Physiol. Res. 51: 587-590, 2002

 

Insulin-Like Growth Factor Binding Protein-3 in Patients with Liver Cirrhosis

K. ŠÍDLOVÁ, M. PECHOVÁ, K. KOTAŠKA, R. PRŮŠA

Department of Clinical Biochemistry and Pathobiochemistry, Second Medical Faculty, Charles University and Faculty Hospital Motol, Prague, Czech Republic
 

Received August 18, 2001
Accepted March 22, 2002


Summary
Aim of the study was to evaluate serum levels of insulin-like growth factor binding protein-3 in patients with liver cirrhosis and to compare serum IGFBP-3 levels with other liver function tests. Fifty-one patients with liver cirrhosis were selected for our study. We measured IGFBP-3 (1.67±1.06 mg/l, mean ± SD), albumin (32±8 g/l), prealbumin (0.22±0.14 g/l), AST (2.29±2.38 mkat/l), ALT (2.11±4.83 mkat/l) and cholinesterase (mean 78.6±45.2 mkat/l) in the serum. There was a significant positive correlation of serum IGFBP-3 with serum albumin and serum cholinesterase. The correlation coefficient was much lower between serum IGFBP-3 and serum prealbumin. There was no significant correlation between serum AST, ALT and IGFBP-3. Serum IGFBP-3 proves to be a better marker for the hepatic synthetic capacity than serum albumin or cholinesterase.


Key words
Liver cirrhosis · GFBP-3 · Liver tests


Reprint requests
K. Šídlová, M.D., Department of Clinical Biochemistry and Pathobiochemistry, Second Faculty of Medicine, Charles University and Faculty Hospital Motol, V úvalu 84, 150 06 Prague 5, Czech Republic. Fax: +420 2 24435320, E-mail: katerina.sidlova@email.cz


PHYSIOLOGICAL RESEARCH
© 2002 by the Institute of Physiology, Czech Academy of Sciences

ISSN 0862 - 8408

Issue 6