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Effects of Short-Period
Exercise Training and Orlistat Therapy on Body Composition and
Maximal Power Production Capacity in Obese Patients
R. COLAK1, O. OZCELIK2
1Department of Endocrinology and Metabolism,
2Department of Physiology, Firat University Faculty of Medicine,
Elazig, Turkey
Received February 6, 2002
Accepted February 25, 2003
Summary
We examined the effects
of weight loss induced by diet-orlistat (DO) and diet-orlistat combined with
exercise (DOE) on maximal work rate production (Wmax) capacity in
obese patients. Total of 24 obese patients were involved in this study. Twelve
of them were subjected to DO therapy only and the remaining 12 patients
participated in a regular aerobic exercise-training program in addition to DO
therapy (DOE). Each patient performed two incremental ramp exercise tests up to
exhaustion using an electromagnetically-braked cycle ergometer: one at the onset
and one at the end of the 4th week. DOE therapy caused a significant decrease in
total body weight: 101.5±17.4
kg (basal) vs 96.3±17.3
kg (4 wk) associated with a significant decrease in body fat mass: 45.0±10.5
kg (basal) vs 40.9±9.8
kg (4 wk). DO therapy also resulted in a significant decrease of total body
weight 94.9±14.9
kg (basal) vs 91.6±13.5
kg (4 wk) associated with small but significant decreases in body fat mass: 37.7±5.6
kg (basal) to 36.0±6.2
kg (4 wk). Weight reduction achieved during DO therapy was not associated with
increased Wmax capacity: 106±32
W (basal) vs 106±33
W (4 wk), while DOE therapy resulted in a markedly increased Wmax
capacity: 109±39
W (basal) vs 138±30
W (4 wk). DO therapy combined with aerobic exercise training resulted in a
significant reduction of fat mass tissue and markedly improved the aerobic
fitness and Wmax capacities of obese patients. Considering this
improvement within such a short period, physicians should consider applying an
aerobic exercise-training program to sedentary obese patients for improving
their physical fitness and thereby reduce the negative outcomes of obesity.
Key words
Obesity • Body mass index • Aerobic exercise intensity
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