Recovery of Peripheral Blood Cells in Irradiated Mice Pretreated With Bacterial Extract IRS-19

N.O. MACKOVÁ, P. FEDOROČKO

Department of Cellular and Molecular Biology, Faculty of Science, Šafárik University, Košice, Slovak Republic

Received October 18, 1999
Accepted January 21, 2000

Summary
The effect of antigenic bacterial lysate IRS-19 on the recovery of blood cells was studied in mice injured by a single dose of 7 Gy irradiation. The preirradiation administration of IRS-19 accelerated the recovery of leukocytes, reticulocytes and platelets in peripheral blood. The recovery of leukocytes 9-14 days after irradiation in protected animals was accompanied by a higher level of band forms of granulocytes as well as activated lymphoid and monocytoid cells.

Key words
IRS-19 · Irradiation · Hematopoiesis · Radioprotection

Reprint requests
Dr. N.O. Macková, Department of Cellular and Molecular Biology, Faculty of Sciences, P.J. Šafárik University, Moyzesova 11, 041 67 Košice, Slovak Republic. fax: ++421 95 6222124, e-mail: fedvox@kosice.upjs.sk