Twenty-Four
Hour Blood Pressure Profile in Subjects with
Different Subtypes of Primary Aldosteronism
T.
ZELINKA, J. WIDIMSKÝ
Third
Medical Department, First Medical School of
Charles University, Prague, Czech RepublicReceived April
6, 2000
Accepted June 22, 2000
Summary
The
aim of our study was to evaluate the potential
differences in blood pressure (BP) profile in
subjects with different forms of primary
aldosteronism (PA). Simultaneously, we studied
the effects of PA treatment on BP curve. We
therefore monitored 24-hour ambulatory blood
pressure values in 22 subjects with
aldosterone-producing adenoma (APA), 22 subjects
with idiopathic hyperaldosteronism (IHA) and 33
subjects with essential hypertension (EH) as
controls. We found a significantly attenuated
nighttime systolic BP decline in the APA group
(P=0.02). Patients with IHA had lower nighttime
systolic BP values (P=0.01) and also a diastolic
BP decline (P=0.02) during the night in
comparison with EH. We did not detect any
significant differences in BP profile
characteristics between APA and IHA. Specific
treatment of primary aldosteronism
(adrenalectomy, treatment with spironolactone)
led to the normalization of the BP curve with a
marked BP decline. Our study thus demonstrates a
blunted diurnal BP variability in patients with
primary aldosteronism the specific treatment of
which normalized previously attenuated nocturnal
BP fall.
Key
words
Ambulatory
blood pressure monitoring · Primary
aldosteronism · Circadian blood pressure
variability
Reprint
requests
Dr.
T. Zelinka, Third Medical Department, First
Faculty of Medicine, Charles University, U
nemocnice 1, 128 08 Prague 2, Czech Republic,
e-mail: tzeli@lf1.cuni.cz
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