Volume 50: 43-50, 2001

 

The Association Study of DRD2, ACE and AGT Gene Polymorphisms and Metamphetamine Dependence

O. ŠERÝ1, V. VOJTOVÁ2, P. ZVOLSKÝ3

1Department of Comparative Animal Physiology and General Zoology, Masaryk University, Faculty of Science, Brno, 2Association Podané ruce, Brno and 3Department of Psychiatry, Charles University, First Medical Faculty, Prague, Czech Republic


Received November 1, 1999
Accepted April 4, 2000


Summary
We investigated the association between metamphetamine dependence and TaqI A polymorphism of the dopamine receptor D2 gene (DRD2), I/D polymorphism in angiotensin-converting enzyme (ACE) and M235T polymorphism of the angiotensinogen gene (AGT) in 93 unrelated metamphetamine-dependent subjects and 131 controls. Our results did not prove any association of TaqI A polymorphism of the DRD2 gene, I/D polymorphism of ACE gene, and M235T polymorphism of AGT gene with the metamphetamine dependence in Caucasians of Czech origin. However, a significant difference in allele I frequency between male and female control groups for the I/D ACE polymorphism (p<0.03) was found.


Key words
TaqI A polymorphism · DRD2 · ACE · M235T · Angiotensinogen · Metamphetamine dependence

Reprint requests
Omar Šerý, PhD, Department of Comparative Animal Physiology and General Zoology, Masaryk University, Faculty of Science, 611 37 Brno, Czech Republic, e-mail: omarsery@sci.muni.cz

 

PHYSIOLOGICAL RESEARCH
© 2001 by the Institute of Physiology, Czech Academy of Sciences

ISSN 0862 - 8408

Issue 1