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BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250206T140000
DTEND;TZID=Europe/Prague:20250206T150000
DTSTAMP:20260426T135233
CREATED:20250204T105313Z
LAST-MODIFIED:20250204T105353Z
UID:2299-1738850400-1738854000@www.biomed.cas.cz
SUMMARY:Seminář - Prof. Cheng Zhu - "Mechanotransduction through immunoreceptors"
DESCRIPTION:Dear colleagues\, \nI am delighted to invite you to a seminar by Prof. Cheng Zhu (Georgia Institute of Technology\, USA) at the Institute of Molecular Genetics on February 6 at 14:00 (Hasek Lecture Hall). Prof. Zhu is a recognized leader and pioneer at the interface of immunology\, structural biology\, and mechanosensing with groundbreaking contributions that have advanced our understanding of how immune receptors work at the cell-cell contacts. \nInvitation: https://www.img.cas.cz/files/2025/01/20250206_Cheng_Zhu.pdf \nPublication profile: https://scholar.google.com/citations?user=_tPv2wEAAAAJ&hl=en&oi=ao \nWith best regards\, \nOndrej Stepanek
URL:https://www.biomed.cas.cz/event/seminar-mechanotransduction-through-immunoreceptors/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250205T150000
DTEND;TZID=Europe/Prague:20250205T160000
DTSTAMP:20260426T135233
CREATED:20250122T070222Z
LAST-MODIFIED:20250122T070222Z
UID:2292-1738767600-1738771200@www.biomed.cas.cz
SUMMARY:Seminář Lenka Ungrová\, M.Sc.
DESCRIPTION:“Birds do it their way: avian interferon regulatory factors (almost) resolved” \nInterferon regulatory factors (IRFs) are transcription factors that play a key role in vertebrate innate antiviral immunity. IRF3 and IRF7 activate the expression of IFN-β\, which in response induces the assembly of STAT1\, STAT2 and IRF9 into the ISGF3 complex. Subsequently\, this complex activates the expression of interferon-stimulated genes (ISGs) mounting the antiviral state of the cell. Interestingly\, IRF9 and IRF3 have been reported to be missing in birds. As part of our efforts to search for hidden genes in avian genomes\, we have identified IRF3 in paleognathous birds and IRF9 in most bird orders with the notable exception of the chicken. We focus on the experimental characterization of IRF9 in a duck cell line and also look for a possible substitute for IRF9 in chickens.
URL:https://www.biomed.cas.cz/event/seminar-lenka-ungrova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250129T150000
DTEND;TZID=Europe/Prague:20250129T160000
DTSTAMP:20260426T135233
CREATED:20250114T125756Z
LAST-MODIFIED:20250114T125756Z
UID:2284-1738162800-1738166400@www.biomed.cas.cz
SUMMARY:Seminář Mgr. et Mgr. Evžen Bouřa\, Ph.D.
DESCRIPTION:“RNA cap methylation in poxviruses and coronavirus – differences and similarities” \nRNA methyltransferases (MTases) are responsible for synthesizing the 5′ RNA cap\, which plays a crucial role in RNA stability and efficient translation. Over the past two years\, both our research team and others have developed numerous inhibitors targeting coronaviral MTases. Through our efforts\, we have successfully determined the crystal structures of these inhibitors bound to the coronaviral nsp14 and nsp16/nsp10 MTases. Additionally\, we recently elucidated the crystal structure of the monkeypox virus MTase VP39\, in complex with the broad-spectrum MTase inhibitor sinefungin and several other inhibitors. These structural studies have unveiled notable distinctions between coronaviral and poxviral MTases\, while also highlighting the potential for targeting these enzymes with the same or closely related compounds.
URL:https://www.biomed.cas.cz/event/seminar-mgr-et-mgr-evzen-boura-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250122T150000
DTEND;TZID=Europe/Prague:20250122T160000
DTSTAMP:20260426T135233
CREATED:20250113T124228Z
LAST-MODIFIED:20250113T124228Z
UID:2282-1737558000-1737561600@www.biomed.cas.cz
SUMMARY:Seminář Michal Mrkáček\, M.Sc.
