RAPID COMMUNICATION

Action of GABA-B Antagonist on Cortical Epileptic Afterdischarges in Rats is Similar to that of GABA-A Antagonist

D. ŽIVANOVIĆ^1,2, K. BERNÁŠKOVÁ^1,3, YU. KAMINSKIJ¹, P. MAREŠ<sup>1

1</sup>Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
²Institute of Physiology, Medical School, Belgrade, Yugoslavia, ³Charles University, Third Faculty of Medicine, Department of Normal, Pathological, and Clinical Physiology, Prague, Czech Republic

Received July 2, 2003
Accepted July 25, 2003

Summary
Threshold intensities for epileptic phenomena induced by cortical stimulation were used for comparison of the action of GABA-B and GABA-A antagonists in rats with implanted electrodes. Both CGP 35348 (200 mg/kg i.p.) and bicuculline (4 mg/kg i.p.) significantly decreased thresholds for spike-and-wave afterdischarges and their motor counterpart (clonic seizures) whilst transition into the second, limbic type of afterdischarge as well as threshold for movements directly bound to stimulation remained uninfluenced by either drug.

Key words
Epileptic seizures • Cerebral cortex • Rat • CGP 35348 • Bicuculline

Reprint requests
Prof. P. Mareš, M.D., D.Sc., Institute of Physiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, 142 20 Prague 4, Czech Republic, e-mail: maresp@biomed.cas.cz