SHORT
COMMUNICATION
Activation
of Mitochondrial Glycerophosphate Cytochrome c
Reductase in Regenerating Rat Liver by
Triiodothyronine
H.
LOTKOVÁ, H. RAUCHOVÁ1, Z. DRAHOTA1
Department
of Physiology, Faculty of Medicine, Charles
University, Hradec Králové and 1Center for
Experimental Cardiovascular Research, Institute
of Physiology, Academy of Sciences of the Czech
Republic, Prague, Czech Republic
Received
August 8, 2000
Accepted October 17, 2000
Summary
Triiodothyronine
administration before partial hepatectomy
increased the activity of mitochondrial
glycerophosphate cytochrome c reductase. The
enzyme activity was further activated after
partial hepatectomy during the regenerative
process. Our findings showed that: a) the
increase of glycerophosphate cytochrome c
reductase induced by triiodothyronine was further
potentiated by the regeneration process, b) the
high activity of the glycerophosphate shuttle was
maintained after partial hepatectomy during the
period, when most of the liver tissue had again
been recovered.
Key
words
Liver
regeneration · Triiodothyronine · Mitochondria
· Glycerophosphate cytochrome c reductase ·
Cytochrome c oxidase
Reprint
requests
RNDr. Zdeněk Drahota, Institute of Physiology,
Academy of Sciences of the Czech Republic,
Vídeňská 1083, 14220 Prague-4, Czech Republic,
e-mail: drahota@biomed.cas.cz
|