DESCRIPTION:“Tipping the Lipid Scales: Negative Feedback Regulation via ORMDLs Protein Degradation Ensures Sphingolipid Homeostasis” \nSphingolipids are essential lipid molecules that contribute to cellular structure and signaling. Their de novo synthesis is initiated in the endoplasmic reticulum (ER) and catalyzed by the multimeric serine palmitoyltransferase (SPT) complex. The ER-resident ORMDL proteins are well-established regulators of sphingolipid synthesis\, directly inhibiting the SPT complex to control the pathway at its origin. Here\, we identify a negative feedback loop that fine-tunes this regulatory mechanism. Using pharmacological inhibitors such as myriocin and fumonisin B1\, which target different steps of the sphingolipid pathway\, we demonstrate that reduced sphingolipid levels promote enhanced degradation of ORMDL proteins. This degradation alleviates SPT inhibition\, thereby accelerating de novo sphingolipid biosynthesis and restoring metabolic balance.
URL:https://www.biomed.cas.cz/event/seminar-michal-mrkacek-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250120T150000
DTEND;TZID=Europe/Prague:20250120T160000
DTSTAMP:20260426T135233
CREATED:20250113T092008Z
LAST-MODIFIED:20250113T092128Z
UID:2279-1737385200-1737388800@www.biomed.cas.cz
SUMMARY:Lecture “Iron and bone: a (not so) unusual liaison? Unraveling the role of cell metabolism in osteoblasts during iron overload”
DESCRIPTION:Speaker: Martina Rauner\, Technische Universität Dresden\, Germany
URL:https://www.biomed.cas.cz/event/lecture-iron-and-bone-a-not-so-unusual-liaison-unraveling-the-role-of-cell-metabolism-in-osteoblasts-during-iron-overload/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250115T150000
DTEND;TZID=Europe/Prague:20250115T160000
DTSTAMP:20260426T135233
CREATED:20250106T090313Z
LAST-MODIFIED:20250106T090313Z
UID:2276-1736953200-1736956800@www.biomed.cas.cz
SUMMARY:Seminář Karolína Vaníčková\, M.Sc.
DESCRIPTION:“Infections and hematopoietic stem cells: how do they communicate?” \nInfections are primarily cleared by immune cells in our bodies. However\, we observed that the most immature hematopoietic stem cells also contribute to this process. In this lecture\, we will report on the mechanisms that activate an hematopoietic stem cell during infection and the cellular adaptations that these cells undertake. Special attention will be given to the contribution of the Wnt/beta-catenin signaling pathway.
URL:https://www.biomed.cas.cz/event/seminar-karolina-vanickova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20250108T150000
DTEND;TZID=Europe/Prague:20250108T160000
DTSTAMP:20260426T135233
CREATED:20241128T122535Z
LAST-MODIFIED:20241128T122535Z
UID:2267-1736348400-1736352000@www.biomed.cas.cz
SUMMARY:Seminář Dr. Nicolas Rivron
DESCRIPTION:Modeling human early pregnancy with stem cells” \nThe blastocyst is the early mammalian organism before implantation in the uterus. We have promoted the self-organization of stem cells into models of mouse and human blastocysts\, which we have named blastoids (Nature 2018\, Nature 2021). Blastoids are morphologically and transcriptionally similar to the blastocyst and contain analogs of all three cell types that would eventually develop into the complete organism (embryonic and extraembryonic). Because blastoids are complete and model the preimplantation stage\, they can be introduced into the uterus (mouse model) or combined in vitro with uterine cells (human model) to recapitulate aspects of the normally hidden implantation processes. Unlike blastocysts\, blastoids come in large numbers and facilitate a more systematic modulation and analysis of development. As such\, they represent both a scientific and ethical alternative to the use of embryos for research. Using this approach\, we are investigating the genome evolution underlying species-specific aspects of blastocyst development and implantation\, with the long-term goal of understanding the evolutionary basis of human pregnancy characteristics (50% of fertilized eggs never develop). This knowledge could help solve the global health problems of family planning\, fertility decline and prenatal preventive medicine.
