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Short-Term Dynamics of
Coherence between Respiratory Movements, Heart Rate, and
Arterial Pressure Fluctuations in Severe Acute Brain Disorders
U. ZWIENER1, CH.
SCHELENZ2, S. BRAMER1, D. HOYER1
1Institute of Pathophysiology and 2Clinic
of Anesthesiology and Intensive Care, Friedrich-Schiller
University, Jena, Germany
Received August 26, 2002
Accepted November 14, 2002
Summary
In our previous study, healthy volunteers showed considerable
short-term dynamics and patterns of the coherence of high time
resolution between respiratory movements (RESP), heart rate
fluctuations (HRF), and arterial blood pressure fluctuations (BPF).
These are physiological indicators of autonomic short-term
coordination mediated mainly by the brainstem which could be
impaired in severe brain disorders. We hypothesized a direct or
indirect impairment of these functions by these disorders and
examined these patterns in 16 patients suffering from severe
brain disorders. We calculated partial and ordinary coherence
sequences and found almost the same patterns of coherence
sequences as in healthy volunteers, but a distinctly reduced
frequency of pattern incidence in patients (2.8*1.5/10
min/patient and 9.5*2.8/10 min/subject, P<0.05). Furthermore,
there is a significantly smaller frequency of HRF-related
patterns in patients with poor outcome, compared with those in
patients with good outcome (1.8*0.8/10 min/patient and
4.5*2.7/10 min/patient, P<0.05). We conclude that severe brain
disorders reduce physiological short-term dynamics of autonomic
coordination patterns in the mean values of patients, but not in
every patient.
Key words
Autonomic short-term coordination • Coherence sequence • High
time resolution • Heart rate fluctuations • Arterial pressure
fluctuations • Severe brain disorders
Reprint requests
Prof. Dr. Ulrich Zwiener,
Institut für Pathophysiologie, Klinikum der Friedrich-Schiller-Universität,
Nonnenplan 2, D-07740 Jena, Germany, e-mail:
uzwi@mti-n.uni-jena.de
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