Different Patterns of Serum Interleukin 10 Response to
Treatment with Anti-Tumor Necrosis Factor α Antibody (Infliximab)
in Crohn´s Disease
Z. DETKOVÁ1, V.
KUPČOVÁ1, M. PRÍKAZSKÁ2, L. TURECKÝ3,
S. WEISSOVÁ2, E. JAHNOVÁ2
1Department of Internal Medicine, Dérer´s
Hospital, Medical Faculty of Comenius University,
2Institute of Preventive and Clinical Medicine,
and 3Institute of Chemistry, Biochemistry and Clinical
Biochemistry, Medical Faculty of Comenius University,
Bratislava, Slovak Republic
Received February 26, 2002
Accepted August 29, 2002
Summary
Administration of anti-tumor necrosis factor antibody (anti-TNF,
infliximab) down-regulates T helper 1 (Th 1) cytokines
production in intestinal mucosa of patients with Crohn´s disease
(CD). Interleukin 10 (IL-10) is thought to be involved in CD
pathogenesis through regulation of the Th 1 response. The aim of
this study was to determine the IL-10 response in CD patients
treated with anti-TNF. Fourteen patients with active CD received
5 mg/kg of infliximab; clinical activity assessed by Crohn´s
Disease Activity Index (CDAI), α1-acid glycoprotein and serum
IL-10 were determined before and after treatment, in month 0, 1
and 5. In the group with a good clinical response, IL-10 levels
diminished significantly in month 1 (p<0.05) and remained
decreased in month 5. The group with a lower response showed a
significant increase in IL-10 levels in month 1 (p<0.05).
α1-acid glycoprotein levels obtained before treatment were
significantly elevated in the group with a good clinical
response (p<0.05) and a significant decrease in month 1 was
observed in this group (p<0.05). These observations suggest that
a pattern of IL-10 response might be related to the clinical
response to anti-TNF treatment in CD.
Key
words
Crohn´s disease • Anti-tumor necrosis factor therapy •
Interleukin 10 • α1-acid glycoprotein
Reprint
requests
Dr. Zuzana
Detková, Department of Internal Medicine, Dérer´s Hospital,
Medical Faculty of Comenius University, Limbova 5, 833 05
Bratislava, Slovak Republic, e-mail:
zdetkova@yahoo.co.uk
|