URL:https://www.biomed.cas.cz/event/seminar-dr-nicolas-rivron/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241218T150000
DTEND;TZID=Europe/Prague:20241218T160000
DTSTAMP:20260426T135233
CREATED:20241204T070320Z
LAST-MODIFIED:20241204T070320Z
UID:2270-1734534000-1734537600@www.biomed.cas.cz
SUMMARY:Seminář Karolina Kowalska\, M.Sc.
DESCRIPTION:“Structural basis of MICAL autoinhibition and activation” \nIn this talk\, we will explore the role of MICAL proteins in cellular dynamics\, focusing on their ability to disassemble actin filaments and their implications for processes like axon guidance\, cytokinesis\, and cell morphology. We will present our recent findings based on the cryoEM structure of human MICAL1\, which reveal the molecular mechanisms underlying MICAL1 autoinhibition. Specifically\, we will discuss how an intramolecular interaction between the N-terminal catalytic and C-terminal coiled-coil domains blocks F-actin interaction\, and how structural changes and domain interactions mediate activation. These findings highlight evolutionarily conserved mechanisms within the MICAL family\, shedding light on their broader functional relevance.
URL:https://www.biomed.cas.cz/event/seminar-karolina-kowalska-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241217T100000
DTEND;TZID=Europe/Prague:20241217T110000
DTSTAMP:20260426T135233
CREATED:20241205T094751Z
LAST-MODIFIED:20241205T094751Z
UID:2273-1734429600-1734433200@www.biomed.cas.cz
SUMMARY:Lecture „Unlocking the secrets of the heart – toward an understanding of molecular sex differences in cardiac health and disease“
DESCRIPTION:Lukáš Chmátal\, Ph.D.\, Whitehead Institute for Biomedical Research\, MIT\, USA \nHeart disease is the leading cause of death worldwide\, but its effects are far from uniform. Men and women experience striking differences in symptoms\, prevalence\, and outcomes – yet the molecular mechanisms underlying these differences remain poorly understood. In this lecture\, I will reveal how male and female hearts fundamentally differ in their energy metabolism\, which is driven by mitochondria\, the cell’s powerhouse. I will also outline innovative experimental approaches to uncover the role of sex chromosomes in regulating these differences – insights that will shape the research agenda of my own laboratory. Please\, join me to explore how understanding these mechanisms could transform the way we approach cardiac health for both sexes. \nMore: https://fgu.cas.cz/udalost/lukas-chmatal-ph-d/
URL:https://www.biomed.cas.cz/event/lecture-unlocking-the-secrets-of-the-heart-toward-an-understanding-of-molecular-sex-differences-in-cardiac-health-and-disease/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241211T080000
DTEND;TZID=Europe/Prague:20241211T170000
DTSTAMP:20260426T135233
CREATED:20241126T132105Z
LAST-MODIFIED:20241126T132105Z
UID:2265-1733904000-1733936400@www.biomed.cas.cz
SUMMARY:Seminář Nenad Radivojević\, M.Sc.
DESCRIPTION:“Quality control in snRNP biogenesis” \nBefore being assembled into spliceosomes\, small nuclear ribonucleoprotein particles (snRNPs) undergo a complex and regulated maturation pathway. Cajal bodies (CBs) have been shown to monitor the final stage of this process by sequestering immature or misassembled particles through a yet unknown quality control mechanism. Here\, we have identified coilin\, a CB marker protein\, as the quality control factor. We further characterize coilin domains interacting with snRNPs and elucidate the molecular mechanism how coilin recognize immature snRNPs. \n 
URL:https://www.biomed.cas.cz/event/seminar-nenad-radivojevic-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20241210
DTEND;VALUE=DATE:20241212
DTSTAMP:20260426T135233
CREATED:20241107T124538Z
LAST-MODIFIED:20241107T124639Z
UID:2251-1733788800-1733961599@www.biomed.cas.cz
SUMMARY:IDP – Image Data Presentation
