Changes in Acute Phase Proteins after Anti-Tumor
Necrosis Factor Antibody (Infliximab) Treatment in Patients with
Crohn´s Disease
V. KUPČOVÁ1, L. TURECKÝ2, Z. DETKOVÁ1,
M. PRÍKAZSKÁ3, A. KELEOVÁ3
1Third Department of Internal Medicine, Dérer´s
Hospital, Medical Faculty of Comenius University, 2Institute
of Chemistry, Biochemistry and Clinical Biochemistry,
Medical Faculty of Comenius University, and 3Institute of
Preventive and Clinical Medicine, Bratislava, Slovak
Republic
Received
February 26, 2002
Accepted July 2, 2002
Summary
Acute phase proteins and markers of proteosynthetic activity
reflect the clinical activity in Crohn´s disease (CD). The
impact of anti-tumor necrosis factor antibody (anti-TNF) therapy
on serum levels of acute phase proteins and proteosynthetic
markers was studied. Fourteen patients with active CD were
treated with 5 mg per kg of anti-TNF in intravenous infusion.
Clinical activity (assessed by Crohn´s disease activity index –
CDAI), α-1-acid glycoprotein, haptoglobin, cholinesterase and
prealbumin were assessed before and in months 1 and 5 after
treatment. A sustained decrease in CDAI was observed. This was
accompanied by a significant decrease in α-1-acid glycoprotein
and haptoglobin in month 1 (p=0.005 and p=0.01, respectively)
while in month 5 the levels of both acute phase proteins rose
significantly (p=0.003 for α-1-acid glycoprotein and p=0.02 for
haptoglobin). Cholinesterase and prealbumin significantly
increased in month 1 after the treatment (p=0.02 and p=0.0006,
respectively), the increase was sustained in cholinesterase
while prealbumin levels diminished in month 5. We conclude that
the clinical improvement after anti-TNF therapy for CD is
accompanied by changes of acute phase proteins and
proteosynthetic markers. The assessment of these laboratory
markers may be useful in the management of CD patients treated
with anti-TNF.
Key
words
Crohn´s disease • Anti-tumor necrosis factor antibody • Acute
phase proteins • Cholinesterase • Prealbumin
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requests
Doc. Dr. Kupčová Viera, CSc., Department of Internal Medicine,
Dérer´s Hospital, Medical Faculty of Comenius University,
Limbova 5, 833 05 Bratislava, Slovak Republic, e-mail:
kupcova@cent.sk
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