| Influence of
b-Resorcylidene Aminoguanidine on Selected
Metabolic Parameters and Antioxidant Status of
Rats with Diabetes Mellitus
A.
LIPTÁKOVÁ, J. ČÁRSKY, O. ULIČNÁ1,
O. VANČOVÁ1, P. BOŽEK2,
Z. ĎURAČKOVÁ
Institute
of Medical Chemistry, Biochemistry and Clinical
Biochemistry and 1Pharmacobiochemical
Laboratory of the Third Internal Clinic, Faculty
of Medicine, Comenius University, 2Department
of Clinical Biochemistry and Hematology, State
Hospital, Bratislava, Slovak republic
Received June 14, 2001
Accepted September 27, 2001
Summary
We studied the effects of administration
of b-resorcylidene aminoguanidine (RAG) to Wistar
strain rats with experimental diabetes mellitus
(DM) induced by streptozotocin. The effects
studied included antioxidant levels in plasma and
the liver, oxidative damage of lipids represented
by the formation of substances reacting with
thiobarbituric acid (TBARP) and selected
biochemical indicators. The administration of RAG
did not significantly affect antioxidant status
of diabetic rats or hemoglobin glycation and
plasma concentration of fructosamine. In diabetic
rats, application of RAG decreased formation of
TBARP in plasma but not in the liver. Moderate
steatosis of liver and increased plasma levels of
triacylglycerols in diabetic rats were
significantly improved by application of RAG.
.
Key
words
Diabetes
mellitus · b-resorcylidene aminoguanidine ·
Lipid peroxidation · Antioxidants
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Ing. A. Liptáková, CSc., Department of Medical
Chemistry, Biochemistry and Clinical
Biochemistry, Faculty of Medicine, Comenius
University, Sasinkova 2, 813 72 Bratislava,
Slovak Republic, e-mail: durackova@fmed.uniba.sk
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