DESCRIPTION:The human eye is our primary tool for interpreting images\, so scientific images should be adjusted with this perception in mind. However\, display and print transfer characteristics often degrade images\, making them differ from reality. This course offers a unique approach\, focusing on preparing image data for presentation. \nWe’ll cover essential topics like gamma correction and print preparation to ensure your posters and figures appear as true-to-life as possible. \nDay 1: Lectures with scientific colleagues and the opportunity to consult with top experts in advanced graphic displays (Antonin Charvat\, EIZO) and professional photo preparation for print (Karel Pones\, ITF). \nDay 2: Hands-on practice with image processing software and figure-making techniques (Adobe CS and freeware alternatives). \nYou’re welcome to attend the lectures without registration\, but registration is required for the practical sessions. \nWe look forward to seeing you! \nThe Organizing Team \n Oldrich Benada\, MBU & Ivan Novotny\, IMG
URL:https://www.biomed.cas.cz/event/idp-image-data-presentation/
LOCATION:IMG
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241209T150000
DTEND;TZID=Europe/Prague:20241209T163000
DTSTAMP:20260426T135233
CREATED:20241021T123023Z
LAST-MODIFIED:20241021T123023Z
UID:2217-1733756400-1733761800@www.biomed.cas.cz
SUMMARY:19th BioCEV-Krč Methodological Seminar
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/19th-biocev-krc-methodological-seminar/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241204T150000
DTEND;TZID=Europe/Prague:20241204T160000
DTSTAMP:20260426T135233
CREATED:20241126T132009Z
LAST-MODIFIED:20241126T132009Z
UID:2263-1733324400-1733328000@www.biomed.cas.cz
SUMMARY:Seminář Marie Zelená\, M.Sc.
DESCRIPTION:“Every stick has two ends – Using high resolution imaging to characterize both ends of the eukaryotic flagellum” \nThe eukaryotic flagellum is important for cell motility. The microtubule-based axoneme generating the flagellar beating has been extensively studied. However\, additional structures are associated with the proximal and distal end of the flagellum\, with their composition and processes of their formation being poorly understood. \nTo gain an insigth into these structures we have studied them in the protozoan parasite Trypanosoma brucei\, which is experimentally highly tractable. First\, we focused on the flagellar pocket around the proximal end of the flagellum\, which is the exclusive site for endocytosis and exocytosis of the parasite. Using expansion microscopy we were able to define discrete stages of the flagellar pocket division and formation of the flagellar pocket collar\, which seals the pocket. Second\, we took advantage of our knowledge of the flagellum distal-end proteome and combined it with expansion microscopy and cryo-electron tomography to characterize the enigmatic microtubule plugs at the distal end of the flagellum. \nOur work elucidates aspects of the flagellar biology of an important parasite. Moreover\, given the conserved nature of the organelle\, our results have also implications for flagella across eukaryotes.
URL:https://www.biomed.cas.cz/event/seminar-marie-zelena-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20241203
DTEND;VALUE=DATE:20241206
DTSTAMP:20260426T135233
CREATED:20241101T112749Z
LAST-MODIFIED:20241101T112841Z
UID:2242-1733184000-1733443199@www.biomed.cas.cz
SUMMARY:Live Cell Imaging Course 2024
DESCRIPTION:The course is very practically-oriented\, theoretical lectures are followed by 6 hours of hands-on session every day in small groups. You will learn widefield\, confocal\, and advanced methods including super-resolution\, photomanipulation\, and FLIM. You will have a chance to work on high-end microscopes and compare wide variety of approaches and instrumentation. \nFor detailed program and overview of taught methods and microscopes please check course webpage: https://course.img.cas.cz/lci/ \nLooking forward to seeing you! \nJan Valečka and Helena Chmelová
URL:https://www.biomed.cas.cz/event/live-cell-imaging-course-2024/
LOCATION:IMG
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241127T150000
DTEND;TZID=Europe/Prague:20241127T160000
DTSTAMP:20260426T135233
CREATED:20241118T123730Z
LAST-MODIFIED:20241118T123730Z
UID:2260-1732719600-1732723200@www.biomed.cas.cz
SUMMARY:Seminář Michaela Procházková\, M.Sc.
