Serum Leptin
Levels in Patients with Sideropenic and
Pernicious Anemia: The Influence of Anemia
Treatment
M.
MARKOVÁ , M. HALUZÍK1, J. SVOBODOVÁ1, M. ROSICKÁ1,
J. NEDVÍDKOVÁ2, T. HAAS1
Institute
of Hematology and Blood Transfusion, 1Third
Department of Medicine, First Faculty of
Medicine, Charles University and 2Institute
of Endocrinology, Prague, Czech Republic
Received January 10, 2000
Accepted March 10, 2000
Summary
Leptin
is a 16 kDa protein hormone involved in food
intake, energy expenditure regulation and
numerous other physiological processes. Recently, leptin has been demonstrated to stimulate hematopoietic stem cells in vitro. The aim of our
study was to measure serum leptin and
erythropoietin levels in patients with sideropenic (n =18) and pernicious anemia (n=7)
before and during anemia treatment. Blood samples
for the blood count, leptin and erythropoietin
determinations were obtained by venepunction at
the time of the diagnosis of anemia and after
partial and complete anemia recovery. The
relationships of serum leptin levels to
erythropoietin levels and blood count parameters
were also studied. No significant differences in
serum leptin levels between the groups studied
were found. The serum leptin levels in none of
groups were modified by treatment of anemia
(basal levels, the levels during treatment and
after anemia recovery were 13.1±14.5 vs 12.8±15.6
vs 12.0±14.8 ng/ml in patients with sideropenic
anemia and 7.8±8.5 vs 9.5±10.0 vs 8.9±6.6
ng/ml in patients with pernicious anemia). The
erythropoietin levels were higher at the time of
anemia in both groups and decreased significantly
after partial or complete recovery. Serum leptin
levels in both groups correlated positively with
the body mass index. No significant relationships
were found between serum leptin levels and
erythropoietin values or various parameters of
the peripheral blood count. We conclude that
serum leptin levels in patients with sideropenic
and pernicious anemia positively correlate with
the body mass index but are not influenced by the
treatment of anemia.
Key words
Leptin
· Hematopoiesis · Anemia · Body mass index ·
Blood count · Stem cells
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requests
M.Haluzík, M.D., Ph.D., Third Department of
Medicine, First Faculty of Medicine, Charles
University, U nemocnice 1, Praha 2, 128 08, Czech
Republic, e-mail:MHALU@LF1.CUNI.CZ
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