Soluble Leptin Receptor Levels in Patients with Chronic
Renal Failure
J. KŘÍŽOVÁ1, S.
SULKOVÁ2, V. BEDNÁŘOVÁ2, J. PAŘÍZKOVÁ1,
E. KOTRLÍKOVÁ1, M. HALUZÍK1
1Third Department of Medicine and 2Department
of Internal Medicine Strahov, First Medical Faculty,
Charles University, Prague, Czech Republic
Received
March 25, 2002
Accepted June 25, 2002
Summary
Soluble leptin
receptor (SLR) is the extracellular part of the leptin receptor.
This protein is released into circulation and constitutes the
main circulating leptin-binding protein. The aim of our study
was to measure SLR concentrations in patients with chronic renal
failure (CRF) and healthy subjects and to explore the
relationship of SLR to other hormones and cytokines. The
patients with CRF had significantly higher serum leptin, TNF-a
and insulin levels than healthy subjects (25.1±23.5
vs. 9.4±7.6
ng.ml-1 (S.D.); 14.2±4.2
vs. 4.55±2.5
ng.ml-1; 39.8±36.1
vs. 20.3±11.1
mU.l-1). Serum soluble leptin receptor levels did not
differ between these groups (19.1±11.3
vs. 19.6±6.1
U.ml-1). An inverse relationship between serum SLR
and leptin levels was found in both groups. In patients with CRF
the inverse relationship between SLR and insulin, body fat
content and total protein levels were also found, while in
healthy subjects only inverse relationship of SLR with insulin
and albumin concentrations were detected. We conclude that
soluble leptin receptor levels in patients with chronic renal
failure do not differ from those of healthy subjects despite
higher serum leptin levels in CRF patients. The physiological
consequences of this finding require further investigation.
Key
words
Soluble leptin receptor • Leptin • Anorexia • Chronic
renal failure
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requests
Jarmila Křížová, MD, Third Medical Department, First Faculty of
Medicine, Charles University, U nemocnice 1, 120 00 Prague 2,
Czech Republic, e-mail:
jsvob@email.cz
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