DESCRIPTION:“CRL4COP1 ubiquitination complex as a balancer of early odontogenesis” \nCullin-RING ubiquitin ligase (CRL) complexes have been heavily studied in connection to cancer progression but there is limited evidence about their physiological roles. One of the exceptions is disruption of limb development by thalidomide induced by inhibition of CRL4 complex via regulation of Fgf8 (Ito et al.\, 2010). Notably\, Fgf8 expressing population is essential also for development of tooth primordia and we found CRL4 genes to be specifically expressed within odontognic epithelium. We further identified COP1 as a substrate binding protein which can bind ETS transcription factors\, downstream targets of Fgf pathway\, and unveiled that conditional deletion of CRL4 genes severly affects size and morphology of molar primordia and future teeth.
URL:https://www.biomed.cas.cz/event/seminar-michaela-prochazkova-m-sc/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241127T080000
DTEND;TZID=Europe/Prague:20241129T170000
DTSTAMP:20260426T135233
CREATED:20240917T090109Z
LAST-MODIFIED:20241014T102557Z
UID:2148-1732694400-1732899600@www.biomed.cas.cz
SUMMARY:IEM CAS Introduction to Programming for Image Processing 2024
DESCRIPTION:Due to reaching capacity for in-person participation\, registration is now only available for online attendance. Thank you for your understanding.  \nBasic information\nThe course is tailored to users already familiar with the basics of image processing. It will be focused on automatization\, high throughput and basic scripting. Course participants will learn how to create and edit macros in ImageJ and how to write more sophisticated scripts for batch processing. Furthermore\, they will learn the basics of image processing in Matlab and Cellpose. \nDuration: 3 days \nLanguage: English \nProgramme\nLocation: Turquoise Auditorium \nSpeakers: Barbora Hyklová\, Štěpán Kortus\, Iva Švecová\, Jakub Zahumenský \nDay 1 / Wednesday / 27. 11. 2024\n\nIntroduction\, macro recording and editing in ImageJ\nWriting a complex macro for batch processing – automatic data import\, cell segmentation\, measurements\, export in organized format\n\nDay 2 / Thursday / 28. 11. 2024\n\nScript automation\, ImageJ customization\nCell segmentation using Cellpose and integration of Cellpose into the workflow\nDemonstration of a complex ImageJ/Cellpose workflow\n\nDay 3 / Friday / 29.11. 2024\n\nOptional: Discussion of individual projects and data analysis questions. \n\nRequirements\nPrior Experience with ImageJ: Participants should have a basic familiarity with ImageJ and its fundamental features. They should be comfortable with tasks like image import\, basic processing (e.g.\, brightness/contrast adjustments)\, and measurements.  \nOwn laptop: Participants are required to bring their own laptop for hands-on exercises. If you do not have access to a laptop\, please inform us in advance\, and we will provide you with one. Prior to the event\, you will receive a list of required software programs to install for the course. \n\n\n\n\n\n\n\n\n\n\nRegistration\nRegistration here: free of charge \n  \n\n\n 
URL:https://www.biomed.cas.cz/event/introduction-to-programming-for-image-processing-2024-preliminary-date/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241126T100000
DTEND;TZID=Europe/Prague:20241126T173000
DTSTAMP:20260426T135233
CREATED:20241115T065915Z
LAST-MODIFIED:20241115T070057Z
UID:2256-1732615200-1732642200@www.biomed.cas.cz
SUMMARY:IEM CAS - BIOCEV Regeneration IV
DESCRIPTION:We are pleased to announce the annual mini-symposium BIOCEV Regeneration IV\, which will be held on November 26th\, 2024\, in BIOCEV Centre\, Vestec. \nBIOCEV Regeneration is an annual open one-day mini-symposium that brings together researchers from different fields of biomedicine\, from regenerative medicine and tissue engineering to cancer research\, drug discovery\, and cryobiology. \nThis year\, the BIOCEV Regeneration IV will focus on the exciting field of cryobiology and cryobanking and highlight its important role in state-of-the-art biomedical research. The mini-symposium is endorsed by the international Society for Low Temperature Biology (SLTB) and will bring together keynote speakers and young researchers from different biomedical disciplines\, employing low temperatures in their research and development. This year we will focus on two major directions of cryobiology: cryotechnologies in clinically-oriented research (ATMP production\, cell and tissue banking for therapy and diagnostics) and biodiversity preservation and regeneration. \nThe mini-symposium will be held in the main conference hall and surrounding spaces of the BIOCEV and broadcast online. \nAlong with several lectures given by our invited speakers\, we encourage early career researchers to contribute to our symposium and share achievements in stem cell research\, tissue engineering\, 3D culture\, cancer research or cryobiology during the poster session. \nThe event is free of charge. More information can be found in the official invitation. \nWe look forward to seeing you. \n  \nRegistration
