Effect of Indomethacin and Deendothelisation on
Vascular Responses in the Renal Artery
V. Kristová, M. Kriška, R. Vojtko, A. Kurtanský1
Department of Pharmacology and 1Department
of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic
Received July 30, 1999
Accepted September 21, 1999
Summary
Vasodilator prostaglandins (PGE2, PGI2) play an important role in
the regulation of renal blood flow. Hence, inhibition of their production with nonsteroidal anti-inflammatory drugs increases renal vascular resistance and exerts
adverse renal effects. It has been reported that besides endothelium-derived prostaglandin
products, nitric oxide (NO) may be mainly involved in regulation of renal functions. The
aim of our study was to evaluate the effect of cyclooxygenase inhibition with indomethacin
and endothelium removal on vascular responses of the renal artery as a model vessel.
Isolated segments of rabbit renal arteries were perfused at constant flow. Indomethacin
administration (10-5mol.l-1) significantly increased the responses
to single doses (0.1, 1, 10 m g) of noradrenaline (NA) as compared with the controls. In indomethacin-pretreated vessels, subsequent deendothelisation by air bubbles enhanced the
constrictor responses to NA. In reversed order, when deendothelisation was followed by indomethacin administration, the responses to NA were similar in character. A comparison
of renal artery responses to NA in both experimental situations did not reveal any
significant differences. It can be supposed that endothelial and non-endothelial factors
may be involved in local regulation of renal vascular tone.
Key words
Renal artery · Vasoconstrictor responses · Indomethacin · Deendothelisation
Reprint requests
V. Kristová, M.D., Ph.D., Department of Pharmacology, Faculty of Medicine, Comenius
University, Sasinkova 4, 813 72 Bratislava, Slovak Republic, e-mail: farmakologia@fmed.uniba.sk.
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