The Association
Study of DRD2, ACE and AGT Gene Polymorphisms and
Metamphetamine Dependence
O.
ŠERÝ1, V. VOJTOVÁ2, P.
ZVOLSKÝ3
1Department
of Comparative Animal Physiology and General
Zoology, Masaryk University, Faculty of Science,
Brno, 2Association
Podané ruce, Brno and 3Department
of Psychiatry, Charles University, First Medical
Faculty, Prague, Czech Republic
Received November 1, 1999
Accepted April 4, 2000
Summary
We
investigated the association between
metamphetamine dependence and TaqI A polymorphism
of the dopamine receptor D2 gene (DRD2), I/D
polymorphism in angiotensin-converting enzyme
(ACE) and M235T polymorphism of the
angiotensinogen gene (AGT) in 93 unrelated
metamphetamine-dependent subjects and 131
controls. Our results did not prove any
association of TaqI A polymorphism of the DRD2
gene, I/D polymorphism of ACE gene, and M235T
polymorphism of AGT gene with the metamphetamine
dependence in Caucasians of Czech origin.
However, a significant difference in allele I
frequency between male and female control groups
for the I/D ACE polymorphism (p<0.03) was
found.
Key
words
TaqI
A polymorphism · DRD2 · ACE · M235T ·
Angiotensinogen · Metamphetamine dependence
Reprint
requests
Omar
Šerý, PhD, Department of Comparative Animal
Physiology and General Zoology, Masaryk
University, Faculty of Science, 611 37 Brno,
Czech Republic, e-mail: omarsery@sci.muni.cz
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