URL:https://www.biomed.cas.cz/event/iem-cas-biocev-regeneration-iv/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241125T150000
DTEND;TZID=Europe/Prague:20241125T160000
DTSTAMP:20260426T135233
CREATED:20241021T122910Z
LAST-MODIFIED:20241021T122910Z
UID:2215-1732546800-1732550400@www.biomed.cas.cz
SUMMARY:18th BioCEV-Krč Methodological Seminar
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/18th-biocev-krc-methodological-seminar/
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241121T110000
DTEND;TZID=Europe/Prague:20241121T120000
DTSTAMP:20260426T135233
CREATED:20241111T071221Z
LAST-MODIFIED:20241111T071221Z
UID:2253-1732186800-1732190400@www.biomed.cas.cz
SUMMARY:Seminář Matthias G. Fischer
DESCRIPTION:Max Planck Institute for Medical Research\, Heidelberg \n“Viruses of unicellular eukaryotes: A tale of giants and hyperparasites” \nViruses of protists play important roles in ecology and evolution by influencing microbial population dynamics and shaping eukaryotic genomes by endogenization. Of particular interest are complex DNA viruses whose particle and genome sizes overlap with those of bacteria. In this talk\, I will highlight some remarkable properties of these giant viruses and explore their relationship with smaller DNA viruses\, called virophages\, which can parasitize giant viruses and thus act as an antiviral defense system in certain protist species.
URL:https://www.biomed.cas.cz/event/seminar-matthias-g-fischer/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241120T150000
DTEND;TZID=Europe/Prague:20241120T160000
DTSTAMP:20260426T135233
CREATED:20241104T072502Z
LAST-MODIFIED:20241120T070615Z
UID:2249-1732114800-1732118400@www.biomed.cas.cz
SUMMARY:Seminář doc. Mgr. Lumír Krejčí\, Ph.D. - ZRUŠENO
DESCRIPTION:“Homologous Recombination – From Repair of DSBs to Processing Stalled Replication Forks and Human Diseases” \nOur lab focuses on the mechanisms ensuring accurate DNA replication and the role of homologous recombination (HR) in preventing genome instability. We investigate how endogenous hard-to-replicate regions\, G-quadruplexes (G4) and R-loops\, impact replication and contribute to disease development. A key aspect involves studying the formation and regulation of RAD51 filaments during HR. We explore how positive regulators like BRCA2 and RAD51 paralogs promote filament assembly and its stability\, while negative regulators like RECQ5 and RECQ4 helicase help balance replication stress and genome stability.
URL:https://www.biomed.cas.cz/event/seminar-doc-mgr-lumir-krejci-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241119T090000
DTEND;TZID=Europe/Prague:20241119T140000
DTSTAMP:20260426T135233
CREATED:20241101T113131Z
LAST-MODIFIED:20241101T113131Z
UID:2245-1732006800-1732024800@www.biomed.cas.cz
SUMMARY:Den otevřených dveří
DESCRIPTION:Prohlídka laboratoří\, ukázky experimentů v oblasti molekulární genetiky\, imunologie\, buněčné biologie\, virologie\, prohlídka posterů a diskuse k vybraným tématům.
URL:https://www.biomed.cas.cz/event/den-otevrenych-dveri/
LOCATION:IMG
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241118T160000
DTEND;TZID=Europe/Prague:20241118T170000
DTSTAMP:20260426T135233
CREATED:20241021T122808Z
LAST-MODIFIED:20241021T122808Z
UID:2213-1731945600-1731949200@www.biomed.cas.cz
SUMMARY:Lecture „The role of cornichons in the biogenesis and functioning of monovalent-cation transport systems“
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/lecture-the-role-of-cornichons-in-the-biogenesis-and-functioning-of-monovalent-cation-transport-systems/
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241113T150000
DTEND;TZID=Europe/Prague:20241113T160000
DTSTAMP:20260426T135233
CREATED:20241104T072334Z
LAST-MODIFIED:20241104T072334Z
UID:2247-1731510000-1731513600@www.biomed.cas.cz
SUMMARY:Seminář Aleš Neuwirth\, Ph.D.
