabolic-system/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231004T150000
DTEND;TZID=Europe/Prague:20231004T160000
DTSTAMP:20260427T083231
CREATED:20230822T085825Z
LAST-MODIFIED:20230822T112804Z
UID:633-1696431600-1696435200@www.biomed.cas.cz
SUMMARY:Pravidelný středeční seminář / Regular Wednesday Seminar
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/pravidelny-stredecni-seminar/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20231002T123000
DTEND;TZID=Europe/Prague:20231002T150000
DTSTAMP:20260427T083231
CREATED:20230908T101722Z
LAST-MODIFIED:20230908T101817Z
UID:640-1696249800-1696258800@www.biomed.cas.cz
SUMMARY:Miloš Pěkný - Astrocytes as a treatment target in neurological diseases  Marcela Pěkná - Novel therapeutic strategy to promote recovery after stroke
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/640/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20230821
DTEND;VALUE=DATE:20230822
DTSTAMP:20260427T083231
CREATED:20230721T104647Z
LAST-MODIFIED:20230721T104647Z
UID:617-1692576000-1692662399@www.biomed.cas.cz
SUMMARY:NIVB Networking Meeting
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/nivb-networking-meeting/
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
END:VCALENDAR