Postoperative Residual Paralysis and Respiratory Status: Comparative
Study of Pancuronium and Vecuronium
U. Bissinger, F. Schimek1, G. Lenz2
Department of Anesthesiology, Faculty of Medicine, University of Tübingen,
Germany
1 Department of Physiology, Third Faculty of Medicine, Charles
University, Prague, Czech Republic and 2Institute of Anesthesiology and Intensive Care
Medicine, Ingolstadt, Germany
Received November 2, 1999
Accepted March 13, 2000
Summary
The objective of this prospective double-blind study was to
determine whether postoperative residual paralysis (PORP) after pancuronium or
vecuronium results in hypoxemia and hypercapnia in the immediate admission
period to the recovery ward. Eighty-three consecutive surgical patients received
balanced or intravenous anesthesia with pancuronium for operations lasting
longer than one hour or vecuronium for those lasting less than 60 min, both
combined with neostigmine at the end of anesthesia. Standard clinical criteria
assessed neuromuscular function intraoperatively. Postoperatively, we determined
neuromuscular function (acceleromyography with supramaximal train-of-four (TOF)
stimulation of the ulnar nerve, and a 5-s head lift) and pulmonary function
(pulse oximetry: SpO2, and blood gas analysis: SaO2, PaCO2).
We defined PORP as a TOF-ratio 70 %, hypoxemia as a postoperative SpO2
³ 5 % below the pre-anesthestic level together
with a postoperative SaO293 %, and hypercapnia as a PaCO2
³ 46 mm Hg. Among the 49 pancuronium and 27 vecuronium patients studied, the PORP rates were 20 % in the pancuronium group
and 7 % in the vecuronium group (p>0.05). Hypoxemia and hypercapnia occurred
more often in pancuronium patients with PORP than in those without PORP namely
60 % vs. 10% (p<0.05) and 30 % vs. 8 % (p>0.05), respectively. We conclude
that PORP after pancuronium is a significant risk factor for hypoxemia.
Key words
Postoperative residual paralysis · Pancuronium · Vecuronium ·
Neuromuscular function · Pulse oximetry ·
Arterial blood gas analysis · Pulmonary function ·
Hypoxemia · Hypercapnia
Reprint requests
Dr. U. Bissinger, Klinik für Anästhesiologie und
Transfusionsmedizin, Abteilung Anästhesiologie, Universität Tübingen, Hoppe-Seyler-Str.
3, D-72076 Tübingen, Germany Fax: 0049 (0)7071-29 5533.
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