DESCRIPTION:“Unravelling autoimmunity in Addison’s disease using a new mouse model” \nAutoimmune Addison’s disease is a disorder targeting steroid-producing cells in the adrenal glands. Due to the lack of suitable animal models\, the immune mechanisms underlying adrenal destruction remain largely unknown. To address this\, we developed the first defined mouse model of experimental autoimmune adrenalitis by immunizing C57BL/6 mice with immunogenic peptides derived from CYP11A1\, a rate-limiting enzyme in steroidogenesis. This model allows us to study the pathogenesis of Addison’s disease and provides a unique opportunity to investigate the fate decisions of self-reactive CD4+ T cells and their clonal lineages in a well-defined autoimmune setting.
URL:https://www.biomed.cas.cz/event/seminar-ales-neuwirth-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241111T150000
DTEND;TZID=Europe/Prague:20241111T160000
DTSTAMP:20260426T135233
CREATED:20241021T122639Z
LAST-MODIFIED:20241021T122639Z
UID:2211-1731337200-1731340800@www.biomed.cas.cz
SUMMARY:Lecture „Tissue-specific sex-dependent difference in the metabolism of fatty acid esters of hydroxy fatty acids“
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/lecture-tissue-specific-sex-dependent-difference-in-the-metabolism-of-fatty-acid-esters-of-hydroxy-fatty-acids/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
ORGANIZER;CN="FGU":MAILTO:Olga.Zimmermannova@fgu.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241107T140000
DTEND;TZID=Europe/Prague:20241107T150000
DTSTAMP:20260426T135233
CREATED:20241014T093123Z
LAST-MODIFIED:20241101T163717Z
UID:2177-1730988000-1730991600@www.biomed.cas.cz
SUMMARY:IEM CAS Institutional Seminar Series 11/2024
DESCRIPTION:Conserved mechanism of Xrn1 regulation by glycolytic flux and protein aggregation\nLecturer: Satyendra Mondal\, MSc. / Department of Functional Organisation of Biomembranes \nAnnotation: The regulation of eukaryotic gene expression via mRNA degradation is an evolutionarily conserved process\, with the 5′-3′ exoribonuclease 1 (Xrn1) playing a pivotal role. In yeast\, following the depletion of fermentable carbon source\, Xrn1 is sequestered at the plasma membrane-associated protein complex\, the eisosome\, where it becomes inactive. In this study\, we show that the plasma membrane localisation of Xrn1 requires the core eisosome components and identify a putative eisosome-binding domain of Xrn1. Our findings demonstrate that the eisosome binding of Xrn1 is subject to the halting of ongoing glycolytic flux rather than the availability of fermentable carbon sources. Furthermore\, we show that the localisation of the human orthologue of Xrn1 resembles that of its yeast counterpart when expressed in yeast. Our results advance our understanding of the plasma membrane-associated regulation of Xrn1 and indicate that the regulation principle may be evolutionarily conserved from yeast to humans. \nThe seminar will take place on 7. 11. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS. \nWe look forward to your participation.
URL:https://www.biomed.cas.cz/event/iem-cas-institutional-seminar-series-11-2024/
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20241107
DTEND;VALUE=DATE:20241108
DTSTAMP:20260426T135233
CREATED:20241021T122515Z
LAST-MODIFIED:20241021T122515Z
UID:2209-1730937600-1731023999@www.biomed.cas.cz
SUMMARY:Den otevřených dveří - FGÚ
DESCRIPTION:
URL:https://www.biomed.cas.cz/event/den-otevrenych-dveri-fgu-2/
LOCATION:Kinosal\, Vídeňská 1083\, Praha
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20241104
DTEND;VALUE=DATE:20241108
DTSTAMP:20260426T135233
CREATED:20241018T065127Z
LAST-MODIFIED:20241101T113003Z
UID:2201-1730678400-1731023999@www.biomed.cas.cz
SUMMARY:3-day course on Single cell analysis - from qPCR to sequencing
DESCRIPTION:This course will provide valuable insights and practical skills in the rapidly evolving field of single cell analyses and spatial transcriptomics. With a maximum of 10 participants\, you’ll receive personalized attention and the opportunity to engage deeply with the subject. \nIf you’re interested in joining us\, please respond via email to sindelka@ibt.cas.cz as soon as possible\, as space is limited. \nWe look forward to an enriching experience together!
URL:https://www.biomed.cas.cz/event/3-day-course-on-single-cell-analysis-from-qpcr-to-sequencing/
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241030T150000
DTEND;TZID=Europe/Prague:20241030T160000
DTSTAMP:20260426T135233
CREATED:20241016T094609Z
LAST-MODIFIED:20241030T074419Z
UID:2198-1730300400-1730304000@www.biomed.cas.cz
SUMMARY:Seminář Martina Zíková\, Ph.D. - ZRUŠENO
DESCRIPTION:“Impact of Medulloblastoma-Derived Extracellular Vesicles on Neural Stem/Progenitor Cells” \nMedulloblastoma is the most common malignant brain tumor in children. Recent advances in understanding its genetic and molecular heterogeneity have uncovered at least four distinct subgroups\, each characterized by unique transcriptional profiles\, DNA alterations and clinical outcomes. Extracellular vesicle secretion has emerged as a critical mediator of communication within the tumor microenvironment. In this presentation\, we will discuss our progress in deciphering the effects of extracellular vesicles derived and purified from medulloblastoma cells on neural stem/progenitor cell gene expressions.
URL:https://www.biomed.cas.cz/event/seminar-martina-zikova-ph-d/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241023T150000
DTEND;TZID=Europe/Prague:20241023T160000
DTSTAMP:20260426T135233
CREATED:20241016T085332Z
LAST-MODIFIED:20241016T085332Z
UID:2196-1729695600-1729699200@www.biomed.cas.cz
SUMMARY:Seminář Prof. Dr. Daniel Sauter
DESCRIPTION:“Viral Influencers: How endogenous retroviruses regulate innate immunity and senescence” \nThe human genome harbors a significant number of endogenous retroviral elements\, remnants of ancient viral integration events. While often referred to as “genomic fossils“ and “dark matter of the genome” many of these elements function as promoters or enhancers for cellular genes. This presentation will show how a specific subset of endogenous retroviruses is activated during infection\, orchestrating the expression of genes involved antiviral immunity and cell cycle regulation.
URL:https://www.biomed.cas.cz/event/seminar-prof-dr-daniel-sauter/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
ORGANIZER;CN="%C3%9AMG":MAILTO:leona.krausova@img.cas.cz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Prague:20241022T103000
DTEND;TZID=Europe/Prague:20241022T113000
DTSTAMP:20260426T135233
CREATED:20241014T061308Z
LAST-MODIFIED:20241014T061308Z
UID:2174-1729593000-1729596600@www.biomed.cas.cz
SUMMARY:Představení kandidáta na předsedu AV ČR - prof. RNDr. Libor Grubhoffer\, CSc.\, dr. h. c. mult.
DESCRIPTION:Dne 24. 3. 2025 skončí druhé čtyřleté období ve funkci předsedkyně AV ČR prof. RNDr. Evě Zažímalové\, CSc. Volba kandidátky/kandidáta na předsedu AV ČR pro následné funkční období proběhne na zasedání sněmu AV ČR dne 10. 12. 2024.\n \nJedním z kandidátů na předsedu AV ČR je prof. RNDr. Libor Grubhoffer\, CSc.\, dr. h. c. mult.\, který představí zaměstnancům krčského kampusu svou vizi o řízení AV ČR na jednání v úterý 22. 10. 2024 od 10:30 hod. v posluchárně Milana Haška na ÚMG.
URL:https://www.biomed.cas.cz/event/predstaveni-kandidata-na-predsedu-av-cr-prof-rndr-libor-grubhoffer-csc-dr-h-c-mult/
LOCATION:Posluchárna Milana Haška / Milan Hašek Auditorium
END:VEVENT
END:VCALENDAR